The effects of body mass index on complications and survival outcomes in patients with cervical carcinoma undergoing curative chemoradiation therapy.
Identifieur interne : 002871 ( PubMed/Corpus ); précédent : 002870; suivant : 002872The effects of body mass index on complications and survival outcomes in patients with cervical carcinoma undergoing curative chemoradiation therapy.
Auteurs : Nora T. Kizer ; Premal H. Thaker ; Feng Gao ; Israel Zighelboim ; Matthew A. Powell ; Janet S. Rader ; David G. Mutch ; Perry W. GrigsbySource :
- Cancer [ 0008-543X ] ; 2011.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols (adverse effects), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Body Mass Index, Carcinoma, Squamous Cell (complications), Carcinoma, Squamous Cell (mortality), Carcinoma, Squamous Cell (therapy), Combined Modality Therapy, Female, Follow-Up Studies, Humans, Middle Aged, Obesity (complications), Obesity (mortality), Radiotherapy (adverse effects), Radiotherapy (methods), Remission Induction, Survival Analysis, Treatment Outcome, Uterine Cervical Neoplasms (complications), Uterine Cervical Neoplasms (mortality), Uterine Cervical Neoplasms (therapy), Young Adult.
- MESH :
- adverse effects : Antineoplastic Combined Chemotherapy Protocols, Radiotherapy.
- complications : Carcinoma, Squamous Cell, Obesity, Uterine Cervical Neoplasms.
- methods : Radiotherapy.
- mortality : Carcinoma, Squamous Cell, Obesity, Uterine Cervical Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- therapy : Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- Adult, Aged, Aged, 80 and over, Body Mass Index, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Middle Aged, Remission Induction, Survival Analysis, Treatment Outcome, Young Adult.
Abstract
The effect of body mass index (BMI) on treatment outcomes for patients with locally advanced cervical carcinoma who receive definitive chemoradiation is unclear.
DOI: 10.1002/cncr.25544
PubMed: 20945318
Links to Exploration step
pubmed:20945318Le document en format XML
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Thaker</name></author><author><name sortKey="Gao, Feng" sort="Gao, Feng" uniqKey="Gao F" first="Feng" last="Gao">Feng Gao</name></author><author><name sortKey="Zighelboim, Israel" sort="Zighelboim, Israel" uniqKey="Zighelboim I" first="Israel" last="Zighelboim">Israel Zighelboim</name></author><author><name sortKey="Powell, Matthew A" sort="Powell, Matthew A" uniqKey="Powell M" first="Matthew A" last="Powell">Matthew A. Powell</name></author><author><name sortKey="Rader, Janet S" sort="Rader, Janet S" uniqKey="Rader J" first="Janet S" last="Rader">Janet S. Rader</name></author><author><name sortKey="Mutch, David G" sort="Mutch, David G" uniqKey="Mutch D" first="David G" last="Mutch">David G. Mutch</name></author><author><name sortKey="Grigsby, Perry W" sort="Grigsby, Perry W" uniqKey="Grigsby P" first="Perry W" last="Grigsby">Perry W. Grigsby</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:20945318</idno><idno type="pmid">20945318</idno><idno type="doi">10.1002/cncr.25544</idno><idno type="wicri:Area/PubMed/Corpus">002871</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002871</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effects of body mass index on complications and survival outcomes in patients with cervical carcinoma undergoing curative chemoradiation therapy.</title><author><name sortKey="Kizer, Nora T" sort="Kizer, Nora T" uniqKey="Kizer N" first="Nora T" last="Kizer">Nora T. Kizer</name><affiliation><nlm:affiliation>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Thaker, Premal H" sort="Thaker, Premal H" uniqKey="Thaker P" first="Premal H" last="Thaker">Premal H. Thaker</name></author><author><name sortKey="Gao, Feng" sort="Gao, Feng" uniqKey="Gao F" first="Feng" last="Gao">Feng Gao</name></author><author><name sortKey="Zighelboim, Israel" sort="Zighelboim, Israel" uniqKey="Zighelboim I" first="Israel" last="Zighelboim">Israel Zighelboim</name></author><author><name sortKey="Powell, Matthew A" sort="Powell, Matthew A" uniqKey="Powell M" first="Matthew A" last="Powell">Matthew A. Powell</name></author><author><name sortKey="Rader, Janet S" sort="Rader, Janet S" uniqKey="Rader J" first="Janet S" last="Rader">Janet S. Rader</name></author><author><name sortKey="Mutch, David G" sort="Mutch, David G" uniqKey="Mutch D" first="David G" last="Mutch">David G. Mutch</name></author><author><name sortKey="Grigsby, Perry W" sort="Grigsby, Perry W" uniqKey="Grigsby P" first="Perry W" last="Grigsby">Perry W. Grigsby</name></author></analytic><series><title level="j">Cancer</title><idno type="ISSN">0008-543X</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antineoplastic Combined Chemotherapy Protocols (adverse effects)</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Body Mass Index</term><term>Carcinoma, Squamous Cell (complications)</term><term>Carcinoma, Squamous Cell (mortality)</term><term>Carcinoma, Squamous Cell (therapy)</term><term>Combined Modality Therapy</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Middle Aged</term><term>Obesity (complications)</term><term>Obesity (mortality)</term><term>Radiotherapy (adverse effects)</term><term>Radiotherapy (methods)</term><term>Remission Induction</term><term>Survival Analysis</term><term>Treatment Outcome</term><term>Uterine Cervical Neoplasms (complications)</term><term>Uterine Cervical Neoplasms (mortality)</term><term>Uterine Cervical Neoplasms (therapy)</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term><term>Radiotherapy</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Obesity</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Radiotherapy</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Obesity</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Body Mass Index</term><term>Combined Modality Therapy</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Middle Aged</term><term>Remission Induction</term><term>Survival Analysis</term><term>Treatment Outcome</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of body mass index (BMI) on treatment outcomes for patients with locally advanced cervical carcinoma who receive definitive chemoradiation is unclear.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20945318</PMID><DateCreated><Year>2011</Year><Month>02</Month><Day>25</Day></DateCreated><DateCompleted><Year>2011</Year><Month>05</Month><Day>12</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0008-543X</ISSN><JournalIssue CitedMedium="Print"><Volume>117</Volume><Issue>5</Issue><PubDate><Year>2011</Year><Month>Mar</Month><Day>01</Day></PubDate></JournalIssue><Title>Cancer</Title><ISOAbbreviation>Cancer</ISOAbbreviation></Journal><ArticleTitle>The effects of body mass index on complications and survival outcomes in patients with cervical carcinoma undergoing curative chemoradiation therapy.</ArticleTitle><Pagination><MedlinePgn>948-56</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/cncr.25544</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The effect of body mass index (BMI) on treatment outcomes for patients with locally advanced cervical carcinoma who receive definitive chemoradiation is unclear.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The cohort in this study included all patients with cervical carcinoma (n = 404) who had stage IB(1) disease and positive lymph nodes or stage ≥IB(2) disease and received treatment at the authors' facility between January 1998 and January 2008. The mean follow-up was 47.2 months. BMI was calculated using the National Institute of Health online calculator. BMI categories were created according to the World Health Organization classification system. Primary outcomes were overall survival, disease-free survival, and complication rate. Univariate and multivariate analyses were performed. Kaplan-Meier survival curves were generated and compared using Cox proportional hazard models.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">On multivariate analysis, compared with normal weight (BMI 18.5-24.9 kg/m(2) ), a BMI <18.5 kg/m(2) was associated with decreased overall survival (hazard ratio, 2.37; 95% confidence interval, 1.28-4.38; P < .01). The 5-year overall survival rate was 33%, 60%, and 68% for a of BMI <18.5 kg/m(2) , a BMI from 18.5 kg/m(2) to 24.9 kg/m(2) , and a BMI >24.9 kg/m(2) , respectively. A BMI <18.5 kg/m(2) was associated with increased risk of grade 3 or 4 complications compared with a BMI >24.9 kg/m(2) (radiation enteritis: 16.7% vs 13.6%, respectively; P = .03; fistula: 11.1% vs 8.8%, respectively; P = .05; bowel obstruction: 33.3% vs 4.4%, respectively; P < .001; lymphedema: 5.6% vs 1.2%, respectively; P = .02).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Underweight patients (BMI <18.5 kg/m(2) ) with locally advanced cervical cancer had diminished overall survival and more complications than normal weight and obese patients.</AbstractText><CopyrightInformation>Copyright © 2010 American Cancer Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kizer</LastName><ForeName>Nora T</ForeName><Initials>NT</Initials><AffiliationInfo><Affiliation>Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thaker</LastName><ForeName>Premal H</ForeName><Initials>PH</Initials></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Feng</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Zighelboim</LastName><ForeName>Israel</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Powell</LastName><ForeName>Matthew A</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Rader</LastName><ForeName>Janet S</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Mutch</LastName><ForeName>David G</ForeName><Initials>DG</Initials></Author><Author ValidYN="Y"><LastName>Grigsby</LastName><ForeName>Perry W</ForeName><Initials>PW</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>T32 HD055172</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 HD055172-03</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR000448</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D023362">Evaluation Studies</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>10</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer</MedlineTA><NlmUniqueID>0374236</NlmUniqueID><ISSNLinking>0008-543X</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Obesity (Silver Spring). 2009 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Version="1">20010519</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000971" MajorTopicYN="N">Antineoplastic Combined Chemotherapy Protocols</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015992" MajorTopicYN="Y">Body Mass Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002294" MajorTopicYN="N">Carcinoma, Squamous Cell</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009765" MajorTopicYN="N">Obesity</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011878" MajorTopicYN="Y">Radiotherapy</DescriptorName><QualifierName UI="Q000009" 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