Mechanisms of lymphatic regeneration after tissue transfer.
Identifieur interne : 002732 ( PubMed/Corpus ); précédent : 002731; suivant : 002733Mechanisms of lymphatic regeneration after tissue transfer.
Auteurs : Alan Yan ; Tomer Avraham ; Jamie C. Zampell ; Seth Z. Aschen ; Babak J. MehraraSource :
- PloS one [ 1932-6203 ] ; 2011.
English descriptors
- KwdEn :
- Animals, Dermis (anatomy & histology), Dermis (physiology), Female, Glycoproteins (genetics), Lymphatic System (physiology), Lymphatic Vessels (diagnostic imaging), Lymphatic Vessels (transplantation), Lymphedema (pathology), Lymphedema (rehabilitation), Lymphedema (surgery), Lymphography, Mice, Mice, Knockout, Mice, Nude, Micromanipulation (methods), Organ Size, Regeneration (physiology), Skin Transplantation, Tail (cytology), Tail (diagnostic imaging), Tail (physiology), Tail (surgery).
- MESH :
- chemical , genetics : Glycoproteins.
- anatomy & histology : Dermis.
- cytology : Tail.
- diagnostic imaging : Lymphatic Vessels, Tail.
- methods : Micromanipulation.
- pathology : Lymphedema.
- physiology : Dermis, Lymphatic System, Regeneration, Tail.
- rehabilitation : Lymphedema.
- surgery : Lymphedema, Tail.
- transplantation : Lymphatic Vessels.
- Animals, Female, Lymphography, Mice, Mice, Knockout, Mice, Nude, Organ Size, Skin Transplantation.
Abstract
Lymphedema is the chronic swelling of an extremity that occurs commonly after lymph node resection for cancer treatment. Recent studies have demonstrated that transfer of healthy tissues can be used as a means of bypassing damaged lymphatics and ameliorating lymphedema. The purpose of these studies was to investigate the mechanisms that regulate lymphatic regeneration after tissue transfer.
DOI: 10.1371/journal.pone.0017201
PubMed: 21359148
Links to Exploration step
pubmed:21359148Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mechanisms of lymphatic regeneration after tissue transfer.</title><author><name sortKey="Yan, Alan" sort="Yan, Alan" uniqKey="Yan A" first="Alan" last="Yan">Alan Yan</name><affiliation><nlm:affiliation>The Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Avraham, Tomer" sort="Avraham, Tomer" uniqKey="Avraham T" first="Tomer" last="Avraham">Tomer Avraham</name></author><author><name sortKey="Zampell, Jamie C" sort="Zampell, Jamie C" uniqKey="Zampell J" first="Jamie C" last="Zampell">Jamie C. Zampell</name></author><author><name sortKey="Aschen, Seth Z" sort="Aschen, Seth Z" uniqKey="Aschen S" first="Seth Z" last="Aschen">Seth Z. Aschen</name></author><author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J" last="Mehrara">Babak J. Mehrara</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21359148</idno><idno type="pmid">21359148</idno><idno type="doi">10.1371/journal.pone.0017201</idno><idno type="wicri:Area/PubMed/Corpus">002732</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002732</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Mechanisms of lymphatic regeneration after tissue transfer.</title><author><name sortKey="Yan, Alan" sort="Yan, Alan" uniqKey="Yan A" first="Alan" last="Yan">Alan Yan</name><affiliation><nlm:affiliation>The Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Avraham, Tomer" sort="Avraham, Tomer" uniqKey="Avraham T" first="Tomer" last="Avraham">Tomer Avraham</name></author><author><name sortKey="Zampell, Jamie C" sort="Zampell, Jamie C" uniqKey="Zampell J" first="Jamie C" last="Zampell">Jamie C. Zampell</name></author><author><name sortKey="Aschen, Seth Z" sort="Aschen, Seth Z" uniqKey="Aschen S" first="Seth Z" last="Aschen">Seth Z. Aschen</name></author><author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J" last="Mehrara">Babak J. Mehrara</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Dermis (anatomy & histology)</term><term>Dermis (physiology)</term><term>Female</term><term>Glycoproteins (genetics)</term><term>Lymphatic System (physiology)</term><term>Lymphatic Vessels (diagnostic imaging)</term><term>Lymphatic Vessels (transplantation)</term><term>Lymphedema (pathology)</term><term>Lymphedema (rehabilitation)</term><term>Lymphedema (surgery)</term><term>Lymphography</term><term>Mice</term><term>Mice, Knockout</term><term>Mice, Nude</term><term>Micromanipulation (methods)</term><term>Organ Size</term><term>Regeneration (physiology)</term><term>Skin Transplantation</term><term>Tail (cytology)</term><term>Tail (diagnostic imaging)</term><term>Tail (physiology)</term><term>Tail (surgery)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glycoproteins</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Dermis</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Tail</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lymphatic Vessels</term><term>Tail</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Micromanipulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dermis</term><term>Lymphatic System</term><term>Regeneration</term><term>Tail</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Lymphedema</term><term>Tail</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Lymphography</term><term>Mice</term><term>Mice, Knockout</term><term>Mice, Nude</term><term>Organ Size</term><term>Skin Transplantation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphedema is the chronic swelling of an extremity that occurs commonly after lymph node resection for cancer treatment. Recent studies have demonstrated that transfer of healthy tissues can be used as a means of bypassing damaged lymphatics and ameliorating lymphedema. The purpose of these studies was to investigate the mechanisms that regulate lymphatic regeneration after tissue transfer.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21359148</PMID><DateCreated><Year>2011</Year><Month>03</Month><Day>01</Day></DateCreated><DateCompleted><Year>2011</Year><Month>09</Month><Day>01</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>2</Issue><PubDate><Year>2011</Year><Month>Feb</Month><Day>17</Day></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Mechanisms of lymphatic regeneration after tissue transfer.</ArticleTitle><Pagination><MedlinePgn>e17201</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0017201</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Lymphedema is the chronic swelling of an extremity that occurs commonly after lymph node resection for cancer treatment. Recent studies have demonstrated that transfer of healthy tissues can be used as a means of bypassing damaged lymphatics and ameliorating lymphedema. The purpose of these studies was to investigate the mechanisms that regulate lymphatic regeneration after tissue transfer.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Nude mice (recipients) underwent 2-mm tail skin excisions that were either left open or repaired with full-thickness skin grafts harvested from donor transgenic mice that expressed green fluorescent protein in all tissues or from LYVE-1 knockout mice. Lymphatic regeneration, expression of VEGF-C, macrophage infiltration, and potential for skin grafting to bypass damaged lymphatics were assessed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Skin grafts healed rapidly and restored lymphatic flow. Lymphatic regeneration occurred beginning at the peripheral edges of the graft, primarily from ingrowth of new lymphatic vessels originating from the recipient mouse. In addition, donor lymphatic vessels appeared to spontaneously re-anastomose with recipient vessels. Patterns of VEGF-C expression and macrophage infiltration were temporally and spatially associated with lymphatic regeneration. When compared to mice treated with excision only, there was a 4-fold decrease in tail volumes, 2.5-fold increase in lymphatic transport by lymphoscintigraphy, 40% decrease in dermal thickness, and 54% decrease in scar index in skin-grafted animals, indicating that tissue transfer could bypass damaged lymphatics and promote rapid lymphatic regeneration.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our studies suggest that lymphatic regeneration after tissue transfer occurs by ingrowth of lymphatic vessels and spontaneous re-connection of existing lymphatics. This process is temporally and spatially associated with VEGF-C expression and macrophage infiltration. Finally, tissue transfer can be used to bypass damaged lymphatics and promote rapid lymphatic regeneration.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Alan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Avraham</LastName><ForeName>Tomer</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Zampell</LastName><ForeName>Jamie C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Aschen</LastName><ForeName>Seth Z</ForeName><Initials>SZ</Initials></Author><Author ValidYN="Y"><LastName>Mehrara</LastName><ForeName>Babak J</ForeName><Initials>BJ</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>T-32 CA0095001</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D023362">Evaluation Studies</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>02</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006023">Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C492273">Xlkd1 protein, mouse</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2008 Nov 10;26(32):5213-9</RefSource><PMID Version="1">18838709</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2008 Nov 10;26(32):5220-6</RefSource><PMID Version="1">18838708</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2176-83</RefSource><PMID Version="1">17189348</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Treat Options Cardiovasc Med. 2006 Apr;8(2):129-36</RefSource><PMID Version="1">16533487</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 2006 Sep;169(3):1080-7</RefSource><PMID Version="1">16936280</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol Heart Circ Physiol. 2006 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MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006023" MajorTopicYN="N">Glycoproteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000637" MajorTopicYN="Y">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000534" MajorTopicYN="N">rehabilitation</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008220" MajorTopicYN="N">Lymphography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008819" MajorTopicYN="N">Mice, Nude</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008846" MajorTopicYN="N">Micromanipulation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009929" MajorTopicYN="N">Organ Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012038" MajorTopicYN="N">Regeneration</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016038" MajorTopicYN="N">Skin Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013623" MajorTopicYN="N">Tail</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3040774</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>09</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>01</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>3</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>3</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>9</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21359148</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0017201</ArticleId><ArticleId IdType="pmc">PMC3040774</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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