LymphedemaV1, PubMed, Corpus, bibRecord, 002628

Lymphatic vascular morphogenesis in development, physiology, and disease.

Identifieur interne : 002628 ( PubMed/Corpus ); précédent : 002627; suivant : 002629

Lymphatic vascular morphogenesis in development, physiology, and disease.

Auteurs : Stefan Schulte-Merker ; Amélie Sabine ; Tatiana V. Petrova

Source :

The Journal of cell biology [ 1540-8140 ] ; 2011.

RBID : pubmed:21576390

English descriptors

KwdEn :
- Animals, Biological Transport, Gene Expression Regulation, Hematopoietic Stem Cells (metabolism), Homeostasis, Humans, Lymph (metabolism), Lymphangiogenesis (genetics), Lymphatic Vessels (embryology), Lymphatic Vessels (metabolism), Lymphatic Vessels (physiopathology), Lymphedema (genetics), Lymphedema (metabolism), Lymphedema (physiopathology), Morphogenesis.
MESH :
- embryology : Lymphatic Vessels.
- genetics : Lymphangiogenesis, Lymphedema.
- metabolism : Hematopoietic Stem Cells, Lymph, Lymphatic Vessels, Lymphedema.
- physiopathology : Lymphatic Vessels, Lymphedema.
- Animals, Biological Transport, Gene Expression Regulation, Homeostasis, Humans, Morphogenesis.

Abstract

The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases.

DOI: 10.1083/jcb.201012094
PubMed: 21576390

Links to Exploration step

pubmed:21576390

Le document en format XML

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<author><name sortKey="Schulte Merker, Stefan" sort="Schulte Merker, Stefan" uniqKey="Schulte Merker S" first="Stefan" last="Schulte-Merker">Stefan Schulte-Merker</name>
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<author><name sortKey="Sabine, Amelie" sort="Sabine, Amelie" uniqKey="Sabine A" first="Amélie" last="Sabine">Amélie Sabine</name>
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<author><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V" last="Petrova">Tatiana V. Petrova</name>
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<term>Homeostasis</term>
<term>Humans</term>
<term>Lymph (metabolism)</term>
<term>Lymphangiogenesis (genetics)</term>
<term>Lymphatic Vessels (embryology)</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Lymphatic Vessels (physiopathology)</term>
<term>Lymphedema (genetics)</term>
<term>Lymphedema (metabolism)</term>
<term>Lymphedema (physiopathology)</term>
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<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hematopoietic Stem Cells</term>
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<front><div type="abstract" xml:lang="en">The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases.</div>
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<Day>21</Day>
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<Month>02</Month>
<Day>04</Day>
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<Title>The Journal of cell biology</Title>
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<Abstract><AbstractText>The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases.</AbstractText>
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   |texte=   Lymphatic vascular morphogenesis in development, physiology, and disease.
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Lymphatic vascular morphogenesis in development, physiology, and disease.

Lymphatic vascular morphogenesis in development, physiology, and disease.

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