Experimental treatment of bilateral fetal chylothorax using in-utero pleurodesis.
Identifieur interne : 002625 ( PubMed/Corpus ); précédent : 002624; suivant : 002626Experimental treatment of bilateral fetal chylothorax using in-utero pleurodesis.
Auteurs : Y-S Yang ; G-C Ma ; J-C Shih ; C-P Chen ; C-H Chou ; K-T Yeh ; S-J Kuo ; T-H Chen ; W-L Hwu ; T-H Lee ; M. ChenSource :
- Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology [ 1469-0705 ] ; 2012.
English descriptors
- KwdEn :
- Amniocentesis, Chylothorax (diagnostic imaging), Chylothorax (genetics), Chylothorax (mortality), Chylothorax (therapy), Female, Fetal Diseases (diagnostic imaging), Fetal Diseases (genetics), Fetal Diseases (mortality), Fetal Diseases (therapy), Humans, Hydrops Fetalis (diagnostic imaging), Hydrops Fetalis (genetics), Hydrops Fetalis (mortality), Hydrops Fetalis (therapy), Karyotyping, Picibanil (administration & dosage), Pleural Effusion (diagnostic imaging), Pleural Effusion (genetics), Pleural Effusion (mortality), Pleural Effusion (therapy), Pleurodesis (methods), Pregnancy, Prognosis, Survival Rate, Taiwan (epidemiology), Ultrasonography, Prenatal.
- MESH :
- chemical , administration & dosage : Picibanil.
- diagnostic imaging : Chylothorax, Fetal Diseases, Hydrops Fetalis, Pleural Effusion.
- epidemiology : Taiwan.
- genetics : Chylothorax, Fetal Diseases, Hydrops Fetalis, Pleural Effusion.
- methods : Pleurodesis.
- mortality : Chylothorax, Fetal Diseases, Hydrops Fetalis, Pleural Effusion.
- therapy : Chylothorax, Fetal Diseases, Hydrops Fetalis, Pleural Effusion.
- Amniocentesis, Female, Humans, Karyotyping, Pregnancy, Prognosis, Survival Rate, Ultrasonography, Prenatal.
Abstract
To assess the use and efficacy of in-utero pleurodesis for experimental treatment of bilateral fetal chylothorax.
DOI: 10.1002/uog.9048
PubMed: 21584887
Links to Exploration step
pubmed:21584887Le document en format XML
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<author><name sortKey="Yang, Y S" sort="Yang, Y S" uniqKey="Yang Y" first="Y-S" last="Yang">Y-S Yang</name>
<affiliation><nlm:affiliation>Department of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Ma, G C" sort="Ma, G C" uniqKey="Ma G" first="G-C" last="Ma">G-C Ma</name>
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<author><name sortKey="Shih, J C" sort="Shih, J C" uniqKey="Shih J" first="J-C" last="Shih">J-C Shih</name>
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<author><name sortKey="Chen, C P" sort="Chen, C P" uniqKey="Chen C" first="C-P" last="Chen">C-P Chen</name>
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<author><name sortKey="Chou, C H" sort="Chou, C H" uniqKey="Chou C" first="C-H" last="Chou">C-H Chou</name>
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<author><name sortKey="Yeh, K T" sort="Yeh, K T" uniqKey="Yeh K" first="K-T" last="Yeh">K-T Yeh</name>
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<author><name sortKey="Kuo, S J" sort="Kuo, S J" uniqKey="Kuo S" first="S-J" last="Kuo">S-J Kuo</name>
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<author><name sortKey="Chen, T H" sort="Chen, T H" uniqKey="Chen T" first="T-H" last="Chen">T-H Chen</name>
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<author><name sortKey="Hwu, W L" sort="Hwu, W L" uniqKey="Hwu W" first="W-L" last="Hwu">W-L Hwu</name>
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<author><name sortKey="Lee, T H" sort="Lee, T H" uniqKey="Lee T" first="T-H" last="Lee">T-H Lee</name>
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<author><name sortKey="Chen, M" sort="Chen, M" uniqKey="Chen M" first="M" last="Chen">M. Chen</name>
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<affiliation><nlm:affiliation>Department of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan.</nlm:affiliation>
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<author><name sortKey="Ma, G C" sort="Ma, G C" uniqKey="Ma G" first="G-C" last="Ma">G-C Ma</name>
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<author><name sortKey="Shih, J C" sort="Shih, J C" uniqKey="Shih J" first="J-C" last="Shih">J-C Shih</name>
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<author><name sortKey="Yeh, K T" sort="Yeh, K T" uniqKey="Yeh K" first="K-T" last="Yeh">K-T Yeh</name>
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<author><name sortKey="Kuo, S J" sort="Kuo, S J" uniqKey="Kuo S" first="S-J" last="Kuo">S-J Kuo</name>
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<author><name sortKey="Chen, T H" sort="Chen, T H" uniqKey="Chen T" first="T-H" last="Chen">T-H Chen</name>
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<author><name sortKey="Hwu, W L" sort="Hwu, W L" uniqKey="Hwu W" first="W-L" last="Hwu">W-L Hwu</name>
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<author><name sortKey="Lee, T H" sort="Lee, T H" uniqKey="Lee T" first="T-H" last="Lee">T-H Lee</name>
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<author><name sortKey="Chen, M" sort="Chen, M" uniqKey="Chen M" first="M" last="Chen">M. Chen</name>
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<series><title level="j">Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology</title>
<idno type="eISSN">1469-0705</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amniocentesis</term>
<term>Chylothorax (diagnostic imaging)</term>
<term>Chylothorax (genetics)</term>
<term>Chylothorax (mortality)</term>
<term>Chylothorax (therapy)</term>
<term>Female</term>
<term>Fetal Diseases (diagnostic imaging)</term>
<term>Fetal Diseases (genetics)</term>
<term>Fetal Diseases (mortality)</term>
<term>Fetal Diseases (therapy)</term>
<term>Humans</term>
<term>Hydrops Fetalis (diagnostic imaging)</term>
<term>Hydrops Fetalis (genetics)</term>
<term>Hydrops Fetalis (mortality)</term>
<term>Hydrops Fetalis (therapy)</term>
<term>Karyotyping</term>
<term>Picibanil (administration & dosage)</term>
<term>Pleural Effusion (diagnostic imaging)</term>
<term>Pleural Effusion (genetics)</term>
<term>Pleural Effusion (mortality)</term>
<term>Pleural Effusion (therapy)</term>
<term>Pleurodesis (methods)</term>
<term>Pregnancy</term>
<term>Prognosis</term>
<term>Survival Rate</term>
<term>Taiwan (epidemiology)</term>
<term>Ultrasonography, Prenatal</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Picibanil</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Chylothorax</term>
<term>Fetal Diseases</term>
<term>Hydrops Fetalis</term>
<term>Pleural Effusion</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Taiwan</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chylothorax</term>
<term>Fetal Diseases</term>
<term>Hydrops Fetalis</term>
<term>Pleural Effusion</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Pleurodesis</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Chylothorax</term>
<term>Fetal Diseases</term>
<term>Hydrops Fetalis</term>
<term>Pleural Effusion</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Chylothorax</term>
<term>Fetal Diseases</term>
<term>Hydrops Fetalis</term>
<term>Pleural Effusion</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amniocentesis</term>
<term>Female</term>
<term>Humans</term>
<term>Karyotyping</term>
<term>Pregnancy</term>
<term>Prognosis</term>
<term>Survival Rate</term>
<term>Ultrasonography, Prenatal</term>
</keywords>
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<front><div type="abstract" xml:lang="en">To assess the use and efficacy of in-utero pleurodesis for experimental treatment of bilateral fetal chylothorax.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21584887</PMID>
<DateCreated><Year>2012</Year>
<Month>01</Month>
<Day>03</Day>
</DateCreated>
<DateCompleted><Year>2012</Year>
<Month>03</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>11</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-0705</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>39</Volume>
<Issue>1</Issue>
<PubDate><Year>2012</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology</Title>
<ISOAbbreviation>Ultrasound Obstet Gynecol</ISOAbbreviation>
</Journal>
<ArticleTitle>Experimental treatment of bilateral fetal chylothorax using in-utero pleurodesis.</ArticleTitle>
<Pagination><MedlinePgn>56-62</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/uog.9048</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To assess the use and efficacy of in-utero pleurodesis for experimental treatment of bilateral fetal chylothorax.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">This was a study of 78 fetuses with bilateral pleural effusion referred to three tertiary referral centers in Taiwan between 2005 and 2009. Fetuses were karyotyped following amniocentesis and the lymphocyte ratio in the pleural effusion was determined following thoracocentesis. Forty-nine (62.8%) fetuses had a normal karyotype and were recognized to have fetal chylothorax; of these, 45 underwent intrapleural injection of 0.1KE OK-432 per side per treatment. We evaluated clinical (hydrops vs. no hydrops) and genetic (mutations in the reported lymphedema-associated loci: VEGFR3, PTPN11, FOXC2, ITGA9) parameters, as well as treatment outcome. Long-term survival was defined as survival to 1 year of age.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The overall long-term survival rate (LSR) was 35.6% (16/45); the LSR for non-hydropic fetuses was 66.7% (12/18) and for hydropic fetuses it was 14.8% (4/27). If we included only fetuses with onset of the condition in the second trimester, excluding those with onset in the third trimester, the LSR decreased to 29.4% (10/34). Notably, 29.6% (8/27) of hydropic fetuses had mutations in three of the four loci examined.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">OK-432 pleurodesis appeared to be an experimental alternative to the gold-standard technique of thoracoamniotic shunting in non-hydropic fetal chylothorax. In hydropic fetuses, pleurodesis appeared less effective.</AbstractText>
<CopyrightInformation>Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Y-S</ForeName>
<Initials>YS</Initials>
<AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan.</Affiliation>
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<Author ValidYN="Y"><LastName>Ma</LastName>
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<Author ValidYN="Y"><LastName>Shih</LastName>
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<Author ValidYN="Y"><LastName>Chen</LastName>
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<Author ValidYN="Y"><LastName>Chou</LastName>
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<Author ValidYN="Y"><LastName>Yeh</LastName>
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<Author ValidYN="Y"><LastName>Kuo</LastName>
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<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>T-H</ForeName>
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<Author ValidYN="Y"><LastName>Hwu</LastName>
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<Initials>WL</Initials>
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<Author ValidYN="Y"><LastName>Lee</LastName>
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<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>M</ForeName>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
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<MedlineJournalInfo><Country>England</Country>
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<ChemicalList><Chemical><RegistryNumber>39325-01-4</RegistryNumber>
<NameOfSubstance UI="D010844">Picibanil</NameOfSubstance>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000649" MajorTopicYN="N">Amniocentesis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002916" MajorTopicYN="N">Chylothorax</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D005315" MajorTopicYN="N">Fetal Diseases</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015160" MajorTopicYN="N">Hydrops Fetalis</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
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<MeshHeading><DescriptorName UI="D007621" MajorTopicYN="N">Karyotyping</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010844" MajorTopicYN="N">Picibanil</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010996" MajorTopicYN="N">Pleural Effusion</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018700" MajorTopicYN="Y">Pleurodesis</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013624" MajorTopicYN="N">Taiwan</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016216" MajorTopicYN="Y">Ultrasonography, Prenatal</DescriptorName>
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