Lymphatic filariasis: a method to identify subclinical lower limb change in PNG adolescents.
Identifieur interne : 002500 ( PubMed/Corpus ); précédent : 002499; suivant : 002501Lymphatic filariasis: a method to identify subclinical lower limb change in PNG adolescents.
Auteurs : Susan Gordon ; Wayne Melrose ; Jeffrey Warner ; Petra Buttner ; Leigh WardSource :
- PLoS neglected tropical diseases [ 1935-2735 ] ; 2011.
English descriptors
- KwdEn :
- Adolescent, Child, Cohort Studies, Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (pathology), Elephantiasis, Filarial (physiopathology), Female, Humans, Leg (parasitology), Leg (pathology), Leg (physiopathology), Lymphedema (diagnosis), Lymphedema (pathology), Lymphedema (physiopathology), Male, Manometry, Papua New Guinea, ROC Curve, Range of Motion, Articular, Statistics, Nonparametric, Young Adult.
- MESH :
- geographic : Papua New Guinea.
- diagnosis : Elephantiasis, Filarial, Lymphedema.
- parasitology : Leg.
- pathology : Elephantiasis, Filarial, Leg, Lymphedema.
- physiopathology : Elephantiasis, Filarial, Leg, Lymphedema.
- Adolescent, Child, Cohort Studies, Female, Humans, Male, Manometry, ROC Curve, Range of Motion, Articular, Statistics, Nonparametric, Young Adult.
Abstract
Lymphedema related to lymphatic filariasis (LF) is a disabling condition that commonly manifests in adolescence. Fifty-three adolescents, 25 LF infected and 28 LF non-infected, in age and sex-matched groups, using the Binax ICT rapid card test for filarial antigen were recruited to the study. None of the participants had overt signs of lymphedema. Lymphedema assessment measures were used to assess lower limb tissue compressibility (tonometry), limb circumference (tape measure), intra- and extra-cellular fluid distribution (bioimpedance) and joint range of motion (goniometry). The mean tonometric measurements from the left, right, and dominant posterior thighs were significantly larger in participants with LF compared to participants who had tested negative for LF (p = 0.005, p = 0.004, and p = 0.003, respectively) indicating increased tissue compressibility in those adolescents with LF. ROC curve analysis to define optimal cut-off of the tonometry measurements indicated that at 3.5, sensitivity of this potential screening test is 100% (95%-CI = 86.3%, 100%) and specificity is 21.4% (95%-CI = 8.3%, 41.0%). It is proposed that this cut-off can be used to indicate tissue change characteristic of LF in an at-risk population of PNG adolescents. Further longitudinal research is required to establish if all those with tissue change subsequently develop lymphedema. However, thigh tonometry to identify early tissue change in LF positive adolescents may enable early intervention to minimize progression of lymphedema and prioritization of limited resources to those at greatest risk of developing lifetime morbidity.
DOI: 10.1371/journal.pntd.0001242
PubMed: 21811644
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphatic filariasis: a method to identify subclinical lower limb change in PNG adolescents.</title><author><name sortKey="Gordon, Susan" sort="Gordon, Susan" uniqKey="Gordon S" first="Susan" last="Gordon">Susan Gordon</name><affiliation><nlm:affiliation>School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Australia. susan.gordon2@jcu.edu.au</nlm:affiliation></affiliation></author><author><name sortKey="Melrose, Wayne" sort="Melrose, Wayne" uniqKey="Melrose W" first="Wayne" last="Melrose">Wayne Melrose</name></author><author><name sortKey="Warner, Jeffrey" sort="Warner, Jeffrey" uniqKey="Warner J" first="Jeffrey" last="Warner">Jeffrey Warner</name></author><author><name sortKey="Buttner, Petra" sort="Buttner, Petra" uniqKey="Buttner P" first="Petra" last="Buttner">Petra Buttner</name></author><author><name sortKey="Ward, Leigh" sort="Ward, Leigh" uniqKey="Ward L" first="Leigh" last="Ward">Leigh Ward</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21811644</idno><idno type="pmid">21811644</idno><idno type="doi">10.1371/journal.pntd.0001242</idno><idno type="wicri:Area/PubMed/Corpus">002500</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002500</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lymphatic filariasis: a method to identify subclinical lower limb change in PNG adolescents.</title><author><name sortKey="Gordon, Susan" sort="Gordon, Susan" uniqKey="Gordon S" first="Susan" last="Gordon">Susan Gordon</name><affiliation><nlm:affiliation>School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Australia. susan.gordon2@jcu.edu.au</nlm:affiliation></affiliation></author><author><name sortKey="Melrose, Wayne" sort="Melrose, Wayne" uniqKey="Melrose W" first="Wayne" last="Melrose">Wayne Melrose</name></author><author><name sortKey="Warner, Jeffrey" sort="Warner, Jeffrey" uniqKey="Warner J" first="Jeffrey" last="Warner">Jeffrey Warner</name></author><author><name sortKey="Buttner, Petra" sort="Buttner, Petra" uniqKey="Buttner P" first="Petra" last="Buttner">Petra Buttner</name></author><author><name sortKey="Ward, Leigh" sort="Ward, Leigh" uniqKey="Ward L" first="Leigh" last="Ward">Leigh Ward</name></author></analytic><series><title level="j">PLoS neglected tropical diseases</title><idno type="eISSN">1935-2735</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Cohort Studies</term><term>Elephantiasis, Filarial (diagnosis)</term><term>Elephantiasis, Filarial (pathology)</term><term>Elephantiasis, Filarial (physiopathology)</term><term>Female</term><term>Humans</term><term>Leg (parasitology)</term><term>Leg (pathology)</term><term>Leg (physiopathology)</term><term>Lymphedema (diagnosis)</term><term>Lymphedema (pathology)</term><term>Lymphedema (physiopathology)</term><term>Male</term><term>Manometry</term><term>Papua New Guinea</term><term>ROC Curve</term><term>Range of Motion, Articular</term><term>Statistics, Nonparametric</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Papua New Guinea</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Leg</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Leg</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Leg</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Manometry</term><term>ROC Curve</term><term>Range of Motion, Articular</term><term>Statistics, Nonparametric</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphedema related to lymphatic filariasis (LF) is a disabling condition that commonly manifests in adolescence. Fifty-three adolescents, 25 LF infected and 28 LF non-infected, in age and sex-matched groups, using the Binax ICT rapid card test for filarial antigen were recruited to the study. None of the participants had overt signs of lymphedema. Lymphedema assessment measures were used to assess lower limb tissue compressibility (tonometry), limb circumference (tape measure), intra- and extra-cellular fluid distribution (bioimpedance) and joint range of motion (goniometry). The mean tonometric measurements from the left, right, and dominant posterior thighs were significantly larger in participants with LF compared to participants who had tested negative for LF (p = 0.005, p = 0.004, and p = 0.003, respectively) indicating increased tissue compressibility in those adolescents with LF. ROC curve analysis to define optimal cut-off of the tonometry measurements indicated that at 3.5, sensitivity of this potential screening test is 100% (95%-CI = 86.3%, 100%) and specificity is 21.4% (95%-CI = 8.3%, 41.0%). It is proposed that this cut-off can be used to indicate tissue change characteristic of LF in an at-risk population of PNG adolescents. Further longitudinal research is required to establish if all those with tissue change subsequently develop lymphedema. However, thigh tonometry to identify early tissue change in LF positive adolescents may enable early intervention to minimize progression of lymphedema and prioritization of limited resources to those at greatest risk of developing lifetime morbidity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21811644</PMID><DateCreated><Year>2011</Year><Month>08</Month><Day>03</Day></DateCreated><DateCompleted><Year>2012</Year><Month>01</Month><Day>05</Day></DateCompleted><DateRevised><Year>2015</Year><Month>02</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1935-2735</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>7</Issue><PubDate><Year>2011</Year><Month>Jul</Month></PubDate></JournalIssue><Title>PLoS neglected tropical diseases</Title><ISOAbbreviation>PLoS Negl Trop Dis</ISOAbbreviation></Journal><ArticleTitle>Lymphatic filariasis: a method to identify subclinical lower limb change in PNG adolescents.</ArticleTitle><Pagination><MedlinePgn>e1242</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pntd.0001242</ELocationID><Abstract><AbstractText>Lymphedema related to lymphatic filariasis (LF) is a disabling condition that commonly manifests in adolescence. Fifty-three adolescents, 25 LF infected and 28 LF non-infected, in age and sex-matched groups, using the Binax ICT rapid card test for filarial antigen were recruited to the study. None of the participants had overt signs of lymphedema. Lymphedema assessment measures were used to assess lower limb tissue compressibility (tonometry), limb circumference (tape measure), intra- and extra-cellular fluid distribution (bioimpedance) and joint range of motion (goniometry). The mean tonometric measurements from the left, right, and dominant posterior thighs were significantly larger in participants with LF compared to participants who had tested negative for LF (p = 0.005, p = 0.004, and p = 0.003, respectively) indicating increased tissue compressibility in those adolescents with LF. ROC curve analysis to define optimal cut-off of the tonometry measurements indicated that at 3.5, sensitivity of this potential screening test is 100% (95%-CI = 86.3%, 100%) and specificity is 21.4% (95%-CI = 8.3%, 41.0%). It is proposed that this cut-off can be used to indicate tissue change characteristic of LF in an at-risk population of PNG adolescents. Further longitudinal research is required to establish if all those with tissue change subsequently develop lymphedema. However, thigh tonometry to identify early tissue change in LF positive adolescents may enable early intervention to minimize progression of lymphedema and prioritization of limited resources to those at greatest risk of developing lifetime morbidity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gordon</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville, Australia. susan.gordon2@jcu.edu.au</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melrose</LastName><ForeName>Wayne</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Warner</LastName><ForeName>Jeffrey</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Buttner</LastName><ForeName>Petra</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Ward</LastName><ForeName>Leigh</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>07</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS Negl Trop Dis</MedlineTA><NlmUniqueID>101291488</NlmUniqueID><ISSNLinking>1935-2727</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 1999 Nov-Dec;93(6):633-6</RefSource><PMID Version="1">10717753</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2010;4(7):e758</RefSource><PMID Version="1">20689574</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trop Med Int Health. 2001 Aug;6(8):582-606</RefSource><PMID Version="1">11555425</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Parasitol. 2002 Jul;32(8):947-60</RefSource><PMID Version="1">12076624</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann N Y Acad Sci. 2002 Dec;979:131-42; discussion 188-96</RefSource><PMID Version="1">12543723</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Trop Med Parasitol. 2003 Dec;97(8):839-45</RefSource><PMID Version="1">14754496</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biometrics. 1989 Mar;45(1):255-68</RefSource><PMID Version="1">2720055</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 1992 Jun;25(2):55-61</RefSource><PMID Version="1">1405748</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Adv Parasitol. 2006;61:395-441</RefSource><PMID Version="1">16735170</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Trop Med Parasitol. 2007 Mar;101(2):173-80</RefSource><PMID Version="1">17316503</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphat Res Biol. 2008;6(2):85-7</RefSource><PMID Version="1">18564923</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Korean J Parasitol. 2008 Sep;46(3):119-25</RefSource><PMID Version="1">18830049</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2008;2(10):e317</RefSource><PMID Version="1">18841205</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Commun Dis. 2008 Jun;40(2):91-100</RefSource><PMID Version="1">19301693</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Trop Med Parasitol. 2009 Apr;103(3):235-47</RefSource><PMID Version="1">19341538</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2009;3(4):e420</RefSource><PMID Version="1">19381284</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parasite Immunol. 2009 Nov;31(11):664-72</RefSource><PMID Version="1">19825106</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2010;4(4):e668</RefSource><PMID Version="1">20422031</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Negl Trop Dis. 2010;4(6):e695</RefSource><PMID Version="1">20532225</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphology. 2001 Mar;34(1):2-11</RefSource><PMID Version="1">11307661</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007866" MajorTopicYN="N">Leg</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008365" MajorTopicYN="N">Manometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010219" MajorTopicYN="N" Type="Geographic">Papua New Guinea</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012372" MajorTopicYN="N">ROC Curve</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016059" MajorTopicYN="N">Range of Motion, Articular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018709" MajorTopicYN="N">Statistics, Nonparametric</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3139669</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>12</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>06</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>1</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21811644</ArticleId><ArticleId IdType="doi">10.1371/journal.pntd.0001242</ArticleId><ArticleId IdType="pii">PNTD-D-10-00277</ArticleId><ArticleId IdType="pmc">PMC3139669</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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