Factors associated with the development of breast cancer-related lymphedema after whole-breast irradiation.
Identifieur interne : 002379 ( PubMed/Corpus ); précédent : 002378; suivant : 002380Factors associated with the development of breast cancer-related lymphedema after whole-breast irradiation.
Auteurs : Chirag Shah ; John Ben Wilkinson ; Andrew Baschnagel ; Mihai Ghilezan ; Justin Riutta ; Nayana Dekhne ; Savitha Balaraman ; Christina Mitchell ; Michelle Wallace ; Frank ViciniSource :
- International journal of radiation oncology, biology, physics [ 1879-355X ] ; 2012.
English descriptors
- KwdEn :
- Actuarial Analysis, Adult, Aged, Aged, 80 and over, Axilla, Breast Neoplasms (drug therapy), Breast Neoplasms (pathology), Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Female, Humans, Lymph Node Excision (adverse effects), Lymph Nodes (pathology), Lymphedema (etiology), Middle Aged, Neoplasm Grading, Radiotherapy, Adjuvant (adverse effects), Risk, Tumor Burden.
- MESH :
- adverse effects : Lymph Node Excision, Radiotherapy, Adjuvant.
- drug therapy : Breast Neoplasms.
- etiology : Lymphedema.
- pathology : Breast Neoplasms, Lymph Nodes.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- Actuarial Analysis, Adult, Aged, Aged, 80 and over, Axilla, Female, Humans, Middle Aged, Neoplasm Grading, Risk, Tumor Burden.
Abstract
To determine the rates of breast cancer-related lymphedema (BCRL) in patients undergoing whole-breast irradiation as part of breast-conserving therapy (BCT) and to identify clinical, pathologic, and treatment factors associated with its development.
DOI: 10.1016/j.ijrobp.2011.09.058
PubMed: 22099041
Links to Exploration step
pubmed:22099041Le document en format XML
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first="Justin" last="Riutta">Justin Riutta</name></author><author><name sortKey="Dekhne, Nayana" sort="Dekhne, Nayana" uniqKey="Dekhne N" first="Nayana" last="Dekhne">Nayana Dekhne</name></author><author><name sortKey="Balaraman, Savitha" sort="Balaraman, Savitha" uniqKey="Balaraman S" first="Savitha" last="Balaraman">Savitha Balaraman</name></author><author><name sortKey="Mitchell, Christina" sort="Mitchell, Christina" uniqKey="Mitchell C" first="Christina" last="Mitchell">Christina Mitchell</name></author><author><name sortKey="Wallace, Michelle" sort="Wallace, Michelle" uniqKey="Wallace M" first="Michelle" last="Wallace">Michelle Wallace</name></author><author><name sortKey="Vicini, Frank" sort="Vicini, Frank" uniqKey="Vicini F" first="Frank" last="Vicini">Frank Vicini</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22099041</idno><idno type="pmid">22099041</idno><idno type="doi">10.1016/j.ijrobp.2011.09.058</idno><idno type="wicri:Area/PubMed/Corpus">002379</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002379</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Factors associated with the development of breast cancer-related lymphedema after whole-breast irradiation.</title><author><name sortKey="Shah, Chirag" sort="Shah, Chirag" uniqKey="Shah C" first="Chirag" last="Shah">Chirag Shah</name><affiliation><nlm:affiliation>Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wilkinson, John Ben" sort="Wilkinson, John Ben" uniqKey="Wilkinson J" first="John Ben" last="Wilkinson">John Ben Wilkinson</name></author><author><name sortKey="Baschnagel, Andrew" sort="Baschnagel, Andrew" uniqKey="Baschnagel A" first="Andrew" last="Baschnagel">Andrew Baschnagel</name></author><author><name sortKey="Ghilezan, Mihai" sort="Ghilezan, Mihai" uniqKey="Ghilezan M" first="Mihai" last="Ghilezan">Mihai Ghilezan</name></author><author><name sortKey="Riutta, Justin" sort="Riutta, Justin" uniqKey="Riutta J" first="Justin" last="Riutta">Justin Riutta</name></author><author><name sortKey="Dekhne, Nayana" sort="Dekhne, Nayana" uniqKey="Dekhne N" first="Nayana" last="Dekhne">Nayana Dekhne</name></author><author><name sortKey="Balaraman, Savitha" sort="Balaraman, Savitha" uniqKey="Balaraman S" first="Savitha" last="Balaraman">Savitha Balaraman</name></author><author><name sortKey="Mitchell, Christina" sort="Mitchell, Christina" uniqKey="Mitchell C" first="Christina" last="Mitchell">Christina Mitchell</name></author><author><name sortKey="Wallace, Michelle" sort="Wallace, Michelle" uniqKey="Wallace M" first="Michelle" last="Wallace">Michelle Wallace</name></author><author><name sortKey="Vicini, Frank" sort="Vicini, Frank" uniqKey="Vicini F" first="Frank" last="Vicini">Frank Vicini</name></author></analytic><series><title level="j">International journal of radiation oncology, biology, physics</title><idno type="eISSN">1879-355X</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actuarial Analysis</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Axilla</term><term>Breast Neoplasms (drug therapy)</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (radiotherapy)</term><term>Breast Neoplasms (surgery)</term><term>Female</term><term>Humans</term><term>Lymph Node Excision (adverse effects)</term><term>Lymph Nodes (pathology)</term><term>Lymphedema (etiology)</term><term>Middle Aged</term><term>Neoplasm Grading</term><term>Radiotherapy, Adjuvant (adverse effects)</term><term>Risk</term><term>Tumor Burden</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lymph Node Excision</term><term>Radiotherapy, Adjuvant</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Actuarial Analysis</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Axilla</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Neoplasm Grading</term><term>Risk</term><term>Tumor Burden</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine the rates of breast cancer-related lymphedema (BCRL) in patients undergoing whole-breast irradiation as part of breast-conserving therapy (BCT) and to identify clinical, pathologic, and treatment factors associated with its development.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22099041</PMID><DateCreated><Year>2012</Year><Month>06</Month><Day>18</Day></DateCreated><DateCompleted><Year>2012</Year><Month>08</Month><Day>16</Day></DateCompleted><DateRevised><Year>2012</Year><Month>06</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-355X</ISSN><JournalIssue CitedMedium="Internet"><Volume>83</Volume><Issue>4</Issue><PubDate><Year>2012</Year><Month>Jul</Month><Day>15</Day></PubDate></JournalIssue><Title>International journal of radiation oncology, biology, physics</Title><ISOAbbreviation>Int. J. Radiat. Oncol. Biol. Phys.</ISOAbbreviation></Journal><ArticleTitle>Factors associated with the development of breast cancer-related lymphedema after whole-breast irradiation.</ArticleTitle><Pagination><MedlinePgn>1095-100</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijrobp.2011.09.058</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To determine the rates of breast cancer-related lymphedema (BCRL) in patients undergoing whole-breast irradiation as part of breast-conserving therapy (BCT) and to identify clinical, pathologic, and treatment factors associated with its development.</AbstractText><AbstractText Label="METHODS AND MATERIALS" NlmCategory="METHODS">A total of 1,861 patients with breast cancer were treated at William Beaumont Hospital with whole-breast irradiation as part of their BCT from January 1980 to February 2006, with 1,497 patients available for analysis. Determination of BCRL was based on clinical assessment. Differences in clinical, pathologic, and treatment characteristics between patients with BCRL and those without BCRL were evaluated, and the actuarial rates of BCRL by regional irradiation technique were determined.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The actuarial rate of any BCRL was 7.4% for the entire cohort and 9.9%, 14.7%, and 8.3% for patients receiving a supraclavicular field, posterior axillary boost, and internal mammary irradiation, respectively. BCRL was more likely to develop in patients with advanced nodal status (11.4% vs. 6.3%, p = 0.001), those who had a greater number of lymph nodes removed (14 nodes) (9.5% vs. 6.0%, p = 0.01), those who had extracapsular extension (13.4% vs. 6.9%, p = 0.009), those with Grade II/III disease (10.8% vs. 2.9%, p < 0.001), and those who received adjuvant chemotherapy (10.5% vs. 6.7%, p = 0.02). Regional irradiation showed small increases in the rates of BCRL (p = not significant).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results suggest that clinically detectable BCRL will develop after traditional BCT in up to 10% of patients. High-risk subgroups include patients with advanced nodal status, those with more nodes removed, and those who receive chemotherapy, with patients receiving regional irradiation showing a trend toward increased rates.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shah</LastName><ForeName>Chirag</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilkinson</LastName><ForeName>John Ben</ForeName><Initials>JB</Initials></Author><Author ValidYN="Y"><LastName>Baschnagel</LastName><ForeName>Andrew</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Ghilezan</LastName><ForeName>Mihai</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Riutta</LastName><ForeName>Justin</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Dekhne</LastName><ForeName>Nayana</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Balaraman</LastName><ForeName>Savitha</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Christina</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Wallace</LastName><ForeName>Michelle</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Vicini</LastName><ForeName>Frank</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>11</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int J Radiat Oncol Biol Phys</MedlineTA><NlmUniqueID>7603616</NlmUniqueID><ISSNLinking>0360-3016</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000206" MajorTopicYN="Y">Actuarial Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001365" MajorTopicYN="N">Axilla</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060787" MajorTopicYN="N">Neoplasm Grading</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018714" MajorTopicYN="N">Radiotherapy, Adjuvant</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012306" MajorTopicYN="N">Risk</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D047368" 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