Is the presence of small volume disease in the sentinel node an indication for axillary clearance?
Identifieur interne : 002070 ( PubMed/Corpus ); précédent : 002069; suivant : 002071Is the presence of small volume disease in the sentinel node an indication for axillary clearance?
Auteurs : Darren K. Patten ; Daniel R. Leff ; Zubair Wani ; Susan J. Cleator ; Carlo Palmieri ; R Charles Coombes ; Dimitri J. HadjiminasSource :
- Breast (Edinburgh, Scotland) [ 1532-3080 ] ; 2013.
English descriptors
- KwdEn :
- Axilla, Breast Neoplasms (mortality), Breast Neoplasms (pathology), Breast Neoplasms (surgery), Female, Humans, Lymph Node Excision, Lymphatic Metastasis, Lymphedema (etiology), Lymphedema (prevention & control), Neoplasm Micrometastasis, Postoperative Complications (prevention & control), Prognosis, Sentinel Lymph Node Biopsy.
- MESH :
- etiology : Lymphedema.
- mortality : Breast Neoplasms.
- pathology : Breast Neoplasms.
- prevention & control : Lymphedema, Postoperative Complications.
- surgery : Breast Neoplasms.
- Axilla, Female, Humans, Lymph Node Excision, Lymphatic Metastasis, Neoplasm Micrometastasis, Prognosis, Sentinel Lymph Node Biopsy.
Abstract
The finding of micrometastases (M(i)) and isolated tumour cells (ITC) within the axillary lymph nodes of patients with breast cancer has raised the question whether either/both have some prognostic significance. Several studies have shown that compared to node-negative patients, prognosis is significantly poorer in patients with M(i) and ITC. The fact that patients with M(i)/ITC in their sentinel lymph nodes have a systemic relapse risk that is higher than that of node-negative patients may be considered as an indication for systemic treatment. Most studies in the literature suggest that in patients with M(i) or ITC in their sentinel nodes who receive systemic therapy and whole breast radiotherapy, the risk of axillary relapse without axillary lymphadenectomy is under 2%. Given the fact that axillary lymphadenectomy is associated with a 5-25% risk of lymphoedema, we propose that a policy of close follow up should be adopted in these patients rather than axillary lymphadenectomy.
DOI: 10.1016/j.breast.2012.05.006
PubMed: 22721758
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pubmed:22721758Le document en format XML
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Cleator</name></author><author><name sortKey="Palmieri, Carlo" sort="Palmieri, Carlo" uniqKey="Palmieri C" first="Carlo" last="Palmieri">Carlo Palmieri</name></author><author><name sortKey="Coombes, R Charles" sort="Coombes, R Charles" uniqKey="Coombes R" first="R Charles" last="Coombes">R Charles Coombes</name></author><author><name sortKey="Hadjiminas, Dimitri J" sort="Hadjiminas, Dimitri J" uniqKey="Hadjiminas D" first="Dimitri J" last="Hadjiminas">Dimitri J. Hadjiminas</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:22721758</idno><idno type="pmid">22721758</idno><idno type="doi">10.1016/j.breast.2012.05.006</idno><idno type="wicri:Area/PubMed/Corpus">002070</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002070</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Is the presence of small volume disease in the sentinel node an indication for axillary clearance?</title><author><name sortKey="Patten, Darren K" sort="Patten, Darren K" uniqKey="Patten D" first="Darren K" last="Patten">Darren K. Patten</name><affiliation><nlm:affiliation>Department of Biosurgery and Surgical Oncology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK. darren.patten@gmail.com</nlm:affiliation></affiliation></author><author><name sortKey="Leff, Daniel R" sort="Leff, Daniel R" uniqKey="Leff D" first="Daniel R" last="Leff">Daniel R. Leff</name></author><author><name sortKey="Wani, Zubair" sort="Wani, Zubair" uniqKey="Wani Z" first="Zubair" last="Wani">Zubair Wani</name></author><author><name sortKey="Cleator, Susan J" sort="Cleator, Susan J" uniqKey="Cleator S" first="Susan J" last="Cleator">Susan J. Cleator</name></author><author><name sortKey="Palmieri, Carlo" sort="Palmieri, Carlo" uniqKey="Palmieri C" first="Carlo" last="Palmieri">Carlo Palmieri</name></author><author><name sortKey="Coombes, R Charles" sort="Coombes, R Charles" uniqKey="Coombes R" first="R Charles" last="Coombes">R Charles Coombes</name></author><author><name sortKey="Hadjiminas, Dimitri J" sort="Hadjiminas, Dimitri J" uniqKey="Hadjiminas D" first="Dimitri J" last="Hadjiminas">Dimitri J. Hadjiminas</name></author></analytic><series><title level="j">Breast (Edinburgh, Scotland)</title><idno type="eISSN">1532-3080</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Axilla</term><term>Breast Neoplasms (mortality)</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (surgery)</term><term>Female</term><term>Humans</term><term>Lymph Node Excision</term><term>Lymphatic Metastasis</term><term>Lymphedema (etiology)</term><term>Lymphedema (prevention & control)</term><term>Neoplasm Micrometastasis</term><term>Postoperative Complications (prevention & control)</term><term>Prognosis</term><term>Sentinel Lymph Node Biopsy</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Lymphedema</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Axilla</term><term>Female</term><term>Humans</term><term>Lymph Node Excision</term><term>Lymphatic Metastasis</term><term>Neoplasm Micrometastasis</term><term>Prognosis</term><term>Sentinel Lymph Node Biopsy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The finding of micrometastases (M(i)) and isolated tumour cells (ITC) within the axillary lymph nodes of patients with breast cancer has raised the question whether either/both have some prognostic significance. Several studies have shown that compared to node-negative patients, prognosis is significantly poorer in patients with M(i) and ITC. The fact that patients with M(i)/ITC in their sentinel lymph nodes have a systemic relapse risk that is higher than that of node-negative patients may be considered as an indication for systemic treatment. Most studies in the literature suggest that in patients with M(i) or ITC in their sentinel nodes who receive systemic therapy and whole breast radiotherapy, the risk of axillary relapse without axillary lymphadenectomy is under 2%. Given the fact that axillary lymphadenectomy is associated with a 5-25% risk of lymphoedema, we propose that a policy of close follow up should be adopted in these patients rather than axillary lymphadenectomy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22721758</PMID><DateCreated><Year>2012</Year><Month>12</Month><Day>31</Day></DateCreated><DateCompleted><Year>2013</Year><Month>05</Month><Day>30</Day></DateCompleted><DateRevised><Year>2012</Year><Month>12</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-3080</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>1</Issue><PubDate><Year>2013</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Breast (Edinburgh, Scotland)</Title><ISOAbbreviation>Breast</ISOAbbreviation></Journal><ArticleTitle>Is the presence of small volume disease in the sentinel node an indication for axillary clearance?</ArticleTitle><Pagination><MedlinePgn>70-3</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.breast.2012.05.006</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0960-9776(12)00088-4</ELocationID><Abstract><AbstractText>The finding of micrometastases (M(i)) and isolated tumour cells (ITC) within the axillary lymph nodes of patients with breast cancer has raised the question whether either/both have some prognostic significance. Several studies have shown that compared to node-negative patients, prognosis is significantly poorer in patients with M(i) and ITC. The fact that patients with M(i)/ITC in their sentinel lymph nodes have a systemic relapse risk that is higher than that of node-negative patients may be considered as an indication for systemic treatment. Most studies in the literature suggest that in patients with M(i) or ITC in their sentinel nodes who receive systemic therapy and whole breast radiotherapy, the risk of axillary relapse without axillary lymphadenectomy is under 2%. Given the fact that axillary lymphadenectomy is associated with a 5-25% risk of lymphoedema, we propose that a policy of close follow up should be adopted in these patients rather than axillary lymphadenectomy.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Patten</LastName><ForeName>Darren K</ForeName><Initials>DK</Initials><AffiliationInfo><Affiliation>Department of Biosurgery and Surgical Oncology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK. darren.patten@gmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leff</LastName><ForeName>Daniel R</ForeName><Initials>DR</Initials></Author><Author ValidYN="Y"><LastName>Wani</LastName><ForeName>Zubair</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Cleator</LastName><ForeName>Susan J</ForeName><Initials>SJ</Initials></Author><Author ValidYN="Y"><LastName>Palmieri</LastName><ForeName>Carlo</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Coombes</LastName><ForeName>R Charles</ForeName><Initials>RC</Initials></Author><Author ValidYN="Y"><LastName>Hadjiminas</LastName><ForeName>Dimitri J</ForeName><Initials>DJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>06</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Breast</MedlineTA><NlmUniqueID>9213011</NlmUniqueID><ISSNLinking>0960-9776</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001365" MajorTopicYN="N">Axilla</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008207" MajorTopicYN="N">Lymphatic Metastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D061206" MajorTopicYN="Y">Neoplasm Micrometastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011183" MajorTopicYN="N">Postoperative Complications</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021701" MajorTopicYN="Y">Sentinel Lymph Node Biopsy</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>04</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>05</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>05</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>6</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22721758</ArticleId><ArticleId IdType="pii">S0960-9776(12)00088-4</ArticleId><ArticleId IdType="doi">10.1016/j.breast.2012.05.006</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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