Pathological steps of cancer-related lymphedema: histological changes in the collecting lymphatic vessels after lymphadenectomy.
Identifieur interne : 001F88 ( PubMed/Corpus ); précédent : 001F87; suivant : 001F89Pathological steps of cancer-related lymphedema: histological changes in the collecting lymphatic vessels after lymphadenectomy.
Auteurs : Makoto Mihara ; Hisako Hara ; Yohei Hayashi ; Mitsunaga Narushima ; Takumi Yamamoto ; Takeshi Todokoro ; Takuya Iida ; Naoya Sawamoto ; Jun Araki ; Kazuki Kikuchi ; Noriyuki Murai ; Taro Okitsu ; Iori Kisu ; Isao KoshimaSource :
- PloS one [ 1932-6203 ] ; 2012.
English descriptors
- KwdEn :
- Adult, Aged, Desmosomes (pathology), Desmosomes (ultrastructure), Endothelial Cells (pathology), Endothelial Cells (ultrastructure), Female, Fibrillar Collagens (ultrastructure), Humans, Lymph Node Excision, Lymphatic Vessels (pathology), Lymphedema (etiology), Lymphedema (pathology), Middle Aged, Myocytes, Smooth Muscle (pathology), Myocytes, Smooth Muscle (ultrastructure), Neoplasms (complications), Neoplasms (surgery).
- MESH :
- chemical , ultrastructure : Fibrillar Collagens.
- complications : Neoplasms.
- etiology : Lymphedema.
- pathology : Desmosomes, Endothelial Cells, Lymphatic Vessels, Lymphedema, Myocytes, Smooth Muscle.
- surgery : Neoplasms.
- ultrastructure : Desmosomes, Endothelial Cells, Myocytes, Smooth Muscle.
- Adult, Aged, Female, Humans, Lymph Node Excision, Middle Aged.
Abstract
To date, an electron microscopy study of the collecting lymphatic vessels has not been conducted to examine the early stages of lymphedema. However, such histological studies could be useful for elucidating the mechanism of lymphedema onset. The aim of this study was to clarify the changes occurring in collecting lymphatic vessels after lymphadenectomy.
DOI: 10.1371/journal.pone.0041126
PubMed: 22911751
Links to Exploration step
pubmed:22911751Le document en format XML
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sort="Yamamoto, Takumi" uniqKey="Yamamoto T" first="Takumi" last="Yamamoto">Takumi Yamamoto</name></author><author><name sortKey="Todokoro, Takeshi" sort="Todokoro, Takeshi" uniqKey="Todokoro T" first="Takeshi" last="Todokoro">Takeshi Todokoro</name></author><author><name sortKey="Iida, Takuya" sort="Iida, Takuya" uniqKey="Iida T" first="Takuya" last="Iida">Takuya Iida</name></author><author><name sortKey="Sawamoto, Naoya" sort="Sawamoto, Naoya" uniqKey="Sawamoto N" first="Naoya" last="Sawamoto">Naoya Sawamoto</name></author><author><name sortKey="Araki, Jun" sort="Araki, Jun" uniqKey="Araki J" first="Jun" last="Araki">Jun Araki</name></author><author><name sortKey="Kikuchi, Kazuki" sort="Kikuchi, Kazuki" uniqKey="Kikuchi K" first="Kazuki" last="Kikuchi">Kazuki Kikuchi</name></author><author><name sortKey="Murai, Noriyuki" sort="Murai, Noriyuki" uniqKey="Murai N" first="Noriyuki" last="Murai">Noriyuki Murai</name></author><author><name sortKey="Okitsu, Taro" sort="Okitsu, Taro" uniqKey="Okitsu T" first="Taro" last="Okitsu">Taro Okitsu</name></author><author><name sortKey="Kisu, Iori" sort="Kisu, Iori" uniqKey="Kisu I" first="Iori" last="Kisu">Iori Kisu</name></author><author><name sortKey="Koshima, Isao" sort="Koshima, Isao" uniqKey="Koshima I" first="Isao" last="Koshima">Isao Koshima</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22911751</idno><idno type="pmid">22911751</idno><idno type="doi">10.1371/journal.pone.0041126</idno><idno type="wicri:Area/PubMed/Corpus">001F88</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F88</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pathological steps of cancer-related lymphedema: histological changes in the collecting lymphatic vessels after lymphadenectomy.</title><author><name sortKey="Mihara, Makoto" sort="Mihara, Makoto" uniqKey="Mihara M" first="Makoto" last="Mihara">Makoto Mihara</name><affiliation><nlm:affiliation>Department of Plastic and Reconstructive Surgery, The University of Tokyo, Tokyo, Japan. mihara@keiseigeka.name</nlm:affiliation></affiliation></author><author><name sortKey="Hara, Hisako" sort="Hara, Hisako" uniqKey="Hara H" first="Hisako" last="Hara">Hisako Hara</name></author><author><name sortKey="Hayashi, Yohei" sort="Hayashi, Yohei" uniqKey="Hayashi Y" first="Yohei" last="Hayashi">Yohei Hayashi</name></author><author><name sortKey="Narushima, Mitsunaga" sort="Narushima, Mitsunaga" uniqKey="Narushima M" first="Mitsunaga" last="Narushima">Mitsunaga Narushima</name></author><author><name sortKey="Yamamoto, Takumi" sort="Yamamoto, Takumi" uniqKey="Yamamoto T" first="Takumi" last="Yamamoto">Takumi Yamamoto</name></author><author><name sortKey="Todokoro, Takeshi" sort="Todokoro, Takeshi" uniqKey="Todokoro T" first="Takeshi" last="Todokoro">Takeshi Todokoro</name></author><author><name sortKey="Iida, Takuya" sort="Iida, Takuya" uniqKey="Iida T" first="Takuya" last="Iida">Takuya Iida</name></author><author><name sortKey="Sawamoto, Naoya" sort="Sawamoto, Naoya" uniqKey="Sawamoto N" first="Naoya" last="Sawamoto">Naoya Sawamoto</name></author><author><name sortKey="Araki, Jun" sort="Araki, Jun" uniqKey="Araki J" first="Jun" last="Araki">Jun Araki</name></author><author><name sortKey="Kikuchi, Kazuki" sort="Kikuchi, Kazuki" uniqKey="Kikuchi K" first="Kazuki" last="Kikuchi">Kazuki Kikuchi</name></author><author><name sortKey="Murai, Noriyuki" sort="Murai, Noriyuki" uniqKey="Murai N" first="Noriyuki" last="Murai">Noriyuki Murai</name></author><author><name sortKey="Okitsu, Taro" sort="Okitsu, Taro" uniqKey="Okitsu T" first="Taro" last="Okitsu">Taro Okitsu</name></author><author><name sortKey="Kisu, Iori" sort="Kisu, Iori" uniqKey="Kisu I" first="Iori" last="Kisu">Iori Kisu</name></author><author><name sortKey="Koshima, Isao" sort="Koshima, Isao" uniqKey="Koshima I" first="Isao" last="Koshima">Isao Koshima</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Desmosomes (pathology)</term><term>Desmosomes (ultrastructure)</term><term>Endothelial Cells (pathology)</term><term>Endothelial Cells (ultrastructure)</term><term>Female</term><term>Fibrillar Collagens (ultrastructure)</term><term>Humans</term><term>Lymph Node Excision</term><term>Lymphatic Vessels (pathology)</term><term>Lymphedema (etiology)</term><term>Lymphedema (pathology)</term><term>Middle Aged</term><term>Myocytes, Smooth Muscle (pathology)</term><term>Myocytes, Smooth Muscle (ultrastructure)</term><term>Neoplasms (complications)</term><term>Neoplasms (surgery)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="ultrastructure" xml:lang="en"><term>Fibrillar Collagens</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Desmosomes</term><term>Endothelial Cells</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Myocytes, Smooth Muscle</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Desmosomes</term><term>Endothelial Cells</term><term>Myocytes, Smooth Muscle</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Lymph Node Excision</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To date, an electron microscopy study of the collecting lymphatic vessels has not been conducted to examine the early stages of lymphedema. However, such histological studies could be useful for elucidating the mechanism of lymphedema onset. The aim of this study was to clarify the changes occurring in collecting lymphatic vessels after lymphadenectomy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22911751</PMID><DateCreated><Year>2012</Year><Month>08</Month><Day>22</Day></DateCreated><DateCompleted><Year>2013</Year><Month>04</Month><Day>19</Day></DateCompleted><DateRevised><Year>2015</Year><Month>02</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>7</Issue><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Pathological steps of cancer-related lymphedema: histological changes in the collecting lymphatic vessels after lymphadenectomy.</ArticleTitle><Pagination><MedlinePgn>e41126</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0041126</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">To date, an electron microscopy study of the collecting lymphatic vessels has not been conducted to examine the early stages of lymphedema. However, such histological studies could be useful for elucidating the mechanism of lymphedema onset. The aim of this study was to clarify the changes occurring in collecting lymphatic vessels after lymphadenectomy.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The study was conducted on 114 specimens from 37 patients who developed lymphedema of the lower limbs after receiving surgical treatment for gynecologic cancers and who consulted the University of Tokyo Hospital and affiliated hospitals from April 2009 to March 2011. Lymphatic vessels that were not needed for lymphatico venous anastomosis surgery were trimmed and subsequently examined using electron microscopy and light microscopy.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Based on macroscopic findings, the histochemical changes in the collecting lymphatic vessels were defined as follows: normal, ectasis, contraction, and sclerosis type (NECST). In the ectasis type, an increase in endolymphatic pressure was accompanied by a flattening of the lymphatic vessel endothelial cells. In the contraction type, smooth muscle cells were transformed into synthetic cells and promoted the growth of collagen fibers. In the sclerosis type, fibrous elements accounted for the majority of the components, the lymphatic vessels lost their transport and concentrating abilities, and the lumen was either narrowed or completely obstructed.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The increase in pressure inside the collecting lymphatic vessels after lymphadenectomy was accompanied by histological changes that began before the onset of lymphedema.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mihara</LastName><ForeName>Makoto</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Plastic and Reconstructive Surgery, The University of Tokyo, Tokyo, Japan. mihara@keiseigeka.name</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hara</LastName><ForeName>Hisako</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Hayashi</LastName><ForeName>Yohei</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Narushima</LastName><ForeName>Mitsunaga</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Yamamoto</LastName><ForeName>Takumi</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Todokoro</LastName><ForeName>Takeshi</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Iida</LastName><ForeName>Takuya</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Sawamoto</LastName><ForeName>Naoya</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Araki</LastName><ForeName>Jun</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Kikuchi</LastName><ForeName>Kazuki</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Murai</LastName><ForeName>Noriyuki</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Okitsu</LastName><ForeName>Taro</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Kisu</LastName><ForeName>Iori</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Koshima</LastName><ForeName>Isao</ForeName><Initials>I</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>07</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D024022">Fibrillar Collagens</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Ann Surg. 2006 Mar;243(3):313-5</RefSource><PMID Version="1">16495693</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Dermatol. 2005 Nov-Dec;15(6):474-7</RefSource><PMID Version="1">16280302</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Vasc Surg. 2007 May;45(5):1016-21</RefSource><PMID Version="1">17391894</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Vasc Endovasc Surg. 2008 Aug;36(2):230-6</RefSource><PMID Version="1">18534875</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H662-8</RefSource><PMID Version="1">19122167</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Biol. 1968 Jan;36(1):129-49</RefSource><PMID 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10.1371/annotation/6fff4d28-3f99-44eb-82d6-ccd885a1ba11</RefSource></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003896" MajorTopicYN="N">Desmosomes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042783" MajorTopicYN="N">Endothelial Cells</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024022" MajorTopicYN="N">Fibrillar Collagens</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032389" MajorTopicYN="N">Myocytes, Smooth Muscle</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3404077</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>01</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>06</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>8</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>8</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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