Regulation of lymphatic vascular morphogenesis: Implications for pathological (tumor) lymphangiogenesis.
Identifieur interne : 001D08 ( PubMed/Corpus ); précédent : 001D07; suivant : 001D09Regulation of lymphatic vascular morphogenesis: Implications for pathological (tumor) lymphangiogenesis.
Auteurs : Ines Martinez-Corral ; Taija MakinenSource :
- Experimental cell research [ 1090-2422 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- pathology : Neoplasms.
- physiopathology : Lymphatic Vessels.
- Animals, Humans, Lymphangiogenesis, Morphogenesis.
Abstract
Lymphatic vasculature forms the second part of our circulatory system that plays a critical role in tissue fluid homeostasis. Failure of the lymphatic system can lead to excessive accumulation of fluid within the tissue, a condition called lymphedema. Lymphatic dysfunction has also been implicated in cancer metastasis as well as pathogenesis of obesity, atherosclerosis and cardiovascular disease. Since the identification of the first lymphatic marker VEGFR-3 and growth factor VEGF-C almost 20 years ago, a great progress has been made in understanding the mechanisms of lymphangiogenesis. This has been achieved largely through characterization of animal models with specific lymphatic defects and identification of genes causative of human hereditary lymphedema syndromes. In this review we will summarize the current understanding of the regulation of lymphatic vascular morphogenesis, focusing on mechanisms that have been implicated in both developmental and pathological (tumor) lymphangiogenesis.
DOI: 10.1016/j.yexcr.2013.01.016
PubMed: 23395992
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pubmed:23395992Le document en format XML
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Electronic address: taija.makinen@cancer.org.uk.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23395992</idno><idno type="pmid">23395992</idno><idno type="doi">10.1016/j.yexcr.2013.01.016</idno><idno type="wicri:Area/PubMed/Corpus">001D08</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Regulation of lymphatic vascular morphogenesis: Implications for pathological (tumor) lymphangiogenesis.</title><author><name sortKey="Martinez Corral, Ines" sort="Martinez Corral, Ines" uniqKey="Martinez Corral I" first="Ines" last="Martinez-Corral">Ines Martinez-Corral</name><affiliation><nlm:affiliation>Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Makinen, Taija" sort="Makinen, Taija" uniqKey="Makinen T" first="Taija" last="Makinen">Taija Makinen</name><affiliation><nlm:affiliation>Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address: taija.makinen@cancer.org.uk.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Experimental cell research</title><idno type="eISSN">1090-2422</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Humans</term><term>Lymphangiogenesis</term><term>Lymphatic Vessels (physiopathology)</term><term>Morphogenesis</term><term>Neoplasms (pathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Lymphangiogenesis</term><term>Morphogenesis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphatic vasculature forms the second part of our circulatory system that plays a critical role in tissue fluid homeostasis. Failure of the lymphatic system can lead to excessive accumulation of fluid within the tissue, a condition called lymphedema. Lymphatic dysfunction has also been implicated in cancer metastasis as well as pathogenesis of obesity, atherosclerosis and cardiovascular disease. Since the identification of the first lymphatic marker VEGFR-3 and growth factor VEGF-C almost 20 years ago, a great progress has been made in understanding the mechanisms of lymphangiogenesis. This has been achieved largely through characterization of animal models with specific lymphatic defects and identification of genes causative of human hereditary lymphedema syndromes. 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Cell Res.</ISOAbbreviation></Journal><ArticleTitle>Regulation of lymphatic vascular morphogenesis: Implications for pathological (tumor) lymphangiogenesis.</ArticleTitle><Pagination><MedlinePgn>1618-25</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.yexcr.2013.01.016</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0014-4827(13)00034-7</ELocationID><Abstract><AbstractText>Lymphatic vasculature forms the second part of our circulatory system that plays a critical role in tissue fluid homeostasis. Failure of the lymphatic system can lead to excessive accumulation of fluid within the tissue, a condition called lymphedema. Lymphatic dysfunction has also been implicated in cancer metastasis as well as pathogenesis of obesity, atherosclerosis and cardiovascular disease. Since the identification of the first lymphatic marker VEGFR-3 and growth factor VEGF-C almost 20 years ago, a great progress has been made in understanding the mechanisms of lymphangiogenesis. This has been achieved largely through characterization of animal models with specific lymphatic defects and identification of genes causative of human hereditary lymphedema syndromes. In this review we will summarize the current understanding of the regulation of lymphatic vascular morphogenesis, focusing on mechanisms that have been implicated in both developmental and pathological (tumor) lymphangiogenesis.</AbstractText><CopyrightInformation>Copyright © 2013 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martinez-Corral</LastName><ForeName>Ines</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Makinen</LastName><ForeName>Taija</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. 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