Long-term prospective longitudinal evaluation of emotional distress and quality of life in cervical cancer patients who remained disease-free 2-years from diagnosis.
Identifieur interne : 001C48 ( PubMed/Corpus ); précédent : 001C47; suivant : 001C49Long-term prospective longitudinal evaluation of emotional distress and quality of life in cervical cancer patients who remained disease-free 2-years from diagnosis.
Auteurs : Giovanna Mantegna ; Marco Petrillo ; Gilda Fuoco ; Laura Venditti ; Serena Terzano ; Luigi Pedone Anchora ; Giovanni Scambia ; Gabriella FerrandinaSource :
- BMC cancer [ 1471-2407 ] ; 2013.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Disease-Free Survival, Female, Humans, Longitudinal Studies, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Quality of Life, Stress, Psychological (etiology), Surveys and Questionnaires, Uterine Cervical Neoplasms (psychology).
- MESH :
- etiology : Stress, Psychological.
- psychology : Uterine Cervical Neoplasms.
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Disease-Free Survival, Female, Humans, Longitudinal Studies, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Quality of Life, Surveys and Questionnaires.
Abstract
A long-term prospective assessment of QoL in cervical cancer patients is still lacking. Here, we provide the first 2-years prospective, longitudinal study evaluating emotional distress and QoL in early stage (ECC) and locally advanced (LACC) cervical cancer patients who remained disease-free 2-years from diagnosis.
DOI: 10.1186/1471-2407-13-127
PubMed: 23506235
Links to Exploration step
pubmed:23506235Le document en format XML
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uniqKey="Terzano S" first="Serena" last="Terzano">Serena Terzano</name></author><author><name sortKey="Anchora, Luigi Pedone" sort="Anchora, Luigi Pedone" uniqKey="Anchora L" first="Luigi Pedone" last="Anchora">Luigi Pedone Anchora</name></author><author><name sortKey="Scambia, Giovanni" sort="Scambia, Giovanni" uniqKey="Scambia G" first="Giovanni" last="Scambia">Giovanni Scambia</name></author><author><name sortKey="Ferrandina, Gabriella" sort="Ferrandina, Gabriella" uniqKey="Ferrandina G" first="Gabriella" last="Ferrandina">Gabriella Ferrandina</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23506235</idno><idno type="pmid">23506235</idno><idno type="doi">10.1186/1471-2407-13-127</idno><idno type="wicri:Area/PubMed/Corpus">001C48</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-term prospective longitudinal evaluation of emotional distress and quality of life in cervical cancer patients who remained disease-free 2-years from diagnosis.</title><author><name sortKey="Mantegna, Giovanna" sort="Mantegna, Giovanna" uniqKey="Mantegna G" first="Giovanna" last="Mantegna">Giovanna Mantegna</name><affiliation><nlm:affiliation>Psycho-Oncology Service, Catholic University, Campobasso, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Petrillo, Marco" sort="Petrillo, Marco" uniqKey="Petrillo M" first="Marco" last="Petrillo">Marco Petrillo</name></author><author><name sortKey="Fuoco, Gilda" sort="Fuoco, Gilda" uniqKey="Fuoco G" first="Gilda" last="Fuoco">Gilda Fuoco</name></author><author><name sortKey="Venditti, Laura" sort="Venditti, Laura" uniqKey="Venditti L" first="Laura" last="Venditti">Laura Venditti</name></author><author><name sortKey="Terzano, Serena" sort="Terzano, Serena" uniqKey="Terzano S" first="Serena" last="Terzano">Serena Terzano</name></author><author><name sortKey="Anchora, Luigi Pedone" sort="Anchora, Luigi Pedone" uniqKey="Anchora L" first="Luigi Pedone" last="Anchora">Luigi Pedone Anchora</name></author><author><name sortKey="Scambia, Giovanni" sort="Scambia, Giovanni" uniqKey="Scambia G" first="Giovanni" last="Scambia">Giovanni Scambia</name></author><author><name sortKey="Ferrandina, Gabriella" sort="Ferrandina, Gabriella" uniqKey="Ferrandina G" first="Gabriella" last="Ferrandina">Gabriella Ferrandina</name></author></analytic><series><title level="j">BMC cancer</title><idno type="eISSN">1471-2407</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Middle Aged</term><term>Prospective Studies</term><term>Psychiatric Status Rating Scales</term><term>Quality of Life</term><term>Stress, Psychological (etiology)</term><term>Surveys and Questionnaires</term><term>Uterine Cervical Neoplasms (psychology)</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Disease-Free Survival</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Middle Aged</term><term>Prospective Studies</term><term>Psychiatric Status Rating Scales</term><term>Quality of Life</term><term>Surveys and Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A long-term prospective assessment of QoL in cervical cancer patients is still lacking. Here, we provide the first 2-years prospective, longitudinal study evaluating emotional distress and QoL in early stage (ECC) and locally advanced (LACC) cervical cancer patients who remained disease-free 2-years from diagnosis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23506235</PMID><DateCreated><Year>2013</Year><Month>03</Month><Day>27</Day></DateCreated><DateCompleted><Year>2013</Year><Month>08</Month><Day>28</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2407</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><PubDate><Year>2013</Year><Month>Mar</Month><Day>18</Day></PubDate></JournalIssue><Title>BMC cancer</Title><ISOAbbreviation>BMC Cancer</ISOAbbreviation></Journal><ArticleTitle>Long-term prospective longitudinal evaluation of emotional distress and quality of life in cervical cancer patients who remained disease-free 2-years from diagnosis.</ArticleTitle><Pagination><MedlinePgn>127</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1471-2407-13-127</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A long-term prospective assessment of QoL in cervical cancer patients is still lacking. Here, we provide the first 2-years prospective, longitudinal study evaluating emotional distress and QoL in early stage (ECC) and locally advanced (LACC) cervical cancer patients who remained disease-free 2-years from diagnosis.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The questionnaires: Hospital Anxiety and Depression Scale (HADS), Global Health Status items of EORTC QLQ-C30 (GHS), and EORTC QLQ-CX24 (CX24) have been administered by a dedicated team of psycho-oncologists, administered at baseline, and after 3, 6, 12 and 24 months from surgery The Generalized Linear Model for repeated measure was used to analyze modifications of QoL measures over time.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In both groups, an early reduction of the percentage of patients with anxiety levels ≥11 was observed at the 3-month evaluation (ECC: 25.7% at baseline Vs 14.7% after 3 months, p value=0.001; LACC: 22.2% at baseline Vs 15.4% after 3 months, p value=0.001). Despite this favorable trend, after 2 years from diagnosis, 11.9% of ECC and 15.6% of LACC patients still showed an anxiety score ≥11. No significant changes over time were observed in term of Depression levels. Focusing on QoL issues, mean GHS and Sexual Activity scores showed an improvement over time in both groups compared to baseline (GHS: 5.7% difference for ECC, p value=0.001, and 11.0% in LACC, p value=0.001; SXA: 13.9% difference for ECC, p value=0.001; and 6.1% in LACC, p value=0.008). On the other hand, Body Image mean scores were significantly impaired by chemoradiation administration in LACC patients, without long-term recovery (7.5% difference, p value=0.001). Finally, in both groups, lymphedema (LY) and menopausal symptoms (MS) showed an early worsening which persisted 2-year after surgery (LY: 19.5% difference for ECC, p value=0.014, and 27.3% in LACC, p value=0.001; MS: 14.4% difference for ECC, p value=0.004, and 16.0% in LACC, p value=0.002).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Despite a significant improvement over time, elevated anxiety levels are still detectable at 24 months after surgery in approximately 10% of cervical cancer patients. Much more attention should be focused on surgical/medical approaches able to minimize the negative impact of lymphedema and menopausal symptoms on QoL.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mantegna</LastName><ForeName>Giovanna</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Psycho-Oncology Service, Catholic University, Campobasso, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petrillo</LastName><ForeName>Marco</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Fuoco</LastName><ForeName>Gilda</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Venditti</LastName><ForeName>Laura</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Terzano</LastName><ForeName>Serena</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Anchora</LastName><ForeName>Luigi Pedone</ForeName><Initials>LP</Initials></Author><Author ValidYN="Y"><LastName>Scambia</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Ferrandina</LastName><ForeName>Gabriella</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>03</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Cancer</MedlineTA><NlmUniqueID>100967800</NlmUniqueID><ISSNLinking>1471-2407</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>BJOG. 2002 Apr;109(4):386-94</RefSource><PMID Version="1">12013159</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer. 2002 Jan 1;94(1):131-40</RefSource><PMID 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Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018572" MajorTopicYN="N">Disease-Free Survival</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008137" MajorTopicYN="N">Longitudinal Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011569" MajorTopicYN="N">Psychiatric Status Rating Scales</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="Y">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName 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