IL-4-, TGF-β-, and IL-1-dependent expansion of parasite antigen-specific Th9 cells is associated with clinical pathology in human lymphatic filariasis.
Identifieur interne : 001986 ( PubMed/Corpus ); précédent : 001985; suivant : 001987IL-4-, TGF-β-, and IL-1-dependent expansion of parasite antigen-specific Th9 cells is associated with clinical pathology in human lymphatic filariasis.
Auteurs : Rajamanickam Anuradha ; Parakkal Jovvian George ; Luke E. Hanna ; Vedachalam Chandrasekaran ; Paul Kumaran ; Thomas B. Nutman ; Subash BabuSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2013.
English descriptors
- KwdEn :
- CD4-Positive T-Lymphocytes (immunology), CD4-Positive T-Lymphocytes (metabolism), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (metabolism), Enzyme-Linked Immunosorbent Assay, Humans, Interleukin-1 (immunology), Interleukin-1 (metabolism), Interleukin-10 (biosynthesis), Interleukin-10 (immunology), Interleukin-4 (immunology), Interleukin-4 (metabolism), Interleukin-9 (biosynthesis), Interleukin-9 (immunology), T-Lymphocyte Subsets (immunology), T-Lymphocyte Subsets (metabolism), Transforming Growth Factor beta (immunology), Transforming Growth Factor beta (metabolism).
- MESH :
- chemical , biosynthesis : Interleukin-10, Interleukin-9.
- chemical , immunology : Interleukin-1, Interleukin-10, Interleukin-4, Interleukin-9, Transforming Growth Factor beta.
- immunology : CD4-Positive T-Lymphocytes, Elephantiasis, Filarial, T-Lymphocyte Subsets.
- metabolism : CD4-Positive T-Lymphocytes, Elephantiasis, Filarial, Interleukin-1, Interleukin-4, T-Lymphocyte Subsets, Transforming Growth Factor beta.
- Enzyme-Linked Immunosorbent Assay, Humans.
Abstract
Th9 cells are a subset of CD4(+) T cells, shown to be important in allergy, autoimmunity, and antitumor responses; however, their role in human infectious diseases has not been explored in detail. We identified a population of IL-9 and IL-10 coexpressing cells (lacking IL-4 expression) in normal individuals. These cells respond to antigenic and mitogenic stimulation, but are distinct from IL-9(+) Th2 cells. We also demonstrate that these Th9 cells exhibit Ag-specific expansion in a chronic helminth infection (lymphatic filariasis). Comparison of Th9 responses reveals that individuals with pathology associated with filarial infection exhibit significantly expanded frequencies of filarial Ag-induced Th9 cells, but not of IL9(+)Th2 cells in comparison with filarial-infected individuals without associated disease. Moreover, the per cell production of IL-9 is significantly higher in Th9 cells compared with IL9(+)Th2 cells, indicating that the Th9 cells are the predominant CD4(+) T cell subset producing IL-9 in the context of human infection. This expansion was reflected in elevated Ag-stimulated IL-9 cytokine levels in whole blood culture supernatants. Finally, the frequencies of Th9 cells correlated positively with the severity of lymphedema (and presumed inflammation) in filarial-diseased individuals. This expansion of Th9 cells was dependent on IL-4, TGF-β, and IL-1 in vitro. We have therefore identified an important human CD4(+) T cell subpopulation coexpressing IL-9 and IL-10, but not IL-4, the expansion of which is associated with disease in chronic lymphatic filariasis and could potentially have an important role in the pathogenesis of other inflammatory disorders.
DOI: 10.4049/jimmunol.1300911
PubMed: 23913964
Links to Exploration step
pubmed:23913964Le document en format XML
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<author><name sortKey="Hanna, Luke E" sort="Hanna, Luke E" uniqKey="Hanna L" first="Luke E" last="Hanna">Luke E. Hanna</name>
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<term>Elephantiasis, Filarial (metabolism)</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Humans</term>
<term>Interleukin-1 (immunology)</term>
<term>Interleukin-1 (metabolism)</term>
<term>Interleukin-10 (biosynthesis)</term>
<term>Interleukin-10 (immunology)</term>
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<front><div type="abstract" xml:lang="en">Th9 cells are a subset of CD4(+) T cells, shown to be important in allergy, autoimmunity, and antitumor responses; however, their role in human infectious diseases has not been explored in detail. We identified a population of IL-9 and IL-10 coexpressing cells (lacking IL-4 expression) in normal individuals. These cells respond to antigenic and mitogenic stimulation, but are distinct from IL-9(+) Th2 cells. We also demonstrate that these Th9 cells exhibit Ag-specific expansion in a chronic helminth infection (lymphatic filariasis). Comparison of Th9 responses reveals that individuals with pathology associated with filarial infection exhibit significantly expanded frequencies of filarial Ag-induced Th9 cells, but not of IL9(+)Th2 cells in comparison with filarial-infected individuals without associated disease. Moreover, the per cell production of IL-9 is significantly higher in Th9 cells compared with IL9(+)Th2 cells, indicating that the Th9 cells are the predominant CD4(+) T cell subset producing IL-9 in the context of human infection. This expansion was reflected in elevated Ag-stimulated IL-9 cytokine levels in whole blood culture supernatants. Finally, the frequencies of Th9 cells correlated positively with the severity of lymphedema (and presumed inflammation) in filarial-diseased individuals. This expansion of Th9 cells was dependent on IL-4, TGF-β, and IL-1 in vitro. We have therefore identified an important human CD4(+) T cell subpopulation coexpressing IL-9 and IL-10, but not IL-4, the expansion of which is associated with disease in chronic lymphatic filariasis and could potentially have an important role in the pathogenesis of other inflammatory disorders.</div>
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