The lymphatics and the inflammatory response: lessons learned from human lymphedema.
Identifieur interne : 001930 ( PubMed/Corpus ); précédent : 001929; suivant : 001931The lymphatics and the inflammatory response: lessons learned from human lymphedema.
Auteurs : Stanley G. RocksonSource :
- Lymphatic research and biology [ 1557-8585 ] ; 2013.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Gene Regulatory Networks, Genetic Predisposition to Disease (genetics), Humans, Inflammation (genetics), Inflammation (pathology), Inflammation (physiopathology), Lymphatic System (metabolism), Lymphatic System (pathology), Lymphatic System (physiopathology), Lymphedema (genetics), Lymphedema (pathology), Lymphedema (physiopathology), Mice, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Transcriptome.
- MESH :
- genetics : Genetic Predisposition to Disease, Inflammation, Lymphedema.
- metabolism : Lymphatic System.
- pathology : Inflammation, Lymphatic System, Lymphedema.
- physiopathology : Inflammation, Lymphatic System, Lymphedema.
- Animals, Disease Models, Animal, Gene Regulatory Networks, Humans, Mice, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Transcriptome.
Abstract
In lymphedema, there is a profound predisposition to infection with bacterial pathogens. It therefore seems appropriate to reconsider our unique functional definition of the lymphatic structures within a circulatory construct. While the lymphatics unquestionably fulfill a vital circulatory function, it seems more appropriate to view this complex network, comprised both of endothelial-lined vessels and of lymphoid tissue, as the nexus between the circulatory and immune systems. Viewed in this fashion, it becomes evident that the complex biology of regional lymphatic disruption is a manifestation of the interplay between these two vital bodily functions. Experimental lymph stasis in murine model has been utilized to effectively demonstrate the pathological attributes of human lymphedema, namely, inflammation, fat deposition, and fibrosis. Large-scale transcriptional corroborates the role of inflammatory mechanisms. The murine studies have set the stage for subsequent translational investigation of human lymphedema. Many of the gene expression pathways invoked by lymphedema are relevant to the inflammatory response and have provided a pragmatic approach to the successful identification of potentially relevant circulating biomarkers for human lymphedema.
DOI: 10.1089/lrb.2013.1132
PubMed: 24024576
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pubmed:24024576Le document en format XML
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It therefore seems appropriate to reconsider our unique functional definition of the lymphatic structures within a circulatory construct. While the lymphatics unquestionably fulfill a vital circulatory function, it seems more appropriate to view this complex network, comprised both of endothelial-lined vessels and of lymphoid tissue, as the nexus between the circulatory and immune systems. Viewed in this fashion, it becomes evident that the complex biology of regional lymphatic disruption is a manifestation of the interplay between these two vital bodily functions. Experimental lymph stasis in murine model has been utilized to effectively demonstrate the pathological attributes of human lymphedema, namely, inflammation, fat deposition, and fibrosis. Large-scale transcriptional corroborates the role of inflammatory mechanisms. The murine studies have set the stage for subsequent translational investigation of human lymphedema. Many of the gene expression pathways invoked by lymphedema are relevant to the inflammatory response and have provided a pragmatic approach to the successful identification of potentially relevant circulating biomarkers for human lymphedema.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24024576</PMID><DateCreated><Year>2013</Year><Month>09</Month><Day>18</Day></DateCreated><DateCompleted><Year>2014</Year><Month>05</Month><Day>02</Day></DateCompleted><DateRevised><Year>2015</Year><Month>04</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-8585</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>3</Issue><PubDate><Year>2013</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Lymphatic research and biology</Title><ISOAbbreviation>Lymphat Res Biol</ISOAbbreviation></Journal><ArticleTitle>The lymphatics and the inflammatory response: lessons learned from human lymphedema.</ArticleTitle><Pagination><MedlinePgn>117-20</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/lrb.2013.1132</ELocationID><Abstract><AbstractText>In lymphedema, there is a profound predisposition to infection with bacterial pathogens. It therefore seems appropriate to reconsider our unique functional definition of the lymphatic structures within a circulatory construct. While the lymphatics unquestionably fulfill a vital circulatory function, it seems more appropriate to view this complex network, comprised both of endothelial-lined vessels and of lymphoid tissue, as the nexus between the circulatory and immune systems. Viewed in this fashion, it becomes evident that the complex biology of regional lymphatic disruption is a manifestation of the interplay between these two vital bodily functions. Experimental lymph stasis in murine model has been utilized to effectively demonstrate the pathological attributes of human lymphedema, namely, inflammation, fat deposition, and fibrosis. Large-scale transcriptional corroborates the role of inflammatory mechanisms. The murine studies have set the stage for subsequent translational investigation of human lymphedema. Many of the gene expression pathways invoked by lymphedema are relevant to the inflammatory response and have provided a pragmatic approach to the successful identification of potentially relevant circulating biomarkers for human lymphedema.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rockson</LastName><ForeName>Stanley G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Stanford University School of Medicine , Stanford, California.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>09</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Lymphat Res Biol</MedlineTA><NlmUniqueID>101163587</NlmUniqueID><ISSNLinking>1539-6851</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2006 Jul;3(7):e264</RefSource><PMID Version="1">16842020</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2006 Jul;3(7):e254</RefSource><PMID Version="1">16834456</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphat Res Biol. 2006;4(4):199-210</RefSource><PMID Version="1">17394403</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphat Res Biol. 2009;7(2):97-100</RefSource><PMID Version="1">19522679</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lymphat Res Biol. 2009 Dec;7(4):181</RefSource><PMID Version="1">20143915</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(12):e52021</RefSource><PMID Version="1">23272198</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann N Y Acad Sci. 2010 Oct;1207 Suppl 1:E2-6</RefSource><PMID Version="1">20961302</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 2010 Dec;177(6):3202-14</RefSource><PMID Version="1">21056998</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Physiol Cell Physiol. 2011 May;300(5):C1107-21</RefSource><PMID Version="1">21248077</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Plast Reconstr Surg. 2012 Apr;129(4):825-34</RefSource><PMID Version="1">22456354</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Plast Reconstr Surg. 2012 Apr;129(4):838-47</RefSource><PMID Version="1">22456356</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Vasc Med. 2010 Jun;15(3):223-31</RefSource><PMID 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