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Indocyanine green lymphography for evaluation of genital lymphedema in secondary lower extremity lymphedema patients.

Identifieur interne : 001905 ( PubMed/Corpus ); précédent : 001904; suivant : 001906

Indocyanine green lymphography for evaluation of genital lymphedema in secondary lower extremity lymphedema patients.

Auteurs : Takumi Yamamoto ; Nana Yamamoto ; Hidehiko Yoshimatsu ; Shinya Hayami ; Mitsunaga Narushima ; Isao Koshima

Source :

RBID : pubmed:26992762

Abstract

Treatment of genital lymphedema (GL) is challenging, and early diagnosis and intervention is important to prevent progression of GL. However, early treatment of GL is difficult due to a lack of appropriate evaluation methods allowing early diagnosis. We sought to develop a novel pathophysiological evaluation method for early diagnosis of GL using indocyanine green (ICG) lymphography.

DOI: 10.1016/j.jvsv.2013.02.001
PubMed: 26992762

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pubmed:26992762

Le document en format XML

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<name sortKey="Yamamoto, Takumi" sort="Yamamoto, Takumi" uniqKey="Yamamoto T" first="Takumi" last="Yamamoto">Takumi Yamamoto</name>
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<nlm:affiliation>Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan. Electronic address: tyamamoto-tky@umin.ac.jp.</nlm:affiliation>
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<name sortKey="Yamamoto, Nana" sort="Yamamoto, Nana" uniqKey="Yamamoto N" first="Nana" last="Yamamoto">Nana Yamamoto</name>
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<name sortKey="Yoshimatsu, Hidehiko" sort="Yoshimatsu, Hidehiko" uniqKey="Yoshimatsu H" first="Hidehiko" last="Yoshimatsu">Hidehiko Yoshimatsu</name>
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<name sortKey="Hayami, Shinya" sort="Hayami, Shinya" uniqKey="Hayami S" first="Shinya" last="Hayami">Shinya Hayami</name>
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<name sortKey="Narushima, Mitsunaga" sort="Narushima, Mitsunaga" uniqKey="Narushima M" first="Mitsunaga" last="Narushima">Mitsunaga Narushima</name>
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<div type="abstract" xml:lang="en">Treatment of genital lymphedema (GL) is challenging, and early diagnosis and intervention is important to prevent progression of GL. However, early treatment of GL is difficult due to a lack of appropriate evaluation methods allowing early diagnosis. We sought to develop a novel pathophysiological evaluation method for early diagnosis of GL using indocyanine green (ICG) lymphography.</div>
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<Title>Journal of vascular surgery. Venous and lymphatic disorders</Title>
<ISOAbbreviation>J Vasc Surg Venous Lymphat Disord</ISOAbbreviation>
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<ArticleTitle>Indocyanine green lymphography for evaluation of genital lymphedema in secondary lower extremity lymphedema patients.</ArticleTitle>
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<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Treatment of genital lymphedema (GL) is challenging, and early diagnosis and intervention is important to prevent progression of GL. However, early treatment of GL is difficult due to a lack of appropriate evaluation methods allowing early diagnosis. We sought to develop a novel pathophysiological evaluation method for early diagnosis of GL using indocyanine green (ICG) lymphography.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">This was a retrospective observational study set in a teaching hospital. Patient characteristics and ICG lymphography findings of 68 lower limb lymphedema patients secondary to gynecologic cancer treatments were reviewed. The clinical data and dermal backflow (DB) stages based on ICG lymphography findings were analyzed to compare between the left and right region with and without symptomatic GL.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Twenty-two of 136 lateralities were symptomatic GL. Univariate analyses revealed statistically significant differences between lateralities with (n = 22) and without GL (n = 114) in the duration of leg edema (6.3 ± 1.1 vs 3.8 ± 0.5 years; P = .032), International Society of Lymphology stage (stage 0/1/2/3: 0/4/15/3 vs 40/32/32/10; P = .001), leg DB stage (stage 0/I/II/III/IV/V: 0/0/7/9/4/2 vs 6/35/23/29/18/3; P = .002), and genital DB stage (stage 0/I/II/III/IV: 0/0/0/20/2 vs 27/43/28/16/0; P < .001).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">ICG lymphography can clearly visualize abnormal lymph circulation in the lower abdominal and genital region. Genital DB stage based on ICG lymphography findings allows early diagnosis of GL before symptom manifestation. Further studies are needed to clarify that ICG lymphography is a key evaluation for prevention and early intervention of GL.</AbstractText>
<CopyrightInformation>Copyright © 2013 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
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