LymphedemaV1, PubMed, Corpus, bibRecord, 001711

Connexins in lymphatic vessel physiology and disease.

Identifieur interne : 001711 ( PubMed/Corpus ); précédent : 001710; suivant : 001712

Connexins in lymphatic vessel physiology and disease.

Auteurs : Merlijn J. Meens ; Amélie Sabine ; Tatiana V. Petrova ; Brenda R. Kwak

Source :

FEBS letters [ 1873-3468 ] ; 2014.

RBID : pubmed:24457200

English descriptors

KwdEn :
- Animals, Connexins (genetics), Connexins (metabolism), Gap Junctions (genetics), Gap Junctions (metabolism), Gap Junctions (pathology), Humans, Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Lymphedema (genetics), Lymphedema (metabolism), Lymphedema (pathology), Mutation.
MESH :
- chemical , genetics : Connexins.
- chemical , metabolism : Connexins.
- genetics : Gap Junctions, Lymphedema.
- metabolism : Gap Junctions, Lymphatic Vessels, Lymphedema.
- pathology : Gap Junctions, Lymphatic Vessels, Lymphedema.
- Animals, Humans, Mutation.

Abstract

Connexins are transmembrane proteins that form gap junction- and hemi-channels. Once inserted into the membrane, hemi-channels (connexons) allow for diffusion of ions and small molecules (<1 kDa) between the extracellular space and the cytosol. Gap junction channels allow diffusion of similar molecules between the cytoplasms of adjacent cells. The expression and function of connexins in blood vessels has been intensely studied in the last few decades. In contrast, only a few studies paid attention to lymphatic vessels; convincing in vivo data with respect to expression patterns of lymphatic connexins and their functional roles have only recently begun to emerge. Interestingly, mutations in connexin genes have been linked to diseases of lymphatic vasculature, most notably primary and secondary lymphedema. This review summarizes the available data regarding lymphatic connexins. More specifically it addresses (i) early studies aimed at presence of gap junction-like structures in lymphatic vessels, (ii) more recent studies focusing on lymphatic connexins using genetically engineered mice, and (iii) results of clinical studies that have reported lymphedema-linked mutations in connexin genes.

DOI: 10.1016/j.febslet.2014.01.011
PubMed: 24457200

Links to Exploration step

pubmed:24457200

Le document en format XML

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<author><name sortKey="Meens, Merlijn J" sort="Meens, Merlijn J" uniqKey="Meens M" first="Merlijn J" last="Meens">Merlijn J. Meens</name>
<affiliation><nlm:affiliation>Department of Pathology and Immunology, University of Geneva, CH-1211 Geneva, Switzerland; Department of Internal Medicine - Cardiology, University of Geneva, CH-1211 Geneva, Switzerland.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Sabine, Amelie" sort="Sabine, Amelie" uniqKey="Sabine A" first="Amélie" last="Sabine">Amélie Sabine</name>
<affiliation><nlm:affiliation>Department of Oncology, University Hospital of Lausanne, 1066 Epalinges, Switzerland; Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.</nlm:affiliation>
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<author><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V" last="Petrova">Tatiana V. Petrova</name>
<affiliation><nlm:affiliation>Department of Oncology, University Hospital of Lausanne, 1066 Epalinges, Switzerland; Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland; École Polytechnique Fédérale de Lausanne (EPFL), Swiss Institute for Experimental Cancer Research (ISREC), 1015 Lausanne, Switzerland.</nlm:affiliation>
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<author><name sortKey="Kwak, Brenda R" sort="Kwak, Brenda R" uniqKey="Kwak B" first="Brenda R" last="Kwak">Brenda R. Kwak</name>
<affiliation><nlm:affiliation>Department of Pathology and Immunology, University of Geneva, CH-1211 Geneva, Switzerland; Department of Internal Medicine - Cardiology, University of Geneva, CH-1211 Geneva, Switzerland. Electronic address: brenda.kwakchanson@unige.ch.</nlm:affiliation>
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<author><name sortKey="Meens, Merlijn J" sort="Meens, Merlijn J" uniqKey="Meens M" first="Merlijn J" last="Meens">Merlijn J. Meens</name>
<affiliation><nlm:affiliation>Department of Pathology and Immunology, University of Geneva, CH-1211 Geneva, Switzerland; Department of Internal Medicine - Cardiology, University of Geneva, CH-1211 Geneva, Switzerland.</nlm:affiliation>
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<author><name sortKey="Sabine, Amelie" sort="Sabine, Amelie" uniqKey="Sabine A" first="Amélie" last="Sabine">Amélie Sabine</name>
<affiliation><nlm:affiliation>Department of Oncology, University Hospital of Lausanne, 1066 Epalinges, Switzerland; Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.</nlm:affiliation>
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<author><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V" last="Petrova">Tatiana V. Petrova</name>
<affiliation><nlm:affiliation>Department of Oncology, University Hospital of Lausanne, 1066 Epalinges, Switzerland; Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland; École Polytechnique Fédérale de Lausanne (EPFL), Swiss Institute for Experimental Cancer Research (ISREC), 1015 Lausanne, Switzerland.</nlm:affiliation>
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<author><name sortKey="Kwak, Brenda R" sort="Kwak, Brenda R" uniqKey="Kwak B" first="Brenda R" last="Kwak">Brenda R. Kwak</name>
<affiliation><nlm:affiliation>Department of Pathology and Immunology, University of Geneva, CH-1211 Geneva, Switzerland; Department of Internal Medicine - Cardiology, University of Geneva, CH-1211 Geneva, Switzerland. Electronic address: brenda.kwakchanson@unige.ch.</nlm:affiliation>
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<series><title level="j">FEBS letters</title>
<idno type="eISSN">1873-3468</idno>
<imprint><date when="2014" type="published">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Connexins (genetics)</term>
<term>Connexins (metabolism)</term>
<term>Gap Junctions (genetics)</term>
<term>Gap Junctions (metabolism)</term>
<term>Gap Junctions (pathology)</term>
<term>Humans</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Lymphatic Vessels (pathology)</term>
<term>Lymphedema (genetics)</term>
<term>Lymphedema (metabolism)</term>
<term>Lymphedema (pathology)</term>
<term>Mutation</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Connexins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Connexins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gap Junctions</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Gap Junctions</term>
<term>Lymphatic Vessels</term>
<term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gap Junctions</term>
<term>Lymphatic Vessels</term>
<term>Lymphedema</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Connexins are transmembrane proteins that form gap junction- and hemi-channels. Once inserted into the membrane, hemi-channels (connexons) allow for diffusion of ions and small molecules (<1 kDa) between the extracellular space and the cytosol. Gap junction channels allow diffusion of similar molecules between the cytoplasms of adjacent cells. The expression and function of connexins in blood vessels has been intensely studied in the last few decades. In contrast, only a few studies paid attention to lymphatic vessels; convincing in vivo data with respect to expression patterns of lymphatic connexins and their functional roles have only recently begun to emerge. Interestingly, mutations in connexin genes have been linked to diseases of lymphatic vasculature, most notably primary and secondary lymphedema. This review summarizes the available data regarding lymphatic connexins. More specifically it addresses (i) early studies aimed at presence of gap junction-like structures in lymphatic vessels, (ii) more recent studies focusing on lymphatic connexins using genetically engineered mice, and (iii) results of clinical studies that have reported lymphedema-linked mutations in connexin genes.</div>
</front>
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<Abstract><AbstractText>Connexins are transmembrane proteins that form gap junction- and hemi-channels. Once inserted into the membrane, hemi-channels (connexons) allow for diffusion of ions and small molecules (<1 kDa) between the extracellular space and the cytosol. Gap junction channels allow diffusion of similar molecules between the cytoplasms of adjacent cells. The expression and function of connexins in blood vessels has been intensely studied in the last few decades. In contrast, only a few studies paid attention to lymphatic vessels; convincing in vivo data with respect to expression patterns of lymphatic connexins and their functional roles have only recently begun to emerge. Interestingly, mutations in connexin genes have been linked to diseases of lymphatic vasculature, most notably primary and secondary lymphedema. This review summarizes the available data regarding lymphatic connexins. More specifically it addresses (i) early studies aimed at presence of gap junction-like structures in lymphatic vessels, (ii) more recent studies focusing on lymphatic connexins using genetically engineered mice, and (iii) results of clinical studies that have reported lymphedema-linked mutations in connexin genes.</AbstractText>
<CopyrightInformation>Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</CopyrightInformation>
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<ForeName>Merlijn J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Immunology, University of Geneva, CH-1211 Geneva, Switzerland; Department of Internal Medicine - Cardiology, University of Geneva, CH-1211 Geneva, Switzerland.</Affiliation>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Connexin</Keyword>
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<Keyword MajorTopicYN="N">Lymphedema</Keyword>
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Connexins in lymphatic vessel physiology and disease.

Connexins in lymphatic vessel physiology and disease.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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