Lymph node transplantation results in spontaneous lymphatic reconnection and restoration of lymphatic flow.
Identifieur interne : 001708 ( PubMed/Corpus ); précédent : 001707; suivant : 001709Lymph node transplantation results in spontaneous lymphatic reconnection and restoration of lymphatic flow.
Auteurs : Seth Z. Aschen ; Gina Farias-Eisner ; Daniel A. Cuzzone ; Nicholas J. Albano ; Swapna Ghanta ; Evan S. Weitman ; Sagrario Ortega ; Babak J. MehraraSource :
- Plastic and reconstructive surgery [ 1529-4242 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- physiology : Lymph Nodes, Lymphatic Vessels.
- surgery : Lymphatic Vessels.
- transplantation : Lymph Nodes.
- Animals, Male, Mice, Mice, Inbred C57BL.
Abstract
Although lymph node transplantation has been shown to improve lymphatic function, the mechanisms regulating lymphatic vessel reconnection and functional status of lymph nodes remains poorly understood.
DOI: 10.1097/01.prs.0000436840.69752.7e
PubMed: 24469165
Links to Exploration step
pubmed:24469165Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymph node transplantation results in spontaneous lymphatic reconnection and restoration of lymphatic flow.</title><author><name sortKey="Aschen, Seth Z" sort="Aschen, Seth Z" uniqKey="Aschen S" first="Seth Z" last="Aschen">Seth Z. Aschen</name><affiliation><nlm:affiliation>New York, N.Y.; and Madrid, Spain From the Division of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Center; and the Biotechnology Programme, Spanish National Cancer Research Centre.</nlm:affiliation></affiliation></author><author><name sortKey="Farias Eisner, Gina" sort="Farias Eisner, Gina" uniqKey="Farias Eisner G" first="Gina" last="Farias-Eisner">Gina Farias-Eisner</name></author><author><name sortKey="Cuzzone, Daniel A" sort="Cuzzone, Daniel A" uniqKey="Cuzzone D" first="Daniel A" last="Cuzzone">Daniel A. Cuzzone</name></author><author><name sortKey="Albano, Nicholas J" sort="Albano, Nicholas J" uniqKey="Albano N" first="Nicholas J" last="Albano">Nicholas J. Albano</name></author><author><name sortKey="Ghanta, Swapna" sort="Ghanta, Swapna" uniqKey="Ghanta S" first="Swapna" last="Ghanta">Swapna Ghanta</name></author><author><name sortKey="Weitman, Evan S" sort="Weitman, Evan S" uniqKey="Weitman E" first="Evan S" last="Weitman">Evan S. Weitman</name></author><author><name sortKey="Ortega, Sagrario" sort="Ortega, Sagrario" uniqKey="Ortega S" first="Sagrario" last="Ortega">Sagrario Ortega</name></author><author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J" last="Mehrara">Babak J. Mehrara</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24469165</idno><idno type="pmid">24469165</idno><idno type="doi">10.1097/01.prs.0000436840.69752.7e</idno><idno type="wicri:Area/PubMed/Corpus">001708</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001708</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lymph node transplantation results in spontaneous lymphatic reconnection and restoration of lymphatic flow.</title><author><name sortKey="Aschen, Seth Z" sort="Aschen, Seth Z" uniqKey="Aschen S" first="Seth Z" last="Aschen">Seth Z. Aschen</name><affiliation><nlm:affiliation>New York, N.Y.; and Madrid, Spain From the Division of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Center; and the Biotechnology Programme, Spanish National Cancer Research Centre.</nlm:affiliation></affiliation></author><author><name sortKey="Farias Eisner, Gina" sort="Farias Eisner, Gina" uniqKey="Farias Eisner G" first="Gina" last="Farias-Eisner">Gina Farias-Eisner</name></author><author><name sortKey="Cuzzone, Daniel A" sort="Cuzzone, Daniel A" uniqKey="Cuzzone D" first="Daniel A" last="Cuzzone">Daniel A. Cuzzone</name></author><author><name sortKey="Albano, Nicholas J" sort="Albano, Nicholas J" uniqKey="Albano N" first="Nicholas J" last="Albano">Nicholas J. Albano</name></author><author><name sortKey="Ghanta, Swapna" sort="Ghanta, Swapna" uniqKey="Ghanta S" first="Swapna" last="Ghanta">Swapna Ghanta</name></author><author><name sortKey="Weitman, Evan S" sort="Weitman, Evan S" uniqKey="Weitman E" first="Evan S" last="Weitman">Evan S. Weitman</name></author><author><name sortKey="Ortega, Sagrario" sort="Ortega, Sagrario" uniqKey="Ortega S" first="Sagrario" last="Ortega">Sagrario Ortega</name></author><author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J" last="Mehrara">Babak J. Mehrara</name></author></analytic><series><title level="j">Plastic and reconstructive surgery</title><idno type="eISSN">1529-4242</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Lymph Nodes (physiology)</term><term>Lymph Nodes (transplantation)</term><term>Lymphatic Vessels (physiology)</term><term>Lymphatic Vessels (surgery)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymph Nodes</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although lymph node transplantation has been shown to improve lymphatic function, the mechanisms regulating lymphatic vessel reconnection and functional status of lymph nodes remains poorly understood.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24469165</PMID><DateCreated><Year>2014</Year><Month>01</Month><Day>28</Day></DateCreated><DateCompleted><Year>2014</Year><Month>03</Month><Day>24</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1529-4242</ISSN><JournalIssue CitedMedium="Internet"><Volume>133</Volume><Issue>2</Issue><PubDate><Year>2014</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Plastic and reconstructive surgery</Title><ISOAbbreviation>Plast. Reconstr. Surg.</ISOAbbreviation></Journal><ArticleTitle>Lymph node transplantation results in spontaneous lymphatic reconnection and restoration of lymphatic flow.</ArticleTitle><Pagination><MedlinePgn>301-10</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/01.prs.0000436840.69752.7e</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Although lymph node transplantation has been shown to improve lymphatic function, the mechanisms regulating lymphatic vessel reconnection and functional status of lymph nodes remains poorly understood.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The authors developed and used LacZ lymphatic reporter mice to examine the lineage of lymphatic vessels infiltrating transferred lymph nodes. In addition, the authors analyzed lymphatic function, expression of vascular endothelial growth factor (VEGF)-C, maintenance of T- and B-cell zone, and anatomical localization of lymphatics and high endothelial venules.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Reporter mice were specific and highly sensitive in identifying lymphatic vessels. Lymph node transfer was associated with rapid return of lymphatic function and clearance of technetium-99 secondary to a massive infiltration of recipient mouse lymphatics and putative connections to donor lymphatics. T- and B-cell populations in the lymph node were maintained. These changes correlated with marked increases in the expression of VEGF-C in the perinodal fat and infiltrating lymphatics. Newly formed lymphatic channels in transferred lymph nodes were in close anatomical proximity to high endothelial venules.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Transferred lymph nodes have rapid infiltration of functional host lymphatic vessels and maintain T- and B-cell populations. This process correlates with increased endogenous expression of VEGF-C in the perinodal fat and infiltrating lymphatics. Anatomical proximity of newly formed lymphatics and high endothelial venules supports the hypothesis that lymph node transfer can improve lymphedema by exchanges with the systemic circulation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Aschen</LastName><ForeName>Seth Z</ForeName><Initials>SZ</Initials><AffiliationInfo><Affiliation>New York, N.Y.; and Madrid, Spain From the Division of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Center; and the Biotechnology Programme, Spanish National Cancer Research Centre.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farias-Eisner</LastName><ForeName>Gina</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Cuzzone</LastName><ForeName>Daniel A</ForeName><Initials>DA</Initials></Author><Author ValidYN="Y"><LastName>Albano</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials></Author><Author ValidYN="Y"><LastName>Ghanta</LastName><ForeName>Swapna</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Weitman</LastName><ForeName>Evan S</ForeName><Initials>ES</Initials></Author><Author ValidYN="Y"><LastName>Ortega</LastName><ForeName>Sagrario</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Mehrara</LastName><ForeName>Babak J</ForeName><Initials>BJ</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 HL111130</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 CA009501</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL111130-02</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Plast Reconstr Surg</MedlineTA><NlmUniqueID>1306050</NlmUniqueID><ISSNLinking>0032-1052</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2000 Aug 15;60(16):4324-7</RefSource><PMID Version="1">10969769</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Plast Reconstr Surg. 2013 Jun;131(6):1286-98</RefSource><PMID Version="1">23714790</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Res. 2004 Jul 1;64(13):4400-4</RefSource><PMID Version="1">15231646</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dev Dyn. 1995 Apr;202(4):325-32</RefSource><PMID 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Version="1">22067482</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6223-8</RefSource><PMID Version="1">22474390</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FASEB J. 2013 Mar;27(3):1114-26</RefSource><PMID Version="1">23193171</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Thromb Haemost. 2003 Aug;90(2):167-84</RefSource><PMID Version="1">12888864</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName><QualifierName UI="Q000637" MajorTopicYN="Y">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS542812</OtherID><OtherID Source="NLM">PMC4066306</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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