Fatal lower limb infection by Trichosporon asahii in an immunocompetent patient.
Identifieur interne : 001704 ( PubMed/Corpus ); précédent : 001703; suivant : 001705Fatal lower limb infection by Trichosporon asahii in an immunocompetent patient.
Auteurs : Stavroula Baka ; Iliana Tsouma ; Evangelia KouskouniSource :
- Acta dermatovenerologica Croatica : ADC [ 1847-6538 ] ; 2013.
English descriptors
- KwdEn :
- Amphotericin B (therapeutic use), Antifungal Agents (administration & dosage), Dermatomycoses (microbiology), Edema (microbiology), Fatal Outcome, Female, Humans, Immunocompetence, Leg (microbiology), Middle Aged, Trichosporonosis (diagnosis), Trichosporonosis (drug therapy), Voriconazole (administration & dosage).
- MESH :
- chemical , administration & dosage : Antifungal Agents, Voriconazole.
- chemical , therapeutic use : Amphotericin B.
- diagnosis : Trichosporonosis.
- drug therapy : Trichosporonosis.
- microbiology : Dermatomycoses, Edema, Leg.
- Fatal Outcome, Female, Humans, Immunocompetence, Middle Aged.
Abstract
Trichosporon (T.) asahii can cause superficial skin infections and can be an opportunistic pathogen that produces potentially fatal systemic infections in immunocompromised hosts. We report a case of lower limb infection due to T. asahii in an immunocompetent patient who displayed no evidence of underlying disease. There is a strong possibility that our patient had been colonized at the infection site as part of the normal skin flora. After one-month bed rest due to an accidental fall and fracture of the right shoulder blade, a 61-year-old woman experienced severe edema and redness in the right lower limb and received topical treatment with iodine solution and antibiotics without improvement. She presented at our Outpatient Clinic with cellulitis and lymphedema. Samples collected from the affected areas revealed T. asahii and the patient was referred to a hospital for infectious diseases for appropriate therapy. The patient was treated with wound dressings until she was admitted to our intensive care unit when her general condition abruptly deteriorated. Despite in vitro susceptibility results, therapy with liposomal amphotericin and voriconazole could not change the fatal outcome. Nowadays, physicians must suspect this emerging difficult-to-treat fungal pathogen and treatment must start promptly in these infections.
PubMed: 24476611
Links to Exploration step
pubmed:24476611Le document en format XML
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Prof. Stavroula Baka, MD, 3, Blessa Street, Papagou, 15669 Athens, Greece; sbaka@aretaieio.uoa.gr.</nlm:affiliation></affiliation></author><author><name sortKey="Tsouma, Iliana" sort="Tsouma, Iliana" uniqKey="Tsouma I" first="Iliana" last="Tsouma">Iliana Tsouma</name></author><author><name sortKey="Kouskouni, Evangelia" sort="Kouskouni, Evangelia" uniqKey="Kouskouni E" first="Evangelia" last="Kouskouni">Evangelia Kouskouni</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24476611</idno><idno type="pmid">24476611</idno><idno type="wicri:Area/PubMed/Corpus">001704</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001704</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Fatal lower limb infection by Trichosporon asahii in an immunocompetent patient.</title><author><name sortKey="Baka, Stavroula" sort="Baka, Stavroula" uniqKey="Baka S" first="Stavroula" last="Baka">Stavroula Baka</name><affiliation><nlm:affiliation>Assist. Prof. Stavroula Baka, MD, 3, Blessa Street, Papagou, 15669 Athens, Greece; sbaka@aretaieio.uoa.gr.</nlm:affiliation></affiliation></author><author><name sortKey="Tsouma, Iliana" sort="Tsouma, Iliana" uniqKey="Tsouma I" first="Iliana" last="Tsouma">Iliana Tsouma</name></author><author><name sortKey="Kouskouni, Evangelia" sort="Kouskouni, Evangelia" uniqKey="Kouskouni E" first="Evangelia" last="Kouskouni">Evangelia Kouskouni</name></author></analytic><series><title level="j">Acta dermatovenerologica Croatica : ADC</title><idno type="eISSN">1847-6538</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amphotericin B (therapeutic use)</term><term>Antifungal Agents (administration & dosage)</term><term>Dermatomycoses (microbiology)</term><term>Edema (microbiology)</term><term>Fatal Outcome</term><term>Female</term><term>Humans</term><term>Immunocompetence</term><term>Leg (microbiology)</term><term>Middle Aged</term><term>Trichosporonosis (diagnosis)</term><term>Trichosporonosis (drug therapy)</term><term>Voriconazole (administration & dosage)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antifungal Agents</term><term>Voriconazole</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Amphotericin B</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Trichosporonosis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Trichosporonosis</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Dermatomycoses</term><term>Edema</term><term>Leg</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Fatal Outcome</term><term>Female</term><term>Humans</term><term>Immunocompetence</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Trichosporon (T.) asahii can cause superficial skin infections and can be an opportunistic pathogen that produces potentially fatal systemic infections in immunocompromised hosts. We report a case of lower limb infection due to T. asahii in an immunocompetent patient who displayed no evidence of underlying disease. There is a strong possibility that our patient had been colonized at the infection site as part of the normal skin flora. After one-month bed rest due to an accidental fall and fracture of the right shoulder blade, a 61-year-old woman experienced severe edema and redness in the right lower limb and received topical treatment with iodine solution and antibiotics without improvement. She presented at our Outpatient Clinic with cellulitis and lymphedema. Samples collected from the affected areas revealed T. asahii and the patient was referred to a hospital for infectious diseases for appropriate therapy. The patient was treated with wound dressings until she was admitted to our intensive care unit when her general condition abruptly deteriorated. Despite in vitro susceptibility results, therapy with liposomal amphotericin and voriconazole could not change the fatal outcome. Nowadays, physicians must suspect this emerging difficult-to-treat fungal pathogen and treatment must start promptly in these infections.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24476611</PMID><DateCreated><Year>2014</Year><Month>01</Month><Day>30</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2015</Year><Month>07</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1847-6538</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>4</Issue><PubDate><Year>2013</Year></PubDate></JournalIssue><Title>Acta dermatovenerologica Croatica : ADC</Title><ISOAbbreviation>Acta Dermatovenerol Croat</ISOAbbreviation></Journal><ArticleTitle>Fatal lower limb infection by Trichosporon asahii in an immunocompetent patient.</ArticleTitle><Pagination><MedlinePgn>241-4</MedlinePgn></Pagination><Abstract><AbstractText>Trichosporon (T.) asahii can cause superficial skin infections and can be an opportunistic pathogen that produces potentially fatal systemic infections in immunocompromised hosts. We report a case of lower limb infection due to T. asahii in an immunocompetent patient who displayed no evidence of underlying disease. There is a strong possibility that our patient had been colonized at the infection site as part of the normal skin flora. After one-month bed rest due to an accidental fall and fracture of the right shoulder blade, a 61-year-old woman experienced severe edema and redness in the right lower limb and received topical treatment with iodine solution and antibiotics without improvement. She presented at our Outpatient Clinic with cellulitis and lymphedema. Samples collected from the affected areas revealed T. asahii and the patient was referred to a hospital for infectious diseases for appropriate therapy. The patient was treated with wound dressings until she was admitted to our intensive care unit when her general condition abruptly deteriorated. Despite in vitro susceptibility results, therapy with liposomal amphotericin and voriconazole could not change the fatal outcome. Nowadays, physicians must suspect this emerging difficult-to-treat fungal pathogen and treatment must start promptly in these infections.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Baka</LastName><ForeName>Stavroula</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Assist. Prof. Stavroula Baka, MD, 3, Blessa Street, Papagou, 15669 Athens, Greece; sbaka@aretaieio.uoa.gr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsouma</LastName><ForeName>Iliana</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Kouskouni</LastName><ForeName>Evangelia</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Croatia</Country><MedlineTA>Acta Dermatovenerol Croat</MedlineTA><NlmUniqueID>9433781</NlmUniqueID><ISSNLinking>1330-027X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C068538">liposomal amphotericin B</NameOfSubstance></Chemical><Chemical><RegistryNumber>7XU7A7DROE</RegistryNumber><NameOfSubstance UI="D000666">Amphotericin B</NameOfSubstance></Chemical><Chemical><RegistryNumber>JFU09I87TR</RegistryNumber><NameOfSubstance UI="D065819">Voriconazole</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000666" MajorTopicYN="N">Amphotericin B</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003881" MajorTopicYN="N">Dermatomycoses</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004487" MajorTopicYN="N">Edema</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017809" MajorTopicYN="N">Fatal Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007121" MajorTopicYN="N">Immunocompetence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007866" MajorTopicYN="N">Leg</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060586" MajorTopicYN="N">Trichosporonosis</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065819" MajorTopicYN="N">Voriconazole</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24476611</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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