An investigation of lymphovenous communications in the upper limbs of breast cancer patients.
Identifieur interne : 001153 ( PubMed/Corpus ); précédent : 001152; suivant : 001154An investigation of lymphovenous communications in the upper limbs of breast cancer patients.
Auteurs : S K Bains ; J. Ballinger ; S. Allen ; A W B. Stanton ; J R Levick ; P S Mortimer ; A D Purushotham ; A M PetersSource :
- European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [ 1532-2157 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Axilla, Breast Neoplasms (pathology), Breast Neoplasms (surgery), Case-Control Studies, Erythrocytes, Female, Humans, Lymph Node Excision (adverse effects), Lymph Nodes (pathology), Lymphatic System (physiopathology), Lymphatic Vessels (physiopathology), Lymphedema (etiology), Lymphedema (physiopathology), Middle Aged, Organotechnetium Compounds, Radioactive Tracers, Upper Extremity.
- MESH :
- chemical : Organotechnetium Compounds, Radioactive Tracers.
- adverse effects : Lymph Node Excision.
- etiology : Lymphedema.
- pathology : Breast Neoplasms, Lymph Nodes.
- physiopathology : Lymphatic System, Lymphatic Vessels, Lymphedema.
- surgery : Breast Neoplasms.
- Adult, Axilla, Case-Control Studies, Erythrocytes, Female, Humans, Middle Aged, Upper Extremity.
Abstract
Approximately 25% of breast cancer patients who undergo treatment to the axilla develop breast cancer-related lymphoedema (BCRL). The aim of this study was to test the hypothesis that lymphovenous communications (LVCs) open and act as a protective mechanism against the development of BCRL.
DOI: 10.1016/j.ejso.2014.11.036
PubMed: 25480305
Links to Exploration step
pubmed:25480305Le document en format XML
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Allen</name><affiliation><nlm:affiliation>Guy's & St Thomas' NHS Foundation Trust, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Stanton, A W B" sort="Stanton, A W B" uniqKey="Stanton A" first="A W B" last="Stanton">A W B. Stanton</name><affiliation><nlm:affiliation>Clinical Sciences, St George's, University of London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name><affiliation><nlm:affiliation>Clinical Sciences, St George's, University of London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">P S Mortimer</name><affiliation><nlm:affiliation>Clinical Sciences, St George's, University of London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Purushotham, A D" sort="Purushotham, A D" uniqKey="Purushotham A" first="A D" last="Purushotham">A D Purushotham</name><affiliation><nlm:affiliation>Division of Cancer Studies, King's College London, UK; Guy's & St Thomas' NHS Foundation Trust, UK. Electronic address: ea-purushotham@kcl.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, A M" sort="Peters, A M" uniqKey="Peters A" first="A M" last="Peters">A M Peters</name><affiliation><nlm:affiliation>Department of Nuclear Medicine, Brighton and Sussex University Hospitals NHS Trust, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25480305</idno><idno type="pmid">25480305</idno><idno type="doi">10.1016/j.ejso.2014.11.036</idno><idno type="wicri:Area/PubMed/Corpus">001153</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001153</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An investigation of lymphovenous communications in the upper limbs of breast cancer patients.</title><author><name sortKey="Bains, S K" sort="Bains, S K" uniqKey="Bains S" first="S K" last="Bains">S K Bains</name><affiliation><nlm:affiliation>Division of Cancer Studies, King's College London, UK; Guy's & St Thomas' NHS Foundation Trust, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ballinger, J" sort="Ballinger, J" uniqKey="Ballinger J" first="J" last="Ballinger">J. Ballinger</name><affiliation><nlm:affiliation>Guy's & St Thomas' NHS Foundation Trust, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Allen, S" sort="Allen, S" uniqKey="Allen S" first="S" last="Allen">S. Allen</name><affiliation><nlm:affiliation>Guy's & St Thomas' NHS Foundation Trust, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Stanton, A W B" sort="Stanton, A W B" uniqKey="Stanton A" first="A W B" last="Stanton">A W B. Stanton</name><affiliation><nlm:affiliation>Clinical Sciences, St George's, University of London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name><affiliation><nlm:affiliation>Clinical Sciences, St George's, University of London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">P S Mortimer</name><affiliation><nlm:affiliation>Clinical Sciences, St George's, University of London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Purushotham, A D" sort="Purushotham, A D" uniqKey="Purushotham A" first="A D" last="Purushotham">A D Purushotham</name><affiliation><nlm:affiliation>Division of Cancer Studies, King's College London, UK; Guy's & St Thomas' NHS Foundation Trust, UK. Electronic address: ea-purushotham@kcl.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, A M" sort="Peters, A M" uniqKey="Peters A" first="A M" last="Peters">A M Peters</name><affiliation><nlm:affiliation>Department of Nuclear Medicine, Brighton and Sussex University Hospitals NHS Trust, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology</title><idno type="eISSN">1532-2157</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Axilla</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (surgery)</term><term>Case-Control Studies</term><term>Erythrocytes</term><term>Female</term><term>Humans</term><term>Lymph Node Excision (adverse effects)</term><term>Lymph Nodes (pathology)</term><term>Lymphatic System (physiopathology)</term><term>Lymphatic Vessels (physiopathology)</term><term>Lymphedema (etiology)</term><term>Lymphedema (physiopathology)</term><term>Middle Aged</term><term>Organotechnetium Compounds</term><term>Radioactive Tracers</term><term>Upper Extremity</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Organotechnetium Compounds</term><term>Radioactive Tracers</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lymph Node Excision</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphatic System</term><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Axilla</term><term>Case-Control Studies</term><term>Erythrocytes</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Upper Extremity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Approximately 25% of breast cancer patients who undergo treatment to the axilla develop breast cancer-related lymphoedema (BCRL). The aim of this study was to test the hypothesis that lymphovenous communications (LVCs) open and act as a protective mechanism against the development of BCRL.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25480305</PMID><DateCreated><Year>2015</Year><Month>02</Month><Day>10</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2157</ISSN><JournalIssue CitedMedium="Internet"><Volume>41</Volume><Issue>3</Issue><PubDate><Year>2015</Year><Month>Mar</Month></PubDate></JournalIssue><Title>European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology</Title><ISOAbbreviation>Eur J Surg Oncol</ISOAbbreviation></Journal><ArticleTitle>An investigation of lymphovenous communications in the upper limbs of breast cancer patients.</ArticleTitle><Pagination><MedlinePgn>433-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejso.2014.11.036</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0748-7983(14)01235-9</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Approximately 25% of breast cancer patients who undergo treatment to the axilla develop breast cancer-related lymphoedema (BCRL). The aim of this study was to test the hypothesis that lymphovenous communications (LVCs) open and act as a protective mechanism against the development of BCRL.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Five patients (Group 1) received intradermal injections of (99m)Technetium-labelled autologous erythrocytes into the 2nd ipsilateral hand webspace before and 6-12 weeks following axillary node clearance surgery (ANC). Ten patients at least three years after ANC were also recruited (Group 2); seven had developed BCRL and three had not. Blood was sampled from ipsilateral and contralateral antecubital veins 5, 15, 30, 60, 120 and 180 min post-injection to assess pre-nodal shunting from lymph to blood (LVCs), since nodes block erythrocyte transit. The proportion of activity remaining in the depot was used to calculate the degree of shunting in those with evidence of LVCs.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Significant erythrocyte-bound activity, increasing over time, was detected contralaterally in 3 of the 5 patients from Group 1 (none of whom developed BCRL) and 3 of 7 patients with BCRL from Group 2, which indicated the presence of LVCs. The degree of shunting was more marked in those patients who did not develop BCRL compared with those who did.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The time-course of erythrocyte-bound contralateral activity indicates transit through lymphovenous communications rather than needle-induced trauma. Lymphovenous communications large enough to transmit erythrocytes are probably constitutional rather than induced. A larger study is warranted to assess any resulting protection against BCRL.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bains</LastName><ForeName>S K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Division of Cancer Studies, King's College London, UK; Guy's & St Thomas' NHS Foundation Trust, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ballinger</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Guy's & St Thomas' NHS Foundation Trust, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allen</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Guy's & St Thomas' NHS Foundation Trust, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stanton</LastName><ForeName>A W B</ForeName><Initials>AW</Initials><AffiliationInfo><Affiliation>Clinical Sciences, St George's, University of London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Levick</LastName><ForeName>J R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Clinical Sciences, St George's, University of London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mortimer</LastName><ForeName>P S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Clinical Sciences, St George's, University of London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Purushotham</LastName><ForeName>A D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Division of Cancer Studies, King's College London, UK; Guy's & St Thomas' NHS Foundation Trust, UK. Electronic address: ea-purushotham@kcl.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>A M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Nuclear Medicine, Brighton and Sussex University Hospitals NHS Trust, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>C19621/A11009</GrantID><Agency>Cancer Research UK</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>11</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur J Surg Oncol</MedlineTA><NlmUniqueID>8504356</NlmUniqueID><ISSNLinking>0748-7983</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015609">Organotechnetium Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011849">Radioactive Tracers</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001365" MajorTopicYN="N">Axilla</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004912" MajorTopicYN="N">Erythrocytes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008197" MajorTopicYN="N">Lymph Node Excision</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042601" MajorTopicYN="N">Lymphatic Vessels</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015609" MajorTopicYN="N">Organotechnetium Compounds</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011849" MajorTopicYN="N">Radioactive Tracers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D034941" MajorTopicYN="Y">Upper Extremity</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Breast cancer</Keyword><Keyword MajorTopicYN="N">Lymphoedema</Keyword><Keyword MajorTopicYN="N">Lymphovenous communications</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>09</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>10</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>11</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25480305</ArticleId><ArticleId IdType="pii">S0748-7983(14)01235-9</ArticleId><ArticleId IdType="doi">10.1016/j.ejso.2014.11.036</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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