cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.
Identifieur interne : 000F87 ( PubMed/Corpus ); précédent : 000F86; suivant : 000F88cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.
Auteurs : Lukas Stanczuk ; Ines Martinez-Corral ; Maria H. Ulvmar ; Yang Zhang ; Bàrbara Lavi A ; Marcus Fruttiger ; Ralf H. Adams ; Dieter Saur ; Christer Betsholtz ; Sagrario Ortega ; Kari Alitalo ; Mariona Graupera ; Taija M KinenSource :
- Cell reports [ 2211-1247 ] ; 2015.
Abstract
Pathological lymphatic diseases mostly affect vessels in specific tissues, yet little is known about organ-specific regulation of the lymphatic vasculature. Here, we show that the vascular endothelial growth factor receptor 3 (VEGFR-3)/p110α PI3-kinase signaling pathway is selectively required for the formation of mesenteric lymphatic vasculature. Using genetic lineage tracing, we demonstrate that part of the mesenteric lymphatic vasculature develops from cKit lineage cells of hemogenic endothelial origin through a process we define as lymphvasculogenesis. This is contrary to the current dogma that all mammalian lymphatic vessels form by sprouting from veins. Our results reveal vascular-bed-specific differences in the origin and mechanisms of vessel formation, which may critically underlie organ-specific manifestation of lymphatic dysfunction in disease. The progenitor cells identified in this study may be exploited to restore lymphatic function following cancer surgery, lymphedema, or tissue trauma.
DOI: 10.1016/j.celrep.2015.02.026
PubMed: 25772358
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Ulvmar</name><affiliation><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yang" sort="Zhang, Yang" uniqKey="Zhang Y" first="Yang" last="Zhang">Yang Zhang</name><affiliation><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lavi A, Barbara" sort="Lavi A, Barbara" uniqKey="Lavi A B" first="Bàrbara" last="Lavi A">Bàrbara Lavi A</name><affiliation><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Fruttiger, Marcus" sort="Fruttiger, Marcus" uniqKey="Fruttiger M" first="Marcus" last="Fruttiger">Marcus Fruttiger</name><affiliation><nlm:affiliation>UCL Institute of Ophthalmology, University College London (UCL), 11-43 Bath Street, London EC1V 9EL, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Adams, Ralf H" sort="Adams, Ralf H" uniqKey="Adams R" first="Ralf H" last="Adams">Ralf H. Adams</name><affiliation><nlm:affiliation>Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster, 48149 Münster, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Saur, Dieter" sort="Saur, Dieter" uniqKey="Saur D" first="Dieter" last="Saur">Dieter Saur</name><affiliation><nlm:affiliation>Department of Internal Medicine 2, Klinikum Rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Betsholtz, Christer" sort="Betsholtz, Christer" uniqKey="Betsholtz C" first="Christer" last="Betsholtz">Christer Betsholtz</name><affiliation><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles Väg 2, 171 77 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ortega, Sagrario" sort="Ortega, Sagrario" uniqKey="Ortega S" first="Sagrario" last="Ortega">Sagrario Ortega</name><affiliation><nlm:affiliation>Biotechnology Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, 28029 Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation><nlm:affiliation>Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Graupera, Mariona" sort="Graupera, Mariona" uniqKey="Graupera M" first="Mariona" last="Graupera">Mariona Graupera</name><affiliation><nlm:affiliation>Vascular Signalling Lab, IDIBELL, 3a planta - Gran Via de l'Hospitalet 199, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name><affiliation><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address: taija.makinen@igp.uu.se.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25772358</idno><idno type="pmid">25772358</idno><idno type="doi">10.1016/j.celrep.2015.02.026</idno><idno type="wicri:Area/PubMed/Corpus">000F87</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F87</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.</title><author><name sortKey="Stanczuk, Lukas" sort="Stanczuk, Lukas" uniqKey="Stanczuk L" first="Lukas" last="Stanczuk">Lukas Stanczuk</name><affiliation><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Martinez Corral, Ines" sort="Martinez Corral, Ines" uniqKey="Martinez Corral I" first="Ines" last="Martinez-Corral">Ines Martinez-Corral</name><affiliation><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ulvmar, Maria H" sort="Ulvmar, Maria H" uniqKey="Ulvmar M" first="Maria H" last="Ulvmar">Maria H. Ulvmar</name><affiliation><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yang" sort="Zhang, Yang" uniqKey="Zhang Y" first="Yang" last="Zhang">Yang Zhang</name><affiliation><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lavi A, Barbara" sort="Lavi A, Barbara" uniqKey="Lavi A B" first="Bàrbara" last="Lavi A">Bàrbara Lavi A</name><affiliation><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Fruttiger, Marcus" sort="Fruttiger, Marcus" uniqKey="Fruttiger M" first="Marcus" last="Fruttiger">Marcus Fruttiger</name><affiliation><nlm:affiliation>UCL Institute of Ophthalmology, University College London (UCL), 11-43 Bath Street, London EC1V 9EL, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Adams, Ralf H" sort="Adams, Ralf H" uniqKey="Adams R" first="Ralf H" last="Adams">Ralf H. Adams</name><affiliation><nlm:affiliation>Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster, 48149 Münster, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Saur, Dieter" sort="Saur, Dieter" uniqKey="Saur D" first="Dieter" last="Saur">Dieter Saur</name><affiliation><nlm:affiliation>Department of Internal Medicine 2, Klinikum Rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Betsholtz, Christer" sort="Betsholtz, Christer" uniqKey="Betsholtz C" first="Christer" last="Betsholtz">Christer Betsholtz</name><affiliation><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles Väg 2, 171 77 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ortega, Sagrario" sort="Ortega, Sagrario" uniqKey="Ortega S" first="Sagrario" last="Ortega">Sagrario Ortega</name><affiliation><nlm:affiliation>Biotechnology Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, 28029 Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation><nlm:affiliation>Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Graupera, Mariona" sort="Graupera, Mariona" uniqKey="Graupera M" first="Mariona" last="Graupera">Mariona Graupera</name><affiliation><nlm:affiliation>Vascular Signalling Lab, IDIBELL, 3a planta - Gran Via de l'Hospitalet 199, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name><affiliation><nlm:affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address: taija.makinen@igp.uu.se.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cell reports</title><idno type="eISSN">2211-1247</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pathological lymphatic diseases mostly affect vessels in specific tissues, yet little is known about organ-specific regulation of the lymphatic vasculature. Here, we show that the vascular endothelial growth factor receptor 3 (VEGFR-3)/p110α PI3-kinase signaling pathway is selectively required for the formation of mesenteric lymphatic vasculature. Using genetic lineage tracing, we demonstrate that part of the mesenteric lymphatic vasculature develops from cKit lineage cells of hemogenic endothelial origin through a process we define as lymphvasculogenesis. This is contrary to the current dogma that all mammalian lymphatic vessels form by sprouting from veins. Our results reveal vascular-bed-specific differences in the origin and mechanisms of vessel formation, which may critically underlie organ-specific manifestation of lymphatic dysfunction in disease. The progenitor cells identified in this study may be exploited to restore lymphatic function following cancer surgery, lymphedema, or tissue trauma.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">25772358</PMID><DateCreated><Year>2015</Year><Month>03</Month><Day>16</Day></DateCreated><DateRevised><Year>2015</Year><Month>03</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2211-1247</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2015</Year><Month>Mar</Month><Day>10</Day></PubDate></JournalIssue><Title>Cell reports</Title><ISOAbbreviation>Cell Rep</ISOAbbreviation></Journal><ArticleTitle>cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S2211-1247(15)00172-2</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.celrep.2015.02.026</ELocationID><Abstract><AbstractText>Pathological lymphatic diseases mostly affect vessels in specific tissues, yet little is known about organ-specific regulation of the lymphatic vasculature. Here, we show that the vascular endothelial growth factor receptor 3 (VEGFR-3)/p110α PI3-kinase signaling pathway is selectively required for the formation of mesenteric lymphatic vasculature. Using genetic lineage tracing, we demonstrate that part of the mesenteric lymphatic vasculature develops from cKit lineage cells of hemogenic endothelial origin through a process we define as lymphvasculogenesis. This is contrary to the current dogma that all mammalian lymphatic vessels form by sprouting from veins. Our results reveal vascular-bed-specific differences in the origin and mechanisms of vessel formation, which may critically underlie organ-specific manifestation of lymphatic dysfunction in disease. The progenitor cells identified in this study may be exploited to restore lymphatic function following cancer surgery, lymphedema, or tissue trauma.</AbstractText><CopyrightInformation>Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stanczuk</LastName><ForeName>Lukas</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martinez-Corral</LastName><ForeName>Ines</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ulvmar</LastName><ForeName>Maria H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laviña</LastName><ForeName>Bàrbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fruttiger</LastName><ForeName>Marcus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>UCL Institute of Ophthalmology, University College London (UCL), 11-43 Bath Street, London EC1V 9EL, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adams</LastName><ForeName>Ralf H</ForeName><Initials>RH</Initials><AffiliationInfo><Affiliation>Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and Faculty of Medicine, University of Münster, 48149 Münster, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saur</LastName><ForeName>Dieter</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine 2, Klinikum Rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Betsholtz</LastName><ForeName>Christer</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles Väg 2, 171 77 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ortega</LastName><ForeName>Sagrario</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Biotechnology Programme, Spanish National Cancer Research Centre, Melchor Fernández Almagro 3, 28029 Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alitalo</LastName><ForeName>Kari</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Graupera</LastName><ForeName>Mariona</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Vascular Signalling Lab, IDIBELL, 3a planta - Gran Via de l'Hospitalet 199, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mäkinen</LastName><ForeName>Taija</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address: taija.makinen@igp.uu.se.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell Rep</MedlineTA><NlmUniqueID>101573691</NlmUniqueID></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>07</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>12</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>02</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25772358</ArticleId><ArticleId IdType="pii">S2211-1247(15)00172-2</ArticleId><ArticleId IdType="doi">10.1016/j.celrep.2015.02.026</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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