Anti-inflammatory effects of flap and lymph node transfer.
Identifieur interne : 000E74 ( PubMed/Corpus ); précédent : 000E73; suivant : 000E75Anti-inflammatory effects of flap and lymph node transfer.
Auteurs : Tiina P. Viitanen ; Mikko T. Visuri ; Eeva Sulo ; Anne M. Saarikko ; Pauliina HartialaSource :
- The Journal of surgical research [ 1095-8673 ] ; 2015.
English descriptors
- KwdEn :
- Axilla, Cytokines (metabolism), Exudates and Transudates (metabolism), Female, Humans, Inflammation (metabolism), Lymph Node Excision, Lymph Nodes (transplantation), Lymphedema (prevention & control), Mammaplasty, Surgical Flaps, Vascular Endothelial Growth Factor C (metabolism), Vascular Endothelial Growth Factor D (metabolism), Wounds and Injuries (metabolism).
- MESH :
- chemical , metabolism : Cytokines, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D.
- metabolism : Exudates and Transudates, Inflammation, Wounds and Injuries.
- prevention & control : Lymphedema.
- transplantation : Lymph Nodes.
- Axilla, Female, Humans, Lymph Node Excision, Mammaplasty, Surgical Flaps.
Abstract
Transfer of healthy tissue is commonly used in the treatment of complicated wounds and in reconstruction of tissue defects. Recently, microvascular lymph node transfer (LN) has been used to improve the lymphatic function in lymphedema patients. To elucidate the biological effects of flap transfer (with and without lymph nodes), we have studied the postoperative production of proinflammatory, anti-inflammatory, prolymphangiogenic and antilymphangiogenic cytokines, and growth factors (interleukin 1α [IL-1α], IL-1β, tumor necrosis factor α [TNF-α], IL-10, transforming growth factor β1 [TGF-β1], IL-4 and IL-13, and vascular endothelial growth factor C [VEGF-C] and VEGF-D) in postoperative wound exudate samples.
DOI: 10.1016/j.jss.2015.04.041
PubMed: 26013441
Links to Exploration step
pubmed:26013441Le document en format XML
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<author><name sortKey="Viitanen, Tiina P" sort="Viitanen, Tiina P" uniqKey="Viitanen T" first="Tiina P" last="Viitanen">Tiina P. Viitanen</name>
<affiliation><nlm:affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Visuri, Mikko T" sort="Visuri, Mikko T" uniqKey="Visuri M" first="Mikko T" last="Visuri">Mikko T. Visuri</name>
<affiliation><nlm:affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Sulo, Eeva" sort="Sulo, Eeva" uniqKey="Sulo E" first="Eeva" last="Sulo">Eeva Sulo</name>
<affiliation><nlm:affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland.</nlm:affiliation>
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<author><name sortKey="Saarikko, Anne M" sort="Saarikko, Anne M" uniqKey="Saarikko A" first="Anne M" last="Saarikko">Anne M. Saarikko</name>
<affiliation><nlm:affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland; Cleft Unit, Department of Plastic Surgery, Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation>
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<author><name sortKey="Hartiala, Pauliina" sort="Hartiala, Pauliina" uniqKey="Hartiala P" first="Pauliina" last="Hartiala">Pauliina Hartiala</name>
<affiliation><nlm:affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland; Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland. Electronic address: pauliina.hartiala@tyks.fi.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Anti-inflammatory effects of flap and lymph node transfer.</title>
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<author><name sortKey="Visuri, Mikko T" sort="Visuri, Mikko T" uniqKey="Visuri M" first="Mikko T" last="Visuri">Mikko T. Visuri</name>
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<author><name sortKey="Sulo, Eeva" sort="Sulo, Eeva" uniqKey="Sulo E" first="Eeva" last="Sulo">Eeva Sulo</name>
<affiliation><nlm:affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland.</nlm:affiliation>
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<author><name sortKey="Saarikko, Anne M" sort="Saarikko, Anne M" uniqKey="Saarikko A" first="Anne M" last="Saarikko">Anne M. Saarikko</name>
<affiliation><nlm:affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland; Cleft Unit, Department of Plastic Surgery, Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation>
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<author><name sortKey="Hartiala, Pauliina" sort="Hartiala, Pauliina" uniqKey="Hartiala P" first="Pauliina" last="Hartiala">Pauliina Hartiala</name>
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<series><title level="j">The Journal of surgical research</title>
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<term>Cytokines (metabolism)</term>
<term>Exudates and Transudates (metabolism)</term>
<term>Female</term>
<term>Humans</term>
<term>Inflammation (metabolism)</term>
<term>Lymph Node Excision</term>
<term>Lymph Nodes (transplantation)</term>
<term>Lymphedema (prevention & control)</term>
<term>Mammaplasty</term>
<term>Surgical Flaps</term>
<term>Vascular Endothelial Growth Factor C (metabolism)</term>
<term>Vascular Endothelial Growth Factor D (metabolism)</term>
<term>Wounds and Injuries (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
<term>Vascular Endothelial Growth Factor C</term>
<term>Vascular Endothelial Growth Factor D</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Exudates and Transudates</term>
<term>Inflammation</term>
<term>Wounds and Injuries</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Lymph Nodes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Axilla</term>
<term>Female</term>
<term>Humans</term>
<term>Lymph Node Excision</term>
<term>Mammaplasty</term>
<term>Surgical Flaps</term>
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<front><div type="abstract" xml:lang="en">Transfer of healthy tissue is commonly used in the treatment of complicated wounds and in reconstruction of tissue defects. Recently, microvascular lymph node transfer (LN) has been used to improve the lymphatic function in lymphedema patients. To elucidate the biological effects of flap transfer (with and without lymph nodes), we have studied the postoperative production of proinflammatory, anti-inflammatory, prolymphangiogenic and antilymphangiogenic cytokines, and growth factors (interleukin 1α [IL-1α], IL-1β, tumor necrosis factor α [TNF-α], IL-10, transforming growth factor β1 [TGF-β1], IL-4 and IL-13, and vascular endothelial growth factor C [VEGF-C] and VEGF-D) in postoperative wound exudate samples.</div>
</front>
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<Month>Dec</Month>
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<Title>The Journal of surgical research</Title>
<ISOAbbreviation>J. Surg. Res.</ISOAbbreviation>
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<ArticleTitle>Anti-inflammatory effects of flap and lymph node transfer.</ArticleTitle>
<Pagination><MedlinePgn>718-25</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jss.2015.04.041</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0022-4804(15)00474-6</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Transfer of healthy tissue is commonly used in the treatment of complicated wounds and in reconstruction of tissue defects. Recently, microvascular lymph node transfer (LN) has been used to improve the lymphatic function in lymphedema patients. To elucidate the biological effects of flap transfer (with and without lymph nodes), we have studied the postoperative production of proinflammatory, anti-inflammatory, prolymphangiogenic and antilymphangiogenic cytokines, and growth factors (interleukin 1α [IL-1α], IL-1β, tumor necrosis factor α [TNF-α], IL-10, transforming growth factor β1 [TGF-β1], IL-4 and IL-13, and vascular endothelial growth factor C [VEGF-C] and VEGF-D) in postoperative wound exudate samples.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Axillary wound exudate samples were analyzed from four patient groups: axillary lymph node dissection (ALND), microvascular breast reconstruction (BR), LN, and combined LN and BR (LN-BR).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The concentration of proinflammatory cytokines was low in all the flap transfer groups as opposed to the ALND group, which showed an extensive proinflammatory response. The level of anti-inflammatory and antifibrotic cytokine IL-10 was increased in the LN-BR group samples compared with the ALND and BR groups. In the LN and LN-BR groups, the cytokine profile showed an anti-inflammatory response.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Transfer of healthy tissue hinders the proinflammatory response after surgery, which may explain the beneficial effects of flap transfer in various patient groups. In addition, flap transfer with lymph nodes seems to also promote an antifibrotic effect. The clinical effects of LN in lymphedema patients may be mediated by the increased production of prolymphangiogenic growth factor (VEGF-C) and antifibrotic cytokine (IL-10).</AbstractText>
<CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
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<ForeName>Tiina P</ForeName>
<Initials>TP</Initials>
<AffiliationInfo><Affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland.</Affiliation>
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<Author ValidYN="Y"><LastName>Visuri</LastName>
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<AffiliationInfo><Affiliation>Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland; Cleft Unit, Department of Plastic Surgery, Helsinki University Hospital, Helsinki, Finland.</Affiliation>
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<Author ValidYN="Y"><LastName>Hartiala</LastName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anti-inflammatory cytokines</Keyword>
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