Dissecting the Immune Response Elicited by WbALT-2, ALT MAP in Clinical Populations and Mouse Model: A Prophylactic Measure Against Lymphatic Filariasis.
Identifieur interne : 000E20 ( PubMed/Corpus ); précédent : 000E19; suivant : 000E21Dissecting the Immune Response Elicited by WbALT-2, ALT MAP in Clinical Populations and Mouse Model: A Prophylactic Measure Against Lymphatic Filariasis.
Auteurs : Aparnaa Ramanathan ; Christiana Immanuel ; Donthamsetty Nageswara Rao ; Perumal KalirajSource :
- Lymphatic research and biology [ 1557-8585 ] ; 2015.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antibodies, Helminth (immunology), Antigens, Helminth (chemistry), Antigens, Helminth (immunology), Brugia malayi (immunology), Disease Models, Animal, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (prevention & control), Epitopes (chemistry), Epitopes (immunology), Humans, Immunity, Cellular, Immunoglobulin G (immunology), India, Larva, Mice, Recombinant Proteins (chemistry), Recombinant Proteins (immunology), T-Lymphocytes (immunology), T-Lymphocytes (metabolism).
- MESH :
- chemical , chemistry : Antigens, Helminth, Epitopes, Recombinant Proteins.
- chemical , immunology : Antibodies, Helminth, Antigens, Helminth, Epitopes, Immunoglobulin G, Recombinant Proteins.
- geographic : India.
- immunology : Brugia malayi, Elephantiasis, Filarial, T-Lymphocytes.
- metabolism : T-Lymphocytes.
- parasitology : Elephantiasis, Filarial.
- prevention & control : Elephantiasis, Filarial.
- Amino Acid Sequence, Animals, Disease Models, Animal, Humans, Immunity, Cellular, Larva, Mice.
Abstract
Abundant Larval Transcript (ALT) is one of the major groups of immune-dominant proteins produced by filarial worms during their larval stage. The major B-cell and T-cell epitopic domains of the ALT-2 antigen were mapped to develop a multiple antigenic peptide (MAP) prophylactic antigen against lymphatic filariasis.
DOI: 10.1089/lrb.2014.0034
PubMed: 26091407
Links to Exploration step
pubmed:26091407Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dissecting the Immune Response Elicited by WbALT-2, ALT MAP in Clinical Populations and Mouse Model: A Prophylactic Measure Against Lymphatic Filariasis.</title><author><name sortKey="Ramanathan, Aparnaa" sort="Ramanathan, Aparnaa" uniqKey="Ramanathan A" first="Aparnaa" last="Ramanathan">Aparnaa Ramanathan</name><affiliation><nlm:affiliation>1 Centre For Biotechnology, Anna University , Chennai, India .</nlm:affiliation></affiliation></author><author><name sortKey="Immanuel, Christiana" sort="Immanuel, Christiana" uniqKey="Immanuel C" first="Christiana" last="Immanuel">Christiana Immanuel</name><affiliation><nlm:affiliation>1 Centre For Biotechnology, Anna University , Chennai, India .</nlm:affiliation></affiliation></author><author><name sortKey="Rao, Donthamsetty Nageswara" sort="Rao, Donthamsetty Nageswara" uniqKey="Rao D" first="Donthamsetty Nageswara" last="Rao">Donthamsetty Nageswara Rao</name><affiliation><nlm:affiliation>2 Department of Biochemistry, All India Institute of Medical Sciences , New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Kaliraj, Perumal" sort="Kaliraj, Perumal" uniqKey="Kaliraj P" first="Perumal" last="Kaliraj">Perumal Kaliraj</name><affiliation><nlm:affiliation>1 Centre For Biotechnology, Anna University , Chennai, India .</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26091407</idno><idno type="pmid">26091407</idno><idno type="doi">10.1089/lrb.2014.0034</idno><idno type="wicri:Area/PubMed/Corpus">000E20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E20</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dissecting the Immune Response Elicited by WbALT-2, ALT MAP in Clinical Populations and Mouse Model: A Prophylactic Measure Against Lymphatic Filariasis.</title><author><name sortKey="Ramanathan, Aparnaa" sort="Ramanathan, Aparnaa" uniqKey="Ramanathan A" first="Aparnaa" last="Ramanathan">Aparnaa Ramanathan</name><affiliation><nlm:affiliation>1 Centre For Biotechnology, Anna University , Chennai, India .</nlm:affiliation></affiliation></author><author><name sortKey="Immanuel, Christiana" sort="Immanuel, Christiana" uniqKey="Immanuel C" first="Christiana" last="Immanuel">Christiana Immanuel</name><affiliation><nlm:affiliation>1 Centre For Biotechnology, Anna University , Chennai, India .</nlm:affiliation></affiliation></author><author><name sortKey="Rao, Donthamsetty Nageswara" sort="Rao, Donthamsetty Nageswara" uniqKey="Rao D" first="Donthamsetty Nageswara" last="Rao">Donthamsetty Nageswara Rao</name><affiliation><nlm:affiliation>2 Department of Biochemistry, All India Institute of Medical Sciences , New Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Kaliraj, Perumal" sort="Kaliraj, Perumal" uniqKey="Kaliraj P" first="Perumal" last="Kaliraj">Perumal Kaliraj</name><affiliation><nlm:affiliation>1 Centre For Biotechnology, Anna University , Chennai, India .</nlm:affiliation></affiliation></author></analytic><series><title level="j">Lymphatic research and biology</title><idno type="eISSN">1557-8585</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Antibodies, Helminth (immunology)</term><term>Antigens, Helminth (chemistry)</term><term>Antigens, Helminth (immunology)</term><term>Brugia malayi (immunology)</term><term>Disease Models, Animal</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Epitopes (chemistry)</term><term>Epitopes (immunology)</term><term>Humans</term><term>Immunity, Cellular</term><term>Immunoglobulin G (immunology)</term><term>India</term><term>Larva</term><term>Mice</term><term>Recombinant Proteins (chemistry)</term><term>Recombinant Proteins (immunology)</term><term>T-Lymphocytes (immunology)</term><term>T-Lymphocytes (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antigens, Helminth</term><term>Epitopes</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigens, Helminth</term><term>Epitopes</term><term>Immunoglobulin G</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>India</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Immunity, Cellular</term><term>Larva</term><term>Mice</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abundant Larval Transcript (ALT) is one of the major groups of immune-dominant proteins produced by filarial worms during their larval stage. The major B-cell and T-cell epitopic domains of the ALT-2 antigen were mapped to develop a multiple antigenic peptide (MAP) prophylactic antigen against lymphatic filariasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26091407</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>20</Day></DateCreated><DateCompleted><Year>2016</Year><Month>03</Month><Day>24</Day></DateCompleted><DateRevised><Year>2015</Year><Month>06</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-8585</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Lymphatic research and biology</Title><ISOAbbreviation>Lymphat Res Biol</ISOAbbreviation></Journal><ArticleTitle>Dissecting the Immune Response Elicited by WbALT-2, ALT MAP in Clinical Populations and Mouse Model: A Prophylactic Measure Against Lymphatic Filariasis.</ArticleTitle><Pagination><MedlinePgn>120-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/lrb.2014.0034</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Abundant Larval Transcript (ALT) is one of the major groups of immune-dominant proteins produced by filarial worms during their larval stage. The major B-cell and T-cell epitopic domains of the ALT-2 antigen were mapped to develop a multiple antigenic peptide (MAP) prophylactic antigen against lymphatic filariasis.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">ALT MAP was constructed by solid phase peptide synthesis. The reactivity of whole ALT protein and ALT MAP against clinical sera described a high reactivity of endemic normal sera against ALT MAP compared to WbALT-2 protein. The antibody isotype pattern revealed elevated levels of IgG1 and IgG2 against ALT MAP, followed by IgG3 and IgG4. In this study we also analyzed the immune response pattern elicited by ALT MAP, ALT in mice models, which revealed similar pattern of humoral response, while low T cell proliferation in ALT MAP groups. The low proliferation could be attributed to T/B epitope arrangement on the construct, MHC restriction, and incomplete signal delivery by T cell receptor.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The immunodominant epitopes in ALT MAP were found to play a crucial role in inducing high antigen specific proliferation. This revealed the significance of ALT MAP in stimulating innate immunity in offering protective immune response probably through the activation of complement cascade along with stimulation of cellular response. An improved understanding, including the construction of ALT MAP and parasite challenge study in jirds to determine the worm clearance would give a better insight in the characterization ALT MAP construct as a prophylactic vaccine candidate.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ramanathan</LastName><ForeName>Aparnaa</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>1 Centre For Biotechnology, Anna University , Chennai, India .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Immanuel</LastName><ForeName>Christiana</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>1 Centre For Biotechnology, Anna University , Chennai, India .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rao</LastName><ForeName>Donthamsetty Nageswara</ForeName><Initials>DN</Initials><AffiliationInfo><Affiliation>2 Department of Biochemistry, All India Institute of Medical Sciences , New Delhi, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaliraj</LastName><ForeName>Perumal</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>1 Centre For Biotechnology, Anna University , Chennai, India .</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>06</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Lymphat Res Biol</MedlineTA><NlmUniqueID>101163587</NlmUniqueID><ISSNLinking>1539-6851</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000939">Epitopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017178" MajorTopicYN="N">Brugia malayi</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000939" MajorTopicYN="N">Epitopes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007111" MajorTopicYN="N">Immunity, Cellular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007194" MajorTopicYN="N" Type="Geographic">India</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007814" MajorTopicYN="N">Larva</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" 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