Verrucous lesions arising in lymphedema and diabetic neuropathy: Elephantiasis nostras verrucosa or verrucous skin lesions on the feet of patients with diabetic neuropathy?
Identifieur interne : 000D10 ( PubMed/Corpus ); précédent : 000D09; suivant : 000D11Verrucous lesions arising in lymphedema and diabetic neuropathy: Elephantiasis nostras verrucosa or verrucous skin lesions on the feet of patients with diabetic neuropathy?
Auteurs : Eri Hotta ; Jun Asai ; Yasutaro Okuzawa ; Keiji Hanada ; Tomoko Nomiyama ; Hideya Takenaka ; Norito KatohSource :
- The Journal of dermatology [ 1346-8138 ] ; 2016.
English descriptors
- KwdEn :
- Aged, 80 and over, Diabetic Foot (complications), Diabetic Foot (pathology), Diabetic Neuropathies (complications), Diabetic Neuropathies (pathology), Elephantiasis (etiology), Elephantiasis (pathology), Elephantiasis (therapy), Humans, Hydrocortisone (administration & dosage), Lymphedema (etiology), Lymphedema (pathology), Lymphedema (therapy), Male, Stockings, Compression.
- MESH :
- chemical , administration & dosage : Hydrocortisone.
- complications : Diabetic Foot, Diabetic Neuropathies.
- etiology : Elephantiasis, Lymphedema.
- pathology : Diabetic Foot, Diabetic Neuropathies, Elephantiasis, Lymphedema.
- therapy : Elephantiasis, Lymphedema.
- Aged, 80 and over, Humans, Male, Stockings, Compression.
Abstract
Verrucous skin lesions on the feet in diabetic neuropathy (VSLDN) develop in areas with sensory loss in diabetic patients. Although various types of chronic stimulation, such as pressure or friction, are considered an important factor in the development of such lesions, the precise pathogenesis of VSLDN remains obscure, and there is currently no established treatment for this disease. Here, we present a case of VSLDN on the dorsum of the right foot. However, because lymphedema was also observed at the same site, this lesion could also be diagnosed as elephantiasis nostras verrucosa arising in diabetic neuropathy. The lesion was successfully treated with a combination of elastic stocking and mixed killed bacterial suspension and hydrocortisone ointment, which suggested that VSLDN might have been exacerbated by the pre-existing lymphedema. Because various types of chronic stimulation can trigger VSLDN, treatment plans should be devised on a case-by-case basis. Therefore, it is important to investigate the presence of factors that can induce or exacerbate chronic inflammatory stimulation, such as lymphedema in our case, in each patient with VSLDN.
DOI: 10.1111/1346-8138.13063
PubMed: 26281791
Links to Exploration step
pubmed:26281791Le document en format XML
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Okuzawa</name><affiliation><nlm:affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Hanada, Keiji" sort="Hanada, Keiji" uniqKey="Hanada K" first="Keiji" last="Hanada">Keiji Hanada</name><affiliation><nlm:affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Nomiyama, Tomoko" sort="Nomiyama, Tomoko" uniqKey="Nomiyama T" first="Tomoko" last="Nomiyama">Tomoko Nomiyama</name><affiliation><nlm:affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Takenaka, Hideya" sort="Takenaka, Hideya" uniqKey="Takenaka H" first="Hideya" last="Takenaka">Hideya Takenaka</name><affiliation><nlm:affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Katoh, Norito" sort="Katoh, Norito" uniqKey="Katoh N" first="Norito" last="Katoh">Norito Katoh</name><affiliation><nlm:affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26281791</idno><idno type="pmid">26281791</idno><idno type="doi">10.1111/1346-8138.13063</idno><idno type="wicri:Area/PubMed/Corpus">000D10</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D10</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Verrucous lesions arising in lymphedema and diabetic neuropathy: Elephantiasis nostras verrucosa or verrucous skin lesions on the feet of patients with diabetic neuropathy?</title><author><name sortKey="Hotta, Eri" sort="Hotta, Eri" uniqKey="Hotta E" first="Eri" last="Hotta">Eri Hotta</name><affiliation><nlm:affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Asai, Jun" sort="Asai, Jun" uniqKey="Asai J" first="Jun" last="Asai">Jun Asai</name><affiliation><nlm:affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Okuzawa, Yasutaro" sort="Okuzawa, Yasutaro" uniqKey="Okuzawa Y" first="Yasutaro" last="Okuzawa">Yasutaro Okuzawa</name><affiliation><nlm:affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Hanada, Keiji" sort="Hanada, Keiji" uniqKey="Hanada K" first="Keiji" last="Hanada">Keiji Hanada</name><affiliation><nlm:affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Nomiyama, Tomoko" sort="Nomiyama, Tomoko" uniqKey="Nomiyama T" first="Tomoko" last="Nomiyama">Tomoko Nomiyama</name><affiliation><nlm:affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Takenaka, Hideya" sort="Takenaka, Hideya" uniqKey="Takenaka H" first="Hideya" last="Takenaka">Hideya Takenaka</name><affiliation><nlm:affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Katoh, Norito" sort="Katoh, Norito" uniqKey="Katoh N" first="Norito" last="Katoh">Norito Katoh</name><affiliation><nlm:affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Journal of dermatology</title><idno type="eISSN">1346-8138</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged, 80 and over</term><term>Diabetic Foot (complications)</term><term>Diabetic Foot (pathology)</term><term>Diabetic Neuropathies (complications)</term><term>Diabetic Neuropathies (pathology)</term><term>Elephantiasis (etiology)</term><term>Elephantiasis (pathology)</term><term>Elephantiasis (therapy)</term><term>Humans</term><term>Hydrocortisone (administration & dosage)</term><term>Lymphedema (etiology)</term><term>Lymphedema (pathology)</term><term>Lymphedema (therapy)</term><term>Male</term><term>Stockings, Compression</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Diabetic Foot</term><term>Diabetic Neuropathies</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Elephantiasis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Diabetic Foot</term><term>Diabetic Neuropathies</term><term>Elephantiasis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Elephantiasis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged, 80 and over</term><term>Humans</term><term>Male</term><term>Stockings, Compression</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Verrucous skin lesions on the feet in diabetic neuropathy (VSLDN) develop in areas with sensory loss in diabetic patients. Although various types of chronic stimulation, such as pressure or friction, are considered an important factor in the development of such lesions, the precise pathogenesis of VSLDN remains obscure, and there is currently no established treatment for this disease. Here, we present a case of VSLDN on the dorsum of the right foot. However, because lymphedema was also observed at the same site, this lesion could also be diagnosed as elephantiasis nostras verrucosa arising in diabetic neuropathy. The lesion was successfully treated with a combination of elastic stocking and mixed killed bacterial suspension and hydrocortisone ointment, which suggested that VSLDN might have been exacerbated by the pre-existing lymphedema. Because various types of chronic stimulation can trigger VSLDN, treatment plans should be devised on a case-by-case basis. Therefore, it is important to investigate the presence of factors that can induce or exacerbate chronic inflammatory stimulation, such as lymphedema in our case, in each patient with VSLDN.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26281791</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>07</Day></DateCreated><DateCompleted><Year>2017</Year><Month>01</Month><Day>23</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1346-8138</ISSN><JournalIssue CitedMedium="Internet"><Volume>43</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Mar</Month></PubDate></JournalIssue><Title>The Journal of dermatology</Title><ISOAbbreviation>J. Dermatol.</ISOAbbreviation></Journal><ArticleTitle>Verrucous lesions arising in lymphedema and diabetic neuropathy: Elephantiasis nostras verrucosa or verrucous skin lesions on the feet of patients with diabetic neuropathy?</ArticleTitle><Pagination><MedlinePgn>329-31</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/1346-8138.13063</ELocationID><Abstract><AbstractText>Verrucous skin lesions on the feet in diabetic neuropathy (VSLDN) develop in areas with sensory loss in diabetic patients. Although various types of chronic stimulation, such as pressure or friction, are considered an important factor in the development of such lesions, the precise pathogenesis of VSLDN remains obscure, and there is currently no established treatment for this disease. Here, we present a case of VSLDN on the dorsum of the right foot. However, because lymphedema was also observed at the same site, this lesion could also be diagnosed as elephantiasis nostras verrucosa arising in diabetic neuropathy. The lesion was successfully treated with a combination of elastic stocking and mixed killed bacterial suspension and hydrocortisone ointment, which suggested that VSLDN might have been exacerbated by the pre-existing lymphedema. Because various types of chronic stimulation can trigger VSLDN, treatment plans should be devised on a case-by-case basis. Therefore, it is important to investigate the presence of factors that can induce or exacerbate chronic inflammatory stimulation, such as lymphedema in our case, in each patient with VSLDN.</AbstractText><CopyrightInformation>© 2015 Japanese Dermatological Association.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hotta</LastName><ForeName>Eri</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asai</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Okuzawa</LastName><ForeName>Yasutaro</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hanada</LastName><ForeName>Keiji</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nomiyama</LastName><ForeName>Tomoko</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Takenaka</LastName><ForeName>Hideya</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Katoh</LastName><ForeName>Norito</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>08</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Dermatol</MedlineTA><NlmUniqueID>7600545</NlmUniqueID><ISSNLinking>0385-2407</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017719" MajorTopicYN="N">Diabetic Foot</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003929" MajorTopicYN="N">Diabetic Neuropathies</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004604" MajorTopicYN="N">Elephantiasis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053828" MajorTopicYN="N">Stockings, Compression</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">diabetes</Keyword><Keyword MajorTopicYN="N">elastic stocking</Keyword><Keyword MajorTopicYN="N">elephantiasis nostras verrucosa</Keyword><Keyword MajorTopicYN="N">mixed killed bacterial suspension hydrocortisone ointment</Keyword><Keyword MajorTopicYN="N">verrucous skin lesion on the feet in diabetic neuropathy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>03</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>07</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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