Lymphatic edema of the lower limbs after orthopedic surgery: results of a randomized, open-label clinical trial with a new extended-release preparation.
Identifieur interne : 000A60 ( PubMed/Corpus ); précédent : 000A59; suivant : 000A61Lymphatic edema of the lower limbs after orthopedic surgery: results of a randomized, open-label clinical trial with a new extended-release preparation.
Auteurs : G. Lessiani ; P. Iodice ; E. Nicolucci ; M. GentiliSource :
- Journal of biological regulators and homeostatic agents [ 0393-974X ]
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Coumarins, Proanthocyanidins.
- adverse effects : Orthopedic Procedures.
- drug therapy : Lymphedema.
- etiology : Lymphedema.
- Aged, Delayed-Action Preparations, Female, Humans, Lower Extremity, Male, Middle Aged.
Abstract
The lymphedema is a high interstitial protein concentration edema, caused by impaired lymphatic transport capacity. It can be primary or secondary. The secondary form may be caused by a lesion of the lymphatic vessels and/or lymph nodes during diagnostic or therapeutic procedures such as surgical interventions. Often, in clinical practice, there is lymphedema after orthopedic surgery, even in minor orthopedic surgery. Lymphedema, typically presents symptoms of swelling, pain, inflammation, and itching, and it can generate, over the years, acute disability in the affected limbs. The standard therapy is mainly represented by medical treatment, such as manual lymphatic drainage and compression with bandages and stockings. In literature it is documented that lymphedema is responsive to alpha and the gamma benzopyrones. The aim of this study was to determine the effectiveness of delayed extended-release formulation of a compound containing apha-benzo-pyrone (Coumarin), benzo-gamma-pyrone (Troxuretina) and oligomeric proanthocyanidins from Vitis vinifera (OPC), in addition to compression therapy, in the reduction of lymphatic edema after prosthetic hip and knee surgery. In the group treated, after 30 days, a reduction was observed of the edema of 4.8% in the ankle area (p less than 0.008) and 2.7% in the calf area (p less than 0.013). The control group showed no significant reduction. The treated group showed a marked reduction of all the secondary symptoms considered in the study, although variations were not significant. The results show that the compound used was effective in reducing edema after major orthopedic surgery, and consequently in alleviating some related symptoms, such as pain, itching, and burning. As an edema has extensive inflammatory components in patients with reduced mobility, the final data seems interesting, however, further investigations and a better follow-up are required.
PubMed: 26753640
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphatic edema of the lower limbs after orthopedic surgery: results of a randomized, open-label clinical trial with a new extended-release preparation.</title><author><name sortKey="Lessiani, G" sort="Lessiani, G" uniqKey="Lessiani G" first="G" last="Lessiani">G. Lessiani</name><affiliation><nlm:affiliation>Vascular Medicine Unit, Private Hospital Villa Serena, Città SantAngelo (PE), Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Iodice, P" sort="Iodice, P" uniqKey="Iodice P" first="P" last="Iodice">P. Iodice</name><affiliation><nlm:affiliation>Orthopedic Rehabilitation Unit, Private Hospital Villa Serena, Città SantAngelo (PE), Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Nicolucci, E" sort="Nicolucci, E" uniqKey="Nicolucci E" first="E" last="Nicolucci">E. Nicolucci</name><affiliation><nlm:affiliation>Institute of Cognitive Sciences and Technologies, National Research Council, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gentili, M" sort="Gentili, M" uniqKey="Gentili M" first="M" last="Gentili">M. Gentili</name><affiliation><nlm:affiliation>Institute of Cognitive Sciences and Technologies, National Research Council, Rome, Italy.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2015 Oct-Dec</MedlineDate></PubDate></date><idno type="RBID">pubmed:26753640</idno><idno type="pmid">26753640</idno><idno type="wicri:Area/PubMed/Corpus">000A60</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lymphatic edema of the lower limbs after orthopedic surgery: results of a randomized, open-label clinical trial with a new extended-release preparation.</title><author><name sortKey="Lessiani, G" sort="Lessiani, G" uniqKey="Lessiani G" first="G" last="Lessiani">G. Lessiani</name><affiliation><nlm:affiliation>Vascular Medicine Unit, Private Hospital Villa Serena, Città SantAngelo (PE), Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Iodice, P" sort="Iodice, P" uniqKey="Iodice P" first="P" last="Iodice">P. Iodice</name><affiliation><nlm:affiliation>Orthopedic Rehabilitation Unit, Private Hospital Villa Serena, Città SantAngelo (PE), Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Nicolucci, E" sort="Nicolucci, E" uniqKey="Nicolucci E" first="E" last="Nicolucci">E. Nicolucci</name><affiliation><nlm:affiliation>Institute of Cognitive Sciences and Technologies, National Research Council, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gentili, M" sort="Gentili, M" uniqKey="Gentili M" first="M" last="Gentili">M. Gentili</name><affiliation><nlm:affiliation>Institute of Cognitive Sciences and Technologies, National Research Council, Rome, Italy.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of biological regulators and homeostatic agents</title><idno type="ISSN">0393-974X</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Coumarins (administration & dosage)</term><term>Delayed-Action Preparations</term><term>Female</term><term>Humans</term><term>Lower Extremity</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (etiology)</term><term>Male</term><term>Middle Aged</term><term>Orthopedic Procedures (adverse effects)</term><term>Proanthocyanidins (administration & dosage)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Coumarins</term><term>Proanthocyanidins</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Orthopedic Procedures</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Delayed-Action Preparations</term><term>Female</term><term>Humans</term><term>Lower Extremity</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lymphedema is a high interstitial protein concentration edema, caused by impaired lymphatic transport capacity. It can be primary or secondary. The secondary form may be caused by a lesion of the lymphatic vessels and/or lymph nodes during diagnostic or therapeutic procedures such as surgical interventions. Often, in clinical practice, there is lymphedema after orthopedic surgery, even in minor orthopedic surgery. Lymphedema, typically presents symptoms of swelling, pain, inflammation, and itching, and it can generate, over the years, acute disability in the affected limbs. The standard therapy is mainly represented by medical treatment, such as manual lymphatic drainage and compression with bandages and stockings. In literature it is documented that lymphedema is responsive to alpha and the gamma benzopyrones. The aim of this study was to determine the effectiveness of delayed extended-release formulation of a compound containing apha-benzo-pyrone (Coumarin), benzo-gamma-pyrone (Troxuretina) and oligomeric proanthocyanidins from Vitis vinifera (OPC), in addition to compression therapy, in the reduction of lymphatic edema after prosthetic hip and knee surgery. In the group treated, after 30 days, a reduction was observed of the edema of 4.8% in the ankle area (p less than 0.008) and 2.7% in the calf area (p less than 0.013). The control group showed no significant reduction. The treated group showed a marked reduction of all the secondary symptoms considered in the study, although variations were not significant. The results show that the compound used was effective in reducing edema after major orthopedic surgery, and consequently in alleviating some related symptoms, such as pain, itching, and burning. As an edema has extensive inflammatory components in patients with reduced mobility, the final data seems interesting, however, further investigations and a better follow-up are required.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26753640</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>12</Day></DateCreated><DateCompleted><Year>2016</Year><Month>03</Month><Day>03</Day></DateCompleted><DateRevised><Year>2016</Year><Month>01</Month><Day>12</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0393-974X</ISSN><JournalIssue CitedMedium="Print"><Volume>29</Volume><Issue>4</Issue><PubDate><MedlineDate>2015 Oct-Dec</MedlineDate></PubDate></JournalIssue><Title>Journal of biological regulators and homeostatic agents</Title><ISOAbbreviation>J. Biol. Regul. Homeost. Agents</ISOAbbreviation></Journal><ArticleTitle>Lymphatic edema of the lower limbs after orthopedic surgery: results of a randomized, open-label clinical trial with a new extended-release preparation.</ArticleTitle><Pagination><MedlinePgn>805-12</MedlinePgn></Pagination><Abstract><AbstractText>The lymphedema is a high interstitial protein concentration edema, caused by impaired lymphatic transport capacity. It can be primary or secondary. The secondary form may be caused by a lesion of the lymphatic vessels and/or lymph nodes during diagnostic or therapeutic procedures such as surgical interventions. Often, in clinical practice, there is lymphedema after orthopedic surgery, even in minor orthopedic surgery. Lymphedema, typically presents symptoms of swelling, pain, inflammation, and itching, and it can generate, over the years, acute disability in the affected limbs. The standard therapy is mainly represented by medical treatment, such as manual lymphatic drainage and compression with bandages and stockings. In literature it is documented that lymphedema is responsive to alpha and the gamma benzopyrones. The aim of this study was to determine the effectiveness of delayed extended-release formulation of a compound containing apha-benzo-pyrone (Coumarin), benzo-gamma-pyrone (Troxuretina) and oligomeric proanthocyanidins from Vitis vinifera (OPC), in addition to compression therapy, in the reduction of lymphatic edema after prosthetic hip and knee surgery. In the group treated, after 30 days, a reduction was observed of the edema of 4.8% in the ankle area (p less than 0.008) and 2.7% in the calf area (p less than 0.013). The control group showed no significant reduction. The treated group showed a marked reduction of all the secondary symptoms considered in the study, although variations were not significant. The results show that the compound used was effective in reducing edema after major orthopedic surgery, and consequently in alleviating some related symptoms, such as pain, itching, and burning. As an edema has extensive inflammatory components in patients with reduced mobility, the final data seems interesting, however, further investigations and a better follow-up are required.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lessiani</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Vascular Medicine Unit, Private Hospital Villa Serena, Città SantAngelo (PE), Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iodice</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Orthopedic Rehabilitation Unit, Private Hospital Villa Serena, Città SantAngelo (PE), Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicolucci</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Cognitive Sciences and Technologies, National Research Council, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gentili</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Cognitive Sciences and Technologies, National Research Council, Rome, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>J Biol Regul Homeost Agents</MedlineTA><NlmUniqueID>8809253</NlmUniqueID><ISSNLinking>0393-974X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003374">Coumarins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003692">Delayed-Action Preparations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044945">Proanthocyanidins</NameOfSubstance></Chemical><Chemical><RegistryNumber>A4VZ22K1WT</RegistryNumber><NameOfSubstance UI="C030123">coumarin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003374" MajorTopicYN="N">Coumarins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003692" MajorTopicYN="N">Delayed-Action Preparations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D035002" MajorTopicYN="N">Lower Extremity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019637" MajorTopicYN="N">Orthopedic Procedures</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044945" MajorTopicYN="N">Proanthocyanidins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>1</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26753640</ArticleId><ArticleId IdType="pii">7</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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