Health-Related Quality of Life in Locally Advanced Cervical Cancer Patients After Definitive Chemoradiation Therapy Including Image Guided Adaptive Brachytherapy: An Analysis From the EMBRACE Study.
Identifieur interne : 000A01 ( PubMed/Corpus ); précédent : 000A00; suivant : 000A02Health-Related Quality of Life in Locally Advanced Cervical Cancer Patients After Definitive Chemoradiation Therapy Including Image Guided Adaptive Brachytherapy: An Analysis From the EMBRACE Study.
Auteurs : Kathrin Kirchheiner ; Richard Pötter ; Kari Tanderup ; Jacob C. Lindegaard ; Christine Haie-Meder ; Primož Petri ; Umesh Mahantshetty ; Ina M. Jürgenliemk-Schulz ; Bhavana Rai ; Rachel Cooper ; Wolfgang Dörr ; Remi A. NoutSource :
- International journal of radiation oncology, biology, physics [ 1879-355X ] ; 2016.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Brachytherapy (adverse effects), Brachytherapy (methods), Chemoradiotherapy (adverse effects), Chemoradiotherapy (methods), Female, Follow-Up Studies, Health Status, Humans, Middle Aged, Prospective Studies, Quality of Life, Radiotherapy Dosage, Radiotherapy, Image-Guided, Recovery of Function, Sexual Behavior, Surveys and Questionnaires, Time Factors, Uterine Cervical Neoplasms (complications), Uterine Cervical Neoplasms (pathology), Uterine Cervical Neoplasms (psychology), Uterine Cervical Neoplasms (therapy), Young Adult.
- MESH :
- adverse effects : Brachytherapy, Chemoradiotherapy.
- complications : Uterine Cervical Neoplasms.
- methods : Brachytherapy, Chemoradiotherapy.
- pathology : Uterine Cervical Neoplasms.
- psychology : Uterine Cervical Neoplasms.
- therapy : Uterine Cervical Neoplasms.
- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Health Status, Humans, Middle Aged, Prospective Studies, Quality of Life, Radiotherapy Dosage, Radiotherapy, Image-Guided, Recovery of Function, Sexual Behavior, Surveys and Questionnaires, Time Factors, Young Adult.
Abstract
This study analyzed functioning and symptom scores for longitudinal quality of life (QoL) from patients with locally advanced cervical cancer who underwent definitive chemoradiation therapy with image guided adaptive brachytherapy in the EMBRACE study.
DOI: 10.1016/j.ijrobp.2015.12.363
PubMed: 26876955
Links to Exploration step
pubmed:26876955Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Health-Related Quality of Life in Locally Advanced Cervical Cancer Patients After Definitive Chemoradiation Therapy Including Image Guided Adaptive Brachytherapy: An Analysis From the EMBRACE Study.</title><author><name sortKey="Kirchheiner, Kathrin" sort="Kirchheiner, Kathrin" uniqKey="Kirchheiner K" first="Kathrin" last="Kirchheiner">Kathrin Kirchheiner</name><affiliation><nlm:affiliation>Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna and General Hospital of Vienna, Vienna, Austria. Electronic address: kathrin.kirchheiner@meduniwien.ac.at.</nlm:affiliation></affiliation></author><author><name sortKey="Potter, Richard" sort="Potter, Richard" uniqKey="Potter R" first="Richard" last="Pötter">Richard Pötter</name><affiliation><nlm:affiliation>Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna and General Hospital of Vienna, Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Tanderup, Kari" sort="Tanderup, Kari" uniqKey="Tanderup K" first="Kari" last="Tanderup">Kari Tanderup</name><affiliation><nlm:affiliation>Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Lindegaard, Jacob C" sort="Lindegaard, Jacob C" uniqKey="Lindegaard J" first="Jacob C" last="Lindegaard">Jacob C. Lindegaard</name><affiliation><nlm:affiliation>Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Haie Meder, Christine" sort="Haie Meder, Christine" uniqKey="Haie Meder C" first="Christine" last="Haie-Meder">Christine Haie-Meder</name><affiliation><nlm:affiliation>Department of Radiotherapy, Gustave-Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Petri, Primoz" sort="Petri, Primoz" uniqKey="Petri P" first="Primož" last="Petri">Primož Petri</name><affiliation><nlm:affiliation>Department of Radiotherapy, Institute of Oncology Ljubljana, Ljubljana, Slovenia; Department of Radiation Oncology, National Center for Cancer Care and Research, Doha, Qatar.</nlm:affiliation></affiliation></author><author><name sortKey="Mahantshetty, Umesh" sort="Mahantshetty, Umesh" uniqKey="Mahantshetty U" first="Umesh" last="Mahantshetty">Umesh Mahantshetty</name><affiliation><nlm:affiliation>Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.</nlm:affiliation></affiliation></author><author><name sortKey="Jurgenliemk Schulz, Ina M" sort="Jurgenliemk Schulz, Ina M" uniqKey="Jurgenliemk Schulz I" first="Ina M" last="Jürgenliemk-Schulz">Ina M. Jürgenliemk-Schulz</name><affiliation><nlm:affiliation>Department of Radiation Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rai, Bhavana" sort="Rai, Bhavana" uniqKey="Rai B" first="Bhavana" last="Rai">Bhavana Rai</name><affiliation><nlm:affiliation>Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Rachel" sort="Cooper, Rachel" uniqKey="Cooper R" first="Rachel" last="Cooper">Rachel Cooper</name><affiliation><nlm:affiliation>Leeds Cancer Centre, St James's University Hospital, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Dorr, Wolfgang" sort="Dorr, Wolfgang" uniqKey="Dorr W" first="Wolfgang" last="Dörr">Wolfgang Dörr</name><affiliation><nlm:affiliation>Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna and General Hospital of Vienna, Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Nout, Remi A" sort="Nout, Remi A" uniqKey="Nout R" first="Remi A" last="Nout">Remi A. Nout</name><affiliation><nlm:affiliation>Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26876955</idno><idno type="pmid">26876955</idno><idno type="doi">10.1016/j.ijrobp.2015.12.363</idno><idno type="wicri:Area/PubMed/Corpus">000A01</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A01</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Health-Related Quality of Life in Locally Advanced Cervical Cancer Patients After Definitive Chemoradiation Therapy Including Image Guided Adaptive Brachytherapy: An Analysis From the EMBRACE Study.</title><author><name sortKey="Kirchheiner, Kathrin" sort="Kirchheiner, Kathrin" uniqKey="Kirchheiner K" first="Kathrin" last="Kirchheiner">Kathrin Kirchheiner</name><affiliation><nlm:affiliation>Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna and General Hospital of Vienna, Vienna, Austria. Electronic address: kathrin.kirchheiner@meduniwien.ac.at.</nlm:affiliation></affiliation></author><author><name sortKey="Potter, Richard" sort="Potter, Richard" uniqKey="Potter R" first="Richard" last="Pötter">Richard Pötter</name><affiliation><nlm:affiliation>Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna and General Hospital of Vienna, Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Tanderup, Kari" sort="Tanderup, Kari" uniqKey="Tanderup K" first="Kari" last="Tanderup">Kari Tanderup</name><affiliation><nlm:affiliation>Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Lindegaard, Jacob C" sort="Lindegaard, Jacob C" uniqKey="Lindegaard J" first="Jacob C" last="Lindegaard">Jacob C. Lindegaard</name><affiliation><nlm:affiliation>Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Haie Meder, Christine" sort="Haie Meder, Christine" uniqKey="Haie Meder C" first="Christine" last="Haie-Meder">Christine Haie-Meder</name><affiliation><nlm:affiliation>Department of Radiotherapy, Gustave-Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Petri, Primoz" sort="Petri, Primoz" uniqKey="Petri P" first="Primož" last="Petri">Primož Petri</name><affiliation><nlm:affiliation>Department of Radiotherapy, Institute of Oncology Ljubljana, Ljubljana, Slovenia; Department of Radiation Oncology, National Center for Cancer Care and Research, Doha, Qatar.</nlm:affiliation></affiliation></author><author><name sortKey="Mahantshetty, Umesh" sort="Mahantshetty, Umesh" uniqKey="Mahantshetty U" first="Umesh" last="Mahantshetty">Umesh Mahantshetty</name><affiliation><nlm:affiliation>Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.</nlm:affiliation></affiliation></author><author><name sortKey="Jurgenliemk Schulz, Ina M" sort="Jurgenliemk Schulz, Ina M" uniqKey="Jurgenliemk Schulz I" first="Ina M" last="Jürgenliemk-Schulz">Ina M. Jürgenliemk-Schulz</name><affiliation><nlm:affiliation>Department of Radiation Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rai, Bhavana" sort="Rai, Bhavana" uniqKey="Rai B" first="Bhavana" last="Rai">Bhavana Rai</name><affiliation><nlm:affiliation>Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Rachel" sort="Cooper, Rachel" uniqKey="Cooper R" first="Rachel" last="Cooper">Rachel Cooper</name><affiliation><nlm:affiliation>Leeds Cancer Centre, St James's University Hospital, Leeds, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Dorr, Wolfgang" sort="Dorr, Wolfgang" uniqKey="Dorr W" first="Wolfgang" last="Dörr">Wolfgang Dörr</name><affiliation><nlm:affiliation>Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna and General Hospital of Vienna, Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Nout, Remi A" sort="Nout, Remi A" uniqKey="Nout R" first="Remi A" last="Nout">Remi A. Nout</name><affiliation><nlm:affiliation>Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author></analytic><series><title level="j">International journal of radiation oncology, biology, physics</title><idno type="eISSN">1879-355X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Brachytherapy (adverse effects)</term><term>Brachytherapy (methods)</term><term>Chemoradiotherapy (adverse effects)</term><term>Chemoradiotherapy (methods)</term><term>Female</term><term>Follow-Up Studies</term><term>Health Status</term><term>Humans</term><term>Middle Aged</term><term>Prospective Studies</term><term>Quality of Life</term><term>Radiotherapy Dosage</term><term>Radiotherapy, Image-Guided</term><term>Recovery of Function</term><term>Sexual Behavior</term><term>Surveys and Questionnaires</term><term>Time Factors</term><term>Uterine Cervical Neoplasms (complications)</term><term>Uterine Cervical Neoplasms (pathology)</term><term>Uterine Cervical Neoplasms (psychology)</term><term>Uterine Cervical Neoplasms (therapy)</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Brachytherapy</term><term>Chemoradiotherapy</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Brachytherapy</term><term>Chemoradiotherapy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Follow-Up Studies</term><term>Health Status</term><term>Humans</term><term>Middle Aged</term><term>Prospective Studies</term><term>Quality of Life</term><term>Radiotherapy Dosage</term><term>Radiotherapy, Image-Guided</term><term>Recovery of Function</term><term>Sexual Behavior</term><term>Surveys and Questionnaires</term><term>Time Factors</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study analyzed functioning and symptom scores for longitudinal quality of life (QoL) from patients with locally advanced cervical cancer who underwent definitive chemoradiation therapy with image guided adaptive brachytherapy in the EMBRACE study.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26876955</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>30</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>03</Day></DateCompleted><DateRevised><Year>2016</Year><Month>03</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-355X</ISSN><JournalIssue CitedMedium="Internet"><Volume>94</Volume><Issue>5</Issue><PubDate><Year>2016</Year><Month>Apr</Month><Day>01</Day></PubDate></JournalIssue><Title>International journal of radiation oncology, biology, physics</Title><ISOAbbreviation>Int. J. Radiat. Oncol. Biol. Phys.</ISOAbbreviation></Journal><ArticleTitle>Health-Related Quality of Life in Locally Advanced Cervical Cancer Patients After Definitive Chemoradiation Therapy Including Image Guided Adaptive Brachytherapy: An Analysis From the EMBRACE Study.</ArticleTitle><Pagination><MedlinePgn>1088-98</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijrobp.2015.12.363</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0360-3016(15)27202-1</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">This study analyzed functioning and symptom scores for longitudinal quality of life (QoL) from patients with locally advanced cervical cancer who underwent definitive chemoradiation therapy with image guided adaptive brachytherapy in the EMBRACE study.</AbstractText><AbstractText Label="METHODS AND MATERIALS" NlmCategory="METHODS">In total, 744 patients at a median follow-up of 21 months were included. QoL was prospectively assessed using European Organization for Research and Treatment of Cancer Quality of Life core module 30 (EORTC QLQ-C30) and EORTC cervical cancer module 24 (CX24) questionnaires at baseline, then every 3 months during the first year, every 6 months in the second and third years, and finally yearly thereafter in patients with no evidence of disease. Outcomes were evaluated over time and compared to those from an age-matched female reference population.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">General QoL and emotional and social functioning were impaired at baseline but improved during the first 6 months after treatment, to reach a level comparable to that of the reference population, whereas cognitive functioning remained impaired. Both social and role functioning showed the lowest scores at baseline but which increased after treatment to reach a plateau at 6 months and then declined slightly at 3 and 4 years. The overall symptom experience was elevated at baseline and decreased to a level within the range of that of the reference population. Similarly, tumor-related symptoms (eg, pain, appetite loss, and constipation), which were present before treatment, decreased substantially at the first follow-up after treatment. Several treatment-related symptoms developed either immediately after and persisted over time (diarrhea, menopausal symptoms, peripheral neuropathy, and sexual functioning problems) or developed gradually after treatment (lymphedema and dyspnea).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This longitudinal prospective QoL analysis showed that patients' general QoL and functioning were impaired before treatment compared to those of reference data. Several tumor-related symptoms resolved after treatment, and functioning and general QoL returned to that of the level of the reference population, indicating a transient impact of diagnosis and treatment. However, several treatment-related symptoms and problems did develop and persist, either immediately or gradually after treatment.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kirchheiner</LastName><ForeName>Kathrin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna and General Hospital of Vienna, Vienna, Austria. Electronic address: kathrin.kirchheiner@meduniwien.ac.at.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pötter</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna and General Hospital of Vienna, Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tanderup</LastName><ForeName>Kari</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lindegaard</LastName><ForeName>Jacob C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haie-Meder</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Radiotherapy, Gustave-Roussy, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petrič</LastName><ForeName>Primož</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Radiotherapy, Institute of Oncology Ljubljana, Ljubljana, Slovenia; Department of Radiation Oncology, National Center for Cancer Care and Research, Doha, Qatar.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mahantshetty</LastName><ForeName>Umesh</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jürgenliemk-Schulz</LastName><ForeName>Ina M</ForeName><Initials>IM</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, University Medical Centre Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rai</LastName><ForeName>Bhavana</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>Rachel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Leeds Cancer Centre, St James's University Hospital, Leeds, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dörr</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna and General Hospital of Vienna, Vienna, Austria; Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nout</LastName><ForeName>Remi A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>EMBRACE Collaborative Group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>12</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Int J Radiat Oncol Biol Phys</MedlineTA><NlmUniqueID>7603616</NlmUniqueID><ISSNLinking>0360-3016</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001918" MajorTopicYN="N">Brachytherapy</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059248" MajorTopicYN="N">Chemoradiotherapy</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006304" MajorTopicYN="Y">Health Status</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="Y">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011879" MajorTopicYN="N">Radiotherapy Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D061089" MajorTopicYN="Y">Radiotherapy, Image-Guided</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020127" MajorTopicYN="N">Recovery of Function</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012725" MajorTopicYN="N">Sexual Behavior</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002583" MajorTopicYN="N">Uterine Cervical Neoplasms</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><InvestigatorList><Investigator ValidYN="Y"><LastName>Lindegaard</LastName><ForeName>Jacob</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tanderup</LastName><ForeName>Kari</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fokdal</LastName><ForeName>Lars</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Van Der Steen Banasik</LastName><ForeName>Elzbieta</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Haie-Meder</LastName><ForeName>Christine</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dumas</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chargari</LastName><ForeName>Cyrus</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nout</LastName><ForeName>Remi A</ForeName><Initials>RA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Van 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