Necrotizing cellulitis with multiple abscesses on the leg caused by Serratia marcescens.
Identifieur interne : 000905 ( PubMed/Corpus ); précédent : 000904; suivant : 000906Necrotizing cellulitis with multiple abscesses on the leg caused by Serratia marcescens.
Auteurs : Estelle Hau ; Jean-David Bouaziz ; Matthieu Lafaurie ; Anne Saussine ; Vincent Masson ; Jonathan Rausky ; Martine Bagot ; Fabien GuibalSource :
- Cutis [ 2326-6929 ] ; 2016.
English descriptors
- KwdEn :
- Abscess (microbiology), Abscess (pathology), Aged, Anti-Bacterial Agents (therapeutic use), Cellulitis (diagnosis), Cellulitis (microbiology), Cellulitis (pathology), Fasciitis, Necrotizing (diagnosis), Fasciitis, Necrotizing (microbiology), Fasciitis, Necrotizing (pathology), Female, Humans, Leg, Serratia Infections (diagnosis), Serratia Infections (microbiology), Serratia Infections (pathology), Serratia marcescens (isolation & purification).
- MESH :
- chemical , therapeutic use : Anti-Bacterial Agents.
- diagnosis : Cellulitis, Fasciitis, Necrotizing, Serratia Infections.
- isolation & purification : Serratia marcescens.
- microbiology : Abscess, Cellulitis, Fasciitis, Necrotizing, Serratia Infections.
- pathology : Abscess, Cellulitis, Fasciitis, Necrotizing, Serratia Infections.
- Aged, Female, Humans, Leg.
Abstract
Serratia marcescens is an unusual cause of severe skin infection initially described in immunocompromised patients. We report a case of necrotizing cellulitis of the leg caused by S marcescens in a 68-year-old woman with diabetes mellitus and a history of chronic lymphoedema of the leg. We reviewed the literature and found 49 cases of severe skin infections from S marcescens that included 20 cases of necrotizing fasciitis (NF) as well as 29 cases of severe skin infections without NF (non-NF cases). Patients were immunocompromised in 59% to 70% of cases. The mortality rate was high in NF cases (60%) versus non-NF cases (3%). Surgery was required in 95% of NF cases and in 24% of non-NF cases. The other clinical manifestations of S marcescens skin infection reported in the literature included disseminated papular eruptions in patients infected with human immunodeficiency virus with folliculitis on the trunk. Serratia marcescens is naturally resistant to amoxicillin alone and amoxicillin associated with clavulanic acid. Broad-spectrum antibiotics are indicated to treat S marcescens skin infections, and surgery should be promptly considered in cases of severe skin infections if appropriate antibiotic therapy does not lead to rapid improvement.
PubMed: 27023094
Links to Exploration step
pubmed:27023094Le document en format XML
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Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bagot, Martine" sort="Bagot, Martine" uniqKey="Bagot M" first="Martine" last="Bagot">Martine Bagot</name><affiliation><nlm:affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</nlm:affiliation></affiliation></author><author><name sortKey="Guibal, Fabien" sort="Guibal, Fabien" uniqKey="Guibal F" first="Fabien" last="Guibal">Fabien Guibal</name><affiliation><nlm:affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27023094</idno><idno type="pmid">27023094</idno><idno type="wicri:Area/PubMed/Corpus">000905</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000905</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Necrotizing cellulitis with multiple abscesses on the leg caused by Serratia marcescens.</title><author><name sortKey="Hau, Estelle" sort="Hau, Estelle" uniqKey="Hau E" first="Estelle" last="Hau">Estelle Hau</name><affiliation><nlm:affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bouaziz, Jean David" sort="Bouaziz, Jean David" uniqKey="Bouaziz J" first="Jean-David" last="Bouaziz">Jean-David Bouaziz</name><affiliation><nlm:affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lafaurie, Matthieu" sort="Lafaurie, Matthieu" uniqKey="Lafaurie M" first="Matthieu" last="Lafaurie">Matthieu Lafaurie</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</nlm:affiliation></affiliation></author><author><name sortKey="Saussine, Anne" sort="Saussine, Anne" uniqKey="Saussine A" first="Anne" last="Saussine">Anne Saussine</name><affiliation><nlm:affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</nlm:affiliation></affiliation></author><author><name sortKey="Masson, Vincent" sort="Masson, Vincent" uniqKey="Masson V" first="Vincent" last="Masson">Vincent Masson</name><affiliation><nlm:affiliation>Department of Plastic Surgery, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rausky, Jonathan" sort="Rausky, Jonathan" uniqKey="Rausky J" first="Jonathan" last="Rausky">Jonathan Rausky</name><affiliation><nlm:affiliation>Department of Plastic Surgery, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bagot, Martine" sort="Bagot, Martine" uniqKey="Bagot M" first="Martine" last="Bagot">Martine Bagot</name><affiliation><nlm:affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</nlm:affiliation></affiliation></author><author><name sortKey="Guibal, Fabien" sort="Guibal, Fabien" uniqKey="Guibal F" first="Fabien" last="Guibal">Fabien Guibal</name><affiliation><nlm:affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cutis</title><idno type="eISSN">2326-6929</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abscess (microbiology)</term><term>Abscess (pathology)</term><term>Aged</term><term>Anti-Bacterial Agents (therapeutic use)</term><term>Cellulitis (diagnosis)</term><term>Cellulitis (microbiology)</term><term>Cellulitis (pathology)</term><term>Fasciitis, Necrotizing (diagnosis)</term><term>Fasciitis, Necrotizing (microbiology)</term><term>Fasciitis, Necrotizing (pathology)</term><term>Female</term><term>Humans</term><term>Leg</term><term>Serratia Infections (diagnosis)</term><term>Serratia Infections (microbiology)</term><term>Serratia Infections (pathology)</term><term>Serratia marcescens (isolation & purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cellulitis</term><term>Fasciitis, Necrotizing</term><term>Serratia Infections</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Serratia marcescens</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Abscess</term><term>Cellulitis</term><term>Fasciitis, Necrotizing</term><term>Serratia Infections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Abscess</term><term>Cellulitis</term><term>Fasciitis, Necrotizing</term><term>Serratia Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Leg</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Serratia marcescens is an unusual cause of severe skin infection initially described in immunocompromised patients. We report a case of necrotizing cellulitis of the leg caused by S marcescens in a 68-year-old woman with diabetes mellitus and a history of chronic lymphoedema of the leg. We reviewed the literature and found 49 cases of severe skin infections from S marcescens that included 20 cases of necrotizing fasciitis (NF) as well as 29 cases of severe skin infections without NF (non-NF cases). Patients were immunocompromised in 59% to 70% of cases. The mortality rate was high in NF cases (60%) versus non-NF cases (3%). Surgery was required in 95% of NF cases and in 24% of non-NF cases. The other clinical manifestations of S marcescens skin infection reported in the literature included disseminated papular eruptions in patients infected with human immunodeficiency virus with folliculitis on the trunk. Serratia marcescens is naturally resistant to amoxicillin alone and amoxicillin associated with clavulanic acid. Broad-spectrum antibiotics are indicated to treat S marcescens skin infections, and surgery should be promptly considered in cases of severe skin infections if appropriate antibiotic therapy does not lead to rapid improvement.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27023094</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>30</Day></DateCreated><DateCompleted><Year>2017</Year><Month>01</Month><Day>02</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>04</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2326-6929</ISSN><JournalIssue CitedMedium="Internet"><Volume>97</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Cutis</Title><ISOAbbreviation>Cutis</ISOAbbreviation></Journal><ArticleTitle>Necrotizing cellulitis with multiple abscesses on the leg caused by Serratia marcescens.</ArticleTitle><Pagination><MedlinePgn>E8-E12</MedlinePgn></Pagination><Abstract><AbstractText>Serratia marcescens is an unusual cause of severe skin infection initially described in immunocompromised patients. We report a case of necrotizing cellulitis of the leg caused by S marcescens in a 68-year-old woman with diabetes mellitus and a history of chronic lymphoedema of the leg. We reviewed the literature and found 49 cases of severe skin infections from S marcescens that included 20 cases of necrotizing fasciitis (NF) as well as 29 cases of severe skin infections without NF (non-NF cases). Patients were immunocompromised in 59% to 70% of cases. The mortality rate was high in NF cases (60%) versus non-NF cases (3%). Surgery was required in 95% of NF cases and in 24% of non-NF cases. The other clinical manifestations of S marcescens skin infection reported in the literature included disseminated papular eruptions in patients infected with human immunodeficiency virus with folliculitis on the trunk. Serratia marcescens is naturally resistant to amoxicillin alone and amoxicillin associated with clavulanic acid. Broad-spectrum antibiotics are indicated to treat S marcescens skin infections, and surgery should be promptly considered in cases of severe skin infections if appropriate antibiotic therapy does not lead to rapid improvement.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hau</LastName><ForeName>Estelle</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouaziz</LastName><ForeName>Jean-David</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lafaurie</LastName><ForeName>Matthieu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saussine</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masson</LastName><ForeName>Vincent</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Plastic Surgery, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rausky</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Plastic Surgery, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bagot</LastName><ForeName>Martine</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guibal</LastName><ForeName>Fabien</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Saint Louis Hospital and Université Paris Diderot, Sorbonne Paris Cité, AP-HP, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cutis</MedlineTA><NlmUniqueID>0006440</NlmUniqueID><ISSNLinking>0011-4162</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000038" MajorTopicYN="N">Abscess</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002481" MajorTopicYN="N">Cellulitis</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019115" MajorTopicYN="N">Fasciitis, Necrotizing</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007866" MajorTopicYN="N">Leg</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016868" MajorTopicYN="N">Serratia Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName 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