A lumped parameter model of mechanically mediated acute and long-term adaptations of contractility and geometry in lymphatics for characterization of lymphedema.
Identifieur interne : 000900 ( PubMed/Corpus ); précédent : 000899; suivant : 000901A lumped parameter model of mechanically mediated acute and long-term adaptations of contractility and geometry in lymphatics for characterization of lymphedema.
Auteurs : Alexander W. Caulk ; J Brandon Dixon ; Rudolph L. GleasonSource :
- Biomechanics and modeling in mechanobiology [ 1617-7940 ] ; 2016.
Abstract
A primary purpose of the lymphatic system is to transport fluid from peripheral tissues to the central venous system in order to maintain tissue-fluid balance. Failure to perform this task results in lymphedema marked by swelling of the affected limb as well as geometric remodeling and reduced contractility of the affected lymphatic vessels. The mechanical environment has been implicated in the regulation of lymphatic contractility, but it is unknown how changes in the mechanical environment are related to loss of contractile function and remodeling of the tissue. The purpose of this paper was to introduce a new theoretical framework for acute and long-term adaptations of lymphatic vessels to changes in mechanical loading. This theoretical framework combines a simplified version of a published lumped parameter model for lymphangion function and lymph transport, a published microstructurally motivated constitutive model for the active and passive mechanical behavior of isolated rat thoracic ducts, and novel models for acute mechanically mediated vasoreactive adaptations and long-term volumetric growth to simulate changes in muscle contractility and geometry of a single isolated rat thoracic duct in response to a sustained elevation in afterload. The illustrative examples highlight the potential role of the mechanical environment in the acute maintenance of contractility and long-term geometric remodeling, presumably aimed at meeting fluid flow demands while also maintaining mechanical homeostasis. Results demonstrate that contractility may adapt in response to shear stress to meet fluid flow demands and show that pressure-induced long-term geometric remodeling may attenuate these adaptations and reduce fluid flow. The modeling framework and illustrative simulations help suggest relevant experiments that are necessary to accurately quantify and predict the acute and long-term adaptations of lymphangions to altered mechanical loading.
DOI: 10.1007/s10237-016-0785-2
PubMed: 27043026
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A lumped parameter model of mechanically mediated acute and long-term adaptations of contractility and geometry in lymphatics for characterization of lymphedema.</title><author><name sortKey="Caulk, Alexander W" sort="Caulk, Alexander W" uniqKey="Caulk A" first="Alexander W" last="Caulk">Alexander W. Caulk</name><affiliation><nlm:affiliation>The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive, Atlanta, GA, 30332, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J Brandon" last="Dixon">J Brandon Dixon</name><affiliation><nlm:affiliation>The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive, Atlanta, GA, 30332, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gleason, Rudolph L" sort="Gleason, Rudolph L" uniqKey="Gleason R" first="Rudolph L" last="Gleason">Rudolph L. Gleason</name><affiliation><nlm:affiliation>The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive, Atlanta, GA, 30332, USA. rudy.gleason@me.gatech.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27043026</idno><idno type="pmid">27043026</idno><idno type="doi">10.1007/s10237-016-0785-2</idno><idno type="wicri:Area/PubMed/Corpus">000900</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000900</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A lumped parameter model of mechanically mediated acute and long-term adaptations of contractility and geometry in lymphatics for characterization of lymphedema.</title><author><name sortKey="Caulk, Alexander W" sort="Caulk, Alexander W" uniqKey="Caulk A" first="Alexander W" last="Caulk">Alexander W. Caulk</name><affiliation><nlm:affiliation>The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive, Atlanta, GA, 30332, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J Brandon" last="Dixon">J Brandon Dixon</name><affiliation><nlm:affiliation>The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive, Atlanta, GA, 30332, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gleason, Rudolph L" sort="Gleason, Rudolph L" uniqKey="Gleason R" first="Rudolph L" last="Gleason">Rudolph L. Gleason</name><affiliation><nlm:affiliation>The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive, Atlanta, GA, 30332, USA. rudy.gleason@me.gatech.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Biomechanics and modeling in mechanobiology</title><idno type="eISSN">1617-7940</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A primary purpose of the lymphatic system is to transport fluid from peripheral tissues to the central venous system in order to maintain tissue-fluid balance. Failure to perform this task results in lymphedema marked by swelling of the affected limb as well as geometric remodeling and reduced contractility of the affected lymphatic vessels. The mechanical environment has been implicated in the regulation of lymphatic contractility, but it is unknown how changes in the mechanical environment are related to loss of contractile function and remodeling of the tissue. The purpose of this paper was to introduce a new theoretical framework for acute and long-term adaptations of lymphatic vessels to changes in mechanical loading. This theoretical framework combines a simplified version of a published lumped parameter model for lymphangion function and lymph transport, a published microstructurally motivated constitutive model for the active and passive mechanical behavior of isolated rat thoracic ducts, and novel models for acute mechanically mediated vasoreactive adaptations and long-term volumetric growth to simulate changes in muscle contractility and geometry of a single isolated rat thoracic duct in response to a sustained elevation in afterload. The illustrative examples highlight the potential role of the mechanical environment in the acute maintenance of contractility and long-term geometric remodeling, presumably aimed at meeting fluid flow demands while also maintaining mechanical homeostasis. Results demonstrate that contractility may adapt in response to shear stress to meet fluid flow demands and show that pressure-induced long-term geometric remodeling may attenuate these adaptations and reduce fluid flow. The modeling framework and illustrative simulations help suggest relevant experiments that are necessary to accurately quantify and predict the acute and long-term adaptations of lymphangions to altered mechanical loading.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27043026</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>04</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1617-7940</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>6</Issue><PubDate><Year>2016</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Biomechanics and modeling in mechanobiology</Title><ISOAbbreviation>Biomech Model Mechanobiol</ISOAbbreviation></Journal><ArticleTitle>A lumped parameter model of mechanically mediated acute and long-term adaptations of contractility and geometry in lymphatics for characterization of lymphedema.</ArticleTitle><Pagination><MedlinePgn>1601-1618</MedlinePgn></Pagination><Abstract><AbstractText>A primary purpose of the lymphatic system is to transport fluid from peripheral tissues to the central venous system in order to maintain tissue-fluid balance. Failure to perform this task results in lymphedema marked by swelling of the affected limb as well as geometric remodeling and reduced contractility of the affected lymphatic vessels. The mechanical environment has been implicated in the regulation of lymphatic contractility, but it is unknown how changes in the mechanical environment are related to loss of contractile function and remodeling of the tissue. The purpose of this paper was to introduce a new theoretical framework for acute and long-term adaptations of lymphatic vessels to changes in mechanical loading. This theoretical framework combines a simplified version of a published lumped parameter model for lymphangion function and lymph transport, a published microstructurally motivated constitutive model for the active and passive mechanical behavior of isolated rat thoracic ducts, and novel models for acute mechanically mediated vasoreactive adaptations and long-term volumetric growth to simulate changes in muscle contractility and geometry of a single isolated rat thoracic duct in response to a sustained elevation in afterload. The illustrative examples highlight the potential role of the mechanical environment in the acute maintenance of contractility and long-term geometric remodeling, presumably aimed at meeting fluid flow demands while also maintaining mechanical homeostasis. Results demonstrate that contractility may adapt in response to shear stress to meet fluid flow demands and show that pressure-induced long-term geometric remodeling may attenuate these adaptations and reduce fluid flow. The modeling framework and illustrative simulations help suggest relevant experiments that are necessary to accurately quantify and predict the acute and long-term adaptations of lymphangions to altered mechanical loading.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Caulk</LastName><ForeName>Alexander W</ForeName><Initials>AW</Initials><AffiliationInfo><Affiliation>The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive, Atlanta, GA, 30332, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dixon</LastName><ForeName>J Brandon</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive, Atlanta, GA, 30332, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA, 30332, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gleason</LastName><ForeName>Rudolph L</ForeName><Initials>RL</Initials><Suffix>Jr</Suffix><AffiliationInfo><Affiliation>The George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive, Atlanta, GA, 30332, USA. rudy.gleason@me.gatech.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA, 30332, USA. rudy.gleason@me.gatech.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Wallace H. Coulter Georgia Tech/Emory Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive, Atlanta, GA, 30332, USA. rudy.gleason@me.gatech.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 HL113061</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Biomech Model Mechanobiol</MedlineTA><NlmUniqueID>101135325</NlmUniqueID><ISSNLinking>1617-7940</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Physiol. 2002 May 1;540(Pt 3):1023-37</RefSource><PMID 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MajorTopicYN="N">Contractility</Keyword><Keyword MajorTopicYN="N">Fluid transport</Keyword><Keyword MajorTopicYN="N">Growth and remodeling</Keyword><Keyword MajorTopicYN="N">Lumped parameter model</Keyword><Keyword MajorTopicYN="N">Lymphatics</Keyword><Keyword MajorTopicYN="N">Lymphedema</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>09</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>03</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2017</Year><Month>12</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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