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Prognostic Impact of Elective Supraclavicular Nodal Irradiation for Patients with N1 Breast Cancer after Lumpectomy and Anthracycline plus Taxane-based Chemotherapy (KROG 1418): A Multicenter Case-Controlled Study.

Identifieur interne : 000428 ( PubMed/Corpus ); précédent : 000427; suivant : 000429

Prognostic Impact of Elective Supraclavicular Nodal Irradiation for Patients with N1 Breast Cancer after Lumpectomy and Anthracycline plus Taxane-based Chemotherapy (KROG 1418): A Multicenter Case-Controlled Study.

Auteurs : Haeyoung Kim ; Won Park ; Jeong Il Yu ; Doo Ho Choi ; Seung Jae Huh ; Yeon-Joo Kim ; Eun Sook Lee ; Keun Seok Lee ; Han-Sung Kang ; In Hae Park ; Kyung Hwan Shin ; Chan Woo Wee ; Kyubo Kim ; Kyung Ran Park ; Yong Bae Kim ; Sung Ja Ahn ; Jong Hoon Lee ; Jin Hee Kim ; Mison Chun ; Hyung-Sik Lee ; Jung Soo Kim ; Jihye Cha

Source :

RBID : pubmed:28052649

Abstract

This study was conducted to evaluate the impact of supraclavicular lymph node radiotherapy (SCNRT) on N1 breast cancer patients receiving post-lumpectomy whole-breast irradiation (WBI) and anthracycline plus taxane-based (AT) chemotherapy.

DOI: 10.4143/crt.2016.382
PubMed: 28052649

Links to Exploration step

pubmed:28052649

Le document en format XML

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<name sortKey="Yu, Jeong Il" sort="Yu, Jeong Il" uniqKey="Yu J" first="Jeong Il" last="Yu">Jeong Il Yu</name>
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<name sortKey="Choi, Doo Ho" sort="Choi, Doo Ho" uniqKey="Choi D" first="Doo Ho" last="Choi">Doo Ho Choi</name>
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<name sortKey="Huh, Seung Jae" sort="Huh, Seung Jae" uniqKey="Huh S" first="Seung Jae" last="Huh">Seung Jae Huh</name>
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<nlm:affiliation>Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.</nlm:affiliation>
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<name sortKey="Lee, Keun Seok" sort="Lee, Keun Seok" uniqKey="Lee K" first="Keun Seok" last="Lee">Keun Seok Lee</name>
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<nlm:affiliation>Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.</nlm:affiliation>
</affiliation>
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<name sortKey="Kang, Han Sung" sort="Kang, Han Sung" uniqKey="Kang H" first="Han-Sung" last="Kang">Han-Sung Kang</name>
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<name sortKey="Park, In Hae" sort="Park, In Hae" uniqKey="Park I" first="In Hae" last="Park">In Hae Park</name>
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<name sortKey="Shin, Kyung Hwan" sort="Shin, Kyung Hwan" uniqKey="Shin K" first="Kyung Hwan" last="Shin">Kyung Hwan Shin</name>
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<nlm:affiliation>Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Wee, Chan Woo" sort="Wee, Chan Woo" uniqKey="Wee C" first="Chan Woo" last="Wee">Chan Woo Wee</name>
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<nlm:affiliation>Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation>
</affiliation>
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<name sortKey="Kim, Kyubo" sort="Kim, Kyubo" uniqKey="Kim K" first="Kyubo" last="Kim">Kyubo Kim</name>
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<nlm:affiliation>Department of Radiation Oncology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea.</nlm:affiliation>
</affiliation>
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<name sortKey="Park, Kyung Ran" sort="Park, Kyung Ran" uniqKey="Park K" first="Kyung Ran" last="Park">Kyung Ran Park</name>
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</affiliation>
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<name sortKey="Kim, Yong Bae" sort="Kim, Yong Bae" uniqKey="Kim Y" first="Yong Bae" last="Kim">Yong Bae Kim</name>
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<nlm:affiliation>Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ahn, Sung Ja" sort="Ahn, Sung Ja" uniqKey="Ahn S" first="Sung Ja" last="Ahn">Sung Ja Ahn</name>
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<nlm:affiliation>Department of Radiation Oncology, Chonnam National University Medical School, Gwangju, Korea.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Lee, Jong Hoon" sort="Lee, Jong Hoon" uniqKey="Lee J" first="Jong Hoon" last="Lee">Jong Hoon Lee</name>
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<nlm:affiliation>Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea.</nlm:affiliation>
</affiliation>
</author>
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<name sortKey="Kim, Jin Hee" sort="Kim, Jin Hee" uniqKey="Kim J" first="Jin Hee" last="Kim">Jin Hee Kim</name>
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<nlm:affiliation>Department of Radiation Oncology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.</nlm:affiliation>
</affiliation>
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<name sortKey="Chun, Mison" sort="Chun, Mison" uniqKey="Chun M" first="Mison" last="Chun">Mison Chun</name>
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<nlm:affiliation>Department of Radiation Oncology, Ajou University School of Medicine, Suwon, Korea.</nlm:affiliation>
</affiliation>
</author>
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<name sortKey="Lee, Hyung Sik" sort="Lee, Hyung Sik" uniqKey="Lee H" first="Hyung-Sik" last="Lee">Hyung-Sik Lee</name>
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<nlm:affiliation>Department of Radiation Oncology, Dong-A University Hospital, Dong-A University School of Medicine, Busan, Korea.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Kim, Jung Soo" sort="Kim, Jung Soo" uniqKey="Kim J" first="Jung Soo" last="Kim">Jung Soo Kim</name>
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<nlm:affiliation>Department of Radiation Oncology, Chonbuk National University Medical School, Jeonju, Korea.</nlm:affiliation>
</affiliation>
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<name sortKey="Cha, Jihye" sort="Cha, Jihye" uniqKey="Cha J" first="Jihye" last="Cha">Jihye Cha</name>
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<nlm:affiliation>Department of Radiation Oncology, Wonju Severance Christian Hospital, Wonju, Korea.</nlm:affiliation>
</affiliation>
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<title level="j">Cancer research and treatment : official journal of Korean Cancer Association</title>
<idno type="eISSN">2005-9256</idno>
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<front>
<div type="abstract" xml:lang="en">This study was conducted to evaluate the impact of supraclavicular lymph node radiotherapy (SCNRT) on N1 breast cancer patients receiving post-lumpectomy whole-breast irradiation (WBI) and anthracycline plus taxane-based (AT) chemotherapy.</div>
</front>
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<PMID Version="1">28052649</PMID>
<DateCreated>
<Year>2017</Year>
<Month>01</Month>
<Day>05</Day>
</DateCreated>
<DateRevised>
<Year>2017</Year>
<Month>01</Month>
<Day>06</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">2005-9256</ISSN>
<JournalIssue CitedMedium="Internet">
<PubDate>
<Year>2017</Year>
<Month>Jan</Month>
<Day>04</Day>
</PubDate>
</JournalIssue>
<Title>Cancer research and treatment : official journal of Korean Cancer Association</Title>
<ISOAbbreviation>Cancer Res Treat</ISOAbbreviation>
</Journal>
<ArticleTitle>Prognostic Impact of Elective Supraclavicular Nodal Irradiation for Patients with N1 Breast Cancer after Lumpectomy and Anthracycline plus Taxane-based Chemotherapy (KROG 1418): A Multicenter Case-Controlled Study.</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.4143/crt.2016.382</ELocationID>
<Abstract>
<AbstractText Label="Purpose" NlmCategory="UNASSIGNED">This study was conducted to evaluate the impact of supraclavicular lymph node radiotherapy (SCNRT) on N1 breast cancer patients receiving post-lumpectomy whole-breast irradiation (WBI) and anthracycline plus taxane-based (AT) chemotherapy.</AbstractText>
<AbstractText Label="Materials and Methods" NlmCategory="UNASSIGNED">We performed a case-control analysis to compare the outcomes of WBI and WBI plus SCNRT (WBI+SCNRT). Among 1,147 patients with N1 breast cancer who received post-lumpectomy radiotherapy and AT-based chemotherapy in 12 hospitals, 542 were selected after propensity score matching. Patterns of failure, disease-free survival (DFS), distant metastasis-free survival (DMFS), and treatment-related toxicity were compared between groups.</AbstractText>
<AbstractText Label="Results" NlmCategory="UNASSIGNED">A total of 41 (7.6%) patients were found to have recurrence. SCN failure was detected in three patients, two in WBI and one in WBI+SCNRT. All SCN failures were found simultaneously with distant metastasis. There was no significant difference in patterns of failure or survival between groups. The 5-year DFS and DMFS for patients with WBI and WBI+SCNRT were 94.4% vs. 92.6% (p=0.50) and 95.1% vs. 94.5% (p=0.99), respectively. The rates of lymphedema and radiation pneumonitis were significantly higher in the WBI+SCNRT than in the WBI.</AbstractText>
<AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">We did not find a benefit of SCNRT for N1 breast cancer patients receiving AT-based chemotherapy.</AbstractText>
</Abstract>
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<LastName>Kim</LastName>
<ForeName>Haeyoung</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Park</LastName>
<ForeName>Won</ForeName>
<Initials>W</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Yu</LastName>
<ForeName>Jeong Il</ForeName>
<Initials>JI</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Choi</LastName>
<ForeName>Doo Ho</ForeName>
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<Affiliation>Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Huh</LastName>
<ForeName>Seung Jae</ForeName>
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<Affiliation>Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
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<LastName>Kim</LastName>
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<Initials>YJ</Initials>
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<Affiliation>Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Lee</LastName>
<ForeName>Eun Sook</ForeName>
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<Affiliation>Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Lee</LastName>
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<Affiliation>Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kang</LastName>
<ForeName>Han-Sung</ForeName>
<Initials>HS</Initials>
<AffiliationInfo>
<Affiliation>Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Park</LastName>
<ForeName>In Hae</ForeName>
<Initials>IH</Initials>
<AffiliationInfo>
<Affiliation>Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Shin</LastName>
<ForeName>Kyung Hwan</ForeName>
<Initials>KH</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Wee</LastName>
<ForeName>Chan Woo</ForeName>
<Initials>CW</Initials>
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<Affiliation>Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kim</LastName>
<ForeName>Kyubo</ForeName>
<Initials>K</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Park</LastName>
<ForeName>Kyung Ran</ForeName>
<Initials>KR</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kim</LastName>
<ForeName>Yong Bae</ForeName>
<Initials>YB</Initials>
<AffiliationInfo>
<Affiliation>Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y">
<LastName>Ahn</LastName>
<ForeName>Sung Ja</ForeName>
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<Affiliation>Department of Radiation Oncology, Chonnam National University Medical School, Gwangju, Korea.</Affiliation>
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<LastName>Lee</LastName>
<ForeName>Jong Hoon</ForeName>
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<Affiliation>Department of Radiation Oncology, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kim</LastName>
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<Affiliation>Department of Radiation Oncology, Chonbuk National University Medical School, Jeonju, Korea.</Affiliation>
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<Keyword MajorTopicYN="N">Adjuvant radiotherapy</Keyword>
<Keyword MajorTopicYN="N">Breast neoplasms</Keyword>
<Keyword MajorTopicYN="N">Case-control studies</Keyword>
<Keyword MajorTopicYN="N">Lymphatic irradiation</Keyword>
<Keyword MajorTopicYN="N">Taxane</Keyword>
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<Year>2016</Year>
<Month>08</Month>
<Day>16</Day>
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<PubMedPubDate PubStatus="accepted">
<Year>2016</Year>
<Month>12</Month>
<Day>23</Day>
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<ArticleId IdType="pubmed">28052649</ArticleId>
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<ArticleId IdType="doi">10.4143/crt.2016.382</ArticleId>
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