The lymphatic vasculature revisited-new developments in the zebrafish.
Identifieur interne : 000391 ( PubMed/Corpus ); précédent : 000390; suivant : 000392The lymphatic vasculature revisited-new developments in the zebrafish.
Auteurs : Y. Padberg ; S. Schulte-Merker ; A. Van ImpelSource :
- Methods in cell biology [ 0091-679X ] ; 2017.
English descriptors
- KwdEn :
- Animals, Arthritis, Rheumatoid (diagnostic imaging), Arthritis, Rheumatoid (physiopathology), Disease Models, Animal, Endothelial Cells (pathology), Endothelial Cells (ultrastructure), Humans, Lymphangiogenesis, Lymphatic Vessels (diagnostic imaging), Lymphatic Vessels (physiopathology), Lymphedema (diagnostic imaging), Lymphedema (physiopathology), Molecular Imaging (methods), Obesity (diagnostic imaging), Obesity (physiopathology), Zebrafish (physiology).
- MESH :
- diagnostic imaging : Arthritis, Rheumatoid, Lymphatic Vessels, Lymphedema, Obesity.
- methods : Molecular Imaging.
- pathology : Endothelial Cells.
- physiology : Zebrafish.
- physiopathology : Arthritis, Rheumatoid, Lymphatic Vessels, Lymphedema, Obesity.
- ultrastructure : Endothelial Cells.
- Animals, Disease Models, Animal, Humans, Lymphangiogenesis.
Abstract
The lymphatic system is lined by endothelial cells and part of the vasculature. It is essential for tissue fluid homeostasis, absorption of dietary fats, and immune surveillance in vertebrates. Misregulation of lymphatic vessel formation and dysfunction of the lymphatic system have been indicated in a number of pathological conditions including lymphedema formation, obesity or chronic inflammatory diseases such as rheumatoid arthritis. In zebrafish, lymphatics were discovered about 10years ago, and the underlying molecular pathways involved in its development have since been studied in detail. Due to its superior live cell imaging possibilities and the broad tool kit for forward and reverse genetics, the zebrafish has become an important model organism to study the development of the lymphatic system during early embryonic development. In the current review, we will focus on the key players during zebrafish lymphangiogenesis and compare the roles of these genes to their mammalian counterparts. In particular, we will focus on novel findings that shed new light on the molecular mechanisms of lymphatic cell fate specification, as well as sprouting and migration of lymphatic precursor cells.
DOI: 10.1016/bs.mcb.2016.11.001
PubMed: 28129845
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pubmed:28129845Le document en format XML
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Schulte-Merker</name><affiliation><nlm:affiliation>Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster, Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC M 1003-CiM), University of Münster, Münster, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Van Impel, A" sort="Van Impel, A" uniqKey="Van Impel A" first="A" last="Van Impel">A. Van Impel</name><affiliation><nlm:affiliation>Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster, Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC M 1003-CiM), University of Münster, Münster, Germany.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28129845</idno><idno type="pmid">28129845</idno><idno type="doi">10.1016/bs.mcb.2016.11.001</idno><idno type="wicri:Area/PubMed/Corpus">000391</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000391</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The lymphatic vasculature revisited-new developments in the zebrafish.</title><author><name sortKey="Padberg, Y" sort="Padberg, Y" uniqKey="Padberg Y" first="Y" last="Padberg">Y. Padberg</name><affiliation><nlm:affiliation>Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster, Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC M 1003-CiM), University of Münster, Münster, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schulte Merker, S" sort="Schulte Merker, S" uniqKey="Schulte Merker S" first="S" last="Schulte-Merker">S. Schulte-Merker</name><affiliation><nlm:affiliation>Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster, Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC M 1003-CiM), University of Münster, Münster, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Van Impel, A" sort="Van Impel, A" uniqKey="Van Impel A" first="A" last="Van Impel">A. Van Impel</name><affiliation><nlm:affiliation>Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, University of Münster, Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC M 1003-CiM), University of Münster, Münster, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Methods in cell biology</title><idno type="ISSN">0091-679X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Arthritis, Rheumatoid (diagnostic imaging)</term><term>Arthritis, Rheumatoid (physiopathology)</term><term>Disease Models, Animal</term><term>Endothelial Cells (pathology)</term><term>Endothelial Cells (ultrastructure)</term><term>Humans</term><term>Lymphangiogenesis</term><term>Lymphatic Vessels (diagnostic imaging)</term><term>Lymphatic Vessels (physiopathology)</term><term>Lymphedema (diagnostic imaging)</term><term>Lymphedema (physiopathology)</term><term>Molecular Imaging (methods)</term><term>Obesity (diagnostic imaging)</term><term>Obesity (physiopathology)</term><term>Zebrafish (physiology)</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Molecular Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Endothelial Cells</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Zebrafish</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Endothelial Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Lymphangiogenesis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lymphatic system is lined by endothelial cells and part of the vasculature. It is essential for tissue fluid homeostasis, absorption of dietary fats, and immune surveillance in vertebrates. Misregulation of lymphatic vessel formation and dysfunction of the lymphatic system have been indicated in a number of pathological conditions including lymphedema formation, obesity or chronic inflammatory diseases such as rheumatoid arthritis. In zebrafish, lymphatics were discovered about 10years ago, and the underlying molecular pathways involved in its development have since been studied in detail. Due to its superior live cell imaging possibilities and the broad tool kit for forward and reverse genetics, the zebrafish has become an important model organism to study the development of the lymphatic system during early embryonic development. In the current review, we will focus on the key players during zebrafish lymphangiogenesis and compare the roles of these genes to their mammalian counterparts. In particular, we will focus on novel findings that shed new light on the molecular mechanisms of lymphatic cell fate specification, as well as sprouting and migration of lymphatic precursor cells.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28129845</PMID><DateCreated><Year>2017</Year><Month>01</Month><Day>28</Day></DateCreated><DateCompleted><Year>2017</Year><Month>08</Month><Day>18</Day></DateCompleted><DateRevised><Year>2017</Year><Month>08</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0091-679X</ISSN><JournalIssue CitedMedium="Internet"><Volume>138</Volume><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Methods in cell biology</Title><ISOAbbreviation>Methods Cell Biol.</ISOAbbreviation></Journal><ArticleTitle>The lymphatic vasculature revisited-new developments in the zebrafish.</ArticleTitle><Pagination><MedlinePgn>221-238</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0091-679X(16)30153-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/bs.mcb.2016.11.001</ELocationID><Abstract><AbstractText>The lymphatic system is lined by endothelial cells and part of the vasculature. It is essential for tissue fluid homeostasis, absorption of dietary fats, and immune surveillance in vertebrates. Misregulation of lymphatic vessel formation and dysfunction of the lymphatic system have been indicated in a number of pathological conditions including lymphedema formation, obesity or chronic inflammatory diseases such as rheumatoid arthritis. In zebrafish, lymphatics were discovered about 10years ago, and the underlying molecular pathways involved in its development have since been studied in detail. Due to its superior live cell imaging possibilities and the broad tool kit for forward and reverse genetics, the zebrafish has become an important model organism to study the development of the lymphatic system during early embryonic development. In the current review, we will focus on the key players during zebrafish lymphangiogenesis and compare the roles of these genes to their mammalian counterparts. In particular, we will focus on novel findings that shed new light on the molecular mechanisms of lymphatic cell fate specification, as well as sprouting and migration of lymphatic precursor cells.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Inc. 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