Modified Mouse Models of Chronic Secondary Lymphedema: Tail and Hind Limb Models.
Identifieur interne : 000220 ( PubMed/Corpus ); précédent : 000219; suivant : 000221Modified Mouse Models of Chronic Secondary Lymphedema: Tail and Hind Limb Models.
Auteurs : Heungman Jun ; Ji Yoon Lee ; Ji Hun Kim ; Minsu Noh ; Tae-Won Kwon ; Yong-Pil Cho ; Young-Sup YoonSource :
- Annals of vascular surgery [ 1615-5947 ] ; 2017.
Abstract
Postsurgical secondary lymphedema is usually a progressive and lifelong condition lacking any curative treatment. The aim of this study was to develop new, simple surgical mouse models of chronic lymphedema, better simulating chronic nature of human postsurgical lymphedema.
DOI: 10.1016/j.avsg.2017.01.023
PubMed: 28479437
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modified Mouse Models of Chronic Secondary Lymphedema: Tail and Hind Limb Models.</title><author><name sortKey="Jun, Heungman" sort="Jun, Heungman" uniqKey="Jun H" first="Heungman" last="Jun">Heungman Jun</name><affiliation><nlm:affiliation>Department of Surgery, Korea University Anam Hospital, Seoul, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Ji Yoon" sort="Lee, Ji Yoon" uniqKey="Lee J" first="Ji Yoon" last="Lee">Ji Yoon Lee</name><affiliation><nlm:affiliation>Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Ji Hun" sort="Kim, Ji Hun" uniqKey="Kim J" first="Ji Hun" last="Kim">Ji Hun Kim</name><affiliation><nlm:affiliation>Department of Pathology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Noh, Minsu" sort="Noh, Minsu" uniqKey="Noh M" first="Minsu" last="Noh">Minsu Noh</name><affiliation><nlm:affiliation>Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kwon, Tae Won" sort="Kwon, Tae Won" uniqKey="Kwon T" first="Tae-Won" last="Kwon">Tae-Won Kwon</name><affiliation><nlm:affiliation>Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Cho, Yong Pil" sort="Cho, Yong Pil" uniqKey="Cho Y" first="Yong-Pil" last="Cho">Yong-Pil Cho</name><affiliation><nlm:affiliation>Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea. Electronic address: ypcho@amc.seoul.kr.</nlm:affiliation></affiliation></author><author><name sortKey="Yoon, Young Sup" sort="Yoon, Young Sup" uniqKey="Yoon Y" first="Young-Sup" last="Yoon">Young-Sup Yoon</name><affiliation><nlm:affiliation>Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Medicine, Emory University School of medicine, Atlanta, GA. Electronic address: yyoon5@emory.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28479437</idno><idno type="pmid">28479437</idno><idno type="doi">10.1016/j.avsg.2017.01.023</idno><idno type="wicri:Area/PubMed/Corpus">000220</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000220</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Modified Mouse Models of Chronic Secondary Lymphedema: Tail and Hind Limb Models.</title><author><name sortKey="Jun, Heungman" sort="Jun, Heungman" uniqKey="Jun H" first="Heungman" last="Jun">Heungman Jun</name><affiliation><nlm:affiliation>Department of Surgery, Korea University Anam Hospital, Seoul, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Ji Yoon" sort="Lee, Ji Yoon" uniqKey="Lee J" first="Ji Yoon" last="Lee">Ji Yoon Lee</name><affiliation><nlm:affiliation>Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Ji Hun" sort="Kim, Ji Hun" uniqKey="Kim J" first="Ji Hun" last="Kim">Ji Hun Kim</name><affiliation><nlm:affiliation>Department of Pathology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Noh, Minsu" sort="Noh, Minsu" uniqKey="Noh M" first="Minsu" last="Noh">Minsu Noh</name><affiliation><nlm:affiliation>Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kwon, Tae Won" sort="Kwon, Tae Won" uniqKey="Kwon T" first="Tae-Won" last="Kwon">Tae-Won Kwon</name><affiliation><nlm:affiliation>Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Cho, Yong Pil" sort="Cho, Yong Pil" uniqKey="Cho Y" first="Yong-Pil" last="Cho">Yong-Pil Cho</name><affiliation><nlm:affiliation>Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea. Electronic address: ypcho@amc.seoul.kr.</nlm:affiliation></affiliation></author><author><name sortKey="Yoon, Young Sup" sort="Yoon, Young Sup" uniqKey="Yoon Y" first="Young-Sup" last="Yoon">Young-Sup Yoon</name><affiliation><nlm:affiliation>Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Medicine, Emory University School of medicine, Atlanta, GA. Electronic address: yyoon5@emory.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Annals of vascular surgery</title><idno type="eISSN">1615-5947</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Postsurgical secondary lymphedema is usually a progressive and lifelong condition lacking any curative treatment. The aim of this study was to develop new, simple surgical mouse models of chronic lymphedema, better simulating chronic nature of human postsurgical lymphedema.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28479437</PMID><DateCreated><Year>2017</Year><Month>05</Month><Day>08</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1615-5947</ISSN><JournalIssue CitedMedium="Internet"><Volume>43</Volume><PubDate><Year>2017</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Annals of vascular surgery</Title><ISOAbbreviation>Ann Vasc Surg</ISOAbbreviation></Journal><ArticleTitle>Modified Mouse Models of Chronic Secondary Lymphedema: Tail and Hind Limb Models.</ArticleTitle><Pagination><MedlinePgn>288-295</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0890-5096(17)30656-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.avsg.2017.01.023</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Postsurgical secondary lymphedema is usually a progressive and lifelong condition lacking any curative treatment. The aim of this study was to develop new, simple surgical mouse models of chronic lymphedema, better simulating chronic nature of human postsurgical lymphedema.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Two experimental mouse models of secondary lymphedema were created surgically without radiation by modifications of the previously described methods: the tail model and the hind limb model. Lymphedema formation was clinically assessed and quantitatively evaluated by measuring circumferences and limb volumes. Postmortem specimens were assessed histologically to examine the efficacy of the models.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In the tail models, although a substantial frequency of tail necrosis (30.0%) was noted and the increase in circumference was maintained for only limited times postoperatively depending on the particular tail model, the overall success rate was 65.0%. In the mouse hind limb model, the overall success rate was 88.9%, and the increased circumference and limb volume were maintained over the entire study period of 8 weeks. The overall success rate of the mouse hind limb model was significantly higher than that of the mouse tail model(s).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We have successfully established modified mouse tail and hind limb lymphedema models via only surgical techniques without radiation, which have characteristics of chronic secondary lymphedema. The mouse hind limb model has a higher success rate than the mouse tail model and has advantages of having the healthy contralateral hind limbs as an internal control.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jun</LastName><ForeName>Heungman</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Surgery, Korea University Anam Hospital, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Ji Yoon</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Ji Hun</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Noh</LastName><ForeName>Minsu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwon</LastName><ForeName>Tae-Won</ForeName><Initials>TW</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cho</LastName><ForeName>Yong-Pil</ForeName><Initials>YP</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea. Electronic address: ypcho@amc.seoul.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yoon</LastName><ForeName>Young-Sup</ForeName><Initials>YS</Initials><AffiliationInfo><Affiliation>Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Medicine, Emory University School of medicine, Atlanta, GA. Electronic address: yyoon5@emory.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>05</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Ann Vasc Surg</MedlineTA><NlmUniqueID>8703941</NlmUniqueID><ISSNLinking>0890-5096</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>12</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>01</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28479437</ArticleId><ArticleId IdType="pii">S0890-5096(17)30656-8</ArticleId><ArticleId IdType="doi">10.1016/j.avsg.2017.01.023</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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