[Acute toxicity of breast cancer irradiation with modulated intensity by tomotherapy(®)].
Identifieur interne : 000205 ( PubMed/Corpus ); précédent : 000204; suivant : 000206[Acute toxicity of breast cancer irradiation with modulated intensity by tomotherapy(®)].
Auteurs : N. Aoulad ; C. Massabeau ; B. De Lafontan ; L. Vieillevigne ; G. Hangard ; C. Ciprian ; L. Chaltiel ; É Moyal ; F. IzarSource :
- Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [ 1769-6658 ] ; 2017.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Radiotherapy, Intensity-Modulated.
- etiology : Esophageal Diseases, Lung Diseases, Radiation Injuries, Radiodermatitis.
- radiotherapy : Breast Neoplasms.
- Acute Disease, Female, Humans, Middle Aged, Retrospective Studies.
Abstract
Helical radiation intensity modulated by tomotherapy improves dose distribution to complex and large volumes. The aim of the study was to assess acute toxicity of this technique during breast cancer irradiation after conserving surgery or mastectomy.
DOI: 10.1016/j.canrad.2016.11.008
PubMed: 28499662
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De Lafontan</name><affiliation><nlm:affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vieillevigne, L" sort="Vieillevigne, L" uniqKey="Vieillevigne L" first="L" last="Vieillevigne">L. Vieillevigne</name><affiliation><nlm:affiliation>Département de radiophysique, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hangard, G" sort="Hangard, G" uniqKey="Hangard G" first="G" last="Hangard">G. Hangard</name><affiliation><nlm:affiliation>Département de radiophysique, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ciprian, C" sort="Ciprian, C" uniqKey="Ciprian C" first="C" last="Ciprian">C. Ciprian</name><affiliation><nlm:affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chaltiel, L" sort="Chaltiel, L" uniqKey="Chaltiel L" first="L" last="Chaltiel">L. Chaltiel</name><affiliation><nlm:affiliation>Département de biostatistiques, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="Moyal, E" sort="Moyal, E" uniqKey="Moyal E" first="É" last="Moyal">É Moyal</name><affiliation><nlm:affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France; Département de radiophysique, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France; Département de biostatistiques, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="Izar, F" sort="Izar, F" uniqKey="Izar F" first="F" last="Izar">F. Izar</name><affiliation><nlm:affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28499662</idno><idno type="pmid">28499662</idno><idno type="doi">10.1016/j.canrad.2016.11.008</idno><idno type="wicri:Area/PubMed/Corpus">000205</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000205</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Acute toxicity of breast cancer irradiation with modulated intensity by tomotherapy(®)].</title><author><name sortKey="Aoulad, N" sort="Aoulad, N" uniqKey="Aoulad N" first="N" last="Aoulad">N. Aoulad</name><affiliation><nlm:affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France. Electronic address: nadia.elmokadem@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Massabeau, C" sort="Massabeau, C" uniqKey="Massabeau C" first="C" last="Massabeau">C. Massabeau</name><affiliation><nlm:affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="De Lafontan, B" sort="De Lafontan, B" uniqKey="De Lafontan B" first="B" last="De Lafontan">B. De Lafontan</name><affiliation><nlm:affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vieillevigne, L" sort="Vieillevigne, L" uniqKey="Vieillevigne L" first="L" last="Vieillevigne">L. Vieillevigne</name><affiliation><nlm:affiliation>Département de radiophysique, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hangard, G" sort="Hangard, G" uniqKey="Hangard G" first="G" last="Hangard">G. Hangard</name><affiliation><nlm:affiliation>Département de radiophysique, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ciprian, C" sort="Ciprian, C" uniqKey="Ciprian C" first="C" last="Ciprian">C. Ciprian</name><affiliation><nlm:affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chaltiel, L" sort="Chaltiel, L" uniqKey="Chaltiel L" first="L" last="Chaltiel">L. Chaltiel</name><affiliation><nlm:affiliation>Département de biostatistiques, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="Moyal, E" sort="Moyal, E" uniqKey="Moyal E" first="É" last="Moyal">É Moyal</name><affiliation><nlm:affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France; Département de radiophysique, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France; Département de biostatistiques, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author><author><name sortKey="Izar, F" sort="Izar, F" uniqKey="Izar F" first="F" last="Izar">F. Izar</name><affiliation><nlm:affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique</title><idno type="eISSN">1769-6658</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Disease</term><term>Breast Neoplasms (radiotherapy)</term><term>Esophageal Diseases (etiology)</term><term>Female</term><term>Humans</term><term>Lung Diseases (etiology)</term><term>Middle Aged</term><term>Radiation Injuries (etiology)</term><term>Radiodermatitis (etiology)</term><term>Radiotherapy, Intensity-Modulated (adverse effects)</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Radiotherapy, Intensity-Modulated</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Esophageal Diseases</term><term>Lung Diseases</term><term>Radiation Injuries</term><term>Radiodermatitis</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acute Disease</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Helical radiation intensity modulated by tomotherapy improves dose distribution to complex and large volumes. The aim of the study was to assess acute toxicity of this technique during breast cancer irradiation after conserving surgery or mastectomy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28499662</PMID><DateCreated><Year>2017</Year><Month>05</Month><Day>13</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>21</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1769-6658</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>3</Issue><PubDate><Year>2017</Year><Month>May</Month></PubDate></JournalIssue><Title>Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique</Title><ISOAbbreviation>Cancer Radiother</ISOAbbreviation></Journal><ArticleTitle>[Acute toxicity of breast cancer irradiation with modulated intensity by tomotherapy(®)].</ArticleTitle><Pagination><MedlinePgn>180-189</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1278-3218(17)30061-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.canrad.2016.11.008</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Helical radiation intensity modulated by tomotherapy improves dose distribution to complex and large volumes. The aim of the study was to assess acute toxicity of this technique during breast cancer irradiation after conserving surgery or mastectomy.</AbstractText><AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Cutaneous toxicities, lung and oesophageal side effects, and breast lymphedema were retrospectively collected according to the Common Terminology Criteria for Adverse Events Version 4.0 (CTCAE v4.0) in 292 patients treated for a breast cancer by tomotherapy between May 2010 and December 2014. After conservative surgery, the dose administered to breast volume and the tumour bed was respectively 52.2Gy and 63.8Gy in 29 fractions. After mastectomy, the dose was 50Gy in 25 fractions. Univariate and multivariate analyses were performed to highlight risk factors for dermatitis and breast oedema.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The rate of dermatitis grade 2 and 3 were 22.9% and 1.7% respectively. In univariate analysis, factors associated with acute radiation dermatitis were breast volume (P=0.002), body mass index (BMI) (P<0.0001), the use of chest compression mask (net) (P=0.005) and the localization of the irradiation (P <0.0001). In multivariate analysis, BMI greater than 25kg/m(2) (odds ratio [OR]: 3.61, 95% confidence interval [CI]: [1.93-6.74], P<0.0001), the use of a chest mask (OR 2.01, 95% CI [1.06-3.79] P=0.0328) and irradiation after conservative treatment increase the risk of acute radiation dermatitis (mastectomy: OR 0.64, 95% CI [0.04-0.43]; mastectomy with immediate reconstruction with prosthesis: OR 0.13 95% CI [0.10-0.38] P=0.0003). The incidence of breast oedema grade 2 or above was 19.5%, in univariate analysis, there was a correlation with BMI (P=0.003) and smoking (P=0.009). In multivariate analysis, smoking and BMI greater than 25kg/m(2) increased the risk of breast oedema (OR 2.47, respectively [95% CI 1.22-5.01] P=0.012 and OR 2.37 [95% CI 1.22-4.59] P=0.01). The rate of radiation pneumonitis of grade 2 or above was 1.4%. Among the patients, 19.9% had esophagitis grade 1 or 2.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The helical irradiation intensity modulation tomotherapy is a well-tolerated treatment for breast cancer that reduces the high radiation doses to organs at risk.</AbstractText><CopyrightInformation>Copyright © 2017 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Aoulad</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France. Electronic address: nadia.elmokadem@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Massabeau</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Lafontan</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vieillevigne</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Département de radiophysique, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hangard</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Département de radiophysique, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ciprian</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chaltiel</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Département de biostatistiques, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moyal</LastName><ForeName>É</ForeName><Initials>É</Initials><AffiliationInfo><Affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France; Département de radiophysique, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France; Département de biostatistiques, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Izar</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Département de radiothérapie, institut universitaire du cancer de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>fre</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Toxicité aiguë de la tomothérapie des cancers mammaires.</VernacularTitle><ArticleDate DateType="Electronic"><Year>2017</Year><Month>05</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Cancer Radiother</MedlineTA><NlmUniqueID>9711272</NlmUniqueID><ISSNLinking>1278-3218</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000208" MajorTopicYN="N">Acute Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001943" MajorTopicYN="N">Breast Neoplasms</DescriptorName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004935" MajorTopicYN="N">Esophageal Diseases</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008171" MajorTopicYN="N">Lung Diseases</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011832" MajorTopicYN="N">Radiation Injuries</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011855" MajorTopicYN="N">Radiodermatitis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050397" MajorTopicYN="N">Radiotherapy, Intensity-Modulated</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute toxicities</Keyword><Keyword MajorTopicYN="N">Breast cancer</Keyword><Keyword MajorTopicYN="N">Cancer du sein</Keyword><Keyword MajorTopicYN="N">Modulated radiation therapy</Keyword><Keyword MajorTopicYN="N">Modulation d’intensité</Keyword><Keyword MajorTopicYN="N">Radiothérapie</Keyword><Keyword MajorTopicYN="N">Tomotherapy(®)</Keyword><Keyword MajorTopicYN="N">Tomothérapie</Keyword><Keyword MajorTopicYN="N">Toxicité aiguë</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>11</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>11</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28499662</ArticleId><ArticleId IdType="pii">S1278-3218(17)30061-6</ArticleId><ArticleId IdType="doi">10.1016/j.canrad.2016.11.008</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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