Therapeutic Value of Standard Versus Extended Pelvic Lymph Node Dissection During Radical Prostatectomy for High-Risk Prostate Cancer.
Identifieur interne : 000157 ( PubMed/Corpus ); précédent : 000156; suivant : 000158Therapeutic Value of Standard Versus Extended Pelvic Lymph Node Dissection During Radical Prostatectomy for High-Risk Prostate Cancer.
Auteurs : Michele Colicchia ; Vidit Sharma ; Firas Abdollah ; Alberto Briganti ; R. Jeffrey KarnesSource :
- Current urology reports [ 1534-6285 ] ; 2017.
Abstract
Extent of pelvic lymph node dissection (PLND) during radical prostatectomy (RP) remains a subject of debate. Here, we review the literature covering the value of extended PLND (ePLND) during RP for high-risk prostate cancer (PCa) over a standard PLND, with a focus on potential therapeutic advantage. PLND may provide valuable prognostic information to high-risk PCa patients, and incorporating the common iliac and presacral nodes to ePLND templates further improves pathologic nodal staging accuracy. Although increased PLND extent is associated with increased lymphocele/lymphedema rates, it is not associated with increased venous thromboembolism rates. The therapeutic role of ePLND remains uncertain. While recent retrospective studies suggest an increased number of nodes removed within the ePLND template are associated with improved survival outcomes, such retrospective studies cannot completely adjust for the Will Rodgers phenomenon or surgeon-specific factors. Thus, the results of randomized trials are eagerly awaited in this arena.
DOI: 10.1007/s11934-017-0696-5
PubMed: 28589397
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Therapeutic Value of Standard Versus Extended Pelvic Lymph Node Dissection During Radical Prostatectomy for High-Risk Prostate Cancer.</title><author><name sortKey="Colicchia, Michele" sort="Colicchia, Michele" uniqKey="Colicchia M" first="Michele" last="Colicchia">Michele Colicchia</name><affiliation><nlm:affiliation>Department of Urology, Mayo Clinic Rochester, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma, Vidit" sort="Sharma, Vidit" uniqKey="Sharma V" first="Vidit" last="Sharma">Vidit Sharma</name><affiliation><nlm:affiliation>Department of Urology, Mayo Clinic Rochester, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Abdollah, Firas" sort="Abdollah, Firas" uniqKey="Abdollah F" first="Firas" last="Abdollah">Firas Abdollah</name><affiliation><nlm:affiliation>Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Briganti, Alberto" sort="Briganti, Alberto" uniqKey="Briganti A" first="Alberto" last="Briganti">Alberto Briganti</name><affiliation><nlm:affiliation>Division of Oncology/Unit of Urology, Urological Research Institute, San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Jeffrey Karnes, R" sort="Jeffrey Karnes, R" uniqKey="Jeffrey Karnes R" first="R" last="Jeffrey Karnes">R. Jeffrey Karnes</name><affiliation><nlm:affiliation>Department of Urology, Mayo Clinic Rochester, Rochester, MN, USA. karnes.r@mayo.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28589397</idno><idno type="pmid">28589397</idno><idno type="doi">10.1007/s11934-017-0696-5</idno><idno type="wicri:Area/PubMed/Corpus">000157</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000157</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Therapeutic Value of Standard Versus Extended Pelvic Lymph Node Dissection During Radical Prostatectomy for High-Risk Prostate Cancer.</title><author><name sortKey="Colicchia, Michele" sort="Colicchia, Michele" uniqKey="Colicchia M" first="Michele" last="Colicchia">Michele Colicchia</name><affiliation><nlm:affiliation>Department of Urology, Mayo Clinic Rochester, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma, Vidit" sort="Sharma, Vidit" uniqKey="Sharma V" first="Vidit" last="Sharma">Vidit Sharma</name><affiliation><nlm:affiliation>Department of Urology, Mayo Clinic Rochester, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Abdollah, Firas" sort="Abdollah, Firas" uniqKey="Abdollah F" first="Firas" last="Abdollah">Firas Abdollah</name><affiliation><nlm:affiliation>Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Briganti, Alberto" sort="Briganti, Alberto" uniqKey="Briganti A" first="Alberto" last="Briganti">Alberto Briganti</name><affiliation><nlm:affiliation>Division of Oncology/Unit of Urology, Urological Research Institute, San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Jeffrey Karnes, R" sort="Jeffrey Karnes, R" uniqKey="Jeffrey Karnes R" first="R" last="Jeffrey Karnes">R. Jeffrey Karnes</name><affiliation><nlm:affiliation>Department of Urology, Mayo Clinic Rochester, Rochester, MN, USA. karnes.r@mayo.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Current urology reports</title><idno type="eISSN">1534-6285</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Extent of pelvic lymph node dissection (PLND) during radical prostatectomy (RP) remains a subject of debate. Here, we review the literature covering the value of extended PLND (ePLND) during RP for high-risk prostate cancer (PCa) over a standard PLND, with a focus on potential therapeutic advantage. PLND may provide valuable prognostic information to high-risk PCa patients, and incorporating the common iliac and presacral nodes to ePLND templates further improves pathologic nodal staging accuracy. Although increased PLND extent is associated with increased lymphocele/lymphedema rates, it is not associated with increased venous thromboembolism rates. The therapeutic role of ePLND remains uncertain. While recent retrospective studies suggest an increased number of nodes removed within the ePLND template are associated with improved survival outcomes, such retrospective studies cannot completely adjust for the Will Rodgers phenomenon or surgeon-specific factors. Thus, the results of randomized trials are eagerly awaited in this arena.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28589397</PMID><DateCreated><Year>2017</Year><Month>06</Month><Day>07</Day></DateCreated><DateRevised><Year>2017</Year><Month>06</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1534-6285</ISSN><JournalIssue CitedMedium="Internet"><Volume>18</Volume><Issue>7</Issue><PubDate><Year>2017</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Current urology reports</Title><ISOAbbreviation>Curr Urol Rep</ISOAbbreviation></Journal><ArticleTitle>Therapeutic Value of Standard Versus Extended Pelvic Lymph Node Dissection During Radical Prostatectomy for High-Risk Prostate Cancer.</ArticleTitle><Pagination><MedlinePgn>51</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11934-017-0696-5</ELocationID><Abstract><AbstractText>Extent of pelvic lymph node dissection (PLND) during radical prostatectomy (RP) remains a subject of debate. Here, we review the literature covering the value of extended PLND (ePLND) during RP for high-risk prostate cancer (PCa) over a standard PLND, with a focus on potential therapeutic advantage. PLND may provide valuable prognostic information to high-risk PCa patients, and incorporating the common iliac and presacral nodes to ePLND templates further improves pathologic nodal staging accuracy. Although increased PLND extent is associated with increased lymphocele/lymphedema rates, it is not associated with increased venous thromboembolism rates. The therapeutic role of ePLND remains uncertain. While recent retrospective studies suggest an increased number of nodes removed within the ePLND template are associated with improved survival outcomes, such retrospective studies cannot completely adjust for the Will Rodgers phenomenon or surgeon-specific factors. Thus, the results of randomized trials are eagerly awaited in this arena.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Colicchia</LastName><ForeName>Michele</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Urology, Mayo Clinic Rochester, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>Vidit</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Urology, Mayo Clinic Rochester, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abdollah</LastName><ForeName>Firas</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Center for Outcomes Research Analytics and Evaluation, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Briganti</LastName><ForeName>Alberto</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Oncology/Unit of Urology, Urological Research Institute, San Raffaele Scientific Institute, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeffrey Karnes</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Urology, Mayo Clinic Rochester, Rochester, MN, USA. karnes.r@mayo.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Curr Urol Rep</MedlineTA><NlmUniqueID>100900943</NlmUniqueID><ISSNLinking>1527-2737</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Extended lymphadenectomy</Keyword><Keyword MajorTopicYN="N">Pelvic lymphadenectomy</Keyword><Keyword MajorTopicYN="N">Prostate cancer</Keyword><Keyword MajorTopicYN="N">Radical prostatectomy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28589397</ArticleId><ArticleId IdType="doi">10.1007/s11934-017-0696-5</ArticleId><ArticleId IdType="pii">10.1007/s11934-017-0696-5</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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