Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study.
Identifieur interne : 000126 ( PubMed/Corpus ); précédent : 000125; suivant : 000127Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study.
Auteurs : Navid Mohamadpour Toyserkani ; Charlotte Harken Jensen ; Ditte Caroline Andersen ; S Ren Paludan Sheikh ; Jens Ahm S RensenSource :
- Stem cells translational medicine [ 2157-6564 ] ; 2017.
Abstract
Breast cancer-related lymphedema (BCRL) is a debilitating late complication with a lack of treatment opportunities. Recent studies have suggested that mesenchymal stromal cells can alleviate lymphedema. Herein, we report the results from the first human pilot study with freshly isolated adipose-derived regenerative cells (ADRC) for treating lymphedema with 6 months follow-up. Ten BCRL patients were included. ADRC was injected directly into the axillary region, which was combined with a scar-releasing fat graft procedure. Primary endpoints were change in arm volume. Secondary endpoints were change in patient reported outcome and safety. The study is registered with ClinicalTrials.gov (NCT02592213). During follow-up, a small volume reduction was noted but was not significant. Five patients reduced their use of conservative management. Patient-reported outcomes improved significantly over time. ADRCs were well tolerated and only minor transient adverse events related to liposuction were noted. In this pilot study, a single injection of ADRC improved lymphedema based on patient-reported outcome measures, and there were no serious adverse events in the 6 months follow-up period. In addition, half of the patients reduced their use of conservative management. ADRC therapy is a promising interventional therapy for alleviating lymphedema, but results need to be confirmed in randomized clinical trials. Stem Cells Translational Medicine 2017;6:1666-1672.
DOI: 10.1002/sctm.17-0037
PubMed: 28653440
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study.</title><author><name sortKey="Toyserkani, Navid Mohamadpour" sort="Toyserkani, Navid Mohamadpour" uniqKey="Toyserkani N" first="Navid Mohamadpour" last="Toyserkani">Navid Mohamadpour Toyserkani</name><affiliation><nlm:affiliation>Departments of Plastic Surgery, Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Jensen, Charlotte Harken" sort="Jensen, Charlotte Harken" uniqKey="Jensen C" first="Charlotte Harken" last="Jensen">Charlotte Harken Jensen</name><affiliation><nlm:affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Andersen, Ditte Caroline" sort="Andersen, Ditte Caroline" uniqKey="Andersen D" first="Ditte Caroline" last="Andersen">Ditte Caroline Andersen</name><affiliation><nlm:affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Sheikh, S Ren Paludan" sort="Sheikh, S Ren Paludan" uniqKey="Sheikh S" first="S Ren Paludan" last="Sheikh">S Ren Paludan Sheikh</name><affiliation><nlm:affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="S Rensen, Jens Ahm" sort="S Rensen, Jens Ahm" uniqKey="S Rensen J" first="Jens Ahm" last="S Rensen">Jens Ahm S Rensen</name><affiliation><nlm:affiliation>Departments of Plastic Surgery, Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28653440</idno><idno type="pmid">28653440</idno><idno type="doi">10.1002/sctm.17-0037</idno><idno type="wicri:Area/PubMed/Corpus">000126</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000126</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study.</title><author><name sortKey="Toyserkani, Navid Mohamadpour" sort="Toyserkani, Navid Mohamadpour" uniqKey="Toyserkani N" first="Navid Mohamadpour" last="Toyserkani">Navid Mohamadpour Toyserkani</name><affiliation><nlm:affiliation>Departments of Plastic Surgery, Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Jensen, Charlotte Harken" sort="Jensen, Charlotte Harken" uniqKey="Jensen C" first="Charlotte Harken" last="Jensen">Charlotte Harken Jensen</name><affiliation><nlm:affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Andersen, Ditte Caroline" sort="Andersen, Ditte Caroline" uniqKey="Andersen D" first="Ditte Caroline" last="Andersen">Ditte Caroline Andersen</name><affiliation><nlm:affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Sheikh, S Ren Paludan" sort="Sheikh, S Ren Paludan" uniqKey="Sheikh S" first="S Ren Paludan" last="Sheikh">S Ren Paludan Sheikh</name><affiliation><nlm:affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="S Rensen, Jens Ahm" sort="S Rensen, Jens Ahm" uniqKey="S Rensen J" first="Jens Ahm" last="S Rensen">Jens Ahm S Rensen</name><affiliation><nlm:affiliation>Departments of Plastic Surgery, Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Stem cells translational medicine</title><idno type="ISSN">2157-6564</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Breast cancer-related lymphedema (BCRL) is a debilitating late complication with a lack of treatment opportunities. Recent studies have suggested that mesenchymal stromal cells can alleviate lymphedema. Herein, we report the results from the first human pilot study with freshly isolated adipose-derived regenerative cells (ADRC) for treating lymphedema with 6 months follow-up. Ten BCRL patients were included. ADRC was injected directly into the axillary region, which was combined with a scar-releasing fat graft procedure. Primary endpoints were change in arm volume. Secondary endpoints were change in patient reported outcome and safety. The study is registered with ClinicalTrials.gov (NCT02592213). During follow-up, a small volume reduction was noted but was not significant. Five patients reduced their use of conservative management. Patient-reported outcomes improved significantly over time. ADRCs were well tolerated and only minor transient adverse events related to liposuction were noted. In this pilot study, a single injection of ADRC improved lymphedema based on patient-reported outcome measures, and there were no serious adverse events in the 6 months follow-up period. In addition, half of the patients reduced their use of conservative management. ADRC therapy is a promising interventional therapy for alleviating lymphedema, but results need to be confirmed in randomized clinical trials. Stem Cells Translational Medicine 2017;6:1666-1672.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28653440</PMID><DateCreated><Year>2017</Year><Month>06</Month><Day>27</Day></DateCreated><DateRevised><Year>2017</Year><Month>07</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2157-6564</ISSN><JournalIssue CitedMedium="Print"><Volume>6</Volume><Issue>8</Issue><PubDate><Year>2017</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Stem cells translational medicine</Title><ISOAbbreviation>Stem Cells Transl Med</ISOAbbreviation></Journal><ArticleTitle>Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study.</ArticleTitle><Pagination><MedlinePgn>1666-1672</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/sctm.17-0037</ELocationID><Abstract><AbstractText>Breast cancer-related lymphedema (BCRL) is a debilitating late complication with a lack of treatment opportunities. Recent studies have suggested that mesenchymal stromal cells can alleviate lymphedema. Herein, we report the results from the first human pilot study with freshly isolated adipose-derived regenerative cells (ADRC) for treating lymphedema with 6 months follow-up. Ten BCRL patients were included. ADRC was injected directly into the axillary region, which was combined with a scar-releasing fat graft procedure. Primary endpoints were change in arm volume. Secondary endpoints were change in patient reported outcome and safety. The study is registered with ClinicalTrials.gov (NCT02592213). During follow-up, a small volume reduction was noted but was not significant. Five patients reduced their use of conservative management. Patient-reported outcomes improved significantly over time. ADRCs were well tolerated and only minor transient adverse events related to liposuction were noted. In this pilot study, a single injection of ADRC improved lymphedema based on patient-reported outcome measures, and there were no serious adverse events in the 6 months follow-up period. In addition, half of the patients reduced their use of conservative management. ADRC therapy is a promising interventional therapy for alleviating lymphedema, but results need to be confirmed in randomized clinical trials. Stem Cells Translational Medicine 2017;6:1666-1672.</AbstractText><CopyrightInformation>© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Toyserkani</LastName><ForeName>Navid Mohamadpour</ForeName><Initials>NM</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-5619-4711</Identifier><AffiliationInfo><Affiliation>Departments of Plastic Surgery, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Institute, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jensen</LastName><ForeName>Charlotte Harken</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Molecular and Cellular Cardiology, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Biochemistry and Pharmacology, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andersen</LastName><ForeName>Ditte Caroline</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Molecular and Cellular Cardiology, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Institute, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Biochemistry and Pharmacology, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sheikh</LastName><ForeName>Søren Paludan</ForeName><Initials>SP</Initials><AffiliationInfo><Affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Molecular and Cellular Cardiology, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Biochemistry and Pharmacology, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sørensen</LastName><ForeName>Jens Ahm</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Departments of Plastic Surgery, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Danish Centre for Regenerative Medicine, Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Institute, University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>06</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Stem Cells Transl Med</MedlineTA><NlmUniqueID>101578022</NlmUniqueID><ISSNLinking>2157-6564</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Adipose-derived regenerative cells</Keyword><Keyword MajorTopicYN="N">Fat graft</Keyword><Keyword MajorTopicYN="N">Lymphedema</Keyword><Keyword MajorTopicYN="N">Regenerative medicine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>02</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>05</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28653440</ArticleId><ArticleId IdType="doi">10.1002/sctm.17-0037</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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