Pemetrexed-Associated Eyelid Edema: Effective Treatment by Excision of Lymphedematous Eyelid Tissue.
Identifieur interne : 007930 ( PubMed/Checkpoint ); précédent : 007929; suivant : 007931Pemetrexed-Associated Eyelid Edema: Effective Treatment by Excision of Lymphedematous Eyelid Tissue.
Auteurs : Neeraj Mangla [États-Unis] ; Andrew Carlson ; Aida Wakil ; Nini Wu ; Edward J. WladisSource :
- Ophthalmic plastic and reconstructive surgery [ 1537-2677 ]
Descripteurs français
- KwdFr :
- Adénocarcinome (traitement médicamenteux), Antienzymes (effets indésirables), Femelle, Humains, Lymphoedème (), Lymphoedème (anatomopathologie), Maladies de la paupière (), Maladies de la paupière (anatomopathologie), Procédures de chirurgie ophtalmologique, Pémétrexed (effets indésirables), Sujet âgé, Tumeurs du poumon (traitement médicamenteux).
- MESH :
- anatomopathologie : Lymphoedème, Maladies de la paupière.
- effets indésirables : Antienzymes, Pémétrexed.
- traitement médicamenteux : Adénocarcinome, Tumeurs du poumon.
- Femelle, Humains, Lymphoedème, Maladies de la paupière, Procédures de chirurgie ophtalmologique, Sujet âgé.
English descriptors
- KwdEn :
- Adenocarcinoma (drug therapy), Aged, Enzyme Inhibitors (adverse effects), Eyelid Diseases (chemically induced), Eyelid Diseases (pathology), Eyelid Diseases (surgery), Female, Humans, Lung Neoplasms (drug therapy), Lymphedema (chemically induced), Lymphedema (pathology), Lymphedema (surgery), Ophthalmologic Surgical Procedures, Pemetrexed (adverse effects).
- MESH :
- chemical , adverse effects : Enzyme Inhibitors, Pemetrexed.
- chemically induced : Eyelid Diseases, Lymphedema.
- drug therapy : Adenocarcinoma, Lung Neoplasms.
- pathology : Eyelid Diseases, Lymphedema.
- surgery : Eyelid Diseases, Lymphedema.
- Aged, Female, Humans, Ophthalmologic Surgical Procedures.
Abstract
Pemetrexed is an antimetabolite agent that inhibits multiple folate-requiring enzymes and is used in the treatment of mesothelioma and non-small-cell lung cancer. One of its toxicities is isolated cutaneous swelling affecting the eyelids and/or orbit. The pathologic assessment or its management has not been addressed to date. Herein, the authors report a case of a 77-year-old woman treated with pemetrexed for non-small-cell lung adenocarcinoma who developed persistent, severe bilateral lower eyelid swelling for several months, despite compresses and oral diphenhydramine. Elective excision was performed with good results and no recurrence after 6 months' follow up. Histopathologically, the excised tissue showed changes typical of dermatochalasis with dissolution of collagen and elastic bundles and marked dilation of lymphatic vessels. The combination of pre-existing, localized lymphatic failure and capillary leakage secondary to pemetrexed therapy can explain the onset and worsening swelling with successive rounds of chemotherapy.
DOI: 10.1097/IOP.0000000000000186
PubMed: 24911536
Affiliations:
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One of its toxicities is isolated cutaneous swelling affecting the eyelids and/or orbit. The pathologic assessment or its management has not been addressed to date. Herein, the authors report a case of a 77-year-old woman treated with pemetrexed for non-small-cell lung adenocarcinoma who developed persistent, severe bilateral lower eyelid swelling for several months, despite compresses and oral diphenhydramine. Elective excision was performed with good results and no recurrence after 6 months' follow up. Histopathologically, the excised tissue showed changes typical of dermatochalasis with dissolution of collagen and elastic bundles and marked dilation of lymphatic vessels. The combination of pre-existing, localized lymphatic failure and capillary leakage secondary to pemetrexed therapy can explain the onset and worsening swelling with successive rounds of chemotherapy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24911536</PMID><DateCreated><Year>2015</Year><Month>11</Month><Day>11</Day></DateCreated><DateCompleted><Year>2016</Year><Month>06</Month><Day>10</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-2677</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>6</Issue><PubDate><MedlineDate>2015 Nov-Dec</MedlineDate></PubDate></JournalIssue><Title>Ophthalmic plastic and reconstructive surgery</Title><ISOAbbreviation>Ophthal Plast Reconstr Surg</ISOAbbreviation></Journal><ArticleTitle>Pemetrexed-Associated Eyelid Edema: Effective Treatment by Excision of Lymphedematous Eyelid Tissue.</ArticleTitle><Pagination><MedlinePgn>e155-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/IOP.0000000000000186</ELocationID><Abstract><AbstractText>Pemetrexed is an antimetabolite agent that inhibits multiple folate-requiring enzymes and is used in the treatment of mesothelioma and non-small-cell lung cancer. One of its toxicities is isolated cutaneous swelling affecting the eyelids and/or orbit. The pathologic assessment or its management has not been addressed to date. Herein, the authors report a case of a 77-year-old woman treated with pemetrexed for non-small-cell lung adenocarcinoma who developed persistent, severe bilateral lower eyelid swelling for several months, despite compresses and oral diphenhydramine. Elective excision was performed with good results and no recurrence after 6 months' follow up. Histopathologically, the excised tissue showed changes typical of dermatochalasis with dissolution of collagen and elastic bundles and marked dilation of lymphatic vessels. The combination of pre-existing, localized lymphatic failure and capillary leakage secondary to pemetrexed therapy can explain the onset and worsening swelling with successive rounds of chemotherapy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mangla</LastName><ForeName>Neeraj</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>*Department of Ophthalmology and †Department of Pathology, Albany Medical College; ‡New York Oncology-Hematology; and §Ophthalmic Plastic Surgery, Department of Ophthalmology, Albany, New York, U.S.A.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carlson</LastName><ForeName>Andrew</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Wakil</LastName><ForeName>Aida</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Nini</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Wladis</LastName><ForeName>Edward J</ForeName><Initials>EJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ophthal Plast Reconstr Surg</MedlineTA><NlmUniqueID>8508431</NlmUniqueID><ISSNLinking>0740-9303</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004791">Enzyme Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>04Q9AIZ7NO</RegistryNumber><NameOfSubstance UI="D000068437">Pemetrexed</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000230" MajorTopicYN="N">Adenocarcinoma</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004791" MajorTopicYN="N">Enzyme Inhibitors</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005141" MajorTopicYN="N">Eyelid Diseases</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008175" MajorTopicYN="N">Lung Neoplasms</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013508" MajorTopicYN="Y">Ophthalmologic Surgical Procedures</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000068437" MajorTopicYN="N">Pemetrexed</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24911536</ArticleId><ArticleId IdType="doi">10.1097/IOP.0000000000000186</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><noCountry><name sortKey="Carlson, Andrew" sort="Carlson, Andrew" uniqKey="Carlson A" first="Andrew" last="Carlson">Andrew Carlson</name><name sortKey="Wakil, Aida" sort="Wakil, Aida" uniqKey="Wakil A" first="Aida" last="Wakil">Aida Wakil</name><name sortKey="Wladis, Edward J" sort="Wladis, Edward J" uniqKey="Wladis E" first="Edward J" last="Wladis">Edward J. Wladis</name><name sortKey="Wu, Nini" sort="Wu, Nini" uniqKey="Wu N" first="Nini" last="Wu">Nini Wu</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Mangla, Neeraj" sort="Mangla, Neeraj" uniqKey="Mangla N" first="Neeraj" last="Mangla">Neeraj Mangla</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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