Silica and silicates in femoral lymph nodes of barefooted people in Ethiopia with special reference to elephantiasis of the lower legs.
Identifieur interne : 006530 ( PubMed/Checkpoint ); précédent : 006529; suivant : 006531Silica and silicates in femoral lymph nodes of barefooted people in Ethiopia with special reference to elephantiasis of the lower legs.
Auteurs : E W Price ; W J HendersonSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1979.
Descripteurs français
- KwdFr :
- Acide silicique (analyse), Aluminium (analyse), Cuisse, Humains, Jambe, Lymphoedème (métabolisme), Lysosomes (analyse), Lysosomes (ultrastructure), Macrophages (analyse), Macrophages (ultrastructure), Microscopie électronique, Noeuds lymphatiques (analyse), Noeuds lymphatiques (ultrastructure), Silice (analyse), Éléphantiasis (anatomopathologie), Éléphantiasis (métabolisme), Éléphantiasis (étiologie), Éthiopie.
- MESH :
- analyse : Acide silicique, Aluminium, Lysosomes, Macrophages, Noeuds lymphatiques, Silice.
- anatomopathologie : Éléphantiasis.
- métabolisme : Lymphoedème, Éléphantiasis.
- étiologie : Lysosomes, Macrophages, Noeuds lymphatiques, Éléphantiasis.
- Cuisse, Humains, Jambe, Microscopie électronique, Éthiopie.
- Wicri :
- geographic : Éthiopie.
English descriptors
- KwdEn :
- Aluminum (analysis), Elephantiasis (etiology), Elephantiasis (metabolism), Elephantiasis (pathology), Ethiopia, Humans, Leg, Lymph Nodes (analysis), Lymph Nodes (ultrastructure), Lymphedema (metabolism), Lysosomes (analysis), Lysosomes (ultrastructure), Macrophages (analysis), Macrophages (ultrastructure), Microscopy, Electron, Silicic Acid (analysis), Silicon Dioxide (analysis), Thigh.
- MESH :
- chemical , analysis : Aluminum, Silicic Acid, Silicon Dioxide.
- geographic : Ethiopia.
- analysis : Lymph Nodes, Lysosomes, Macrophages.
- etiology : Elephantiasis.
- metabolism : Elephantiasis, Lymphedema.
- pathology : Elephantiasis.
- ultrastructure : Lymph Nodes, Lysosomes, Macrophages.
- Humans, Leg, Microscopy, Electron, Thigh.
Abstract
Electron microscopy of femoral lymph nodes of barefooted Ethiopians show the presence of numerous particles of colloid-size and electron-density in the lysosomes of the macrophages in the gland. On diffraction analysis, the particles are found to be amorphous. Elemental microanalysis of the X-ray spectrum indicate the predominance of Si, Al and Fe. In elephantiasics some particles contain silicon alone, presumably silica. The distribution of the Al/Si ratios of the particles in subjects with elephantiasis of the lower legs show a difference from that of non-elephantiasics which is statistically "highly significant" at p less than 0.001. The importance of this as a possible aetiological factor in the disease is discussed. The hypothesis that the disease is discussed. The hypothesis that the disease is a silicosis of the peripheral lymphatics of the lower limbs is supported by the present study.
PubMed: 231857
Affiliations:
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xml:lang="fr"><term>Éthiopie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Electron microscopy of femoral lymph nodes of barefooted Ethiopians show the presence of numerous particles of colloid-size and electron-density in the lysosomes of the macrophages in the gland. On diffraction analysis, the particles are found to be amorphous. Elemental microanalysis of the X-ray spectrum indicate the predominance of Si, Al and Fe. In elephantiasics some particles contain silicon alone, presumably silica. The distribution of the Al/Si ratios of the particles in subjects with elephantiasis of the lower legs show a difference from that of non-elephantiasics which is statistically "highly significant" at p less than 0.001. The importance of this as a possible aetiological factor in the disease is discussed. The hypothesis that the disease is discussed. The hypothesis that the disease is a silicosis of the peripheral lymphatics of the lower limbs is supported by the present study.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">231857</PMID><DateCreated><Year>1980</Year><Month>05</Month><Day>14</Day></DateCreated><DateCompleted><Year>1980</Year><Month>05</Month><Day>14</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0035-9203</ISSN><JournalIssue CitedMedium="Print"><Volume>73</Volume><Issue>6</Issue><PubDate><Year>1979</Year></PubDate></JournalIssue><Title>Transactions of the Royal Society of Tropical Medicine and Hygiene</Title><ISOAbbreviation>Trans. R. Soc. Trop. Med. Hyg.</ISOAbbreviation></Journal><ArticleTitle>Silica and silicates in femoral lymph nodes of barefooted people in Ethiopia with special reference to elephantiasis of the lower legs.</ArticleTitle><Pagination><MedlinePgn>640-7</MedlinePgn></Pagination><Abstract><AbstractText>Electron microscopy of femoral lymph nodes of barefooted Ethiopians show the presence of numerous particles of colloid-size and electron-density in the lysosomes of the macrophages in the gland. On diffraction analysis, the particles are found to be amorphous. Elemental microanalysis of the X-ray spectrum indicate the predominance of Si, Al and Fe. In elephantiasics some particles contain silicon alone, presumably silica. The distribution of the Al/Si ratios of the particles in subjects with elephantiasis of the lower legs show a difference from that of non-elephantiasics which is statistically "highly significant" at p less than 0.001. The importance of this as a possible aetiological factor in the disease is discussed. The hypothesis that the disease is discussed. 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