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Preoperative irradiation, lymphadenectomy and 125iodine implant for patients with localized prostatic carcinoma: a correlation of implant dosimetry with clinical results.

Identifieur interne : 006435 ( PubMed/Checkpoint ); précédent : 006434; suivant : 006436

Preoperative irradiation, lymphadenectomy and 125iodine implant for patients with localized prostatic carcinoma: a correlation of implant dosimetry with clinical results.

Auteurs : W U Shipley ; G. Kopelson ; D H Novack ; C C Ling ; S P Dretler ; G R Prout

Source :

RBID : pubmed:7452792

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English descriptors

Abstract

The 30 patients with clinically and surgically localized prostatic carcinoma who were selected for treatment by a short course of preoperative irradiation (1,050 rad), pelvic lymphadenectomy and 125iodine implant have been followed for 1 to 4 years. Perioperative morbidity (10 per cent), postimplant impotence (11 per cent), lymphedema (17 per cent), tumor recurrence (4 per cent) and distant metastasis (4 per cent) have been minimal to date. However, urinary irritative symptoms, which usually subsided in 6 to 9 months, occurred in half of the patients and correlated with implant volume. Total dose and total dose per unit of implanted activity were calculated. Of the various implant parameters evaluated implant dose homogeneity has corrrelated with the rate of tumor regression.

PubMed: 7452792


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pubmed:7452792

Le document en format XML

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<title xml:lang="en">Preoperative irradiation, lymphadenectomy and 125iodine implant for patients with localized prostatic carcinoma: a correlation of implant dosimetry with clinical results.</title>
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<name sortKey="Kopelson, G" sort="Kopelson, G" uniqKey="Kopelson G" first="G" last="Kopelson">G. Kopelson</name>
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<name sortKey="Novack, D H" sort="Novack, D H" uniqKey="Novack D" first="D H" last="Novack">D H Novack</name>
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<name sortKey="Ling, C C" sort="Ling, C C" uniqKey="Ling C" first="C C" last="Ling">C C Ling</name>
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<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Iodine Radioisotopes (adverse effects)</term>
<term>Iodine Radioisotopes (therapeutic use)</term>
<term>Lymph Node Excision</term>
<term>Male</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplasm Seeding</term>
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<term>Preoperative Care</term>
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<term>Curiethérapie (effets indésirables)</term>
<term>Dosimétrie en radiothérapie</term>
<term>Dysfonctionnement érectile (étiologie)</term>
<term>Essaimage tumoral</term>
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<term>Lymphadénectomie</term>
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<term>Radio-isotopes de l'iode (effets indésirables)</term>
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<term>Récidive tumorale locale</term>
<term>Soins préopératoires</term>
<term>Troubles mictionnels (étiologie)</term>
<term>Tumeurs de la prostate ()</term>
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<term>Lymph Node Excision</term>
<term>Male</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplasm Seeding</term>
<term>Pelvis</term>
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<div type="abstract" xml:lang="en">The 30 patients with clinically and surgically localized prostatic carcinoma who were selected for treatment by a short course of preoperative irradiation (1,050 rad), pelvic lymphadenectomy and 125iodine implant have been followed for 1 to 4 years. Perioperative morbidity (10 per cent), postimplant impotence (11 per cent), lymphedema (17 per cent), tumor recurrence (4 per cent) and distant metastasis (4 per cent) have been minimal to date. However, urinary irritative symptoms, which usually subsided in 6 to 9 months, occurred in half of the patients and correlated with implant volume. Total dose and total dose per unit of implanted activity were calculated. Of the various implant parameters evaluated implant dose homogeneity has corrrelated with the rate of tumor regression.</div>
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<AbstractText>The 30 patients with clinically and surgically localized prostatic carcinoma who were selected for treatment by a short course of preoperative irradiation (1,050 rad), pelvic lymphadenectomy and 125iodine implant have been followed for 1 to 4 years. Perioperative morbidity (10 per cent), postimplant impotence (11 per cent), lymphedema (17 per cent), tumor recurrence (4 per cent) and distant metastasis (4 per cent) have been minimal to date. However, urinary irritative symptoms, which usually subsided in 6 to 9 months, occurred in half of the patients and correlated with implant volume. Total dose and total dose per unit of implanted activity were calculated. Of the various implant parameters evaluated implant dose homogeneity has corrrelated with the rate of tumor regression.</AbstractText>
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