Combined low dosage and short term standard dose treatment with diethylcarbamazine to control Timorian filariasis.
Identifieur interne : 005F32 ( PubMed/Checkpoint ); précédent : 005F31; suivant : 005F33Combined low dosage and short term standard dose treatment with diethylcarbamazine to control Timorian filariasis.
Auteurs : F. Partono ; PurnomoSource :
- Acta tropica [ 0001-706X ] ; 1985.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Brugia (), Calendrier d'administration des médicaments, Diéthylcarbamazine (administration et posologie), Diéthylcarbamazine (effets indésirables), Diéthylcarbamazine (usage thérapeutique), Enfant, Enfant d'âge préscolaire, Filariose lymphatique (), Filariose lymphatique (épidémiologie), Humains, Indonésie, Sujet âgé.
- MESH :
- administration et posologie : Diéthylcarbamazine.
- effets indésirables : Diéthylcarbamazine.
- usage thérapeutique : Diéthylcarbamazine.
- épidémiologie : Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Brugia, Calendrier d'administration des médicaments, Enfant, Enfant d'âge préscolaire, Filariose lymphatique, Humains, Indonésie, Sujet âgé.
- Wicri :
- geographic : Indonésie.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Brugia (drug effects), Child, Child, Preschool, Diethylcarbamazine (administration & dosage), Diethylcarbamazine (adverse effects), Diethylcarbamazine (therapeutic use), Drug Administration Schedule, Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (prevention & control), Humans, Indonesia, Middle Aged.
- MESH :
- chemical , administration & dosage : Diethylcarbamazine.
- chemical , adverse effects : Diethylcarbamazine.
- geographic : Indonesia.
- drug effects : Brugia.
- epidemiology : Elephantiasis, Filarial.
- prevention & control : Elephantiasis, Filarial.
- chemical , therapeutic use : Diethylcarbamazine.
- Adolescent, Adult, Aged, Child, Child, Preschool, Drug Administration Schedule, Humans, Middle Aged.
Abstract
A combined weekly low dosage and short term standard dose treatment with diethylcarbamazine (DEC) to control Timorian filariasis is described. Weekly low dosage DEC was distributed by the village chief to all villagers for 6 months. The dosage of DEC was 50 mg weekly for group A, and 100 mg for group B. Children below 10 years of age received half the adult dose. Following the initial phase of low dosage treatment, 5 mg DEC/kg was distributed by one of us to all villagers for 6 consecutive days. The results of treatment were evaluated approximately one year later. There was no difference between the results of treatment with 50 mg DEC weekly compared to the 100 mg dosage. The microfilaria, adenolymphangitis and lymphoedema rates decreased drastically in both groups, similar to the results of our previous studies. Side reactions during low dosage and standard dose treatment of DEC were characteristically mild.
PubMed: 2868638
Affiliations:
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Weekly low dosage DEC was distributed by the village chief to all villagers for 6 months. The dosage of DEC was 50 mg weekly for group A, and 100 mg for group B. Children below 10 years of age received half the adult dose. Following the initial phase of low dosage treatment, 5 mg DEC/kg was distributed by one of us to all villagers for 6 consecutive days. The results of treatment were evaluated approximately one year later. There was no difference between the results of treatment with 50 mg DEC weekly compared to the 100 mg dosage. The microfilaria, adenolymphangitis and lymphoedema rates decreased drastically in both groups, similar to the results of our previous studies. Side reactions during low dosage and standard dose treatment of DEC were characteristically mild.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2868638</PMID><DateCreated><Year>1986</Year><Month>03</Month><Day>03</Day></DateCreated><DateCompleted><Year>1986</Year><Month>03</Month><Day>03</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0001-706X</ISSN><JournalIssue CitedMedium="Print"><Volume>42</Volume><Issue>4</Issue><PubDate><Year>1985</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Acta tropica</Title><ISOAbbreviation>Acta Trop.</ISOAbbreviation></Journal><ArticleTitle>Combined low dosage and short term standard dose treatment with diethylcarbamazine to control Timorian filariasis.</ArticleTitle><Pagination><MedlinePgn>365-70</MedlinePgn></Pagination><Abstract><AbstractText>A combined weekly low dosage and short term standard dose treatment with diethylcarbamazine (DEC) to control Timorian filariasis is described. Weekly low dosage DEC was distributed by the village chief to all villagers for 6 months. The dosage of DEC was 50 mg weekly for group A, and 100 mg for group B. Children below 10 years of age received half the adult dose. Following the initial phase of low dosage treatment, 5 mg DEC/kg was distributed by one of us to all villagers for 6 consecutive days. The results of treatment were evaluated approximately one year later. There was no difference between the results of treatment with 50 mg DEC weekly compared to the 100 mg dosage. The microfilaria, adenolymphangitis and lymphoedema rates decreased drastically in both groups, similar to the results of our previous studies. Side reactions during low dosage and standard dose treatment of DEC were characteristically mild.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Partono</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Purnomo</LastName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Acta Trop</MedlineTA><NlmUniqueID>0370374</NlmUniqueID><ISSNLinking>0001-706X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>V867Q8X3ZD</RegistryNumber><NameOfSubstance UI="D004049">Diethylcarbamazine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002009" MajorTopicYN="N">Brugia</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004049" MajorTopicYN="N">Diethylcarbamazine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004334" MajorTopicYN="N">Drug Administration Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007214" MajorTopicYN="N" Type="Geographic">Indonesia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1985</Year><Month>12</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1985</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1985</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2868638</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Partono, F" sort="Partono, F" uniqKey="Partono F" first="F" last="Partono">F. 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