Perturbation of lymphatic endothelial cells in experimental Brugia malayi infections.
Identifieur interne : 005E76 ( PubMed/Checkpoint ); précédent : 005E75; suivant : 005E77Perturbation of lymphatic endothelial cells in experimental Brugia malayi infections.
Auteurs : M. Sakamoto ; J L Meier ; D S Folse ; A. EwertSource :
- Microcirculation, endothelium, and lymphatics [ 0740-9451 ] ; 1985.
Descripteurs français
- KwdFr :
- Animaux, Brugia, Chats, Cytoplasme (ultrastructure), Endothélium (anatomopathologie), Filariose lymphatique (anatomopathologie), Filariose lymphatique (physiopathologie), Lymphoedème (anatomopathologie), Microscopie électronique, Système lymphatique (anatomopathologie), Système lymphatique (physiopathologie), Vacuoles (ultrastructure).
- MESH :
- anatomopathologie : Endothélium, Filariose lymphatique, Lymphoedème, Système lymphatique.
- physiopathologie : Filariose lymphatique, Système lymphatique.
- ultrastructure : Animaux, Brugia, Chats, Cytoplasme, Microscopie électronique, Vacuoles.
English descriptors
- KwdEn :
- MESH :
- pathology : Elephantiasis, Filarial, Endothelium, Lymphatic System, Lymphedema.
- physiopathology : Elephantiasis, Filarial, Lymphatic System.
- ultrastructure : Cytoplasm, Vacuoles.
- Animals, Brugia, Cats, Microscopy, Electron.
Abstract
Infection with filarial nematodes induces lymphatic dysfunction in many individuals in endemic areas. The present morphometric study describes changes in lymphatic endothelial cells of Brugia-infected cats. Transmission electron microscopy revealed a decrease in the number of cytoplasmic vesicles in endothelial cells from lymphatic vessels harboring filarial nematodes (4.9 vesicles per micron 2 cytoplasm) when compared with similar cells from the contralateral uninfected control vessels (9.0 vesicles per micron 2). The size of the vesicles and their location within the cytoplasm was not changed. Irregular large vacuoles, often containing degenerating organelles, were common in endothelial cells lining Brugia-infected lymphatic vessels. These studies suggest that damage of cells by living or dead worms or worm products may have a direct effect on the endothelial lining of lymphatic vessels. This may compromise the efficiency of vessels that collect and transport edematous fluid in affected limbs.
PubMed: 3836352
Affiliations:
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Ewert</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1985">1985</date><idno type="RBID">pubmed:3836352</idno><idno type="pmid">3836352</idno><idno type="wicri:Area/PubMed/Corpus">006880</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">006880</idno><idno type="wicri:Area/PubMed/Curation">006880</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">006880</idno><idno type="wicri:Area/PubMed/Checkpoint">006880</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">006880</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Perturbation of lymphatic endothelial cells in experimental Brugia malayi infections.</title><author><name sortKey="Sakamoto, M" sort="Sakamoto, M" uniqKey="Sakamoto M" first="M" last="Sakamoto">M. Sakamoto</name></author><author><name sortKey="Meier, J L" sort="Meier, J L" uniqKey="Meier J" first="J L" last="Meier">J L Meier</name></author><author><name sortKey="Folse, D S" sort="Folse, D S" uniqKey="Folse D" first="D S" last="Folse">D S Folse</name></author><author><name sortKey="Ewert, A" sort="Ewert, A" uniqKey="Ewert A" first="A" last="Ewert">A. Ewert</name></author></analytic><series><title level="j">Microcirculation, endothelium, and lymphatics</title><idno type="ISSN">0740-9451</idno><imprint><date when="1985" type="published">1985</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brugia</term><term>Cats</term><term>Cytoplasm (ultrastructure)</term><term>Elephantiasis, Filarial (pathology)</term><term>Elephantiasis, Filarial (physiopathology)</term><term>Endothelium (pathology)</term><term>Lymphatic System (pathology)</term><term>Lymphatic System (physiopathology)</term><term>Lymphedema (pathology)</term><term>Microscopy, Electron</term><term>Vacuoles (ultrastructure)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Brugia</term><term>Chats</term><term>Cytoplasme (ultrastructure)</term><term>Endothélium (anatomopathologie)</term><term>Filariose lymphatique (anatomopathologie)</term><term>Filariose lymphatique (physiopathologie)</term><term>Lymphoedème (anatomopathologie)</term><term>Microscopie électronique</term><term>Système lymphatique (anatomopathologie)</term><term>Système lymphatique (physiopathologie)</term><term>Vacuoles (ultrastructure)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Endothélium</term><term>Filariose lymphatique</term><term>Lymphoedème</term><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Endothelium</term><term>Lymphatic System</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Cytoplasm</term><term>Vacuoles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brugia</term><term>Cats</term><term>Microscopy, Electron</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Animaux</term><term>Brugia</term><term>Chats</term><term>Cytoplasme</term><term>Microscopie électronique</term><term>Vacuoles</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Infection with filarial nematodes induces lymphatic dysfunction in many individuals in endemic areas. The present morphometric study describes changes in lymphatic endothelial cells of Brugia-infected cats. Transmission electron microscopy revealed a decrease in the number of cytoplasmic vesicles in endothelial cells from lymphatic vessels harboring filarial nematodes (4.9 vesicles per micron 2 cytoplasm) when compared with similar cells from the contralateral uninfected control vessels (9.0 vesicles per micron 2). The size of the vesicles and their location within the cytoplasm was not changed. Irregular large vacuoles, often containing degenerating organelles, were common in endothelial cells lining Brugia-infected lymphatic vessels. These studies suggest that damage of cells by living or dead worms or worm products may have a direct effect on the endothelial lining of lymphatic vessels. This may compromise the efficiency of vessels that collect and transport edematous fluid in affected limbs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3836352</PMID><DateCreated><Year>1986</Year><Month>08</Month><Day>12</Day></DateCreated><DateCompleted><Year>1986</Year><Month>08</Month><Day>12</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0740-9451</ISSN><JournalIssue CitedMedium="Print"><Volume>2</Volume><Issue>5</Issue><PubDate><Year>1985</Year></PubDate></JournalIssue><Title>Microcirculation, endothelium, and lymphatics</Title><ISOAbbreviation>Microcirc Endothelium Lymphatics</ISOAbbreviation></Journal><ArticleTitle>Perturbation of lymphatic endothelial cells in experimental Brugia malayi infections.</ArticleTitle><Pagination><MedlinePgn>487-98</MedlinePgn></Pagination><Abstract><AbstractText>Infection with filarial nematodes induces lymphatic dysfunction in many individuals in endemic areas. The present morphometric study describes changes in lymphatic endothelial cells of Brugia-infected cats. Transmission electron microscopy revealed a decrease in the number of cytoplasmic vesicles in endothelial cells from lymphatic vessels harboring filarial nematodes (4.9 vesicles per micron 2 cytoplasm) when compared with similar cells from the contralateral uninfected control vessels (9.0 vesicles per micron 2). The size of the vesicles and their location within the cytoplasm was not changed. Irregular large vacuoles, often containing degenerating organelles, were common in endothelial cells lining Brugia-infected lymphatic vessels. These studies suggest that damage of cells by living or dead worms or worm products may have a direct effect on the endothelial lining of lymphatic vessels. This may compromise the efficiency of vessels that collect and transport edematous fluid in affected limbs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sakamoto</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Meier</LastName><ForeName>J L</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Folse</LastName><ForeName>D S</ForeName><Initials>DS</Initials></Author><Author ValidYN="Y"><LastName>Ewert</LastName><ForeName>A</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Microcirc Endothelium Lymphatics</MedlineTA><NlmUniqueID>8505251</NlmUniqueID><ISSNLinking>0740-9451</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002009" MajorTopicYN="N">Brugia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002415" MajorTopicYN="N">Cats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003593" MajorTopicYN="N">Cytoplasm</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004727" MajorTopicYN="N">Endothelium</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008854" MajorTopicYN="N">Microscopy, Electron</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014617" MajorTopicYN="N">Vacuoles</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1985</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1985</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1985</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3836352</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Ewert, A" sort="Ewert, A" uniqKey="Ewert A" first="A" last="Ewert">A. Ewert</name><name sortKey="Folse, D S" sort="Folse, D S" uniqKey="Folse D" first="D S" last="Folse">D S Folse</name><name sortKey="Meier, J L" sort="Meier, J L" uniqKey="Meier J" first="J L" last="Meier">J L Meier</name><name sortKey="Sakamoto, M" sort="Sakamoto, M" uniqKey="Sakamoto M" first="M" last="Sakamoto">M. Sakamoto</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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