Detection of circulating parasite antigen in bancroftian filariasis by counterimmunoelectrophoresis.
Identifieur interne : 005D40 ( PubMed/Checkpoint ); précédent : 005D39; suivant : 005D41Detection of circulating parasite antigen in bancroftian filariasis by counterimmunoelectrophoresis.
Auteurs : G J Weil ; H. Kumar ; S. Santhanam ; K V Sethumadhavan ; D C JainSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1986.
Descripteurs français
- KwdFr :
- Anticorps (analyse), Antigènes d'helminthe (analyse), Brugia (immunologie), Contre-immunoélectrophorèse, Dirofilaria immitis (immunologie), Diéthylcarbamazine (usage thérapeutique), Filariose lymphatique (immunologie), Filarioses (diagnostic), Filarioses (immunologie), Filarioses (parasitologie), Filarioses (traitement médicamenteux), Humains, Wuchereria (immunologie), Wuchereria bancrofti (immunologie).
- MESH :
- analyse : Anticorps, Antigènes d'helminthe.
- diagnostic : Filarioses.
- immunologie : Brugia, Dirofilaria immitis, Filariose lymphatique, Filarioses, Wuchereria, Wuchereria bancrofti.
- parasitologie : Filarioses.
- traitement médicamenteux : Filarioses.
- usage thérapeutique : Diéthylcarbamazine.
- Contre-immunoélectrophorèse, Humains.
English descriptors
- KwdEn :
- Antibodies (analysis), Antigens, Helminth (analysis), Brugia (immunology), Counterimmunoelectrophoresis, Diethylcarbamazine (therapeutic use), Dirofilaria immitis (immunology), Elephantiasis, Filarial (immunology), Filariasis (diagnosis), Filariasis (drug therapy), Filariasis (immunology), Filariasis (parasitology), Humans, Wuchereria (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , analysis : Antibodies, Antigens, Helminth.
- diagnosis : Filariasis.
- drug therapy : Filariasis.
- immunology : Brugia, Dirofilaria immitis, Elephantiasis, Filarial, Filariasis, Wuchereria, Wuchereria bancrofti.
- parasitology : Filariasis.
- chemical , therapeutic use : Diethylcarbamazine.
- Counterimmunoelectrophoresis, Humans.
Abstract
We used counterimmunoelectrophoresis (CIEP) with rabbit antibodies to Dirofilaria immitis and Brugia malayi to detect soluble filarial antigen in sera collected in a Wuchereria bancrofti-endemic area in South India. Filarial antigen was detected in 38 of 38 sera from microfilaremic patients, 3 of 48 sera from amicrofilaremic patients with lymphatic pathology, and 3 of 5 sera from former microfilaria carriers with negative blood examinations 6 months or more after diethylcarbamazine therapy. One of 32 endemic control sera, 0 of 35 nonendemic sera, and 0 of 20 B. malayi sera were positive. Antigenemia was equally detectable in sera collected at night or during the day (when microfilariae are absent from the blood). Parasite antigen was also detected in the urine of patients with positive serum tests. Antibodies to circulating filarial antigen (also detected by CIEP) were absent in all but 2 antigen-positive sera but present in 22 of 45 antigen-negative sera from clinical filariasis patients and in 9 of 31 antigen-negative sera from endemic controls. Parasite antigen detection by CIEP appears to be a sensitive, specific, and practical diagnostic test for active W. bancrofti infection.
PubMed: 3518508
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:3518508Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Detection of circulating parasite antigen in bancroftian filariasis by counterimmunoelectrophoresis.</title><author><name sortKey="Weil, G J" sort="Weil, G J" uniqKey="Weil G" first="G J" last="Weil">G J Weil</name></author><author><name sortKey="Kumar, H" sort="Kumar, H" uniqKey="Kumar H" first="H" last="Kumar">H. Kumar</name></author><author><name sortKey="Santhanam, S" sort="Santhanam, S" uniqKey="Santhanam S" first="S" last="Santhanam">S. Santhanam</name></author><author><name sortKey="Sethumadhavan, K V" sort="Sethumadhavan, K V" uniqKey="Sethumadhavan K" first="K V" last="Sethumadhavan">K V Sethumadhavan</name></author><author><name sortKey="Jain, D C" sort="Jain, D C" uniqKey="Jain D" first="D C" last="Jain">D C Jain</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1986">1986</date><idno type="RBID">pubmed:3518508</idno><idno type="pmid">3518508</idno><idno type="wicri:Area/PubMed/Corpus">006605</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">006605</idno><idno type="wicri:Area/PubMed/Curation">006605</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">006605</idno><idno type="wicri:Area/PubMed/Checkpoint">006605</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">006605</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Detection of circulating parasite antigen in bancroftian filariasis by counterimmunoelectrophoresis.</title><author><name sortKey="Weil, G J" sort="Weil, G J" uniqKey="Weil G" first="G J" last="Weil">G J Weil</name></author><author><name sortKey="Kumar, H" sort="Kumar, H" uniqKey="Kumar H" first="H" last="Kumar">H. Kumar</name></author><author><name sortKey="Santhanam, S" sort="Santhanam, S" uniqKey="Santhanam S" first="S" last="Santhanam">S. Santhanam</name></author><author><name sortKey="Sethumadhavan, K V" sort="Sethumadhavan, K V" uniqKey="Sethumadhavan K" first="K V" last="Sethumadhavan">K V Sethumadhavan</name></author><author><name sortKey="Jain, D C" sort="Jain, D C" uniqKey="Jain D" first="D C" last="Jain">D C Jain</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><imprint><date when="1986" type="published">1986</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies (analysis)</term><term>Antigens, Helminth (analysis)</term><term>Brugia (immunology)</term><term>Counterimmunoelectrophoresis</term><term>Diethylcarbamazine (therapeutic use)</term><term>Dirofilaria immitis (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Filariasis (diagnosis)</term><term>Filariasis (drug therapy)</term><term>Filariasis (immunology)</term><term>Filariasis (parasitology)</term><term>Humans</term><term>Wuchereria (immunology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps (analyse)</term><term>Antigènes d'helminthe (analyse)</term><term>Brugia (immunologie)</term><term>Contre-immunoélectrophorèse</term><term>Dirofilaria immitis (immunologie)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Filariose lymphatique (immunologie)</term><term>Filarioses (diagnostic)</term><term>Filarioses (immunologie)</term><term>Filarioses (parasitologie)</term><term>Filarioses (traitement médicamenteux)</term><term>Humains</term><term>Wuchereria (immunologie)</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies</term><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps</term><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Filariasis</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filarioses</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Filariasis</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia</term><term>Dirofilaria immitis</term><term>Filariose lymphatique</term><term>Filarioses</term><term>Wuchereria</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Dirofilaria immitis</term><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Wuchereria</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filarioses</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Filariasis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filarioses</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Counterimmunoelectrophoresis</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Contre-immunoélectrophorèse</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We used counterimmunoelectrophoresis (CIEP) with rabbit antibodies to Dirofilaria immitis and Brugia malayi to detect soluble filarial antigen in sera collected in a Wuchereria bancrofti-endemic area in South India. Filarial antigen was detected in 38 of 38 sera from microfilaremic patients, 3 of 48 sera from amicrofilaremic patients with lymphatic pathology, and 3 of 5 sera from former microfilaria carriers with negative blood examinations 6 months or more after diethylcarbamazine therapy. One of 32 endemic control sera, 0 of 35 nonendemic sera, and 0 of 20 B. malayi sera were positive. Antigenemia was equally detectable in sera collected at night or during the day (when microfilariae are absent from the blood). Parasite antigen was also detected in the urine of patients with positive serum tests. Antibodies to circulating filarial antigen (also detected by CIEP) were absent in all but 2 antigen-positive sera but present in 22 of 45 antigen-negative sera from clinical filariasis patients and in 9 of 31 antigen-negative sera from endemic controls. Parasite antigen detection by CIEP appears to be a sensitive, specific, and practical diagnostic test for active W. bancrofti infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3518508</PMID><DateCreated><Year>1986</Year><Month>06</Month><Day>25</Day></DateCreated><DateCompleted><Year>1986</Year><Month>06</Month><Day>25</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9637</ISSN><JournalIssue CitedMedium="Print"><Volume>35</Volume><Issue>3</Issue><PubDate><Year>1986</Year><Month>May</Month></PubDate></JournalIssue><Title>The American journal of tropical medicine and hygiene</Title><ISOAbbreviation>Am. J. Trop. Med. Hyg.</ISOAbbreviation></Journal><ArticleTitle>Detection of circulating parasite antigen in bancroftian filariasis by counterimmunoelectrophoresis.</ArticleTitle><Pagination><MedlinePgn>565-70</MedlinePgn></Pagination><Abstract><AbstractText>We used counterimmunoelectrophoresis (CIEP) with rabbit antibodies to Dirofilaria immitis and Brugia malayi to detect soluble filarial antigen in sera collected in a Wuchereria bancrofti-endemic area in South India. Filarial antigen was detected in 38 of 38 sera from microfilaremic patients, 3 of 48 sera from amicrofilaremic patients with lymphatic pathology, and 3 of 5 sera from former microfilaria carriers with negative blood examinations 6 months or more after diethylcarbamazine therapy. One of 32 endemic control sera, 0 of 35 nonendemic sera, and 0 of 20 B. malayi sera were positive. Antigenemia was equally detectable in sera collected at night or during the day (when microfilariae are absent from the blood). Parasite antigen was also detected in the urine of patients with positive serum tests. Antibodies to circulating filarial antigen (also detected by CIEP) were absent in all but 2 antigen-positive sera but present in 22 of 45 antigen-negative sera from clinical filariasis patients and in 9 of 31 antigen-negative sera from endemic controls. Parasite antigen detection by CIEP appears to be a sensitive, specific, and practical diagnostic test for active W. bancrofti infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Weil</LastName><ForeName>G J</ForeName><Initials>GJ</Initials></Author><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>H</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Santhanam</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Sethumadhavan</LastName><ForeName>K V</ForeName><Initials>KV</Initials></Author><Author ValidYN="Y"><LastName>Jain</LastName><ForeName>D C</ForeName><Initials>DC</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>AI-15353</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Trop Med Hyg</MedlineTA><NlmUniqueID>0370507</NlmUniqueID><ISSNLinking>0002-9637</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000906">Antibodies</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>V867Q8X3ZD</RegistryNumber><NameOfSubstance UI="D004049">Diethylcarbamazine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000906" MajorTopicYN="N">Antibodies</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002009" MajorTopicYN="N">Brugia</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003378" MajorTopicYN="N">Counterimmunoelectrophoresis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004049" MajorTopicYN="N">Diethylcarbamazine</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004183" MajorTopicYN="N">Dirofilaria immitis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014957" MajorTopicYN="N">Wuchereria</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1986</Year><Month>5</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1986</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1986</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3518508</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Jain, D C" sort="Jain, D C" uniqKey="Jain D" first="D C" last="Jain">D C Jain</name><name sortKey="Kumar, H" sort="Kumar, H" uniqKey="Kumar H" first="H" last="Kumar">H. Kumar</name><name sortKey="Santhanam, S" sort="Santhanam, S" uniqKey="Santhanam S" first="S" last="Santhanam">S. Santhanam</name><name sortKey="Sethumadhavan, K V" sort="Sethumadhavan, K V" uniqKey="Sethumadhavan K" first="K V" last="Sethumadhavan">K V Sethumadhavan</name><name sortKey="Weil, G J" sort="Weil, G J" uniqKey="Weil G" first="G J" last="Weil">G J Weil</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005D40 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 005D40 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:3518508
|texte= Detection of circulating parasite antigen in bancroftian filariasis by counterimmunoelectrophoresis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:3518508" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |