Detection of circulating and urinary antigens in Mastomys natalensis experimentally infected with Brugia malayi, Brugia pahangi, or Litomosoides carinii.
Identifieur interne : 005B64 ( PubMed/Checkpoint ); précédent : 005B63; suivant : 005B65Detection of circulating and urinary antigens in Mastomys natalensis experimentally infected with Brugia malayi, Brugia pahangi, or Litomosoides carinii.
Auteurs : C. Lutsch [France] ; J Y Cesbron ; H. Zahner ; A. CapronSource :
- Parasitology research [ 0932-0113 ] ; 1987.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Antigènes d'helminthe.
- immunologie : Brugia, Filarioidea, Filariose lymphatique, Filarioses.
- urine : Antigènes d'helminthe.
- Animaux, Anticorps monoclonaux, Dosage radioimmunologique, Muridae.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Antigens, Helminth.
- chemical , urine : Antigens, Helminth.
- chemical : Antibodies, Monoclonal.
- immunology : Brugia, Elephantiasis, Filarial, Filariasis, Filarioidea.
- Animals, Muridae, Radioimmunoassay.
Abstract
The time-course of the detection of circulating and urinary filarial antigens was followed with a 2S-IRMA assay, using a mouse monoclonal antibody raised against Brugia malayi larvae, in Mastomys natalensis experimentally infected with Brugia malayi, Brugia pahangi, or Litomosoides carinii. In the prepatent phase of the infections, filarial antigen was detected 4-7 weeks before microfilariae appeared in the peripheral blood. Moreover, the sensitivity of the test was greater with urine than with serum. During the patent phase of infection, the level of circulating antigens detected varied considerably. However, there was a positive correlation (P less than 0.05) between antigenemia and microfilaremia. In L. carinii infection, filarial antigen could be easily detected in spite of the disappearance of microfilariae in peripheral blood, 49 weeks post infection. If these results are extrapolated to man, the 2S-IRMA should be useful for epidemiological surveys in endemic areas where transmission has been eliminated.
PubMed: 3438300
Affiliations:
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Lutsch</name><affiliation wicri:level="3"><nlm:affiliation>Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM 167-CNRS 624, Institut Pasteur, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM 167-CNRS 624, Institut Pasteur, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Cesbron, J Y" sort="Cesbron, J Y" uniqKey="Cesbron J" first="J Y" last="Cesbron">J Y Cesbron</name></author><author><name sortKey="Zahner, H" sort="Zahner, H" uniqKey="Zahner H" first="H" last="Zahner">H. Zahner</name></author><author><name sortKey="Capron, A" sort="Capron, A" uniqKey="Capron A" first="A" last="Capron">A. 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Lutsch</name><affiliation wicri:level="3"><nlm:affiliation>Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM 167-CNRS 624, Institut Pasteur, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM 167-CNRS 624, Institut Pasteur, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Cesbron, J Y" sort="Cesbron, J Y" uniqKey="Cesbron J" first="J Y" last="Cesbron">J Y Cesbron</name></author><author><name sortKey="Zahner, H" sort="Zahner, H" uniqKey="Zahner H" first="H" last="Zahner">H. Zahner</name></author><author><name sortKey="Capron, A" sort="Capron, A" uniqKey="Capron A" first="A" last="Capron">A. Capron</name></author></analytic><series><title level="j">Parasitology research</title><idno type="ISSN">0932-0113</idno><imprint><date when="1987" type="published">1987</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal</term><term>Antigens, Helminth (analysis)</term><term>Antigens, Helminth (urine)</term><term>Brugia (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Filariasis (immunology)</term><term>Filarioidea (immunology)</term><term>Muridae</term><term>Radioimmunoassay</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux</term><term>Antigènes d'helminthe (analyse)</term><term>Antigènes d'helminthe (urine)</term><term>Brugia (immunologie)</term><term>Dosage radioimmunologique</term><term>Filarioidea (immunologie)</term><term>Filariose lymphatique (immunologie)</term><term>Filarioses (immunologie)</term><term>Muridae</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia</term><term>Filarioidea</term><term>Filariose lymphatique</term><term>Filarioses</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Filarioidea</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Muridae</term><term>Radioimmunoassay</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux</term><term>Dosage radioimmunologique</term><term>Muridae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The time-course of the detection of circulating and urinary filarial antigens was followed with a 2S-IRMA assay, using a mouse monoclonal antibody raised against Brugia malayi larvae, in Mastomys natalensis experimentally infected with Brugia malayi, Brugia pahangi, or Litomosoides carinii. In the prepatent phase of the infections, filarial antigen was detected 4-7 weeks before microfilariae appeared in the peripheral blood. Moreover, the sensitivity of the test was greater with urine than with serum. During the patent phase of infection, the level of circulating antigens detected varied considerably. However, there was a positive correlation (P less than 0.05) between antigenemia and microfilaremia. In L. carinii infection, filarial antigen could be easily detected in spite of the disappearance of microfilariae in peripheral blood, 49 weeks post infection. If these results are extrapolated to man, the 2S-IRMA should be useful for epidemiological surveys in endemic areas where transmission has been eliminated.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3438300</PMID><DateCreated><Year>1988</Year><Month>04</Month><Day>01</Day></DateCreated><DateCompleted><Year>1988</Year><Month>04</Month><Day>01</Day></DateCompleted><DateRevised><Year>2017</Year><Month>08</Month><Day>08</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0932-0113</ISSN><JournalIssue CitedMedium="Print"><Volume>74</Volume><Issue>2</Issue><PubDate><Year>1987</Year></PubDate></JournalIssue><Title>Parasitology research</Title><ISOAbbreviation>Parasitol. Res.</ISOAbbreviation></Journal><ArticleTitle>Detection of circulating and urinary antigens in Mastomys natalensis experimentally infected with Brugia malayi, Brugia pahangi, or Litomosoides carinii.</ArticleTitle><Pagination><MedlinePgn>191-5</MedlinePgn></Pagination><Abstract><AbstractText>The time-course of the detection of circulating and urinary filarial antigens was followed with a 2S-IRMA assay, using a mouse monoclonal antibody raised against Brugia malayi larvae, in Mastomys natalensis experimentally infected with Brugia malayi, Brugia pahangi, or Litomosoides carinii. In the prepatent phase of the infections, filarial antigen was detected 4-7 weeks before microfilariae appeared in the peripheral blood. Moreover, the sensitivity of the test was greater with urine than with serum. During the patent phase of infection, the level of circulating antigens detected varied considerably. However, there was a positive correlation (P less than 0.05) between antigenemia and microfilaremia. In L. carinii infection, filarial antigen could be easily detected in spite of the disappearance of microfilariae in peripheral blood, 49 weeks post infection. If these results are extrapolated to man, the 2S-IRMA should be useful for epidemiological surveys in endemic areas where transmission has been eliminated.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lutsch</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM 167-CNRS 624, Institut Pasteur, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cesbron</LastName><ForeName>J Y</ForeName><Initials>JY</Initials></Author><Author ValidYN="Y"><LastName>Zahner</LastName><ForeName>H</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Capron</LastName><ForeName>A</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Parasitol Res</MedlineTA><NlmUniqueID>8703571</NlmUniqueID><ISSNLinking>0932-0113</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Z Parasitenkd. 1968;30(4):281-90</RefSource><PMID Version="1">5746888</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Exp Immunol. 1988 Feb;71(2):253-60</RefSource><PMID Version="1">3280185</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Immunology. 1985 Apr;54(4):655-63</RefSource><PMID Version="1">3884492</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Z Parasitenkd. 1983;69(5):681-92</RefSource><PMID Version="1">6685415</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trans R Soc Trop Med Hyg. 1986;80(4):587-91</RefSource><PMID Version="1">3810793</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Trop. 1981 Sep;38(3):277-88</RefSource><PMID Version="1">6118036</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002009" MajorTopicYN="N">Brugia</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005370" MajorTopicYN="N">Filarioidea</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009115" MajorTopicYN="N">Muridae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011863" MajorTopicYN="N">Radioimmunoassay</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1987</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1987</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1987</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3438300</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement></list><tree><noCountry><name sortKey="Capron, A" sort="Capron, A" uniqKey="Capron A" first="A" last="Capron">A. Capron</name><name sortKey="Cesbron, J Y" sort="Cesbron, J Y" uniqKey="Cesbron J" first="J Y" last="Cesbron">J Y Cesbron</name><name sortKey="Zahner, H" sort="Zahner, H" uniqKey="Zahner H" first="H" last="Zahner">H. Zahner</name></noCountry><country name="France"><region name="Hauts-de-France"><name sortKey="Lutsch, C" sort="Lutsch, C" uniqKey="Lutsch C" first="C" last="Lutsch">C. Lutsch</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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