Induction of lymphatic lesions by Brugia pahangi in jirds with large and small preexisting homologous intraperitoneal infections.
Identifieur interne : 005B33 ( PubMed/Checkpoint ); précédent : 005B32; suivant : 005B34Induction of lymphatic lesions by Brugia pahangi in jirds with large and small preexisting homologous intraperitoneal infections.
Auteurs : T R Klei ; K C Mcdonough ; S U Coleman ; F M EnrightSource :
- The Journal of parasitology [ 0022-3395 ] ; 1987.
Descripteurs français
- KwdFr :
- Animaux, Anticorps (analyse), Antigènes d'helminthe (immunologie), Brugia (immunologie), Brugia (isolement et purification), Cavité péritonéale (parasitologie), Filariose lymphatique (anatomopathologie), Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Gerbillinae, Hypersensibilité immédiate, Hypersensibilité retardée, Lymphoedème (parasitologie), Mâle, Système lymphatique (anatomopathologie), Système lymphatique (parasitologie).
- MESH :
- analyse : Anticorps.
- anatomopathologie : Filariose lymphatique, Système lymphatique.
- immunologie : Antigènes d'helminthe, Brugia, Filariose lymphatique.
- isolement et purification : Brugia.
- parasitologie : Cavité péritonéale, Filariose lymphatique, Lymphoedème, Système lymphatique.
- Animaux, Gerbillinae, Hypersensibilité immédiate, Hypersensibilité retardée, Mâle.
English descriptors
- KwdEn :
- Animals, Antibodies (analysis), Antigens, Helminth (immunology), Brugia (immunology), Brugia (isolation & purification), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (pathology), Gerbillinae, Hypersensitivity, Delayed, Hypersensitivity, Immediate, Lymphatic System (parasitology), Lymphatic System (pathology), Lymphedema (parasitology), Male, Peritoneal Cavity (parasitology).
- MESH :
- chemical , analysis : Antibodies.
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia, Elephantiasis, Filarial.
- isolation & purification : Brugia.
- parasitology : Elephantiasis, Filarial, Lymphatic System, Lymphedema, Peritoneal Cavity.
- pathology : Elephantiasis, Filarial, Lymphatic System.
- Animals, Gerbillinae, Hypersensitivity, Delayed, Hypersensitivity, Immediate, Male.
Abstract
The effect of intraperitoneal (i.p.) infections induced by inoculations of 30 or 150 Brugia pahangi third-stage larvae (L3) on the development of infections and lymphatic lesions induced by subsequent homologous subcutaneous (s.c.) inoculations were compared in the present study. Lymphatic lesion severity, as judged by the numbers of lymph thrombi present, and lymphatic lesion scores were significantly reduced in both groups of jirds with existing i.p. infections. The numbers of adult worms that developed, locations of these worms, and the subsequent microfilaremias did not differ significantly between groups. All jirds with i.p. infections developed similar antibody titers to crude somatic adult antigen as measured by ELISA. These levels did not change following s.c. infections. Immediate and delayed footpad swelling responses were also similar in all groups. Results of these experiments support and extend previous studies indicating that i.p. infections of B. pahangi induce a hyporesponsive state in jirds to subsequent s.c. infections without significantly affecting the subsequent parasite burden. This effect appears to be independent of the numbers of L3 inoculated i.p. prior to lymphatic-induced infection. Circulating antibody titers and footpad swelling responses to B. pahangi antigen were not reduced in jirds with the hyporesponsive lymphatic inflammatory response and do not correlate with this condition.
PubMed: 3585623
Affiliations:
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uniqKey="Enright F" first="F M" last="Enright">F M Enright</name></author></analytic><series><title level="j">The Journal of parasitology</title><idno type="ISSN">0022-3395</idno><imprint><date when="1987" type="published">1987</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies (analysis)</term><term>Antigens, Helminth (immunology)</term><term>Brugia (immunology)</term><term>Brugia (isolation & purification)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Elephantiasis, Filarial (pathology)</term><term>Gerbillinae</term><term>Hypersensitivity, Delayed</term><term>Hypersensitivity, Immediate</term><term>Lymphatic System (parasitology)</term><term>Lymphatic System (pathology)</term><term>Lymphedema (parasitology)</term><term>Male</term><term>Peritoneal Cavity (parasitology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps (analyse)</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia (immunologie)</term><term>Brugia (isolement et purification)</term><term>Cavité péritonéale (parasitologie)</term><term>Filariose lymphatique (anatomopathologie)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Gerbillinae</term><term>Hypersensibilité immédiate</term><term>Hypersensibilité retardée</term><term>Lymphoedème (parasitologie)</term><term>Mâle</term><term>Système lymphatique (anatomopathologie)</term><term>Système lymphatique (parasitologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Brugia</term><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Brugia</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Brugia</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Cavité péritonéale</term><term>Filariose lymphatique</term><term>Lymphoedème</term><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphatic System</term><term>Lymphedema</term><term>Peritoneal Cavity</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphatic System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gerbillinae</term><term>Hypersensitivity, Delayed</term><term>Hypersensitivity, Immediate</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Gerbillinae</term><term>Hypersensibilité immédiate</term><term>Hypersensibilité retardée</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of intraperitoneal (i.p.) infections induced by inoculations of 30 or 150 Brugia pahangi third-stage larvae (L3) on the development of infections and lymphatic lesions induced by subsequent homologous subcutaneous (s.c.) inoculations were compared in the present study. Lymphatic lesion severity, as judged by the numbers of lymph thrombi present, and lymphatic lesion scores were significantly reduced in both groups of jirds with existing i.p. infections. The numbers of adult worms that developed, locations of these worms, and the subsequent microfilaremias did not differ significantly between groups. All jirds with i.p. infections developed similar antibody titers to crude somatic adult antigen as measured by ELISA. These levels did not change following s.c. infections. Immediate and delayed footpad swelling responses were also similar in all groups. Results of these experiments support and extend previous studies indicating that i.p. infections of B. pahangi induce a hyporesponsive state in jirds to subsequent s.c. infections without significantly affecting the subsequent parasite burden. This effect appears to be independent of the numbers of L3 inoculated i.p. prior to lymphatic-induced infection. Circulating antibody titers and footpad swelling responses to B. pahangi antigen were not reduced in jirds with the hyporesponsive lymphatic inflammatory response and do not correlate with this condition.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3585623</PMID><DateCreated><Year>1987</Year><Month>07</Month><Day>22</Day></DateCreated><DateCompleted><Year>1987</Year><Month>07</Month><Day>22</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3395</ISSN><JournalIssue CitedMedium="Print"><Volume>73</Volume><Issue>2</Issue><PubDate><Year>1987</Year><Month>Apr</Month></PubDate></JournalIssue><Title>The Journal of parasitology</Title><ISOAbbreviation>J. Parasitol.</ISOAbbreviation></Journal><ArticleTitle>Induction of lymphatic lesions by Brugia pahangi in jirds with large and small preexisting homologous intraperitoneal infections.</ArticleTitle><Pagination><MedlinePgn>290-4</MedlinePgn></Pagination><Abstract><AbstractText>The effect of intraperitoneal (i.p.) infections induced by inoculations of 30 or 150 Brugia pahangi third-stage larvae (L3) on the development of infections and lymphatic lesions induced by subsequent homologous subcutaneous (s.c.) inoculations were compared in the present study. Lymphatic lesion severity, as judged by the numbers of lymph thrombi present, and lymphatic lesion scores were significantly reduced in both groups of jirds with existing i.p. infections. The numbers of adult worms that developed, locations of these worms, and the subsequent microfilaremias did not differ significantly between groups. All jirds with i.p. infections developed similar antibody titers to crude somatic adult antigen as measured by ELISA. These levels did not change following s.c. infections. Immediate and delayed footpad swelling responses were also similar in all groups. Results of these experiments support and extend previous studies indicating that i.p. infections of B. pahangi induce a hyporesponsive state in jirds to subsequent s.c. infections without significantly affecting the subsequent parasite burden. This effect appears to be independent of the numbers of L3 inoculated i.p. prior to lymphatic-induced infection. Circulating antibody titers and footpad swelling responses to B. pahangi antigen were not reduced in jirds with the hyporesponsive lymphatic inflammatory response and do not correlate with this condition.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Klei</LastName><ForeName>T R</ForeName><Initials>TR</Initials></Author><Author ValidYN="Y"><LastName>McDonough</LastName><ForeName>K C</ForeName><Initials>KC</Initials></Author><Author ValidYN="Y"><LastName>Coleman</LastName><ForeName>S U</ForeName><Initials>SU</Initials></Author><Author ValidYN="Y"><LastName>Enright</LastName><ForeName>F M</ForeName><Initials>FM</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>AI-19199-03</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Parasitol</MedlineTA><NlmUniqueID>7803124</NlmUniqueID><ISSNLinking>0022-3395</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000906">Antibodies</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000906" MajorTopicYN="N">Antibodies</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000947" MajorTopicYN="N">Antigens, Helminth</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002009" MajorTopicYN="N">Brugia</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005849" MajorTopicYN="N">Gerbillinae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006968" MajorTopicYN="N">Hypersensitivity, Delayed</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006969" MajorTopicYN="N">Hypersensitivity, Immediate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010529" MajorTopicYN="N">Peritoneal Cavity</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1987</Year><Month>4</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1987</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1987</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3585623</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Coleman, S U" sort="Coleman, S U" uniqKey="Coleman S" first="S U" last="Coleman">S U Coleman</name><name sortKey="Enright, F M" sort="Enright, F M" uniqKey="Enright F" first="F M" last="Enright">F M Enright</name><name sortKey="Klei, T R" sort="Klei, T R" uniqKey="Klei T" first="T R" last="Klei">T R Klei</name><name sortKey="Mcdonough, K C" sort="Mcdonough, K C" uniqKey="Mcdonough K" first="K C" last="Mcdonough">K C Mcdonough</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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