Brugia pahangi in rats: increasing the number of infective larvae inoculated increases the percentage of microfilaremic rats.
Identifieur interne : 005415 ( PubMed/Checkpoint ); précédent : 005414; suivant : 005416Brugia pahangi in rats: increasing the number of infective larvae inoculated increases the percentage of microfilaremic rats.
Auteurs : R. Lawrence [Royaume-Uni] ; D A DenhamSource :
- The Journal of parasitology [ 0022-3395 ] ; 1991.
Descripteurs français
- KwdFr :
- MESH :
- croissance et développement : Brugia, Microfilaria.
- parasitologie : Filariose lymphatique.
- sang : Filariose lymphatique.
- Animaux, Femelle, Mâle, Rats.
English descriptors
- KwdEn :
- MESH :
- blood : Elephantiasis, Filarial.
- growth & development : Brugia, Microfilariae.
- parasitology : Elephantiasis, Filarial.
- Animals, Female, Male, Rats.
Abstract
One hundred Brugia pahangi infective larvae (L3) caused microfilaremic (mf + ve) infection in 56% of inbred PVG rats. Adult worms were recovered consistently from infected rats but worm recovery was very low, only 1-3% of L3 inoculated survived to adulthood and the worms were dispersed in a wide range of anatomical sites. This suggested that lack of microfilaremia may be due to the low probability of male and female worms meeting in the same site and thus may be numerically and topographically based. When the number of infective larvae inoculated was increased to 500, the percentage of mf + ve infections in rats also increased to 94%, corroborating the hypothesis that lack of mf was not due to an immune response. In a further experiment all infected rats had lost both mf and adult worms by day 420. It has yet to be established whether final rejection of the parasite is due to immunity.
PubMed: 1992091
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:1992091Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brugia pahangi in rats: increasing the number of infective larvae inoculated increases the percentage of microfilaremic rats.</title><author><name sortKey="Lawrence, R" sort="Lawrence, R" uniqKey="Lawrence R" first="R" last="Lawrence">R. Lawrence</name><affiliation wicri:level="2"><nlm:affiliation>London School of Hygiene and Tropical Medicine, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>London School of Hygiene and Tropical Medicine</wicri:cityArea></affiliation></author><author><name sortKey="Denham, D A" sort="Denham, D A" uniqKey="Denham D" first="D A" last="Denham">D A Denham</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1992091</idno><idno type="pmid">1992091</idno><idno type="wicri:Area/PubMed/Corpus">005C01</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005C01</idno><idno type="wicri:Area/PubMed/Curation">005C01</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005C01</idno><idno type="wicri:Area/PubMed/Checkpoint">005C01</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005C01</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Brugia pahangi in rats: increasing the number of infective larvae inoculated increases the percentage of microfilaremic rats.</title><author><name sortKey="Lawrence, R" sort="Lawrence, R" uniqKey="Lawrence R" first="R" last="Lawrence">R. Lawrence</name><affiliation wicri:level="2"><nlm:affiliation>London School of Hygiene and Tropical Medicine, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>London School of Hygiene and Tropical Medicine</wicri:cityArea></affiliation></author><author><name sortKey="Denham, D A" sort="Denham, D A" uniqKey="Denham D" first="D A" last="Denham">D A Denham</name></author></analytic><series><title level="j">The Journal of parasitology</title><idno type="ISSN">0022-3395</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brugia (growth & development)</term><term>Elephantiasis, Filarial (blood)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Male</term><term>Microfilariae (growth & development)</term><term>Rats</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Brugia (croissance et développement)</term><term>Femelle</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (sang)</term><term>Microfilaria (croissance et développement)</term><term>Mâle</term><term>Rats</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Brugia</term><term>Microfilaria</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Brugia</term><term>Microfilariae</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Mâle</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One hundred Brugia pahangi infective larvae (L3) caused microfilaremic (mf + ve) infection in 56% of inbred PVG rats. Adult worms were recovered consistently from infected rats but worm recovery was very low, only 1-3% of L3 inoculated survived to adulthood and the worms were dispersed in a wide range of anatomical sites. This suggested that lack of microfilaremia may be due to the low probability of male and female worms meeting in the same site and thus may be numerically and topographically based. When the number of infective larvae inoculated was increased to 500, the percentage of mf + ve infections in rats also increased to 94%, corroborating the hypothesis that lack of mf was not due to an immune response. In a further experiment all infected rats had lost both mf and adult worms by day 420. It has yet to be established whether final rejection of the parasite is due to immunity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1992091</PMID><DateCreated><Year>1991</Year><Month>03</Month><Day>14</Day></DateCreated><DateCompleted><Year>1991</Year><Month>03</Month><Day>14</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3395</ISSN><JournalIssue CitedMedium="Print"><Volume>77</Volume><Issue>1</Issue><PubDate><Year>1991</Year><Month>Feb</Month></PubDate></JournalIssue><Title>The Journal of parasitology</Title><ISOAbbreviation>J. Parasitol.</ISOAbbreviation></Journal><ArticleTitle>Brugia pahangi in rats: increasing the number of infective larvae inoculated increases the percentage of microfilaremic rats.</ArticleTitle><Pagination><MedlinePgn>173-5</MedlinePgn></Pagination><Abstract><AbstractText>One hundred Brugia pahangi infective larvae (L3) caused microfilaremic (mf + ve) infection in 56% of inbred PVG rats. Adult worms were recovered consistently from infected rats but worm recovery was very low, only 1-3% of L3 inoculated survived to adulthood and the worms were dispersed in a wide range of anatomical sites. This suggested that lack of microfilaremia may be due to the low probability of male and female worms meeting in the same site and thus may be numerically and topographically based. When the number of infective larvae inoculated was increased to 500, the percentage of mf + ve infections in rats also increased to 94%, corroborating the hypothesis that lack of mf was not due to an immune response. In a further experiment all infected rats had lost both mf and adult worms by day 420. It has yet to be established whether final rejection of the parasite is due to immunity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lawrence</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>London School of Hygiene and Tropical Medicine, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Denham</LastName><ForeName>D A</ForeName><Initials>DA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Parasitol</MedlineTA><NlmUniqueID>7803124</NlmUniqueID><ISSNLinking>0022-3395</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002009" MajorTopicYN="N">Brugia</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008842" MajorTopicYN="N">Microfilariae</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>2</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1992091</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><noCountry><name sortKey="Denham, D A" sort="Denham, D A" uniqKey="Denham D" first="D A" last="Denham">D A Denham</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lawrence, R" sort="Lawrence, R" uniqKey="Lawrence R" first="R" last="Lawrence">R. Lawrence</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005415 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 005415 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:1992091
|texte= Brugia pahangi in rats: increasing the number of infective larvae inoculated increases the percentage of microfilaremic rats.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:1992091" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |