Combined coumarin and omental transfer treatments for canine proximal obstructive lymphoedema.
Identifieur interne : 005402 ( PubMed/Checkpoint ); précédent : 005401; suivant : 005403Combined coumarin and omental transfer treatments for canine proximal obstructive lymphoedema.
Auteurs : K R Knight [Australie] ; J V Hurley ; M J Hickey ; D A Lepore ; B M O'BrienSource :
- International journal of experimental pathology [ 0959-9673 ] ; 1991.
Descripteurs français
- KwdFr :
- Animaux, Association thérapeutique, Chiens, Collagène (analyse), Coumarines (usage thérapeutique), Endopeptidases (analyse), Espace extracellulaire (enzymologie), Lymphoedème (), Lymphoedème (anatomopathologie), Lymphoedème (métabolisme), Omentum (anatomopathologie), Omentum (transplantation), Peau (), Peau (anatomopathologie).
- MESH :
- analyse : Collagène, Endopeptidases.
- anatomopathologie : Lymphoedème, Omentum, Peau.
- enzymologie : Espace extracellulaire.
- métabolisme : Lymphoedème.
- usage thérapeutique : Coumarines, Omentum.
- Animaux, Association thérapeutique, Chiens, Lymphoedème, Peau.
English descriptors
- KwdEn :
- Animals, Collagen (analysis), Combined Modality Therapy, Coumarins (therapeutic use), Dogs, Endopeptidases (analysis), Extracellular Space (enzymology), Lymphedema (metabolism), Lymphedema (pathology), Lymphedema (therapy), Omentum (pathology), Omentum (transplantation), Skin (chemistry), Skin (pathology).
- MESH :
- chemical , analysis : Collagen, Endopeptidases.
- chemical , therapeutic use : Coumarins.
- chemistry : Skin.
- enzymology : Extracellular Space.
- metabolism : Lymphedema.
- pathology : Lymphedema, Omentum, Skin.
- therapy : Lymphedema.
- transplantation : Omentum.
- Animals, Combined Modality Therapy, Dogs.
Abstract
In a canine model both coumarin treatment (believed to act by increased local proteolysis) and surgical transfer of a bridge of vascularized, lymphatic-rich omentum cause significant reduction of experimental lymphoedema. The present paper describes the effects of consecutive application of these two types of treatment. Ten dogs were divided into two equal groups: Group 1 Coumarin treatment, 6 months; no treatment, 6 months; omental transfer, 6 months; or Group 2 Omental transfer, 12 months (biopsied at 6 months); coumarin treatment, 6 months. Prior to treatment the excess limb circumferences were 2.66 and 3.01 cm in Groups 1 and 2 respectively. In Group 1, 6 months coumarin treatment alone reduced swelling by 0.78 cm and the final reduction in swelling at 18 months was 1.03 cm. In Group 2, reduction in swelling 6 months after omental transfer alone was 0.96 cm and the final reduction at 18 months was 2.05 cm. The findings indicate that in Group 1 there is an additive effect of the two types of treatment. However, in Group 2 it is not possible to be certain whether the improvement that occurred between 6 and 18 months also reflects an additive effect or a later consequence of the earlier omental transfer.
PubMed: 1742206
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uniqKey="Knight K" first="K R" last="Knight">K R Knight</name><affiliation wicri:level="1"><nlm:affiliation>Microsurgery Research Centre, St. Vincent's Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Microsurgery Research Centre, St. Vincent's Hospital, Melbourne</wicri:regionArea><wicri:noRegion>Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Hurley, J V" sort="Hurley, J V" uniqKey="Hurley J" first="J V" last="Hurley">J V Hurley</name></author><author><name sortKey="Hickey, M J" sort="Hickey, M J" uniqKey="Hickey M" first="M J" last="Hickey">M J Hickey</name></author><author><name sortKey="Lepore, D A" sort="Lepore, D A" uniqKey="Lepore D" first="D A" last="Lepore">D A Lepore</name></author><author><name sortKey="O Brien, B M" sort="O Brien, B M" uniqKey="O Brien B" first="B M" last="O'Brien">B M O'Brien</name></author></analytic><series><title level="j">International journal of experimental 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()</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (métabolisme)</term><term>Omentum (anatomopathologie)</term><term>Omentum (transplantation)</term><term>Peau ()</term><term>Peau (anatomopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Collagen</term><term>Endopeptidases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Coumarins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Collagène</term><term>Endopeptidases</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Omentum</term><term>Peau</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Skin</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Espace extracellulaire</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Extracellular Space</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term><term>Omentum</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Omentum</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Coumarines</term><term>Omentum</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Combined Modality Therapy</term><term>Dogs</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Association thérapeutique</term><term>Chiens</term><term>Lymphoedème</term><term>Peau</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In a canine model both coumarin treatment (believed to act by increased local proteolysis) and surgical transfer of a bridge of vascularized, lymphatic-rich omentum cause significant reduction of experimental lymphoedema. The present paper describes the effects of consecutive application of these two types of treatment. Ten dogs were divided into two equal groups: Group 1 Coumarin treatment, 6 months; no treatment, 6 months; omental transfer, 6 months; or Group 2 Omental transfer, 12 months (biopsied at 6 months); coumarin treatment, 6 months. Prior to treatment the excess limb circumferences were 2.66 and 3.01 cm in Groups 1 and 2 respectively. In Group 1, 6 months coumarin treatment alone reduced swelling by 0.78 cm and the final reduction in swelling at 18 months was 1.03 cm. In Group 2, reduction in swelling 6 months after omental transfer alone was 0.96 cm and the final reduction at 18 months was 2.05 cm. The findings indicate that in Group 1 there is an additive effect of the two types of treatment. However, in Group 2 it is not possible to be certain whether the improvement that occurred between 6 and 18 months also reflects an additive effect or a later consequence of the earlier omental transfer.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1742206</PMID><DateCreated><Year>1992</Year><Month>01</Month><Day>14</Day></DateCreated><DateCompleted><Year>1992</Year><Month>01</Month><Day>14</Day></DateCompleted><DateRevised><Year>2012</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0959-9673</ISSN><JournalIssue CitedMedium="Print"><Volume>72</Volume><Issue>5</Issue><PubDate><Year>1991</Year><Month>Oct</Month></PubDate></JournalIssue><Title>International journal of experimental pathology</Title><ISOAbbreviation>Int J Exp Pathol</ISOAbbreviation></Journal><ArticleTitle>Combined coumarin and omental transfer treatments for canine proximal obstructive lymphoedema.</ArticleTitle><Pagination><MedlinePgn>533-42</MedlinePgn></Pagination><Abstract><AbstractText>In a canine model both coumarin treatment (believed to act by increased local proteolysis) and surgical transfer of a bridge of vascularized, lymphatic-rich omentum cause significant reduction of experimental lymphoedema. The present paper describes the effects of consecutive application of these two types of treatment. Ten dogs were divided into two equal groups: Group 1 Coumarin treatment, 6 months; no treatment, 6 months; omental transfer, 6 months; or Group 2 Omental transfer, 12 months (biopsied at 6 months); coumarin treatment, 6 months. Prior to treatment the excess limb circumferences were 2.66 and 3.01 cm in Groups 1 and 2 respectively. In Group 1, 6 months coumarin treatment alone reduced swelling by 0.78 cm and the final reduction in swelling at 18 months was 1.03 cm. In Group 2, reduction in swelling 6 months after omental transfer alone was 0.96 cm and the final reduction at 18 months was 2.05 cm. The findings indicate that in Group 1 there is an additive effect of the two types of treatment. However, in Group 2 it is not possible to be certain whether the improvement that occurred between 6 and 18 months also reflects an additive effect or a later consequence of the earlier omental transfer.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Knight</LastName><ForeName>K R</ForeName><Initials>KR</Initials><AffiliationInfo><Affiliation>Microsurgery Research Centre, St. Vincent's Hospital, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hurley</LastName><ForeName>J V</ForeName><Initials>JV</Initials></Author><Author ValidYN="Y"><LastName>Hickey</LastName><ForeName>M J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Lepore</LastName><ForeName>D A</ForeName><Initials>DA</Initials></Author><Author ValidYN="Y"><LastName>O'Brien</LastName><ForeName>B M</ForeName><Initials>BM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Int J Exp Pathol</MedlineTA><NlmUniqueID>9014042</NlmUniqueID><ISSNLinking>0959-9673</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003374">Coumarins</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-34-5</RegistryNumber><NameOfSubstance UI="D003094">Collagen</NameOfSubstance></Chemical><Chemical><RegistryNumber>A4VZ22K1WT</RegistryNumber><NameOfSubstance UI="C030123">coumarin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.-</RegistryNumber><NameOfSubstance UI="D010450">Endopeptidases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Ann Surg. 1962 Jul;156:61-7</RefSource><PMID Version="1">13883367</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Surgery. 1968 Oct;64(4):821-6</RefSource><PMID Version="1">5683808</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Pharmacol. 1972 Oct;46(2):254-9</RefSource><PMID Version="1">4651772</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Plast Reconstr Surg. 1981 Sep;68(3):422-8</RefSource><PMID Version="1">7267816</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Lab Clin Med. 1987 Nov;110(5):558-66</RefSource><PMID Version="1">2444662</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Sci (Lond). 1989 Jul;77(1):69-76</RefSource><PMID Version="1">2667858</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Plast Surg. 1990 Jul;43(4):440-6</RefSource><PMID Version="1">2393770</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003094" MajorTopicYN="N">Collagen</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003374" MajorTopicYN="N">Coumarins</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010450" MajorTopicYN="N">Endopeptidases</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005110" MajorTopicYN="N">Extracellular Space</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009852" MajorTopicYN="N">Omentum</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000637" MajorTopicYN="Y">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC2002329</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1742206</ArticleId><ArticleId IdType="pmc">PMC2002329</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Hickey, M J" sort="Hickey, M J" uniqKey="Hickey M" first="M J" last="Hickey">M J Hickey</name><name sortKey="Hurley, J V" sort="Hurley, J V" uniqKey="Hurley J" first="J V" last="Hurley">J V Hurley</name><name sortKey="Lepore, D A" sort="Lepore, D A" uniqKey="Lepore D" first="D A" last="Lepore">D A Lepore</name><name sortKey="O Brien, B M" sort="O Brien, B M" uniqKey="O Brien B" first="B M" last="O'Brien">B M O'Brien</name></noCountry><country name="Australie"><noRegion><name sortKey="Knight, K R" sort="Knight, K R" uniqKey="Knight K" first="K R" last="Knight">K R Knight</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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