Lipoperoxide in the dermis of patients with lymph stasis.
Identifieur interne : 005016 ( PubMed/Checkpoint ); précédent : 005015; suivant : 005017Lipoperoxide in the dermis of patients with lymph stasis.
Auteurs : M. Ohkuma [Japon]Source :
- Lymphology [ 0024-7766 ] ; 1993.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Malonaldéhyde, Peroxydes lipidiques.
- métabolisme : Lymphoedème.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Peau, Sujet âgé.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Lipid Peroxides, Malondialdehyde.
- chemistry : Skin.
- metabolism : Lymphedema.
- Adult, Aged, Female, Humans, Male, Middle Aged.
Abstract
Lipoperoxide has been detected in the thoracic duct lymph of the dog. This finding suggests that lipoperoxides are normally transported in lymph and with impaired lymph drainage may be deposited in the skin and contribute to the soft tissue changes characteristic of chronic lymphedema. Accordingly, after obtaining skin specimens taken from 8 patients (7 with obstructive lymphedema) with lower extremity lymph stasis we determined dermal malondialdehyde (MDA) content (after conversion to fluorescent thiobarbituric acid or TBA), a marker of lipoperoxide. In all 7 patients with obstructive lymphedema, the MDA levels were increased compared to control dermis (p < 0.05). We suggest that inability to clear lipoperoxides from the dermis with lymphatic insufficiency may contribute to the pathogenesis and structural skin derangements of chronic lymphedema.
PubMed: 8464224
Affiliations:
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Ohkuma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Kinki University, School of Medicine, Osaka-Sayama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Kinki University, School of Medicine, Osaka-Sayama</wicri:regionArea><wicri:noRegion>Osaka-Sayama</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1993">1993</date><idno type="RBID">pubmed:8464224</idno><idno type="pmid">8464224</idno><idno type="wicri:Area/PubMed/Corpus">005764</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005764</idno><idno type="wicri:Area/PubMed/Curation">005764</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005764</idno><idno type="wicri:Area/PubMed/Checkpoint">005764</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005764</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lipoperoxide in the dermis of patients with lymph stasis.</title><author><name sortKey="Ohkuma, M" sort="Ohkuma, M" uniqKey="Ohkuma M" first="M" last="Ohkuma">M. Ohkuma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Kinki University, School of Medicine, Osaka-Sayama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dermatology, Kinki University, School of Medicine, Osaka-Sayama</wicri:regionArea><wicri:noRegion>Osaka-Sayama</wicri:noRegion></affiliation></author></analytic><series><title level="j">Lymphology</title><idno type="ISSN">0024-7766</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Lipid Peroxides (analysis)</term><term>Lymphedema (metabolism)</term><term>Male</term><term>Malondialdehyde (analysis)</term><term>Middle Aged</term><term>Skin (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Lymphoedème (métabolisme)</term><term>Malonaldéhyde (analyse)</term><term>Mâle</term><term>Peau ()</term><term>Peroxydes lipidiques (analyse)</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Lipid Peroxides</term><term>Malondialdehyde</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Malonaldéhyde</term><term>Peroxydes lipidiques</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Skin</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Peau</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lipoperoxide has been detected in the thoracic duct lymph of the dog. This finding suggests that lipoperoxides are normally transported in lymph and with impaired lymph drainage may be deposited in the skin and contribute to the soft tissue changes characteristic of chronic lymphedema. Accordingly, after obtaining skin specimens taken from 8 patients (7 with obstructive lymphedema) with lower extremity lymph stasis we determined dermal malondialdehyde (MDA) content (after conversion to fluorescent thiobarbituric acid or TBA), a marker of lipoperoxide. In all 7 patients with obstructive lymphedema, the MDA levels were increased compared to control dermis (p < 0.05). We suggest that inability to clear lipoperoxides from the dermis with lymphatic insufficiency may contribute to the pathogenesis and structural skin derangements of chronic lymphedema.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8464224</PMID><DateCreated><Year>1993</Year><Month>05</Month><Day>06</Day></DateCreated><DateCompleted><Year>1993</Year><Month>05</Month><Day>06</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0024-7766</ISSN><JournalIssue CitedMedium="Print"><Volume>26</Volume><Issue>1</Issue><PubDate><Year>1993</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Lymphology</Title><ISOAbbreviation>Lymphology</ISOAbbreviation></Journal><ArticleTitle>Lipoperoxide in the dermis of patients with lymph stasis.</ArticleTitle><Pagination><MedlinePgn>38-41</MedlinePgn></Pagination><Abstract><AbstractText>Lipoperoxide has been detected in the thoracic duct lymph of the dog. This finding suggests that lipoperoxides are normally transported in lymph and with impaired lymph drainage may be deposited in the skin and contribute to the soft tissue changes characteristic of chronic lymphedema. Accordingly, after obtaining skin specimens taken from 8 patients (7 with obstructive lymphedema) with lower extremity lymph stasis we determined dermal malondialdehyde (MDA) content (after conversion to fluorescent thiobarbituric acid or TBA), a marker of lipoperoxide. In all 7 patients with obstructive lymphedema, the MDA levels were increased compared to control dermis (p < 0.05). We suggest that inability to clear lipoperoxides from the dermis with lymphatic insufficiency may contribute to the pathogenesis and structural skin derangements of chronic lymphedema.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ohkuma</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Kinki University, School of Medicine, Osaka-Sayama, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Lymphology</MedlineTA><NlmUniqueID>0155112</NlmUniqueID><ISSNLinking>0024-7766</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008054">Lipid Peroxides</NameOfSubstance></Chemical><Chemical><RegistryNumber>4Y8F71G49Q</RegistryNumber><NameOfSubstance UI="D008315">Malondialdehyde</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008054" MajorTopicYN="N">Lipid Peroxides</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008315" MajorTopicYN="N">Malondialdehyde</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1993</Year><Month>3</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1993</Year><Month>3</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1993</Year><Month>3</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8464224</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Ohkuma, M" sort="Ohkuma, M" uniqKey="Ohkuma M" first="M" last="Ohkuma">M. 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