The association between microfilaraemia and disease in lymphatic filariasis.
Identifieur interne : 004E08 ( PubMed/Checkpoint ); précédent : 004E07; suivant : 004E09The association between microfilaraemia and disease in lymphatic filariasis.
Auteurs : E. Michael [Royaume-Uni] ; B T Grenfell ; D A BundySource :
- Proceedings. Biological sciences [ 0962-8452 ] ; 1994.
Descripteurs français
- KwdFr :
- MESH :
- isolement et purification : Brugia malayi, Microfilaria, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique, Hydrocèle, Lymphoedème.
- sang : Filariose lymphatique.
- Animaux, Femelle, Humains, Mâle.
English descriptors
- KwdEn :
- Animals, Brugia malayi (isolation & purification), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (parasitology), Female, Humans, Lymphedema (parasitology), Male, Microfilariae (isolation & purification), Testicular Hydrocele (parasitology), Wuchereria bancrofti (isolation & purification).
- MESH :
- blood : Elephantiasis, Filarial.
- isolation & purification : Brugia malayi, Microfilariae, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial, Lymphedema, Testicular Hydrocele.
- Animals, Female, Humans, Male.
Abstract
A standard tenet in the epidemiology of lymphatic filariasis is that patent infection is negatively related to chronic disease. We examine the empirical evidence for this relation by using published data from field studies carried out in a variety of bancroftian filariasis endemic areas. Meta-analysis of the individual study results for each disease category of hydrocele in males only, lymphoedema only, and both conditions combined (total chronic disease) indicate, contrary to expectation, no evidence for a negative association between infection and disease. Indeed, the trend of the empirical evidence is towards the opposite direction, with the majority of studies showing equal propensity of disease in microfilaraemics (mf+ves) and amicrofilaraemics (mf-ves), and more studies indicating a positive rather than a negative relation. There was also a trend for more positive studies for hydrocele compared to lymphoedema. Theoretical analysis suggests that between-study differences in blood sample volumes are unlikely to confound this finding. Analysis of between-study heterogeneity suggests that variations in the local incidence or prevalence of infection rather than unique geographical, including vector, differences might underlie the observed between-study variability in the microfilaraemia-disease association. These results are discussed in terms of dynamic explanations for infection-disease relations in lymphatic filariasis.
DOI: 10.1098/rspb.1994.0045
PubMed: 8008755
Affiliations:
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Michael</name><affiliation wicri:level="4"><nlm:affiliation>Department of Zoology, University of Cambridge, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Zoology, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Grenfell, B T" sort="Grenfell, B T" uniqKey="Grenfell B" first="B T" last="Grenfell">B T Grenfell</name></author><author><name sortKey="Bundy, D A" sort="Bundy, D A" uniqKey="Bundy D" first="D A" last="Bundy">D A Bundy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:8008755</idno><idno type="pmid">8008755</idno><idno type="doi">10.1098/rspb.1994.0045</idno><idno type="wicri:Area/PubMed/Corpus">005563</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005563</idno><idno type="wicri:Area/PubMed/Curation">005563</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005563</idno><idno type="wicri:Area/PubMed/Checkpoint">005563</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005563</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The association between microfilaraemia and disease in lymphatic filariasis.</title><author><name sortKey="Michael, E" sort="Michael, E" uniqKey="Michael E" first="E" last="Michael">E. 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We examine the empirical evidence for this relation by using published data from field studies carried out in a variety of bancroftian filariasis endemic areas. Meta-analysis of the individual study results for each disease category of hydrocele in males only, lymphoedema only, and both conditions combined (total chronic disease) indicate, contrary to expectation, no evidence for a negative association between infection and disease. Indeed, the trend of the empirical evidence is towards the opposite direction, with the majority of studies showing equal propensity of disease in microfilaraemics (mf+ves) and amicrofilaraemics (mf-ves), and more studies indicating a positive rather than a negative relation. There was also a trend for more positive studies for hydrocele compared to lymphoedema. Theoretical analysis suggests that between-study differences in blood sample volumes are unlikely to confound this finding. Analysis of between-study heterogeneity suggests that variations in the local incidence or prevalence of infection rather than unique geographical, including vector, differences might underlie the observed between-study variability in the microfilaraemia-disease association. These results are discussed in terms of dynamic explanations for infection-disease relations in lymphatic filariasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8008755</PMID><DateCreated><Year>1994</Year><Month>07</Month><Day>15</Day></DateCreated><DateCompleted><Year>1994</Year><Month>07</Month><Day>15</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0962-8452</ISSN><JournalIssue CitedMedium="Print"><Volume>256</Volume><Issue>1345</Issue><PubDate><Year>1994</Year><Month>Apr</Month><Day>22</Day></PubDate></JournalIssue><Title>Proceedings. Biological sciences</Title><ISOAbbreviation>Proc. Biol. Sci.</ISOAbbreviation></Journal><ArticleTitle>The association between microfilaraemia and disease in lymphatic filariasis.</ArticleTitle><Pagination><MedlinePgn>33-40</MedlinePgn></Pagination><Abstract><AbstractText>A standard tenet in the epidemiology of lymphatic filariasis is that patent infection is negatively related to chronic disease. We examine the empirical evidence for this relation by using published data from field studies carried out in a variety of bancroftian filariasis endemic areas. Meta-analysis of the individual study results for each disease category of hydrocele in males only, lymphoedema only, and both conditions combined (total chronic disease) indicate, contrary to expectation, no evidence for a negative association between infection and disease. Indeed, the trend of the empirical evidence is towards the opposite direction, with the majority of studies showing equal propensity of disease in microfilaraemics (mf+ves) and amicrofilaraemics (mf-ves), and more studies indicating a positive rather than a negative relation. There was also a trend for more positive studies for hydrocele compared to lymphoedema. Theoretical analysis suggests that between-study differences in blood sample volumes are unlikely to confound this finding. Analysis of between-study heterogeneity suggests that variations in the local incidence or prevalence of infection rather than unique geographical, including vector, differences might underlie the observed between-study variability in the microfilaraemia-disease association. 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