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Experimental study on protein transmission through the human muscle fascia: preliminary results and application theory in lymphedema.

Identifieur interne : 004B69 ( PubMed/Checkpoint ); précédent : 004B68; suivant : 004B70

Experimental study on protein transmission through the human muscle fascia: preliminary results and application theory in lymphedema.

Auteurs : G F Vettorello [Italie] ; M. Rubbini ; C. Nastruzzi ; E. Menegatti ; E. Esposito ; F. Mascoli ; E. Pozza ; A. Cataldi ; I G Donini

Source :

RBID : pubmed:8698777

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English descriptors

Abstract

The presence of proteins (albumin and globulins) in lymphedematous tissue not only gives rise to colloidosmotic pressure but also produces an electrostatic charge endowing the proteins with individual features and different migration rates. The working hypothesis of the experimental study is to transfer lymph proteins from the upper fascia accumulation area to a subfascial drainage area by subjecting them to an adequate difference in potential. A double chamber, variable volume system with separation wall able to contain a 1 cm square of muscle fascia, was designed and built; the aim of the apparatus was to reproduce the subcutaneus zone separated by the fascia interposition, from the muscle-vascular zone. At the system was applied a variable electric field in six different experiments: 4 using porous synthetic membranes and 2 using human muscle fascia.

PubMed: 8698777


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pubmed:8698777

Le document en format XML

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<nlm:affiliation>Dipartimento di Scienze Biomediche e Terapie Avanzate (Sez. di Clinica Chirurgica, University of Ferrara, Italy.</nlm:affiliation>
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<wicri:regionArea>Dipartimento di Scienze Biomediche e Terapie Avanzate (Sez. di Clinica Chirurgica, University of Ferrara</wicri:regionArea>
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<name sortKey="Menegatti, E" sort="Menegatti, E" uniqKey="Menegatti E" first="E" last="Menegatti">E. Menegatti</name>
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<name sortKey="Pozza, E" sort="Pozza, E" uniqKey="Pozza E" first="E" last="Pozza">E. Pozza</name>
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<term>Fascia (metabolism)</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
<term>Leg</term>
<term>Lymph (metabolism)</term>
<term>Lymphedema (metabolism)</term>
<term>Membranes, Artificial</term>
<term>Models, Structural</term>
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<term>Proteins (metabolism)</term>
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<term>Fascia (métabolisme)</term>
<term>Humains</term>
<term>Jambe</term>
<term>Lymphe (métabolisme)</term>
<term>Lymphoedème (métabolisme)</term>
<term>Maquettes de structure</term>
<term>Membrane artificielle</term>
<term>Porosité</term>
<term>Protéines (métabolisme)</term>
<term>Techniques in vitro</term>
<term>Transport biologique</term>
<term>Électrophysiologie</term>
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<term>Proteins</term>
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<term>Membranes, Artificial</term>
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<term>Fascia</term>
<term>Lymph</term>
<term>Lymphedema</term>
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<term>Lymphe</term>
<term>Lymphoedème</term>
<term>Protéines</term>
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<div type="abstract" xml:lang="en">The presence of proteins (albumin and globulins) in lymphedematous tissue not only gives rise to colloidosmotic pressure but also produces an electrostatic charge endowing the proteins with individual features and different migration rates. The working hypothesis of the experimental study is to transfer lymph proteins from the upper fascia accumulation area to a subfascial drainage area by subjecting them to an adequate difference in potential. A double chamber, variable volume system with separation wall able to contain a 1 cm square of muscle fascia, was designed and built; the aim of the apparatus was to reproduce the subcutaneus zone separated by the fascia interposition, from the muscle-vascular zone. At the system was applied a variable electric field in six different experiments: 4 using porous synthetic membranes and 2 using human muscle fascia.</div>
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<AbstractText>The presence of proteins (albumin and globulins) in lymphedematous tissue not only gives rise to colloidosmotic pressure but also produces an electrostatic charge endowing the proteins with individual features and different migration rates. The working hypothesis of the experimental study is to transfer lymph proteins from the upper fascia accumulation area to a subfascial drainage area by subjecting them to an adequate difference in potential. A double chamber, variable volume system with separation wall able to contain a 1 cm square of muscle fascia, was designed and built; the aim of the apparatus was to reproduce the subcutaneus zone separated by the fascia interposition, from the muscle-vascular zone. At the system was applied a variable electric field in six different experiments: 4 using porous synthetic membranes and 2 using human muscle fascia.</AbstractText>
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