Postoperative radiotherapy in early stage carcinoma of the uterine cervix: treatment results and prognostic factors.
Identifieur interne : 004593 ( PubMed/Checkpoint ); précédent : 004592; suivant : 004594Postoperative radiotherapy in early stage carcinoma of the uterine cervix: treatment results and prognostic factors.
Auteurs : S A Yeh [Taïwan] ; S. Wan Leung ; C J Wang ; H C ChenSource :
- Gynecologic oncology [ 0090-8258 ] ; 1999.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Adénocarcinome (), Adénocarcinome (anatomopathologie), Adénocarcinome (mortalité), Adénocarcinome (radiothérapie), Analyse multivariée, Carcinome épidermoïde (), Carcinome épidermoïde (anatomopathologie), Carcinome épidermoïde (mortalité), Carcinome épidermoïde (radiothérapie), Femelle, Humains, Métastase tumorale, Pronostic, Radiothérapie (effets indésirables), Radiothérapie adjuvante, Soins postopératoires, Stade de la tumeur, Sujet âgé, Taux de survie, Tumeurs du col de l'utérus (), Tumeurs du col de l'utérus (anatomopathologie), Tumeurs du col de l'utérus (mortalité), Tumeurs du col de l'utérus (radiothérapie).
- MESH :
- anatomopathologie : Adénocarcinome, Carcinome épidermoïde, Tumeurs du col de l'utérus.
- effets indésirables : Radiothérapie.
- mortalité : Adénocarcinome, Carcinome épidermoïde, Tumeurs du col de l'utérus.
- radiothérapie : Adénocarcinome, Carcinome épidermoïde, Tumeurs du col de l'utérus.
- Adulte, Adulte d'âge moyen, Adénocarcinome, Analyse multivariée, Carcinome épidermoïde, Femelle, Humains, Métastase tumorale, Pronostic, Radiothérapie adjuvante, Soins postopératoires, Stade de la tumeur, Sujet âgé, Taux de survie, Tumeurs du col de l'utérus.
English descriptors
- KwdEn :
- Adenocarcinoma (mortality), Adenocarcinoma (pathology), Adenocarcinoma (radiotherapy), Adenocarcinoma (surgery), Adult, Aged, Carcinoma, Squamous Cell (mortality), Carcinoma, Squamous Cell (pathology), Carcinoma, Squamous Cell (radiotherapy), Carcinoma, Squamous Cell (surgery), Female, Humans, Middle Aged, Multivariate Analysis, Neoplasm Metastasis, Neoplasm Staging, Postoperative Care, Prognosis, Radiotherapy (adverse effects), Radiotherapy, Adjuvant, Survival Rate, Uterine Cervical Neoplasms (mortality), Uterine Cervical Neoplasms (pathology), Uterine Cervical Neoplasms (radiotherapy), Uterine Cervical Neoplasms (surgery).
- MESH :
- adverse effects : Radiotherapy.
- mortality : Adenocarcinoma, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- pathology : Adenocarcinoma, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- radiotherapy : Adenocarcinoma, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- surgery : Adenocarcinoma, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- Adult, Aged, Female, Humans, Middle Aged, Multivariate Analysis, Neoplasm Metastasis, Neoplasm Staging, Postoperative Care, Prognosis, Radiotherapy, Adjuvant, Survival Rate.
Abstract
The objective was to investigate the effect of pathologic parameters and other variables on treatment outcome for patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB, IIA cervical carcinoma, as well as to assess the morbidities attributable to radical surgery combined with postoperative radiotherapy.
DOI: 10.1006/gyno.1998.5217
PubMed: 9889023
Affiliations:
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Wan Leung</name></author><author><name sortKey="Wang, C J" sort="Wang, C J" uniqKey="Wang C" first="C J" last="Wang">C J Wang</name></author><author><name sortKey="Chen, H C" sort="Chen, H C" uniqKey="Chen H" first="H C" last="Chen">H C Chen</name></author></analytic><series><title level="j">Gynecologic oncology</title><idno type="ISSN">0090-8258</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (mortality)</term><term>Adenocarcinoma (pathology)</term><term>Adenocarcinoma (radiotherapy)</term><term>Adenocarcinoma (surgery)</term><term>Adult</term><term>Aged</term><term>Carcinoma, Squamous Cell (mortality)</term><term>Carcinoma, Squamous Cell (pathology)</term><term>Carcinoma, Squamous Cell (radiotherapy)</term><term>Carcinoma, Squamous Cell (surgery)</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Neoplasm Metastasis</term><term>Neoplasm Staging</term><term>Postoperative Care</term><term>Prognosis</term><term>Radiotherapy (adverse effects)</term><term>Radiotherapy, Adjuvant</term><term>Survival Rate</term><term>Uterine Cervical Neoplasms (mortality)</term><term>Uterine Cervical Neoplasms (pathology)</term><term>Uterine Cervical Neoplasms (radiotherapy)</term><term>Uterine Cervical Neoplasms (surgery)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Adénocarcinome ()</term><term>Adénocarcinome (anatomopathologie)</term><term>Adénocarcinome (mortalité)</term><term>Adénocarcinome (radiothérapie)</term><term>Analyse multivariée</term><term>Carcinome épidermoïde ()</term><term>Carcinome épidermoïde (anatomopathologie)</term><term>Carcinome épidermoïde (mortalité)</term><term>Carcinome épidermoïde (radiothérapie)</term><term>Femelle</term><term>Humains</term><term>Métastase tumorale</term><term>Pronostic</term><term>Radiothérapie (effets indésirables)</term><term>Radiothérapie adjuvante</term><term>Soins postopératoires</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Taux de survie</term><term>Tumeurs du col de l'utérus ()</term><term>Tumeurs du col de l'utérus (anatomopathologie)</term><term>Tumeurs du col de l'utérus (mortalité)</term><term>Tumeurs du col de l'utérus (radiothérapie)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Radiotherapy</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Adénocarcinome</term><term>Carcinome épidermoïde</term><term>Tumeurs du col de l'utérus</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Radiothérapie</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Adenocarcinoma</term><term>Carcinoma, Squamous Cell</term><term>Uterine Cervical 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xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Neoplasm Metastasis</term><term>Neoplasm Staging</term><term>Postoperative Care</term><term>Prognosis</term><term>Radiotherapy, Adjuvant</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Adénocarcinome</term><term>Analyse multivariée</term><term>Carcinome épidermoïde</term><term>Femelle</term><term>Humains</term><term>Métastase tumorale</term><term>Pronostic</term><term>Radiothérapie adjuvante</term><term>Soins postopératoires</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Taux de survie</term><term>Tumeurs du col de l'utérus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective was to investigate the effect of pathologic parameters and other variables on treatment outcome for patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB, IIA cervical carcinoma, as well as to assess the morbidities attributable to radical surgery combined with postoperative radiotherapy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9889023</PMID><DateCreated><Year>1999</Year><Month>02</Month><Day>22</Day></DateCreated><DateCompleted><Year>1999</Year><Month>02</Month><Day>22</Day></DateCompleted><DateRevised><Year>2010</Year><Month>03</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0090-8258</ISSN><JournalIssue CitedMedium="Print"><Volume>72</Volume><Issue>1</Issue><PubDate><Year>1999</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Gynecologic oncology</Title><ISOAbbreviation>Gynecol. Oncol.</ISOAbbreviation></Journal><ArticleTitle>Postoperative radiotherapy in early stage carcinoma of the uterine cervix: treatment results and prognostic factors.</ArticleTitle><Pagination><MedlinePgn>10-5</MedlinePgn></Pagination><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">The objective was to investigate the effect of pathologic parameters and other variables on treatment outcome for patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB, IIA cervical carcinoma, as well as to assess the morbidities attributable to radical surgery combined with postoperative radiotherapy.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Between January 1980 and June 1994, 179 women with FIGO stage IB, IIA carcinoma of the uterine cervix were treated with radical hysterectomy and postoperative irradiation. The median follow-up of alive patients was 6.8 years. All patients received 44-60 Gy external irradiation. One hundred fifty-nine patients received 3-10 Gy intracavitary brachytherapy. The data were analyzed for overall survival, disease-free survival, pelvic control, and treatment-related complications.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The 5-year overall survival rate, disease-free survival rate, and pelvic control rate for the 179 patients were 72, 74, and 90%, respectively. The 5-year overall survival rate was 81% for patients without pelvic lymphadenopathy and 53% for those with pelvic lymphadenopathy (P = 0.0000). Other independent prognostic factors for overall survival included tumor differentiation and the interval between operation and initiation of radiotherapy. For the endpoint of disease-free survival, pelvic lymph node status, tumor differentiation, the duration of interruption of radiotherapy, and the interval between operation and radiotherapy were of independent prognostic significance. As pelvic control was concerned, the 5-year pelvic control rate was 90% and only the duration of interruption of radiotherapy was noted as an independent predictor of pelvic control. Distant metastases were noted in 43 patients (24%); the most common sites were lung (10%), liver (6%), and bone (6%). The overall 5-year intestinal and urinary complication-free rate was 66 and 82%, respectively. The overall incidence of grade 3 or above late rectal and urinary sequelae was 10%. For patients sustaining leg lymphedema after radiotherapy, there was higher incidence of severe leg cellulitis which warranted antibiotics treatment.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">These prognostic factors should be considered in patient counseling and treatment planning. Based on these factors, a more aggressive treatment to improve survival in these subsets of high-risk patients might be justified. New therapeutic regimens and modalities aimed to overcome treatment failure should be investigated.</AbstractText><CopyrightInformation>Copyright 1999 Academic Press.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yeh</LastName><ForeName>S A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Radiation Oncology, Chang Gung Memorial Hospital-Kaohsiung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wan Leung</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>C J</ForeName><Initials>CJ</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>H C</ForeName><Initials>HC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Gynecol Oncol</MedlineTA><NlmUniqueID>0365304</NlmUniqueID><ISSNLinking>0090-8258</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000230" MajorTopicYN="N">Adenocarcinoma</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002294" MajorTopicYN="N">Carcinoma, Squamous Cell</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009362" MajorTopicYN="N">Neoplasm Metastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009367" MajorTopicYN="N">Neoplasm Staging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011182" MajorTopicYN="N">Postoperative Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011878" MajorTopicYN="N">Radiotherapy</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018714" MajorTopicYN="N">Radiotherapy, Adjuvant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002583" MajorTopicYN="N">Uterine Cervical Neoplasms</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000532" MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>1</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>1</Month><Day>16</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>1</Month><Day>16</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9889023</ArticleId><ArticleId IdType="pii">S0090-8258(98)95217-9</ArticleId><ArticleId IdType="doi">10.1006/gyno.1998.5217</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Chen, H C" sort="Chen, H C" uniqKey="Chen H" first="H C" last="Chen">H C Chen</name><name sortKey="Wan Leung, S" sort="Wan Leung, S" uniqKey="Wan Leung S" first="S" last="Wan Leung">S. Wan Leung</name><name sortKey="Wang, C J" sort="Wang, C J" uniqKey="Wang C" first="C J" last="Wang">C J Wang</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Yeh, S A" sort="Yeh, S A" uniqKey="Yeh S" first="S A" last="Yeh">S A Yeh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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