Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis.
Identifieur interne : 004016 ( PubMed/Checkpoint ); précédent : 004015; suivant : 004017Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis.
Auteurs : Marika J. Karkkainen [Finlande] ; Kari Alitalo [Finlande]Source :
- Seminars in cell & developmental biology [ 1084-9521 ] ; 2002.
Descripteurs français
- KwdFr :
- Agents angiogéniques (métabolisme), Angiopoïétine-2, Animaux, Chylothorax (génétique), Endothélium vasculaire (physiologie), Facteurs de transcription (génétique), Facteurs de transcription Forkhead, Glycoprotéines (métabolisme), Glycoprotéines membranaires (métabolisme), Humains, Intégrines (métabolisme), Ligands, Lymphoedème (génétique), Lymphoedème (physiopathologie), Métastase lymphatique (physiopathologie), Neuropiline 2 (métabolisme), Néovascularisation physiologique, Protéines de liaison à l'ADN (génétique), Protéines du transport vésiculaire, Protéines oncogènes (génétique), Protéines proto-oncogènes c-ets, Protéines suppresseurs de tumeurs, Protéines à homéodomaine (métabolisme), Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme), Récepteurs aux chimiokines (métabolisme), Souris, Souris transgéniques, Système lymphatique (embryologie), Système lymphatique (physiologie).
- MESH :
- embryologie : Système lymphatique.
- génétique : Chylothorax, Facteurs de transcription, Lymphoedème, Protéines de liaison à l'ADN, Protéines oncogènes.
- métabolisme : Agents angiogéniques, Glycoprotéines, Glycoprotéines membranaires, Intégrines, Neuropiline 2, Protéines à homéodomaine, Récepteur-3 au facteur croissance endothéliale vasculaire, Récepteurs aux chimiokines.
- physiologie : Endothélium vasculaire, Système lymphatique.
- physiopathologie : Lymphoedème, Métastase lymphatique.
- Angiopoïétine-2, Animaux, Facteurs de transcription Forkhead, Humains, Ligands, Néovascularisation physiologique, Protéines du transport vésiculaire, Protéines proto-oncogènes c-ets, Protéines suppresseurs de tumeurs, Souris, Souris transgéniques.
English descriptors
- KwdEn :
- Angiogenesis Inducing Agents (metabolism), Angiopoietin-2, Animals, Chylothorax (genetics), DNA-Binding Proteins (genetics), Endothelium, Vascular (physiology), Forkhead Transcription Factors, Glycoproteins (metabolism), Homeodomain Proteins (metabolism), Humans, Integrins (metabolism), Ligands, Lymphatic Metastasis (physiopathology), Lymphatic System (embryology), Lymphatic System (physiology), Lymphedema (genetics), Lymphedema (physiopathology), Membrane Glycoproteins (metabolism), Mice, Mice, Transgenic, Neovascularization, Physiologic, Neuropilin-2 (metabolism), Oncogene Proteins (genetics), Proto-Oncogene Proteins c-ets, Receptors, Chemokine (metabolism), Transcription Factors (genetics), Tumor Suppressor Proteins, Vascular Endothelial Growth Factor Receptor-3 (metabolism), Vesicular Transport Proteins.
- MESH :
- chemical , genetics : DNA-Binding Proteins, Oncogene Proteins, Transcription Factors.
- chemical , metabolism : Angiogenesis Inducing Agents, Glycoproteins, Homeodomain Proteins, Integrins, Membrane Glycoproteins, Neuropilin-2, Receptors, Chemokine, Vascular Endothelial Growth Factor Receptor-3.
- chemical : Angiopoietin-2, Forkhead Transcription Factors, Ligands, Proto-Oncogene Proteins c-ets, Tumor Suppressor Proteins, Vesicular Transport Proteins.
- embryology : Lymphatic System.
- genetics : Chylothorax, Lymphedema.
- physiology : Endothelium, Vascular, Lymphatic System.
- physiopathology : Lymphatic Metastasis, Lymphedema.
- Animals, Humans, Mice, Mice, Transgenic, Neovascularization, Physiologic.
Abstract
Vascular endothelial growth factor receptor-3 (VEGFR-3) mediates lymphatic endothelial cell (LEC) growth, migration, and survival by binding VEGF-C and VEGF-D. Recent studies have revealed new regulators of the lymphatic endothelium, such as the transcription factor Prox1, and the cell surface proteins podoplanin and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1). Furthermore, the isolation of LECs now allows detailed molecular studies of the factors regulating the lymphatic vasculature. These studies are aimed at targeting the lymphatic vasculature in the treatment of various diseases, such as tumour metastasis and lymphoedema.
DOI: 10.1006/scdb.2001.0286
PubMed: 11969367
Affiliations:
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pubmed:11969367Le document en format XML
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Transgenic</term><term>Neovascularization, Physiologic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Angiopoïétine-2</term><term>Animaux</term><term>Facteurs de transcription Forkhead</term><term>Humains</term><term>Ligands</term><term>Néovascularisation physiologique</term><term>Protéines du transport vésiculaire</term><term>Protéines proto-oncogènes c-ets</term><term>Protéines suppresseurs de tumeurs</term><term>Souris</term><term>Souris transgéniques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vascular endothelial growth factor receptor-3 (VEGFR-3) mediates lymphatic endothelial cell (LEC) growth, migration, and survival by binding VEGF-C and VEGF-D. Recent studies have revealed new regulators of the lymphatic endothelium, such as the transcription factor Prox1, and the cell surface proteins podoplanin and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1). Furthermore, the isolation of LECs now allows detailed molecular studies of the factors regulating the lymphatic vasculature. These studies are aimed at targeting the lymphatic vasculature in the treatment of various diseases, such as tumour metastasis and lymphoedema.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11969367</PMID><DateCreated><Year>2002</Year><Month>04</Month><Day>23</Day></DateCreated><DateCompleted><Year>2002</Year><Month>11</Month><Day>27</Day></DateCompleted><DateRevised><Year>2012</Year><Month>03</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1084-9521</ISSN><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>1</Issue><PubDate><Year>2002</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Seminars in cell & developmental biology</Title><ISOAbbreviation>Semin. Cell Dev. Biol.</ISOAbbreviation></Journal><ArticleTitle>Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis.</ArticleTitle><Pagination><MedlinePgn>9-18</MedlinePgn></Pagination><Abstract><AbstractText>Vascular endothelial growth factor receptor-3 (VEGFR-3) mediates lymphatic endothelial cell (LEC) growth, migration, and survival by binding VEGF-C and VEGF-D. Recent studies have revealed new regulators of the lymphatic endothelium, such as the transcription factor Prox1, and the cell surface proteins podoplanin and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1). Furthermore, the isolation of LECs now allows detailed molecular studies of the factors regulating the lymphatic vasculature. These studies are aimed at targeting the lymphatic vasculature in the treatment of various diseases, such as tumour metastasis and lymphoedema.</AbstractText><CopyrightInformation>Copyright 2002 Elsevier Science Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Karkkainen</LastName><ForeName>Marika J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute, Biomedicum Helsinki, Helsinki University Hospital and University of Helsinki, 00014 Helsinki, Finland. 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2.7.10.1</RegistryNumber><NameOfSubstance UI="D040321">Vascular Endothelial Growth Factor Receptor-3</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D043925" MajorTopicYN="N">Angiogenesis Inducing Agents</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042702" MajorTopicYN="N">Angiopoietin-2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002916" MajorTopicYN="N">Chylothorax</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004268" MajorTopicYN="N">DNA-Binding Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004730" MajorTopicYN="N">Endothelium, Vascular</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051858" MajorTopicYN="N">Forkhead Transcription Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006023" MajorTopicYN="N">Glycoproteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018398" MajorTopicYN="N">Homeodomain Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016023" MajorTopicYN="N">Integrins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008024" MajorTopicYN="N">Ligands</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008207" MajorTopicYN="N">Lymphatic Metastasis</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008208" MajorTopicYN="N">Lymphatic System</DescriptorName><QualifierName UI="Q000196" MajorTopicYN="N">embryology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018919" MajorTopicYN="N">Neovascularization, Physiologic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D039943" MajorTopicYN="N">Neuropilin-2</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015513" MajorTopicYN="N">Oncogene Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050783" MajorTopicYN="N">Proto-Oncogene Proteins c-ets</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019707" MajorTopicYN="N">Receptors, Chemokine</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025521" MajorTopicYN="N">Tumor Suppressor Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D040321" MajorTopicYN="N">Vascular Endothelial Growth Factor Receptor-3</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D033921" MajorTopicYN="N">Vesicular Transport Proteins</DescriptorName></MeshHeading></MeshHeadingList><NumberOfReferences>100</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>4</Month><Day>24</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>11</Month><Day>28</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Karkkainen</name></noRegion><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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