Oral infection with chicken anemia virus in 4-wk broiler breeders: lack of effect of major histocompatibility B complex genotype.
Identifieur interne : 003825 ( PubMed/Checkpoint ); précédent : 003824; suivant : 003826Oral infection with chicken anemia virus in 4-wk broiler breeders: lack of effect of major histocompatibility B complex genotype.
Auteurs : K S Joiner [États-Unis] ; S J Ewald ; F J Hoerr ; V L Van Santen ; H. ToroSource :
- Avian diseases [ 0005-2086 ] ; 2005.
Descripteurs français
- KwdFr :
- ADN viral (génétique), ADN viral (isolement et purification), Administration par voie orale, Animaux, Complexe majeur d'histocompatibilité, Génotype, Infections à Circoviridae (génétique), Infections à Circoviridae (immunologie), Infections à Circoviridae (médecine vétérinaire), Infections à Circoviridae (virologie), Maladies de la volaille (anatomopathologie), Maladies de la volaille (génétique), Maladies de la volaille (immunologie), Maladies de la volaille (virologie), Poulets (génétique), Poulets (immunologie), Thymus (glande) (anatomopathologie), Virus de l'anémie du poulet (génétique), Virus de l'anémie du poulet (isolement et purification), Virus de l'anémie du poulet (pathogénicité).
- MESH :
- anatomopathologie : Maladies de la volaille, Thymus (glande).
- génétique : ADN viral, Infections à Circoviridae, Maladies de la volaille, Poulets, Virus de l'anémie du poulet.
- immunologie : Infections à Circoviridae, Maladies de la volaille, Poulets.
- isolement et purification : ADN viral, Virus de l'anémie du poulet.
- médecine vétérinaire : Infections à Circoviridae.
- pathogénicité : Virus de l'anémie du poulet.
- virologie : Infections à Circoviridae, Maladies de la volaille.
- Administration par voie orale, Animaux, Complexe majeur d'histocompatibilité, Génotype.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Chicken anemia virus (genetics), Chicken anemia virus (isolation & purification), Chicken anemia virus (pathogenicity), Chickens (genetics), Chickens (immunology), Circoviridae Infections (genetics), Circoviridae Infections (immunology), Circoviridae Infections (veterinary), Circoviridae Infections (virology), DNA, Viral (genetics), DNA, Viral (isolation & purification), Genotype, Major Histocompatibility Complex, Poultry Diseases (genetics), Poultry Diseases (immunology), Poultry Diseases (pathology), Poultry Diseases (virology), Thymus Gland (pathology).
- MESH :
- chemical , genetics : DNA, Viral.
- genetics : Chicken anemia virus, Chickens, Circoviridae Infections, Poultry Diseases.
- immunology : Chickens, Circoviridae Infections, Poultry Diseases.
- isolation & purification : Chicken anemia virus, DNA, Viral.
- pathogenicity : Chicken anemia virus.
- pathology : Poultry Diseases, Thymus Gland.
- veterinary : Circoviridae Infections.
- virology : Circoviridae Infections, Poultry Diseases.
- Administration, Oral, Animals, Genotype, Major Histocompatibility Complex.
Abstract
The pathologic consequences of chicken anemia virus (CAV) oral inoculation in 4-wk-old broiler breeders of different major histocompatibility B complex (MHC) genotypes were evaluated. MHC B complex was determined by hemagglutination and sequence-based typing. Clinical signs, serology, gross lesions, histopathologic analysis, and CAV genome quantification were used to evaluate disease progression. Clinical disease was not apparent in the inoculated broilers throughout the experimental period. At 14 days postinoculation, antibodies against CAV were detected in 26.4% (29/110) of the inoculated birds. The distribution of percent positive was 34.6% (9/26) and 32.3% (10/31) of the chickens with B A9/A9 and B A9/A4 MHC genotypes, respectively, and seroconversion in six other genotypes was 19% (10/53). These differences among MHC genotypes for specific seroconversion rate were not statistically significant. CAV genomes were detected in the thymus of 87.7% (93/110) of the inoculated birds with no statistically significant differences between MHC genotypes. Mild thymic lymphocytolysis, lymphedema, and medullary hemorrhage were observed in the inoculated chickens. Histomorphometric analysis showed that cortical lymphocyte-to-parenchyma ratios did not differ between inoculated and uninoculated groups or among MHC genotypes. Similar findings have been reported previously in white-leghorn chickens of similar age, suggesting that broilers show a similar resistance to the effects of CAV infection at this age. The absence of significant clinical and pathological changes in the orally inoculated broilers at this age contrasts with CAV-associated thymus damage seen frequently in condemned commercial broilers at harvest.
DOI: 10.1637/7358-031805R.1
PubMed: 16404987
Affiliations:
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MHC B complex was determined by hemagglutination and sequence-based typing. Clinical signs, serology, gross lesions, histopathologic analysis, and CAV genome quantification were used to evaluate disease progression. Clinical disease was not apparent in the inoculated broilers throughout the experimental period. At 14 days postinoculation, antibodies against CAV were detected in 26.4% (29/110) of the inoculated birds. The distribution of percent positive was 34.6% (9/26) and 32.3% (10/31) of the chickens with B A9/A9 and B A9/A4 MHC genotypes, respectively, and seroconversion in six other genotypes was 19% (10/53). These differences among MHC genotypes for specific seroconversion rate were not statistically significant. CAV genomes were detected in the thymus of 87.7% (93/110) of the inoculated birds with no statistically significant differences between MHC genotypes. Mild thymic lymphocytolysis, lymphedema, and medullary hemorrhage were observed in the inoculated chickens. Histomorphometric analysis showed that cortical lymphocyte-to-parenchyma ratios did not differ between inoculated and uninoculated groups or among MHC genotypes. Similar findings have been reported previously in white-leghorn chickens of similar age, suggesting that broilers show a similar resistance to the effects of CAV infection at this age. The absence of significant clinical and pathological changes in the orally inoculated broilers at this age contrasts with CAV-associated thymus damage seen frequently in condemned commercial broilers at harvest.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16404987</PMID><DateCreated><Year>2006</Year><Month>01</Month><Day>12</Day></DateCreated><DateCompleted><Year>2006</Year><Month>02</Month><Day>27</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0005-2086</ISSN><JournalIssue CitedMedium="Print"><Volume>49</Volume><Issue>4</Issue><PubDate><Year>2005</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Avian diseases</Title><ISOAbbreviation>Avian Dis.</ISOAbbreviation></Journal><ArticleTitle>Oral infection with chicken anemia virus in 4-wk broiler breeders: lack of effect of major histocompatibility B complex genotype.</ArticleTitle><Pagination><MedlinePgn>482-7</MedlinePgn></Pagination><Abstract><AbstractText>The pathologic consequences of chicken anemia virus (CAV) oral inoculation in 4-wk-old broiler breeders of different major histocompatibility B complex (MHC) genotypes were evaluated. MHC B complex was determined by hemagglutination and sequence-based typing. Clinical signs, serology, gross lesions, histopathologic analysis, and CAV genome quantification were used to evaluate disease progression. Clinical disease was not apparent in the inoculated broilers throughout the experimental period. At 14 days postinoculation, antibodies against CAV were detected in 26.4% (29/110) of the inoculated birds. The distribution of percent positive was 34.6% (9/26) and 32.3% (10/31) of the chickens with B A9/A9 and B A9/A4 MHC genotypes, respectively, and seroconversion in six other genotypes was 19% (10/53). These differences among MHC genotypes for specific seroconversion rate were not statistically significant. CAV genomes were detected in the thymus of 87.7% (93/110) of the inoculated birds with no statistically significant differences between MHC genotypes. Mild thymic lymphocytolysis, lymphedema, and medullary hemorrhage were observed in the inoculated chickens. Histomorphometric analysis showed that cortical lymphocyte-to-parenchyma ratios did not differ between inoculated and uninoculated groups or among MHC genotypes. Similar findings have been reported previously in white-leghorn chickens of similar age, suggesting that broilers show a similar resistance to the effects of CAV infection at this age. The absence of significant clinical and pathological changes in the orally inoculated broilers at this age contrasts with CAV-associated thymus damage seen frequently in condemned commercial broilers at harvest.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Joiner</LastName><ForeName>K S</ForeName><Initials>KS</Initials><AffiliationInfo><Affiliation>Department of Pathobiology, College of Veterinary Medicine, 264 Greene Hall, Auburn University, AL 36849-5519, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ewald</LastName><ForeName>S J</ForeName><Initials>SJ</Initials></Author><Author ValidYN="Y"><LastName>Hoerr</LastName><ForeName>F J</ForeName><Initials>FJ</Initials></Author><Author ValidYN="Y"><LastName>van Santen</LastName><ForeName>V L</ForeName><Initials>VL</Initials></Author><Author ValidYN="Y"><LastName>Toro</LastName><ForeName>H</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Avian Dis</MedlineTA><NlmUniqueID>0370617</NlmUniqueID><ISSNLinking>0005-2086</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004279">DNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017727" MajorTopicYN="N">Chicken anemia virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002645" MajorTopicYN="N">Chickens</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018173" MajorTopicYN="N">Circoviridae Infections</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004279" MajorTopicYN="N">DNA, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008285" MajorTopicYN="Y">Major Histocompatibility Complex</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011201" MajorTopicYN="N">Poultry Diseases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013950" MajorTopicYN="N">Thymus Gland</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>1</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>2</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>1</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16404987</ArticleId><ArticleId IdType="doi">10.1637/7358-031805R.1</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Alabama</li></region></list><tree><noCountry><name sortKey="Ewald, S J" sort="Ewald, S J" uniqKey="Ewald S" first="S J" last="Ewald">S J Ewald</name><name sortKey="Hoerr, F J" sort="Hoerr, F J" uniqKey="Hoerr F" first="F J" last="Hoerr">F J Hoerr</name><name sortKey="Toro, H" sort="Toro, H" uniqKey="Toro H" first="H" last="Toro">H. Toro</name><name sortKey="Van Santen, V L" sort="Van Santen, V L" uniqKey="Van Santen V" first="V L" last="Van Santen">V L Van Santen</name></noCountry><country name="États-Unis"><region name="Alabama"><name sortKey="Joiner, K S" sort="Joiner, K S" uniqKey="Joiner K" first="K S" last="Joiner">K S Joiner</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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