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Reconstruction following radical resection of recurrent metastatic axillary melanoma.

Identifieur interne : 003520 ( PubMed/Checkpoint ); précédent : 003519; suivant : 003521

Reconstruction following radical resection of recurrent metastatic axillary melanoma.

Auteurs : John Y S. Kim [États-Unis] ; Merrick I. Ross ; Charles E. Butler

Source :

RBID : pubmed:16641728

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English descriptors

Abstract

Recurrent axillary metastasis following axillary lymphadenectomy for melanoma is associated with a poor prognosis. Radical resection of such axillary recurrences with concomitant reconstruction may not only yield significant palliation of symptoms but also improve disease-free survival. The purpose of this study was to evaluate the outcomes of this radical surgical approach and help determine the risks and benefits for this patient population.

DOI: 10.1097/01.prs.0000206305.37147.8d
PubMed: 16641728


Affiliations:


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pubmed:16641728

Le document en format XML

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<title xml:lang="en">Reconstruction following radical resection of recurrent metastatic axillary melanoma.</title>
<author>
<name sortKey="Kim, John Y S" sort="Kim, John Y S" uniqKey="Kim J" first="John Y S" last="Kim">John Y S. Kim</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Plastic Surgery, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Plastic Surgery, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea>
<wicri:noRegion>Texas 77030</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ross, Merrick I" sort="Ross, Merrick I" uniqKey="Ross M" first="Merrick I" last="Ross">Merrick I. Ross</name>
</author>
<author>
<name sortKey="Butler, Charles E" sort="Butler, Charles E" uniqKey="Butler C" first="Charles E" last="Butler">Charles E. Butler</name>
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<title xml:lang="en">Reconstruction following radical resection of recurrent metastatic axillary melanoma.</title>
<author>
<name sortKey="Kim, John Y S" sort="Kim, John Y S" uniqKey="Kim J" first="John Y S" last="Kim">John Y S. Kim</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Plastic Surgery, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Plastic Surgery, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030</wicri:regionArea>
<wicri:noRegion>Texas 77030</wicri:noRegion>
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<author>
<name sortKey="Ross, Merrick I" sort="Ross, Merrick I" uniqKey="Ross M" first="Merrick I" last="Ross">Merrick I. Ross</name>
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<name sortKey="Butler, Charles E" sort="Butler, Charles E" uniqKey="Butler C" first="Charles E" last="Butler">Charles E. Butler</name>
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<series>
<title level="j">Plastic and reconstructive surgery</title>
<idno type="eISSN">1529-4242</idno>
<imprint>
<date when="2006" type="published">2006</date>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Amputation</term>
<term>Arm (surgery)</term>
<term>Axilla</term>
<term>Chemotherapy, Adjuvant</term>
<term>Humans</term>
<term>Lymph Node Excision</term>
<term>Male</term>
<term>Melanoma (secondary)</term>
<term>Melanoma (surgery)</term>
<term>Middle Aged</term>
<term>Neoplasm Recurrence, Local (surgery)</term>
<term>Radiotherapy, Adjuvant</term>
<term>Reconstructive Surgical Procedures</term>
<term>Retrospective Studies</term>
<term>Skin Neoplasms (secondary)</term>
<term>Skin Neoplasms (surgery)</term>
<term>Surgical Mesh</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Aisselle</term>
<term>Amputation chirurgicale</term>
<term>Bras ()</term>
<term>Filet chirurgical</term>
<term>Humains</term>
<term>Lymphadénectomie</term>
<term>Mâle</term>
<term>Mélanome ()</term>
<term>Mélanome (secondaire)</term>
<term>Procédures de chirurgie reconstructive</term>
<term>Radiothérapie adjuvante</term>
<term>Récidive tumorale locale ()</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Traitement médicamenteux adjuvant</term>
<term>Tumeurs cutanées ()</term>
<term>Tumeurs cutanées (secondaire)</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" qualifier="secondaire" xml:lang="fr">
<term>Mélanome</term>
<term>Tumeurs cutanées</term>
</keywords>
<keywords scheme="MESH" qualifier="secondary" xml:lang="en">
<term>Melanoma</term>
<term>Skin Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en">
<term>Arm</term>
<term>Melanoma</term>
<term>Neoplasm Recurrence, Local</term>
<term>Skin Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Amputation</term>
<term>Axilla</term>
<term>Chemotherapy, Adjuvant</term>
<term>Humans</term>
<term>Lymph Node Excision</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Radiotherapy, Adjuvant</term>
<term>Reconstructive Surgical Procedures</term>
<term>Retrospective Studies</term>
<term>Surgical Mesh</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Aisselle</term>
<term>Amputation chirurgicale</term>
<term>Bras</term>
<term>Filet chirurgical</term>
<term>Humains</term>
<term>Lymphadénectomie</term>
<term>Mâle</term>
<term>Mélanome</term>
<term>Procédures de chirurgie reconstructive</term>
<term>Radiothérapie adjuvante</term>
<term>Récidive tumorale locale</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Traitement médicamenteux adjuvant</term>
<term>Tumeurs cutanées</term>
<term>Études rétrospectives</term>
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<front>
<div type="abstract" xml:lang="en">Recurrent axillary metastasis following axillary lymphadenectomy for melanoma is associated with a poor prognosis. Radical resection of such axillary recurrences with concomitant reconstruction may not only yield significant palliation of symptoms but also improve disease-free survival. The purpose of this study was to evaluate the outcomes of this radical surgical approach and help determine the risks and benefits for this patient population.</div>
</front>
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<pubmed>
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<PMID Version="1">16641728</PMID>
<DateCreated>
<Year>2006</Year>
<Month>04</Month>
<Day>27</Day>
</DateCreated>
<DateCompleted>
<Year>2006</Year>
<Month>05</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised>
<Year>2015</Year>
<Month>06</Month>
<Day>24</Day>
</DateRevised>
<Article PubModel="Print">
<Journal>
<ISSN IssnType="Electronic">1529-4242</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>117</Volume>
<Issue>5</Issue>
<PubDate>
<Year>2006</Year>
<Month>Apr</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Plastic and reconstructive surgery</Title>
<ISOAbbreviation>Plast. Reconstr. Surg.</ISOAbbreviation>
</Journal>
<ArticleTitle>Reconstruction following radical resection of recurrent metastatic axillary melanoma.</ArticleTitle>
<Pagination>
<MedlinePgn>1576-83</MedlinePgn>
</Pagination>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Recurrent axillary metastasis following axillary lymphadenectomy for melanoma is associated with a poor prognosis. Radical resection of such axillary recurrences with concomitant reconstruction may not only yield significant palliation of symptoms but also improve disease-free survival. The purpose of this study was to evaluate the outcomes of this radical surgical approach and help determine the risks and benefits for this patient population.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">A retrospective review of all patients who underwent axillary reexcision and reconstruction for metastatic melanoma between 1990 and 2000 was conducted at The University of Texas M. D. Anderson Cancer Center. Nine patients were identified who underwent flap reconstruction following radical excision of axillary recurrence after a previous lymphadenectomy.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 14 flaps were performed on the nine patients (five free flaps and nine pedicled muscle or myocutaneous flaps). Indications for surgery included pain, bleeding, and infection. Seven of the nine patients received perioperative radiation therapy. Palliation of symptoms was achieved in all patients. Free flap survival was 100 percent. Complications occurred in four of nine patients and included seroma, lymphedema, and wound dehiscence. Three patients had second local recurrences necessitating reresection and reconstruction; the mean time to rerecurrence was 6.7 months (range, 2 to 12 months). Four of nine patients were alive with no evidence of disease at the end of the follow-up period, with a mean disease-free interval of 41 months (range, 5 to 77 months). One patient was alive with distant metastasis, and four patients had died of distant metastases. The mean disease-free interval following original lymphedema for the nine patients was 11 months (range, 2 to 40 months).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Aggressive resection of axillary recurrence following lymphadenectomy can palliate symptoms in select individuals and may result in long-term disease-free survival. Critical to this evolving surgical strategy is the use of vascularized soft tissue in the form of pedicled or free flaps to provide durable coverage of the resulting resection defect.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Kim</LastName>
<ForeName>John Y S</ForeName>
<Initials>JY</Initials>
<AffiliationInfo>
<Affiliation>Department of Plastic Surgery, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ross</LastName>
<ForeName>Merrick I</ForeName>
<Initials>MI</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Butler</LastName>
<ForeName>Charles E</ForeName>
<Initials>CE</Initials>
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<Language>eng</Language>
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<Country>United States</Country>
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<ISSNLinking>0032-1052</ISSNLinking>
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<CitationSubset>IM</CitationSubset>
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<DescriptorName UI="D000671" MajorTopicYN="N">Amputation</DescriptorName>
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<DescriptorName UI="D017024" MajorTopicYN="N">Chemotherapy, Adjuvant</DescriptorName>
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<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<DescriptorName UI="D008545" MajorTopicYN="N">Melanoma</DescriptorName>
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<DescriptorName UI="D018714" MajorTopicYN="N">Radiotherapy, Adjuvant</DescriptorName>
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<DescriptorName UI="D019651" MajorTopicYN="Y">Reconstructive Surgical Procedures</DescriptorName>
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<DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
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<DescriptorName UI="D012878" MajorTopicYN="N">Skin Neoplasms</DescriptorName>
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<QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName>
</MeshHeading>
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