Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes.
Identifieur interne : 002C40 ( PubMed/Checkpoint ); précédent : 002C39; suivant : 002C41Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes.
Auteurs : Zakaria Kambris [Royaume-Uni] ; Peter E. Cook ; Hoang K. Phuc ; Steven P. SinkinsSource :
- Science (New York, N.Y.) [ 1095-9203 ] ; 2009.
Descripteurs français
- KwdFr :
- Aedes (génétique), Aedes (immunologie), Aedes (microbiologie), Aedes (parasitologie), Animaux, Brugia pahangi (croissance et développement), Brugia pahangi (physiologie), Filariose lymphatique (), Filariose lymphatique (transmission), Gènes d'insecte, Immunité innée (génétique), Interactions hôte-parasite, Longévité, Lutte contre les moustiques, RT-PCR, Régulation positive, Séquençage par oligonucléotides en batterie, Vecteurs insectes (immunologie), Vecteurs insectes (microbiologie), Vecteurs insectes (parasitologie), Wolbachia (physiologie).
- MESH :
- croissance et développement : Brugia pahangi.
- génétique : Aedes, Immunité innée.
- immunologie : Aedes, Vecteurs insectes.
- microbiologie : Aedes, Vecteurs insectes.
- parasitologie : Aedes, Vecteurs insectes.
- physiologie : Brugia pahangi, Wolbachia.
- Animaux, Filariose lymphatique, Gènes d'insecte, Interactions hôte-parasite, Longévité, Lutte contre les moustiques, RT-PCR, Régulation positive, Séquençage par oligonucléotides en batterie.
English descriptors
- KwdEn :
- Aedes (genetics), Aedes (immunology), Aedes (microbiology), Aedes (parasitology), Animals, Brugia pahangi (growth & development), Brugia pahangi (physiology), Elephantiasis, Filarial (prevention & control), Elephantiasis, Filarial (transmission), Genes, Insect, Host-Parasite Interactions, Immunity, Innate (genetics), Insect Vectors (immunology), Insect Vectors (microbiology), Insect Vectors (parasitology), Longevity, Mosquito Control, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Up-Regulation, Wolbachia (physiology).
- MESH :
- genetics : Aedes, Immunity, Innate.
- growth & development : Brugia pahangi.
- immunology : Aedes, Insect Vectors.
- microbiology : Aedes, Insect Vectors.
- parasitology : Aedes, Insect Vectors.
- physiology : Brugia pahangi, Wolbachia.
- prevention & control : Elephantiasis, Filarial.
- transmission : Elephantiasis, Filarial.
- Animals, Genes, Insect, Host-Parasite Interactions, Longevity, Mosquito Control, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Up-Regulation.
Abstract
Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito's innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype.
DOI: 10.1126/science.1177531
PubMed: 19797660
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:19797660Le document en format XML
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<front><div type="abstract" xml:lang="en">Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito's innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype.</div>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Insect Mol Biol. 2000 Dec;9(6):635-9</RefSource>
<PMID Version="1">11122472</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2009 May;5(5):e1000423</RefSource>
<PMID Version="1">19424427</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Med Entomol. 2003 Mar;40(2):125-32</RefSource>
<PMID Version="1">12693838</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Invertebr Pathol. 2003 Sep;84(1):24-9</RefSource>
<PMID Version="1">13678709</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell. 2004 Mar 5;116(5):661-70</RefSource>
<PMID Version="1">15006349</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Med Entomol. 2004 May;41(3):447-55</RefSource>
<PMID Version="1">15185949</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Trop Med Parasitol. 1982 Jun;76(3):347-54</RefSource>
<PMID Version="1">6751252</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Infect Immun. 1989 Sep;57(9):2628-33</RefSource>
<PMID Version="1">2759705</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Parasitol. 1995 May;80(3):401-6</RefSource>
<PMID Version="1">7729475</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Parasitol. 1996 Jul;83(2):191-201</RefSource>
<PMID Version="1">8682188</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10792-6</RefSource>
<PMID Version="1">9380712</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Gen Virol. 1998 Apr;79 ( Pt 4):731-40</RefSource>
<PMID Version="1">9568968</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2005 May 17;102(20):7257-62</RefSource>
<PMID Version="1">15878994</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11420-5</RefSource>
<PMID Version="1">16076953</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunity. 2006 Oct;25(4):677-85</RefSource>
<PMID Version="1">17045818</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Aging Cell. 2006 Dec;5(6):533-43</RefSource>
<PMID Version="1">17129215</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Adv Exp Med Biol. 2008;627:126-40</RefSource>
<PMID Version="1">18510020</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2008 Jul;4(7):e1000098</RefSource>
<PMID Version="1">18604274</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Mol Life Sci. 2008 Oct;65(19):3081-92</RefSource>
<PMID Version="1">18726072</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2008 Oct 31;322(5902):702</RefSource>
<PMID Version="1">18974344</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2009 Jan 2;323(5910):141-4</RefSource>
<PMID Version="1">19119237</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Biol. 2008 Dec 23;6(12):e2</RefSource>
<PMID Version="1">19222304</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2009 Mar;5(3):e1000335</RefSource>
<PMID Version="1">19282971</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cell Host Microbe. 2009 Mar 19;5(3):273-84</RefSource>
<PMID Version="1">19286136</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2009 Apr 10;324(5924):258-61</RefSource>
<PMID Version="1">19264986</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Trop Med Parasitol. 2002 Dec;96 Suppl 2:S61-9</RefSource>
<PMID Version="1">12625919</PMID>
</CommentsCorrections>
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<name sortKey="Phuc, Hoang K" sort="Phuc, Hoang K" uniqKey="Phuc H" first="Hoang K" last="Phuc">Hoang K. Phuc</name>
<name sortKey="Sinkins, Steven P" sort="Sinkins, Steven P" uniqKey="Sinkins S" first="Steven P" last="Sinkins">Steven P. Sinkins</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kambris, Zakaria" sort="Kambris, Zakaria" uniqKey="Kambris Z" first="Zakaria" last="Kambris">Zakaria Kambris</name>
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