LymphedemaV1, PubMed, Checkpoint, bibRecord, 002C40

Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes.

Identifieur interne : 002C40 ( PubMed/Checkpoint ); précédent : 002C39; suivant : 002C41

Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes.

Auteurs : Zakaria Kambris [Royaume-Uni] ; Peter E. Cook ; Hoang K. Phuc ; Steven P. Sinkins

Source :

Science (New York, N.Y.) [ 1095-9203 ] ; 2009.

RBID : pubmed:19797660

Descripteurs français

KwdFr :
- Aedes (génétique), Aedes (immunologie), Aedes (microbiologie), Aedes (parasitologie), Animaux, Brugia pahangi (croissance et développement), Brugia pahangi (physiologie), Filariose lymphatique (), Filariose lymphatique (transmission), Gènes d'insecte, Immunité innée (génétique), Interactions hôte-parasite, Longévité, Lutte contre les moustiques, RT-PCR, Régulation positive, Séquençage par oligonucléotides en batterie, Vecteurs insectes (immunologie), Vecteurs insectes (microbiologie), Vecteurs insectes (parasitologie), Wolbachia (physiologie).
MESH :
- croissance et développement : Brugia pahangi.
- génétique : Aedes, Immunité innée.
- immunologie : Aedes, Vecteurs insectes.
- microbiologie : Aedes, Vecteurs insectes.
- parasitologie : Aedes, Vecteurs insectes.
- physiologie : Brugia pahangi, Wolbachia.
- Animaux, Filariose lymphatique, Gènes d'insecte, Interactions hôte-parasite, Longévité, Lutte contre les moustiques, RT-PCR, Régulation positive, Séquençage par oligonucléotides en batterie.

English descriptors

KwdEn :
- Aedes (genetics), Aedes (immunology), Aedes (microbiology), Aedes (parasitology), Animals, Brugia pahangi (growth & development), Brugia pahangi (physiology), Elephantiasis, Filarial (prevention & control), Elephantiasis, Filarial (transmission), Genes, Insect, Host-Parasite Interactions, Immunity, Innate (genetics), Insect Vectors (immunology), Insect Vectors (microbiology), Insect Vectors (parasitology), Longevity, Mosquito Control, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Up-Regulation, Wolbachia (physiology).
MESH :
- genetics : Aedes, Immunity, Innate.
- growth & development : Brugia pahangi.
- immunology : Aedes, Insect Vectors.
- microbiology : Aedes, Insect Vectors.
- parasitology : Aedes, Insect Vectors.
- physiology : Brugia pahangi, Wolbachia.
- prevention & control : Elephantiasis, Filarial.
- transmission : Elephantiasis, Filarial.
- Animals, Genes, Insect, Host-Parasite Interactions, Longevity, Mosquito Control, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Up-Regulation.

Abstract

Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito's innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype.

DOI: 10.1126/science.1177531
PubMed: 19797660

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002D30
to stream PubMed, to step Curation: 002D30

Links to Exploration step

pubmed:19797660

Le document en format XML

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<front><div type="abstract" xml:lang="en">Wolbachia strain wMelPop reduces the longevity of its Drosophila melanogaster host and, when introduced into the mosquito Aedes aegypti, halves its life span. We show that wMelPop induces up-regulation of the mosquito's innate immune system and that its presence inhibits the development of filarial nematodes in the mosquito. These data suggest that wMelPop could be used in the global effort to eliminate lymphatic filariasis and possibly for the control of other mosquito-borne parasites where immune preactivation inhibits their development. The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype.</div>
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<tree><noCountry><name sortKey="Cook, Peter E" sort="Cook, Peter E" uniqKey="Cook P" first="Peter E" last="Cook">Peter E. Cook</name>
<name sortKey="Phuc, Hoang K" sort="Phuc, Hoang K" uniqKey="Phuc H" first="Hoang K" last="Phuc">Hoang K. Phuc</name>
<name sortKey="Sinkins, Steven P" sort="Sinkins, Steven P" uniqKey="Sinkins S" first="Steven P" last="Sinkins">Steven P. Sinkins</name>
</noCountry>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kambris, Zakaria" sort="Kambris, Zakaria" uniqKey="Kambris Z" first="Zakaria" last="Kambris">Zakaria Kambris</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/PubMed/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002C40 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 002C40 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:19797660
   |texte=   Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:19797660" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes.

Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes.

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Abstract

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Le document en format XML

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Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki