Interruption of annual single dose DEC regimen administration: impact on Wuchereria bancrofti microfilaraemia, vector infection and infectivity rates.
Identifieur interne : 002C32 ( PubMed/Checkpoint ); précédent : 002C31; suivant : 002C33Interruption of annual single dose DEC regimen administration: impact on Wuchereria bancrofti microfilaraemia, vector infection and infectivity rates.
Auteurs : Vandana Dixit [Inde] ; A K Gupta ; G B K S. PrasadSource :
- The Journal of communicable diseases [ 0019-5138 ] ; 2009.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Calendrier d'administration des médicaments, Culex (), Culex (parasitologie), Diéthylcarbamazine (administration et posologie), Enfant, Enfant d'âge préscolaire, Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Humains, Maladies endémiques, Microfilaria (), Résultat thérapeutique, Vecteurs insectes (), Vecteurs insectes (parasitologie), Virulence, Wuchereria bancrofti (), Wuchereria bancrofti (pathogénicité).
- MESH :
- administration et posologie : Diéthylcarbamazine.
- parasitologie : Culex, Filariose lymphatique, Vecteurs insectes.
- pathogénicité : Wuchereria bancrofti.
- traitement médicamenteux : Filariose lymphatique.
- épidémiologie : Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Calendrier d'administration des médicaments, Culex, Enfant, Enfant d'âge préscolaire, Humains, Maladies endémiques, Microfilaria, Résultat thérapeutique, Vecteurs insectes, Virulence, Wuchereria bancrofti.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Child, Child, Preschool, Culex (drug effects), Culex (parasitology), Diethylcarbamazine (administration & dosage), Drug Administration Schedule, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (parasitology), Endemic Diseases, Humans, Insect Vectors (drug effects), Insect Vectors (parasitology), Microfilariae (drug effects), Middle Aged, Treatment Outcome, Virulence, Wuchereria bancrofti (drug effects), Wuchereria bancrofti (pathogenicity).
- MESH :
- chemical , administration & dosage : Diethylcarbamazine.
- drug effects : Culex, Insect Vectors, Microfilariae, Wuchereria bancrofti.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- parasitology : Culex, Elephantiasis, Filarial, Insect Vectors.
- pathogenicity : Wuchereria bancrofti.
- Adolescent, Adult, Animals, Child, Child, Preschool, Drug Administration Schedule, Endemic Diseases, Humans, Middle Aged, Treatment Outcome, Virulence.
Abstract
The effect of single dose diethylcarbamazine regimen (6 mg/kg body wt.) in comparison to standard DEC regimen i.e; 72 mg/kg body wt (administered in 12 consecutive days) in clearing Wuchereria bancrofti microfilariae from low density micro filariae carriers (1- 8 mf per 20 microl) and its impact on vector infection rate were studied in an urban region endemic for bancroftian filariasis. The efficacy of DEC regimens were determined by assessing the rate of successful treatment, percentage cure rate and percentage decrease in microfilariae count in treated subjects. The 12 days regimen was found very effective with 100% cure rate even after 4 years of drug therapy. In subjects, who received single dose DEC regimen, the rate of successful treatment, cure rate and percent decrease in micro filariae count was significantly low when assessed 24 hour after therapy. Reexamination of subjects in this group at 6,12, 24 and 48 months after therapy showed a sharp decline in all therapeutic indices and the microfilariae count reached pretreatment levels by 4th year of drug therapy. The single dose regimen had a marginal impact on vector infection and infectivity rates in Culex quinquefasciatus. A marked increase of vector infection and infectivity rates in parallel to human microfilaraemia rate was recorded from the same households when examined after 4th yr after therapy. Thus the single dose 6 mg/kg body wt. DEC regimen (administered only once) failed to clear microfilariae even in a situation of filarial low endemicity and did not influence the transmission potential of C. quinquefasciatus.
PubMed: 19886172
Affiliations:
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<front><div type="abstract" xml:lang="en">The effect of single dose diethylcarbamazine regimen (6 mg/kg body wt.) in comparison to standard DEC regimen i.e; 72 mg/kg body wt (administered in 12 consecutive days) in clearing Wuchereria bancrofti microfilariae from low density micro filariae carriers (1- 8 mf per 20 microl) and its impact on vector infection rate were studied in an urban region endemic for bancroftian filariasis. The efficacy of DEC regimens were determined by assessing the rate of successful treatment, percentage cure rate and percentage decrease in microfilariae count in treated subjects. The 12 days regimen was found very effective with 100% cure rate even after 4 years of drug therapy. In subjects, who received single dose DEC regimen, the rate of successful treatment, cure rate and percent decrease in micro filariae count was significantly low when assessed 24 hour after therapy. Reexamination of subjects in this group at 6,12, 24 and 48 months after therapy showed a sharp decline in all therapeutic indices and the microfilariae count reached pretreatment levels by 4th year of drug therapy. The single dose regimen had a marginal impact on vector infection and infectivity rates in Culex quinquefasciatus. A marked increase of vector infection and infectivity rates in parallel to human microfilaraemia rate was recorded from the same households when examined after 4th yr after therapy. Thus the single dose 6 mg/kg body wt. DEC regimen (administered only once) failed to clear microfilariae even in a situation of filarial low endemicity and did not influence the transmission potential of C. quinquefasciatus.</div>
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<Abstract><AbstractText>The effect of single dose diethylcarbamazine regimen (6 mg/kg body wt.) in comparison to standard DEC regimen i.e; 72 mg/kg body wt (administered in 12 consecutive days) in clearing Wuchereria bancrofti microfilariae from low density micro filariae carriers (1- 8 mf per 20 microl) and its impact on vector infection rate were studied in an urban region endemic for bancroftian filariasis. The efficacy of DEC regimens were determined by assessing the rate of successful treatment, percentage cure rate and percentage decrease in microfilariae count in treated subjects. The 12 days regimen was found very effective with 100% cure rate even after 4 years of drug therapy. In subjects, who received single dose DEC regimen, the rate of successful treatment, cure rate and percent decrease in micro filariae count was significantly low when assessed 24 hour after therapy. Reexamination of subjects in this group at 6,12, 24 and 48 months after therapy showed a sharp decline in all therapeutic indices and the microfilariae count reached pretreatment levels by 4th year of drug therapy. The single dose regimen had a marginal impact on vector infection and infectivity rates in Culex quinquefasciatus. A marked increase of vector infection and infectivity rates in parallel to human microfilaraemia rate was recorded from the same households when examined after 4th yr after therapy. Thus the single dose 6 mg/kg body wt. DEC regimen (administered only once) failed to clear microfilariae even in a situation of filarial low endemicity and did not influence the transmission potential of C. quinquefasciatus.</AbstractText>
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